Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVL2_LEIMU

TriTrypDb:

LmxM.22.0280

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.444
CLV_C14_Caspase3-7	532	536	PF00656	0.551
CLV_C14_Caspase3-7	542	546	PF00656	0.457
CLV_C14_Caspase3-7	579	583	PF00656	0.447
CLV_C14_Caspase3-7	722	726	PF00656	0.508
CLV_C14_Caspase3-7	811	815	PF00656	0.644
CLV_C14_Caspase3-7	827	831	PF00656	0.497
CLV_NRD_NRD_1	146	148	PF00675	0.356
CLV_NRD_NRD_1	35	37	PF00675	0.531
CLV_NRD_NRD_1	391	393	PF00675	0.572
CLV_NRD_NRD_1	58	60	PF00675	0.639
CLV_NRD_NRD_1	651	653	PF00675	0.675
CLV_NRD_NRD_1	660	662	PF00675	0.521
CLV_NRD_NRD_1	664	666	PF00675	0.423
CLV_NRD_NRD_1	797	799	PF00675	0.722
CLV_PCSK_FUR_1	649	653	PF00082	0.557
CLV_PCSK_FUR_1	670	674	PF00082	0.394
CLV_PCSK_KEX2_1	146	148	PF00082	0.356
CLV_PCSK_KEX2_1	232	234	PF00082	0.421
CLV_PCSK_KEX2_1	35	37	PF00082	0.476
CLV_PCSK_KEX2_1	58	60	PF00082	0.639
CLV_PCSK_KEX2_1	649	651	PF00082	0.702
CLV_PCSK_KEX2_1	660	662	PF00082	0.507
CLV_PCSK_KEX2_1	664	666	PF00082	0.396
CLV_PCSK_KEX2_1	672	674	PF00082	0.434
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.371
CLV_PCSK_PC1ET2_1	672	674	PF00082	0.341
CLV_PCSK_PC7_1	660	666	PF00082	0.377
CLV_PCSK_SKI1_1	102	106	PF00082	0.388
CLV_PCSK_SKI1_1	108	112	PF00082	0.372
CLV_PCSK_SKI1_1	232	236	PF00082	0.367
CLV_PCSK_SKI1_1	329	333	PF00082	0.527
CLV_PCSK_SKI1_1	392	396	PF00082	0.443
CLV_PCSK_SKI1_1	609	613	PF00082	0.563
CLV_PCSK_SKI1_1	61	65	PF00082	0.553
CLV_PCSK_SKI1_1	642	646	PF00082	0.534
CLV_PCSK_SKI1_1	665	669	PF00082	0.431
CLV_PCSK_SKI1_1	672	676	PF00082	0.414
CLV_PCSK_SKI1_1	737	741	PF00082	0.512
DEG_APCC_DBOX_1	736	744	PF00400	0.474
DEG_SPOP_SBC_1	538	542	PF00917	0.631
DOC_AGCK_PIF_2	675	680	PF00069	0.371
DOC_CKS1_1	565	570	PF01111	0.418
DOC_CYCLIN_RxL_1	102	114	PF00134	0.543
DOC_CYCLIN_RxL_1	56	68	PF00134	0.482
DOC_CYCLIN_RxL_1	669	679	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.526
DOC_MAPK_DCC_7	221	231	PF00069	0.389
DOC_MAPK_DCC_7	355	364	PF00069	0.525
DOC_MAPK_gen_1	355	364	PF00069	0.469
DOC_MAPK_gen_1	454	463	PF00069	0.434
DOC_MAPK_gen_1	58	65	PF00069	0.662
DOC_MAPK_RevD_3	636	650	PF00069	0.309
DOC_PP2B_LxvP_1	788	791	PF13499	0.650
DOC_USP7_MATH_1	280	284	PF00917	0.498
DOC_USP7_MATH_1	311	315	PF00917	0.441
DOC_USP7_MATH_1	546	550	PF00917	0.402
DOC_USP7_MATH_1	640	644	PF00917	0.563
DOC_USP7_MATH_1	742	746	PF00917	0.605
DOC_USP7_MATH_1	8	12	PF00917	0.663
DOC_USP7_UBL2_3	672	676	PF12436	0.371
DOC_WW_Pin1_4	207	212	PF00397	0.459
DOC_WW_Pin1_4	224	229	PF00397	0.544
DOC_WW_Pin1_4	257	262	PF00397	0.600
DOC_WW_Pin1_4	26	31	PF00397	0.781
DOC_WW_Pin1_4	345	350	PF00397	0.450
DOC_WW_Pin1_4	44	49	PF00397	0.657
DOC_WW_Pin1_4	485	490	PF00397	0.383
DOC_WW_Pin1_4	564	569	PF00397	0.406
