Translocon-associated protein subunit alpha

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translocon-associated protein (TRAP), alpha subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AVK9_LEIMU

TriTrypDb:

LmxM.22.0260

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AVK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.477
CLV_NRD_NRD_1	124	126	PF00675	0.345
CLV_NRD_NRD_1	127	129	PF00675	0.341
CLV_NRD_NRD_1	263	265	PF00675	0.440
CLV_NRD_NRD_1	272	274	PF00675	0.529
CLV_NRD_NRD_1	5	7	PF00675	0.606
CLV_PCSK_KEX2_1	272	274	PF00082	0.522
CLV_PCSK_SKI1_1	187	191	PF00082	0.473
CLV_PCSK_SKI1_1	214	218	PF00082	0.334
CLV_PCSK_SKI1_1	6	10	PF00082	0.570
CLV_PCSK_SKI1_1	61	65	PF00082	0.452
DOC_CYCLIN_RxL_1	55	69	PF00134	0.345
DOC_MAPK_gen_1	6	13	PF00069	0.467
DOC_MAPK_gen_1	80	87	PF00069	0.145
DOC_MAPK_MEF2A_6	6	13	PF00069	0.316
DOC_MAPK_MEF2A_6	80	87	PF00069	0.353
DOC_MAPK_NFAT4_5	6	14	PF00069	0.337
DOC_PP2B_LxvP_1	105	108	PF13499	0.334
DOC_USP7_MATH_1	171	175	PF00917	0.296
DOC_USP7_MATH_1	57	61	PF00917	0.310
DOC_WW_Pin1_4	137	142	PF00397	0.231
DOC_WW_Pin1_4	265	270	PF00397	0.603
DOC_WW_Pin1_4	274	279	PF00397	0.710
LIG_14-3-3_CanoR_1	128	135	PF00244	0.228
LIG_14-3-3_CanoR_1	187	193	PF00244	0.294
LIG_14-3-3_CanoR_1	264	269	PF00244	0.533
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_BIR_III_2	25	29	PF00653	0.371
LIG_BRCT_BRCA1_1	68	72	PF00533	0.325
LIG_EH1_1	98	106	PF00400	0.312
LIG_eIF4E_1	58	64	PF01652	0.353
LIG_FHA_1	138	144	PF00498	0.312
LIG_FHA_1	164	170	PF00498	0.283
LIG_FHA_1	173	179	PF00498	0.242
LIG_FHA_1	30	36	PF00498	0.408
LIG_GBD_Chelix_1	212	220	PF00786	0.145
LIG_LIR_Gen_1	147	158	PF02991	0.253
LIG_LIR_Gen_1	191	199	PF02991	0.316
LIG_LIR_Nem_3	147	153	PF02991	0.253
LIG_LIR_Nem_3	191	196	PF02991	0.316
LIG_LIR_Nem_3	69	75	PF02991	0.321
LIG_NRBOX	4	10	PF00104	0.383
LIG_Pex14_2	168	172	PF04695	0.259
LIG_SH2_CRK	150	154	PF00017	0.187
LIG_SH2_GRB2like	249	252	PF00017	0.663
LIG_SH2_GRB2like	36	39	PF00017	0.332
LIG_SH2_NCK_1	245	249	PF00017	0.674
LIG_SH2_SRC	245	248	PF00017	0.647
LIG_SH2_SRC	249	252	PF00017	0.635
LIG_SH2_SRC	36	39	PF00017	0.332
LIG_SH2_SRC	46	49	PF00017	0.228
LIG_SH2_STAT5	137	140	PF00017	0.273
LIG_SH2_STAT5	157	160	PF00017	0.117
LIG_SH2_STAT5	167	170	PF00017	0.284
LIG_SH2_STAT5	192	195	PF00017	0.314
LIG_SH2_STAT5	204	207	PF00017	0.243
LIG_SH2_STAT5	249	252	PF00017	0.577
LIG_SH2_STAT5	36	39	PF00017	0.485
