Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVK2_LEIMU

TriTrypDb:

LmxM.22.0180

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.585
CLV_C14_Caspase3-7	38	42	PF00656	0.618
CLV_NRD_NRD_1	100	102	PF00675	0.535
CLV_PCSK_SKI1_1	165	169	PF00082	0.349
DOC_USP7_MATH_1	118	122	PF00917	0.652
DOC_USP7_MATH_1	125	129	PF00917	0.637
DOC_USP7_MATH_1	153	157	PF00917	0.671
DOC_USP7_MATH_1	32	36	PF00917	0.625
DOC_USP7_UBL2_3	146	150	PF12436	0.608
LIG_14-3-3_CanoR_1	119	123	PF00244	0.702
LIG_14-3-3_CanoR_1	126	133	PF00244	0.617
LIG_14-3-3_CanoR_1	144	154	PF00244	0.529
LIG_14-3-3_CanoR_1	185	191	PF00244	0.485
LIG_14-3-3_CanoR_1	73	82	PF00244	0.712
LIG_14-3-3_CterR_2	255	259	PF00244	0.516
LIG_EH1_1	169	177	PF00400	0.218
LIG_FHA_1	166	172	PF00498	0.283
LIG_FHA_1	185	191	PF00498	0.485
LIG_FHA_1	230	236	PF00498	0.421
LIG_FHA_1	248	254	PF00498	0.355
LIG_FHA_2	36	42	PF00498	0.621
LIG_LIR_Gen_1	156	163	PF02991	0.665
LIG_LIR_Gen_1	166	176	PF02991	0.296
LIG_LIR_Nem_3	156	161	PF02991	0.667
LIG_LIR_Nem_3	166	172	PF02991	0.296
LIG_RPA_C_Fungi	114	126	PF08784	0.651
LIG_SH2_SRC	107	110	PF00017	0.551
LIG_SH2_STAP1	249	253	PF00017	0.428
LIG_SH2_STAT5	107	110	PF00017	0.561
LIG_SH2_STAT5	154	157	PF00017	0.518
LIG_SH2_STAT5	158	161	PF00017	0.536
LIG_SH2_STAT5	181	184	PF00017	0.341
LIG_SH2_STAT5	249	252	PF00017	0.523
LIG_SH2_STAT5	67	70	PF00017	0.659
LIG_SH2_STAT5	96	99	PF00017	0.543
LIG_SH3_3	219	225	PF00018	0.683
LIG_SH3_3	250	256	PF00018	0.427
LIG_UBA3_1	196	203	PF00899	0.596
MOD_CK1_1	128	134	PF00069	0.500
MOD_CK1_1	35	41	PF00069	0.428
MOD_GlcNHglycan	109	112	PF01048	0.543
MOD_GlcNHglycan	116	119	PF01048	0.542
MOD_GlcNHglycan	127	130	PF01048	0.543
MOD_GlcNHglycan	191	194	PF01048	0.493
MOD_GSK3_1	114	121	PF00069	0.695
MOD_GSK3_1	138	145	PF00069	0.697
MOD_GSK3_1	161	168	PF00069	0.447
MOD_GSK3_1	170	177	PF00069	0.351
MOD_N-GLC_1	240	245	PF02516	0.374
MOD_N-GLC_2	237	239	PF02516	0.501
MOD_NEK2_1	161	166	PF00069	0.520
MOD_NEK2_1	247	252	PF00069	0.403
MOD_PIKK_1	148	154	PF00454	0.634
MOD_PIKK_1	184	190	PF00454	0.603
MOD_PIKK_1	207	213	PF00454	0.445
MOD_PIKK_1	32	38	PF00454	0.432
MOD_PKA_2	118	124	PF00069	0.633
MOD_PKA_2	125	131	PF00069	0.513
MOD_PKA_2	184	190	PF00069	0.603
MOD_PKA_2	4	10	PF00069	0.658
MOD_Plk_4	175	181	PF00069	0.311
MOD_Plk_4	212	218	PF00069	0.668
MOD_Plk_4	229	235	PF00069	0.456
MOD_Plk_4	63	69	PF00069	0.659
MOD_SUMO_rev_2	76	80	PF00179	0.640
TRG_ENDOCYTIC_2	158	161	PF00928	0.690
TRG_ER_diArg_1	2	5	PF00400	0.720
TRG_NES_CRM1_1	81	95	PF08389	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW9	Leptomonas seymouri	46%	100%
A0A3Q8IE48	Leishmania donovani	87%	100%
A4HC71	Leishmania braziliensis	78%	100%
A4HZP6	Leishmania infantum	87%	100%
Q4QBX7	Leishmania major	85%	100%