Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized conserved protein (DUF2036), putative

Species:

Leishmania mexicana

UniProt:

E9AVJ9_LEIMU

TriTrypDb:

LmxM.22.0150

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0000775	chromosome, centromeric region	3	1
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098687	chromosomal region	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	11
GO:0007062	sister chromatid cohesion	3	11
GO:0007064	mitotic sister chromatid cohesion	4	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	11
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1903047	mitotic cell cycle process	3	12
GO:0034086	maintenance of sister chromatid cohesion	3	1
GO:0034088	maintenance of mitotic sister chromatid cohesion	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.492
CLV_C14_Caspase3-7	249	253	PF00656	0.184
CLV_NRD_NRD_1	100	102	PF00675	0.330
CLV_NRD_NRD_1	57	59	PF00675	0.367
CLV_NRD_NRD_1	87	89	PF00675	0.329
CLV_PCSK_KEX2_1	100	102	PF00082	0.305
CLV_PCSK_KEX2_1	47	49	PF00082	0.453
CLV_PCSK_KEX2_1	59	61	PF00082	0.438
CLV_PCSK_KEX2_1	87	89	PF00082	0.338
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.453
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.438
CLV_PCSK_SKI1_1	27	31	PF00082	0.372
CLV_PCSK_SKI1_1	421	425	PF00082	0.355
DEG_MDM2_SWIB_1	349	357	PF02201	0.328
DEG_Nend_UBRbox_2	1	3	PF02207	0.671
DEG_SCF_FBW7_1	129	136	PF00400	0.184
DOC_CYCLIN_RxL_1	418	425	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	443	446	PF00134	0.571
DOC_MAPK_gen_1	382	389	PF00069	0.398
DOC_MAPK_gen_1	58	67	PF00069	0.335
DOC_MAPK_MEF2A_6	409	416	PF00069	0.398
DOC_MAPK_MEF2A_6	58	67	PF00069	0.411
DOC_PP2B_LxvP_1	310	313	PF13499	0.409
DOC_PP2B_LxvP_1	443	446	PF13499	0.545
DOC_USP7_MATH_1	105	109	PF00917	0.384
DOC_USP7_MATH_1	193	197	PF00917	0.413
DOC_USP7_MATH_1	240	244	PF00917	0.449
DOC_USP7_MATH_1	356	360	PF00917	0.469
DOC_USP7_MATH_1	408	412	PF00917	0.491
DOC_USP7_MATH_1	446	450	PF00917	0.580
DOC_USP7_MATH_1	49	53	PF00917	0.466
DOC_USP7_MATH_2	408	414	PF00917	0.475
DOC_WW_Pin1_4	129	134	PF00397	0.445
DOC_WW_Pin1_4	209	214	PF00397	0.399
DOC_WW_Pin1_4	35	40	PF00397	0.420
DOC_WW_Pin1_4	50	55	PF00397	0.370
LIG_14-3-3_CanoR_1	17	22	PF00244	0.482
LIG_14-3-3_CanoR_1	198	203	PF00244	0.387
LIG_14-3-3_CanoR_1	207	213	PF00244	0.338
LIG_14-3-3_CanoR_1	333	340	PF00244	0.302
LIG_14-3-3_CanoR_1	48	54	PF00244	0.453
LIG_14-3-3_CanoR_1	58	67	PF00244	0.440
LIG_APCC_ABBA_1	324	329	PF00400	0.184
LIG_BIR_III_2	355	359	PF00653	0.475
LIG_BRCT_BRCA1_1	151	155	PF00533	0.413
LIG_BRCT_BRCA1_1	358	362	PF00533	0.396
LIG_BRCT_BRCA1_1	392	396	PF00533	0.398
LIG_BRCT_BRCA1_1	412	416	PF00533	0.475
LIG_Clathr_ClatBox_1	18	22	PF01394	0.363
LIG_CSL_BTD_1	405	408	PF09270	0.449
LIG_eIF4E_1	91	97	PF01652	0.363
LIG_FHA_1	124	130	PF00498	0.372
LIG_FHA_1	134	140	PF00498	0.329
LIG_FHA_1	141	147	PF00498	0.281
LIG_FHA_1	243	249	PF00498	0.393
LIG_FHA_1	335	341	PF00498	0.413
LIG_FHA_1	81	87	PF00498	0.355
LIG_FHA_1	92	98	PF00498	0.302
LIG_FHA_2	174	180	PF00498	0.328
LIG_FHA_2	247	253	PF00498	0.428
LIG_FHA_2	293	299	PF00498	0.262
LIG_LIR_Apic_2	282	288	PF02991	0.359
LIG_LIR_Apic_2	402	408	PF02991	0.461
LIG_LIR_Apic_2	458	464	PF02991	0.464
LIG_LIR_Gen_1	172	180	PF02991	0.402
LIG_LIR_Gen_1	201	209	PF02991	0.397
LIG_LIR_Gen_1	447	455	PF02991	0.473
LIG_LIR_Nem_3	15	19	PF02991	0.355
LIG_LIR_Nem_3	172	177	PF02991	0.384
LIG_LIR_Nem_3	201	205	PF02991	0.335
LIG_LIR_Nem_3	271	276	PF02991	0.384
LIG_LIR_Nem_3	447	453	PF02991	0.484
LIG_LYPXL_L_2	272	281	PF13949	0.413
LIG_LYPXL_S_1	272	276	PF13949	0.363
LIG_LYPXL_yS_3	273	276	PF13949	0.363
LIG_NRBOX	215	221	PF00104	0.449
LIG_NRBOX	230	236	PF00104	0.449
LIG_PCNA_PIPBox_1	433	442	PF02747	0.262
LIG_PCNA_yPIPBox_3	427	440	PF02747	0.433
LIG_Pex14_2	257	261	PF04695	0.184
LIG_Pex14_2	349	353	PF04695	0.328
LIG_Rb_pABgroove_1	149	157	PF01858	0.449
LIG_SH2_CRK	16	20	PF00017	0.363
LIG_SH2_CRK	285	289	PF00017	0.411
LIG_SH2_CRK	461	465	PF00017	0.502
LIG_SH2_CRK	470	474	PF00017	0.442
LIG_SH2_GRB2like	142	145	PF00017	0.475
LIG_SH2_GRB2like	91	94	PF00017	0.344
LIG_SH2_PTP2	386	389	PF00017	0.475
LIG_SH2_STAP1	142	146	PF00017	0.475
LIG_SH2_STAP1	91	95	PF00017	0.344
LIG_SH2_STAT5	142	145	PF00017	0.455
LIG_SH2_STAT5	174	177	PF00017	0.407
LIG_SH2_STAT5	200	203	PF00017	0.344
LIG_SH2_STAT5	386	389	PF00017	0.475
LIG_SH2_STAT5	439	442	PF00017	0.426
LIG_SH3_1	461	467	PF00018	0.554
LIG_SH3_3	301	307	PF00018	0.475
LIG_SH3_3	461	467	PF00018	0.485
LIG_SUMO_SIM_anti_2	297	305	PF11976	0.376
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.437
LIG_SUMO_SIM_par_1	17	23	PF11976	0.328
LIG_TRAF2_1	176	179	PF00917	0.385
LIG_TRFH_1	424	428	PF08558	0.413
LIG_TYR_ITIM	468	473	PF00017	0.438
LIG_WRC_WIRS_1	247	252	PF05994	0.359
LIG_WRC_WIRS_1	346	351	PF05994	0.413
MOD_CK1_1	173	179	PF00069	0.374
MOD_CK1_1	187	193	PF00069	0.482
MOD_CK1_1	292	298	PF00069	0.345
MOD_CK1_1	53	59	PF00069	0.455
MOD_CK1_1	82	88	PF00069	0.449
MOD_CK2_1	173	179	PF00069	0.330
MOD_CK2_1	209	215	PF00069	0.346
MOD_CK2_1	333	339	PF00069	0.239
MOD_DYRK1A_RPxSP_1	50	54	PF00069	0.475
MOD_GlcNHglycan	107	110	PF01048	0.459
MOD_GlcNHglycan	166	169	PF01048	0.469
MOD_GlcNHglycan	187	190	PF01048	0.429
MOD_GlcNHglycan	195	198	PF01048	0.322
MOD_GlcNHglycan	392	395	PF01048	0.440
MOD_GlcNHglycan	55	58	PF01048	0.457
MOD_GSK3_1	123	130	PF00069	0.446
MOD_GSK3_1	180	187	PF00069	0.423
MOD_GSK3_1	242	249	PF00069	0.339
MOD_GSK3_1	49	56	PF00069	0.424
MOD_N-GLC_1	164	169	PF02516	0.439
MOD_NEK2_1	154	159	PF00069	0.395
MOD_NEK2_1	170	175	PF00069	0.385
MOD_NEK2_1	208	213	PF00069	0.370
MOD_NEK2_1	219	224	PF00069	0.383
MOD_NEK2_1	257	262	PF00069	0.410
MOD_NEK2_1	400	405	PF00069	0.227
MOD_PK_1	17	23	PF00069	0.413
MOD_PKA_1	58	64	PF00069	0.184
MOD_PKA_2	115	121	PF00069	0.398
MOD_PKA_2	455	461	PF00069	0.576
MOD_PKA_2	49	55	PF00069	0.492
MOD_PKB_1	138	146	PF00069	0.398
MOD_Plk_1	164	170	PF00069	0.398
MOD_Plk_1	257	263	PF00069	0.407
MOD_Plk_1	297	303	PF00069	0.475
MOD_Plk_1	446	452	PF00069	0.563
MOD_Plk_2-3	410	416	PF00069	0.398
MOD_Plk_4	170	176	PF00069	0.449
MOD_Plk_4	246	252	PF00069	0.356
MOD_Plk_4	268	274	PF00069	0.358
MOD_Plk_4	357	363	PF00069	0.327
MOD_Plk_4	400	406	PF00069	0.364
MOD_Plk_4	439	445	PF00069	0.469
MOD_Plk_4	91	97	PF00069	0.357
MOD_ProDKin_1	129	135	PF00069	0.445
MOD_ProDKin_1	209	215	PF00069	0.399
MOD_ProDKin_1	35	41	PF00069	0.420
MOD_ProDKin_1	50	56	PF00069	0.370
TRG_DiLeu_BaEn_1	215	220	PF01217	0.449
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.202
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.328
TRG_ENDOCYTIC_2	16	19	PF00928	0.417
TRG_ENDOCYTIC_2	174	177	PF00928	0.392
TRG_ENDOCYTIC_2	273	276	PF00928	0.344
TRG_ENDOCYTIC_2	386	389	PF00928	0.417
TRG_ENDOCYTIC_2	470	473	PF00928	0.439
TRG_ER_diArg_1	100	102	PF00400	0.317
TRG_ER_diArg_1	86	88	PF00400	0.345
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC72	Leptomonas seymouri	56%	98%
A0A0S4JIP1	Bodo saltans	22%	100%
A0A1X0NTK3	Trypanosomatidae	32%	97%
A0A3S7WWY5	Leishmania donovani	92%	100%
A0A422NSK5	Trypanosoma rangeli	35%	100%
A4HC68	Leishmania braziliensis	79%	100%
A4HZP3	Leishmania infantum	92%	100%
C9ZSD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QBY0	Leishmania major	91%	100%
V5BFR5	Trypanosoma cruzi	34%	100%