LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AVL1_LEIMU
TriTrypDb:
LmxM.22.0275
Length:
127

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AVL1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVL1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.549
CLV_PCSK_KEX2_1 2 4 PF00082 0.549
CLV_PCSK_SKI1_1 10 14 PF00082 0.563
DEG_Nend_UBRbox_1 1 4 PF02207 0.556
DEG_ODPH_VHL_1 75 87 PF01847 0.558
DEG_SPOP_SBC_1 33 37 PF00917 0.638
DOC_CYCLIN_yCln2_LP_2 74 80 PF00134 0.574
DOC_PP2B_LxvP_1 74 77 PF13499 0.553
DOC_PP4_FxxP_1 28 31 PF00568 0.662
DOC_USP7_MATH_1 33 37 PF00917 0.633
DOC_USP7_MATH_1 67 71 PF00917 0.555
DOC_WW_Pin1_4 113 118 PF00397 0.671
DOC_WW_Pin1_4 19 24 PF00397 0.528
DOC_WW_Pin1_4 41 46 PF00397 0.586
LIG_14-3-3_CanoR_1 10 17 PF00244 0.526
LIG_14-3-3_CanoR_1 2 6 PF00244 0.553
LIG_FHA_1 24 30 PF00498 0.572
LIG_LIR_Apic_2 26 31 PF02991 0.583
LIG_NRBOX 70 76 PF00104 0.605
LIG_NRBOX 87 93 PF00104 0.592
LIG_SH3_3 39 45 PF00018 0.647
LIG_UBA3_1 74 83 PF00899 0.589
MOD_GlcNHglycan 53 56 PF01048 0.575
MOD_GlcNHglycan 65 68 PF01048 0.533
MOD_GSK3_1 19 26 PF00069 0.528
MOD_GSK3_1 63 70 PF00069 0.586
MOD_GSK3_1 83 90 PF00069 0.544
MOD_N-GLC_1 95 100 PF02516 0.509
MOD_N-GLC_2 18 20 PF02516 0.565
MOD_NEK2_1 1 6 PF00069 0.557
MOD_NEK2_1 34 39 PF00069 0.609
MOD_NEK2_1 8 13 PF00069 0.531
MOD_NEK2_1 87 92 PF00069 0.547
MOD_OFUCOSY 93 100 PF10250 0.533
MOD_PIKK_1 10 16 PF00454 0.546
MOD_PIKK_1 69 75 PF00454 0.604
MOD_PKA_2 1 7 PF00069 0.557
MOD_Plk_1 67 73 PF00069 0.615
MOD_Plk_4 87 93 PF00069 0.541
MOD_ProDKin_1 113 119 PF00069 0.673
MOD_ProDKin_1 19 25 PF00069 0.530
MOD_ProDKin_1 41 47 PF00069 0.585
TRG_ER_diArg_1 1 3 PF00400 0.565
TRG_ER_diArg_1 111 114 PF00400 0.627

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HX62 Leptomonas seymouri 68% 100%
A0A0S4JWJ9 Bodo saltans 39% 100%
A0A1X0NTL3 Trypanosomatidae 47% 100%
A0A3S7WWX1 Leishmania donovani 91% 100%
A0A422NSM5 Trypanosoma rangeli 43% 95%
A4HZQ5 Leishmania infantum 91% 100%
C9ZSE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AIQ6 Leishmania braziliensis 72% 100%
Q4QBW8 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS