RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVK3_LEIMU

TriTrypDb:

LmxM.22.0190

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AVK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVK3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005509	calcium ion binding	5	8
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.483
CLV_NRD_NRD_1	275	277	PF00675	0.383
CLV_NRD_NRD_1	354	356	PF00675	0.605
CLV_NRD_NRD_1	385	387	PF00675	0.442
CLV_NRD_NRD_1	403	405	PF00675	0.366
CLV_PCSK_FUR_1	404	408	PF00082	0.357
CLV_PCSK_KEX2_1	275	277	PF00082	0.383
CLV_PCSK_KEX2_1	353	355	PF00082	0.546
CLV_PCSK_KEX2_1	403	405	PF00082	0.366
CLV_PCSK_KEX2_1	406	408	PF00082	0.347
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.364
CLV_PCSK_SKI1_1	219	223	PF00082	0.370
CLV_PCSK_SKI1_1	247	251	PF00082	0.542
CLV_PCSK_SKI1_1	403	407	PF00082	0.373
CLV_PCSK_SKI1_1	63	67	PF00082	0.429
DOC_ANK_TNKS_1	38	45	PF00023	0.362
DOC_CKS1_1	58	63	PF01111	0.439
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.561
DOC_MAPK_FxFP_2	237	240	PF00069	0.232
DOC_PP1_RVXF_1	230	237	PF00149	0.458
DOC_PP4_FxxP_1	237	240	PF00568	0.232
DOC_USP7_MATH_1	139	143	PF00917	0.621
DOC_USP7_MATH_1	149	153	PF00917	0.561
DOC_USP7_MATH_2	156	162	PF00917	0.502
DOC_WW_Pin1_4	133	138	PF00397	0.706
DOC_WW_Pin1_4	152	157	PF00397	0.595
DOC_WW_Pin1_4	219	224	PF00397	0.301
DOC_WW_Pin1_4	362	367	PF00397	0.351
DOC_WW_Pin1_4	57	62	PF00397	0.431
LIG_14-3-3_CanoR_1	185	189	PF00244	0.532
LIG_14-3-3_CanoR_1	344	348	PF00244	0.401
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	260	264	PF00533	0.328
LIG_CaM_NSCaTE_8	184	191	PF13499	0.465
LIG_Clathr_ClatBox_1	298	302	PF01394	0.440
LIG_Clathr_ClatBox_1	306	310	PF01394	0.405
LIG_FHA_1	111	117	PF00498	0.514
LIG_FHA_1	220	226	PF00498	0.280
LIG_FHA_1	23	29	PF00498	0.446
LIG_FHA_1	257	263	PF00498	0.414
LIG_FHA_1	377	383	PF00498	0.359
LIG_FHA_1	45	51	PF00498	0.375
LIG_FHA_2	102	108	PF00498	0.441
LIG_FHA_2	109	115	PF00498	0.444
LIG_FHA_2	126	132	PF00498	0.530
LIG_FHA_2	189	195	PF00498	0.409
LIG_FHA_2	82	88	PF00498	0.355
LIG_KLC1_Yacidic_2	120	124	PF13176	0.442
LIG_LIR_Apic_2	410	414	PF02991	0.344
LIG_LIR_Gen_1	211	217	PF02991	0.405
LIG_LIR_Gen_1	261	272	PF02991	0.315
LIG_LIR_Gen_1	286	296	PF02991	0.516
LIG_LIR_Gen_1	326	336	PF02991	0.396
LIG_LIR_Gen_1	84	93	PF02991	0.455
LIG_LIR_Nem_3	199	205	PF02991	0.466
LIG_LIR_Nem_3	207	212	PF02991	0.441
LIG_LIR_Nem_3	261	267	PF02991	0.369
LIG_LIR_Nem_3	286	292	PF02991	0.467
LIG_LIR_Nem_3	326	332	PF02991	0.395
LIG_LIR_Nem_3	84	88	PF02991	0.351
LIG_Pex14_1	81	85	PF04695	0.354
LIG_Rb_LxCxE_1	90	107	PF01857	0.461
LIG_SH2_SRC	122	125	PF00017	0.360
LIG_SH2_SRC	412	415	PF00017	0.356
LIG_SH2_STAP1	289	293	PF00017	0.409
LIG_SH2_STAT5	122	125	PF00017	0.452
LIG_SH2_STAT5	319	322	PF00017	0.426
LIG_SH2_STAT5	4	7	PF00017	0.384
LIG_SH2_STAT5	401	404	PF00017	0.372
LIG_SH3_3	211	217	PF00018	0.372
LIG_SH3_3	237	243	PF00018	0.338
LIG_SH3_3	360	366	PF00018	0.421
LIG_SUMO_SIM_par_1	146	152	PF11976	0.470
LIG_SUMO_SIM_par_1	25	32	PF11976	0.346
