TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoinositide phosphatase

Species:

Leishmania mexicana

UniProt:

E9AVK8_LEIMU

TriTrypDb:

LmxM.22.0250

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVK8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016311	dephosphorylation	5	13
GO:0044237	cellular metabolic process	2	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004721	phosphoprotein phosphatase activity	3	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016791	phosphatase activity	5	13
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0042577	lipid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.291
CLV_PCSK_KEX2_1	113	115	PF00082	0.280
CLV_PCSK_KEX2_1	223	225	PF00082	0.256
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.256
CLV_PCSK_SKI1_1	114	118	PF00082	0.247
CLV_PCSK_SKI1_1	124	128	PF00082	0.264
CLV_PCSK_SKI1_1	136	140	PF00082	0.289
CLV_PCSK_SKI1_1	50	54	PF00082	0.343
DEG_SPOP_SBC_1	251	255	PF00917	0.344
DOC_MAPK_gen_1	136	145	PF00069	0.256
DOC_MAPK_gen_1	56	65	PF00069	0.239
DOC_MAPK_MEF2A_6	200	207	PF00069	0.340
DOC_PP2B_LxvP_1	165	168	PF13499	0.280
DOC_PP2B_LxvP_1	84	87	PF13499	0.203
DOC_USP7_UBL2_3	124	128	PF12436	0.381
DOC_USP7_UBL2_3	28	32	PF12436	0.286
DOC_USP7_UBL2_3	56	60	PF12436	0.386
DOC_WW_Pin1_4	43	48	PF00397	0.386
DOC_WW_Pin1_4	71	76	PF00397	0.296
LIG_14-3-3_CanoR_1	113	123	PF00244	0.345
LIG_AP2alpha_1	123	127	PF02296	0.222
LIG_AP2alpha_1	130	134	PF02296	0.250
LIG_FHA_1	115	121	PF00498	0.382
LIG_FHA_1	188	194	PF00498	0.353
LIG_FHA_1	88	94	PF00498	0.332
LIG_FHA_2	161	167	PF00498	0.294
LIG_FHA_2	169	175	PF00498	0.278
LIG_LIR_Gen_1	215	225	PF02991	0.209
LIG_LIR_Nem_3	122	126	PF02991	0.290
LIG_LIR_Nem_3	215	221	PF02991	0.292
LIG_LIR_Nem_3	82	86	PF02991	0.402
LIG_Pex14_2	119	123	PF04695	0.308
LIG_Pex14_2	127	131	PF04695	0.264
LIG_SH2_CRK	225	229	PF00017	0.256
LIG_SH2_STAT5	250	253	PF00017	0.404
LIG_SH2_STAT5	61	64	PF00017	0.340
LIG_SH2_STAT5	83	86	PF00017	0.315
LIG_Sin3_3	157	164	PF02671	0.340
LIG_TYR_ITIM	31	36	PF00017	0.340
LIG_UBA3_1	53	60	PF00899	0.340
MOD_CDK_SPK_2	43	48	PF00069	0.158
MOD_CDK_SPxxK_3	43	50	PF00069	0.386
MOD_CK1_1	187	193	PF00069	0.353
MOD_CK2_1	168	174	PF00069	0.386
MOD_Cter_Amidation	48	51	PF01082	0.340
MOD_GlcNHglycan	106	109	PF01048	0.344
MOD_GSK3_1	250	257	PF00069	0.433
MOD_GSK3_1	87	94	PF00069	0.320
MOD_N-GLC_2	180	182	PF02516	0.340
MOD_NEK2_1	145	150	PF00069	0.227
MOD_NEK2_1	160	165	PF00069	0.260
MOD_NEK2_1	176	181	PF00069	0.316
MOD_NEK2_2	87	92	PF00069	0.256
MOD_OFUCOSY	182	188	PF10250	0.340
MOD_PK_1	224	230	PF00069	0.256
MOD_PKA_2	251	257	PF00069	0.390
MOD_Plk_4	115	121	PF00069	0.284
MOD_Plk_4	168	174	PF00069	0.262
MOD_Plk_4	79	85	PF00069	0.421
MOD_ProDKin_1	43	49	PF00069	0.386
MOD_ProDKin_1	71	77	PF00069	0.296
MOD_SUMO_rev_2	64	72	PF00179	0.261
TRG_ENDOCYTIC_2	225	228	PF00928	0.247
TRG_ENDOCYTIC_2	33	36	PF00928	0.454
TRG_ENDOCYTIC_2	83	86	PF00928	0.386
TRG_ER_diArg_1	112	114	PF00400	0.289
TRG_ER_diArg_1	22	25	PF00400	0.338
TRG_NES_CRM1_1	109	125	PF08389	0.340
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V5	Leptomonas seymouri	63%	100%
A0A0N1HYX0	Leptomonas seymouri	30%	100%
A0A0N1PC37	Leptomonas seymouri	33%	100%
A0A0N1PFC3	Leptomonas seymouri	34%	100%
A0A3S7WWX6	Leishmania donovani	90%	100%
A0A3S7X743	Leishmania donovani	28%	100%
A4HZQ2	Leishmania infantum	90%	100%
A4I9C5	Leishmania infantum	28%	100%
E9B4C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P40289	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	28%	95%
Q05918	Nostoc commune	26%	88%
Q4Q3Q1	Leishmania major	29%	100%
Q4QBX1	Leishmania major	90%	100%