LIG_SH2_STAT5	58	61	PF00017	0.337
LIG_TYR_ITIM	190	195	PF00017	0.316
LIG_UBA3_1	215	223	PF00899	0.523
LIG_WRC_WIRS_1	72	77	PF05994	0.298
MOD_CDC14_SPxK_1	277	280	PF00782	0.664
MOD_CDK_SPK_2	274	279	PF00069	0.734
MOD_CDK_SPxK_1	274	280	PF00069	0.715
MOD_CDK_SPxxK_3	137	144	PF00069	0.226
MOD_CDK_SPxxK_3	265	272	PF00069	0.611
MOD_CDK_SPxxK_3	274	281	PF00069	0.714
MOD_CK1_1	222	228	PF00069	0.505
MOD_CK1_1	68	74	PF00069	0.312
MOD_CK1_1	76	82	PF00069	0.304
MOD_GlcNHglycan	1	4	PF01048	0.618
MOD_GlcNHglycan	146	149	PF01048	0.556
MOD_GlcNHglycan	160	163	PF01048	0.427
MOD_GlcNHglycan	228	231	PF01048	0.320
MOD_GlcNHglycan	274	277	PF01048	0.573
MOD_GSK3_1	127	134	PF00069	0.263
MOD_GSK3_1	163	170	PF00069	0.270
MOD_GSK3_1	181	188	PF00069	0.171
MOD_GSK3_1	219	226	PF00069	0.525
MOD_GSK3_1	264	271	PF00069	0.681
MOD_GSK3_1	46	53	PF00069	0.240
MOD_LATS_1	221	227	PF00433	0.534
MOD_LATS_1	270	276	PF00433	0.747
MOD_N-GLC_1	116	121	PF02516	0.448
MOD_N-GLC_1	163	168	PF02516	0.458
MOD_N-GLC_1	172	177	PF02516	0.448
MOD_N-GLC_1	65	70	PF02516	0.534
MOD_NEK2_1	135	140	PF00069	0.209
MOD_NEK2_1	17	22	PF00069	0.527
MOD_NEK2_1	172	177	PF00069	0.260
MOD_NEK2_1	219	224	PF00069	0.556
MOD_NEK2_1	65	70	PF00069	0.316
MOD_PIKK_1	66	72	PF00454	0.334
MOD_PIKK_1	92	98	PF00454	0.334
MOD_PKA_1	264	270	PF00069	0.679
MOD_PKA_1	272	278	PF00069	0.703
MOD_PKA_2	127	133	PF00069	0.187
MOD_PKA_2	263	269	PF00069	0.584
MOD_PKA_2	272	278	PF00069	0.749
MOD_Plk_1	116	122	PF00069	0.259
MOD_Plk_1	163	169	PF00069	0.262
MOD_Plk_1	172	178	PF00069	0.240
MOD_Plk_1	92	98	PF00069	0.305
MOD_Plk_4	17	23	PF00069	0.530
MOD_Plk_4	188	194	PF00069	0.213
MOD_ProDKin_1	137	143	PF00069	0.231
MOD_ProDKin_1	265	271	PF00069	0.604
MOD_ProDKin_1	274	280	PF00069	0.712
TRG_ENDOCYTIC_2	150	153	PF00928	0.187
TRG_ENDOCYTIC_2	192	195	PF00928	0.316
TRG_ER_diLys_1	279	282	PF00400	0.684
TRG_NLS_MonoExtC_3	124	129	PF00514	0.145
TRG_NLS_MonoExtN_4	122	129	PF00514	0.145

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H4	Leptomonas seymouri	65%	100%
A0A0S4JN42	Bodo saltans	33%	100%
A0A1X0NT38	Trypanosomatidae	46%	100%
A0A3R7KKR8	Trypanosoma rangeli	46%	99%
A0A3S7WWZ6	Leishmania donovani	85%	100%
A4HC76	Leishmania braziliensis	69%	100%
A4HZQ3	Leishmania infantum	85%	100%
C9ZSE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QBX0	Leishmania major	85%	100%
Q54R45	Dictyostelium discoideum	28%	100%
V5AVS0	Trypanosoma cruzi	44%	100%