LIG_SUMO_SIM_par_1	297	302	PF11976	0.349
LIG_TRAF2_1	117	120	PF00917	0.347
LIG_TRAF2_1	428	431	PF00917	0.401
LIG_TRFH_1	362	366	PF08558	0.372
LIG_WRC_WIRS_1	140	145	PF05994	0.512
MOD_CDC14_SPxK_1	365	368	PF00782	0.291
MOD_CDK_SPxK_1	362	368	PF00069	0.338
MOD_CDK_SPxK_1	57	63	PF00069	0.441
MOD_CDK_SPxxK_3	219	226	PF00069	0.289
MOD_CK1_1	152	158	PF00069	0.667
MOD_CK1_1	168	174	PF00069	0.586
MOD_CK1_1	187	193	PF00069	0.576
MOD_CK2_1	100	106	PF00069	0.633
MOD_CK2_1	108	114	PF00069	0.468
MOD_CK2_1	125	131	PF00069	0.518
MOD_CK2_1	152	158	PF00069	0.542
MOD_CK2_1	195	201	PF00069	0.404
MOD_CK2_1	81	87	PF00069	0.301
MOD_GlcNHglycan	124	128	PF01048	0.621
MOD_GlcNHglycan	151	154	PF01048	0.663
MOD_GlcNHglycan	160	163	PF01048	0.707
MOD_GlcNHglycan	167	170	PF01048	0.679
MOD_GlcNHglycan	349	352	PF01048	0.553
MOD_GlcNHglycan	76	79	PF01048	0.389
MOD_GSK3_1	158	165	PF00069	0.719
MOD_GSK3_1	184	191	PF00069	0.596
MOD_GSK3_1	343	350	PF00069	0.429
MOD_GSK3_1	358	365	PF00069	0.455
MOD_GSK3_1	430	437	PF00069	0.441
MOD_GSK3_1	53	60	PF00069	0.403
MOD_N-GLC_1	165	170	PF02516	0.594
MOD_NEK2_1	123	128	PF00069	0.496
MOD_NEK2_1	188	193	PF00069	0.468
MOD_NEK2_1	258	263	PF00069	0.509
MOD_NEK2_1	347	352	PF00069	0.502
MOD_NEK2_1	358	363	PF00069	0.488
MOD_NEK2_1	420	425	PF00069	0.439
MOD_NEK2_1	434	439	PF00069	0.340
MOD_NEK2_1	69	74	PF00069	0.423
MOD_NEK2_1	88	93	PF00069	0.316
MOD_OFUCOSY	41	48	PF10250	0.366
MOD_PIKK_1	69	75	PF00454	0.362
MOD_PKA_2	184	190	PF00069	0.404
MOD_PKA_2	343	349	PF00069	0.404
MOD_Plk_1	358	364	PF00069	0.597
MOD_Plk_1	420	426	PF00069	0.467
MOD_Plk_1	430	436	PF00069	0.445
MOD_Plk_1	7	13	PF00069	0.441
MOD_Plk_4	139	145	PF00069	0.564
MOD_Plk_4	184	190	PF00069	0.310
MOD_Plk_4	343	349	PF00069	0.421
MOD_Plk_4	358	364	PF00069	0.460
MOD_Plk_4	430	436	PF00069	0.395
MOD_ProDKin_1	133	139	PF00069	0.705
MOD_ProDKin_1	152	158	PF00069	0.597
MOD_ProDKin_1	219	225	PF00069	0.290
MOD_ProDKin_1	362	368	PF00069	0.338
MOD_ProDKin_1	57	63	PF00069	0.441
MOD_SUMO_rev_2	100	110	PF00179	0.528
MOD_SUMO_rev_2	244	249	PF00179	0.449
MOD_SUMO_rev_2	86	91	PF00179	0.321
TRG_DiLeu_BaEn_1	201	206	PF01217	0.424
TRG_DiLeu_BaEn_1	430	435	PF01217	0.381
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.322
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.404
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.450
TRG_ENDOCYTIC_2	202	205	PF00928	0.553
TRG_ENDOCYTIC_2	289	292	PF00928	0.445
TRG_ENDOCYTIC_2	85	88	PF00928	0.351
TRG_ER_diArg_1	353	355	PF00400	0.606
TRG_ER_diArg_1	402	404	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILD7	Leptomonas seymouri	59%	98%
A0A1X0NTS2	Trypanosomatidae	35%	100%
A0A3Q8IMS6	Leishmania donovani	24%	100%
A0A3S7WWY0	Leishmania donovani	89%	100%
A0A3S7WYG1	Leishmania donovani	24%	100%
A4HZP7	Leishmania infantum	89%	100%
A4I0X7	Leishmania infantum	25%	100%
A4I0X8	Leishmania infantum	25%	98%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AWY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4QAJ2	Leishmania major	26%	97%
Q4QAJ3	Leishmania major	25%	100%
Q4QBX6	Leishmania major	87%	100%