DOC_WW_Pin1_4	603	608	PF00397	0.596
DOC_WW_Pin1_4	692	697	PF00397	0.482
DOC_WW_Pin1_4	837	842	PF00397	0.603
LIG_14-3-3_CanoR_1	102	107	PF00244	0.421
LIG_14-3-3_CanoR_1	174	181	PF00244	0.305
LIG_14-3-3_CanoR_1	221	226	PF00244	0.398
LIG_14-3-3_CanoR_1	369	378	PF00244	0.598
LIG_14-3-3_CanoR_1	71	81	PF00244	0.635
LIG_14-3-3_CanoR_1	86	91	PF00244	0.586
LIG_Actin_WH2_2	432	448	PF00022	0.432
LIG_Actin_WH2_2	725	743	PF00022	0.472
LIG_AP2alpha_2	803	805	PF02296	0.638
LIG_BIR_III_2	374	378	PF00653	0.476
LIG_BIR_III_2	535	539	PF00653	0.541
LIG_BIR_III_2	628	632	PF00653	0.462
LIG_BRCT_BRCA1_1	202	206	PF00533	0.475
LIG_BRCT_BRCA1_1	554	558	PF00533	0.499
LIG_BRCT_BRCA1_1	83	87	PF00533	0.602
LIG_deltaCOP1_diTrp_1	819	824	PF00928	0.560
LIG_FHA_1	112	118	PF00498	0.470
LIG_FHA_1	178	184	PF00498	0.462
LIG_FHA_1	208	214	PF00498	0.564
LIG_FHA_1	393	399	PF00498	0.493
LIG_FHA_1	485	491	PF00498	0.396
LIG_FHA_1	551	557	PF00498	0.442
LIG_FHA_1	565	571	PF00498	0.329
LIG_FHA_1	727	733	PF00498	0.525
LIG_FHA_1	795	801	PF00498	0.699
LIG_FHA_2	18	24	PF00498	0.441
LIG_FHA_2	210	216	PF00498	0.467
LIG_FHA_2	540	546	PF00498	0.480
LIG_FHA_2	577	583	PF00498	0.544
LIG_LIR_Apic_2	240	246	PF02991	0.428
LIG_LIR_Apic_2	295	300	PF02991	0.354
LIG_LIR_Gen_1	11	21	PF02991	0.565
LIG_LIR_Gen_1	150	158	PF02991	0.426
LIG_LIR_Gen_1	248	258	PF02991	0.511
LIG_LIR_Gen_1	511	520	PF02991	0.455
LIG_LIR_Gen_1	803	813	PF02991	0.678
LIG_LIR_Gen_1	84	95	PF02991	0.425
LIG_LIR_LC3C_4	132	136	PF02991	0.326
LIG_LIR_Nem_3	100	106	PF02991	0.421
LIG_LIR_Nem_3	11	17	PF02991	0.565
LIG_LIR_Nem_3	150	155	PF02991	0.491
LIG_LIR_Nem_3	248	253	PF02991	0.460
LIG_LIR_Nem_3	434	440	PF02991	0.540
LIG_LIR_Nem_3	511	516	PF02991	0.456
LIG_LIR_Nem_3	527	531	PF02991	0.487
LIG_LIR_Nem_3	666	671	PF02991	0.370
LIG_LIR_Nem_3	679	683	PF02991	0.416
LIG_LIR_Nem_3	803	808	PF02991	0.656
LIG_LIR_Nem_3	84	90	PF02991	0.460
LIG_MLH1_MIPbox_1	554	558	PF16413	0.499
LIG_NRBOX	106	112	PF00104	0.445
LIG_Pex14_2	714	718	PF04695	0.248
LIG_PTB_Apo_2	799	806	PF02174	0.677
LIG_REV1ctd_RIR_1	555	564	PF16727	0.524
LIG_REV1ctd_RIR_1	665	674	PF16727	0.360
LIG_SH2_CRK	14	18	PF00017	0.567
LIG_SH2_CRK	297	301	PF00017	0.463
LIG_SH2_CRK	671	675	PF00017	0.354
LIG_SH2_CRK	683	687	PF00017	0.419
LIG_SH2_NCK_1	238	242	PF00017	0.363
LIG_SH2_PTP2	250	253	PF00017	0.320
LIG_SH2_PTP2	773	776	PF00017	0.554
LIG_SH2_SRC	238	241	PF00017	0.442
LIG_SH2_STAP1	238	242	PF00017	0.363
LIG_SH2_STAP1	371	375	PF00017	0.517
LIG_SH2_STAP1	678	682	PF00017	0.502
LIG_SH2_STAP1	683	687	PF00017	0.530
LIG_SH2_STAT5	106	109	PF00017	0.445
LIG_SH2_STAT5	16	19	PF00017	0.435
LIG_SH2_STAT5	250	253	PF00017	0.320
LIG_SH2_STAT5	303	306	PF00017	0.389
LIG_SH2_STAT5	371	374	PF00017	0.541
LIG_SH2_STAT5	566	569	PF00017	0.457
LIG_SH2_STAT5	680	683	PF00017	0.516
LIG_SH2_STAT5	773	776	PF00017	0.422
LIG_SH3_1	798	804	PF00018	0.697
LIG_SH3_2	30	35	PF14604	0.462
LIG_SH3_2	607	612	PF14604	0.589
LIG_SH3_3	152	158	PF00018	0.479
LIG_SH3_3	267	273	PF00018	0.593
LIG_SH3_3	27	33	PF00018	0.768
LIG_SH3_3	503	509	PF00018	0.404
LIG_SH3_3	562	568	PF00018	0.299
LIG_SH3_3	594	600	PF00018	0.729
LIG_SH3_3	604	610	PF00018	0.543
LIG_SH3_3	629	635	PF00018	0.416
LIG_SH3_3	691	697	PF00018	0.551
LIG_SH3_3	798	804	PF00018	0.697
LIG_SUMO_SIM_anti_2	448	453	PF11976	0.376
LIG_SUMO_SIM_par_1	448	453	PF11976	0.432
LIG_SUMO_SIM_par_1	634	639	PF11976	0.459
LIG_TRAF2_1	530	533	PF00917	0.511
LIG_TRAF2_1	571	574	PF00917	0.521
LIG_TRAF2_2	336	341	PF00917	0.464
LIG_TYR_ITIM	12	17	PF00017	0.504
LIG_WRC_WIRS_1	16	21	PF05994	0.434
LIG_WRC_WIRS_1	547	552	PF05994	0.485
MOD_CDK_SPK_2	564	569	PF00069	0.470
MOD_CDK_SPxK_1	603	609	PF00069	0.514
MOD_CDK_SPxxK_3	485	492	PF00069	0.505
MOD_CK1_1	207	213	PF00069	0.500
MOD_CK1_1	224	230	PF00069	0.363
MOD_CK1_1	380	386	PF00069	0.384
MOD_CK1_1	47	53	PF00069	0.536
MOD_CK1_1	481	487	PF00069	0.417
MOD_CK1_1	719	725	PF00069	0.512
MOD_CK2_1	209	215	PF00069	0.461
MOD_CK2_1	546	552	PF00069	0.355
MOD_CK2_1	615	621	PF00069	0.510
MOD_Cter_Amidation	390	393	PF01082	0.434
MOD_DYRK1A_RPxSP_1	564	568	PF00069	0.273
MOD_GlcNHglycan	207	210	PF01048	0.602
MOD_GlcNHglycan	289	292	PF01048	0.531
MOD_GlcNHglycan	313	316	PF01048	0.501
MOD_GlcNHglycan	642	645	PF01048	0.542
MOD_GlcNHglycan	67	70	PF01048	0.653
MOD_GlcNHglycan	721	724	PF01048	0.474
MOD_GlcNHglycan	783	786	PF01048	0.690
MOD_GlcNHglycan	792	795	PF01048	0.592
MOD_GlcNHglycan	96	99	PF01048	0.549
MOD_GSK3_1	102	109	PF00069	0.516
MOD_GSK3_1	117	124	PF00069	0.352
MOD_GSK3_1	168	175	PF00069	0.469
MOD_GSK3_1	195	202	PF00069	0.587
MOD_GSK3_1	205	212	PF00069	0.486
MOD_GSK3_1	22	29	PF00069	0.683
MOD_GSK3_1	253	260	PF00069	0.525
MOD_GSK3_1	307	314	PF00069	0.531
MOD_GSK3_1	40	47	PF00069	0.614
MOD_GSK3_1	474	481	PF00069	0.463
MOD_GSK3_1	546	553	PF00069	0.498
MOD_GSK3_1	717	724	PF00069	0.574
MOD_GSK3_1	777	784	PF00069	0.598
MOD_GSK3_1	790	797	PF00069	0.679
MOD_GSK3_1	86	93	PF00069	0.675
MOD_N-GLC_1	311	316	PF02516	0.458
MOD_N-GLC_1	764	769	PF02516	0.518
MOD_NEK2_1	110	115	PF00069	0.457
MOD_NEK2_1	195	200	PF00069	0.454
MOD_NEK2_1	204	209	PF00069	0.383
MOD_NEK2_1	253	258	PF00069	0.627
MOD_NEK2_1	287	292	PF00069	0.462
MOD_NEK2_1	313	318	PF00069	0.439
MOD_NEK2_1	445	450	PF00069	0.416
MOD_NEK2_1	463	468	PF00069	0.250
MOD_NEK2_1	524	529	PF00069	0.493
MOD_NEK2_1	550	555	PF00069	0.487
MOD_NEK2_1	65	70	PF00069	0.574
MOD_NEK2_1	766	771	PF00069	0.522
MOD_NEK2_1	81	86	PF00069	0.545
MOD_NEK2_2	40	45	PF00069	0.449
MOD_PIKK_1	195	201	PF00454	0.484
MOD_PIKK_1	292	298	PF00454	0.443
MOD_PK_1	86	92	PF00069	0.564
MOD_PKA_1	392	398	PF00069	0.438
MOD_PKA_2	111	117	PF00069	0.410
MOD_PKA_2	173	179	PF00069	0.274
MOD_PKA_2	253	259	PF00069	0.466
MOD_PKA_2	445	451	PF00069	0.388
MOD_PKA_2	703	709	PF00069	0.596
MOD_PKA_2	90	96	PF00069	0.628
MOD_Plk_1	463	469	PF00069	0.412
MOD_Plk_2-3	321	327	PF00069	0.472
MOD_Plk_2-3	807	813	PF00069	0.569
MOD_Plk_4	121	127	PF00069	0.624
MOD_Plk_4	168	174	PF00069	0.310
MOD_Plk_4	245	251	PF00069	0.450
MOD_Plk_4	299	305	PF00069	0.350
MOD_Plk_4	313	319	PF00069	0.419
MOD_Plk_4	385	391	PF00069	0.428
MOD_Plk_4	445	451	PF00069	0.388
MOD_Plk_4	546	552	PF00069	0.368
MOD_Plk_4	766	772	PF00069	0.542
MOD_ProDKin_1	207	213	PF00069	0.450
MOD_ProDKin_1	224	230	PF00069	0.546
MOD_ProDKin_1	257	263	PF00069	0.603
MOD_ProDKin_1	26	32	PF00069	0.781
MOD_ProDKin_1	345	351	PF00069	0.447
MOD_ProDKin_1	44	50	PF00069	0.657
MOD_ProDKin_1	485	491	PF00069	0.377
MOD_ProDKin_1	564	570	PF00069	0.410
MOD_ProDKin_1	603	609	PF00069	0.600
MOD_ProDKin_1	692	698	PF00069	0.494
MOD_ProDKin_1	837	843	PF00069	0.606
MOD_SUMO_rev_2	171	181	PF00179	0.377
MOD_SUMO_rev_2	810	818	PF00179	0.652
MOD_SUMO_rev_2	826	836	PF00179	0.498
TRG_DiLeu_BaEn_2	620	626	PF01217	0.388
TRG_DiLeu_BaEn_4	532	538	PF01217	0.414
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.471
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.520
TRG_ENDOCYTIC_2	14	17	PF00928	0.568
TRG_ENDOCYTIC_2	238	241	PF00928	0.456
TRG_ENDOCYTIC_2	244	247	PF00928	0.496
TRG_ENDOCYTIC_2	250	253	PF00928	0.466
TRG_ENDOCYTIC_2	437	440	PF00928	0.559
TRG_ENDOCYTIC_2	513	516	PF00928	0.455
TRG_ENDOCYTIC_2	528	531	PF00928	0.333
TRG_ENDOCYTIC_2	671	674	PF00928	0.398
TRG_ENDOCYTIC_2	678	681	PF00928	0.369
TRG_ENDOCYTIC_2	683	686	PF00928	0.407
TRG_ER_diArg_1	145	147	PF00400	0.350
TRG_ER_diArg_1	251	254	PF00400	0.504
TRG_ER_diArg_1	34	36	PF00400	0.482
TRG_ER_diArg_1	467	470	PF00400	0.374
TRG_ER_diArg_1	58	61	PF00400	0.588
TRG_ER_diArg_1	588	591	PF00400	0.474
TRG_ER_diArg_1	649	652	PF00400	0.696
TRG_ER_diArg_1	660	662	PF00400	0.499
TRG_ER_diArg_1	663	665	PF00400	0.395
TRG_NES_CRM1_1	453	464	PF08389	0.409
TRG_NES_CRM1_1	507	522	PF08389	0.267
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.719
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	652	657	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	730	735	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S2	Leptomonas seymouri	42%	95%
A0A1X0NUK6	Trypanosomatidae	25%	100%
A0A3Q8IC86	Leishmania donovani	86%	100%
A0A422NSI7	Trypanosoma rangeli	27%	100%
A4HC78	Leishmania braziliensis	70%	100%
A4HZQ6	Leishmania infantum	86%	100%
C9ZSE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QBW7	Leishmania major	84%	100%
V5BB53	Trypanosoma cruzi	27%	100%