BAG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVJ8_LEIMU

TriTrypDb:

LmxM.22.0140

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVJ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0051087	protein-folding chaperone binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	444	448	PF00656	0.530
CLV_NRD_NRD_1	129	131	PF00675	0.748
CLV_NRD_NRD_1	146	148	PF00675	0.810
CLV_NRD_NRD_1	296	298	PF00675	0.735
CLV_NRD_NRD_1	406	408	PF00675	0.327
CLV_NRD_NRD_1	434	436	PF00675	0.287
CLV_PCSK_KEX2_1	162	164	PF00082	0.785
CLV_PCSK_KEX2_1	295	297	PF00082	0.748
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.785
CLV_PCSK_SKI1_1	192	196	PF00082	0.732
CLV_PCSK_SKI1_1	37	41	PF00082	0.462
CLV_PCSK_SKI1_1	416	420	PF00082	0.301
CLV_PCSK_SKI1_1	440	444	PF00082	0.325
CLV_Separin_Metazoa	413	417	PF03568	0.501
DEG_SCF_FBW7_1	107	112	PF00400	0.605
DEG_SCF_FBW7_1	137	142	PF00400	0.492
DEG_SCF_FBW7_1	74	81	PF00400	0.459
DOC_CKS1_1	75	80	PF01111	0.547
DOC_CYCLIN_RxL_1	413	422	PF00134	0.501
DOC_MAPK_gen_1	16	25	PF00069	0.483
DOC_MAPK_gen_1	295	302	PF00069	0.632
DOC_MAPK_MEF2A_6	19	27	PF00069	0.491
DOC_PP1_RVXF_1	414	420	PF00149	0.501
DOC_PP2B_LxvP_1	25	28	PF13499	0.480
DOC_USP7_MATH_1	120	124	PF00917	0.759
DOC_USP7_MATH_1	161	165	PF00917	0.658
DOC_USP7_MATH_1	172	176	PF00917	0.692
DOC_USP7_MATH_1	246	250	PF00917	0.747
DOC_USP7_MATH_1	259	263	PF00917	0.778
DOC_USP7_MATH_1	69	73	PF00917	0.454
DOC_USP7_UBL2_3	169	173	PF12436	0.755
DOC_USP7_UBL2_3	436	440	PF12436	0.560
DOC_WW_Pin1_4	105	110	PF00397	0.651
DOC_WW_Pin1_4	116	121	PF00397	0.647
DOC_WW_Pin1_4	135	140	PF00397	0.569
DOC_WW_Pin1_4	147	152	PF00397	0.727
DOC_WW_Pin1_4	207	212	PF00397	0.729
DOC_WW_Pin1_4	223	228	PF00397	0.567
DOC_WW_Pin1_4	242	247	PF00397	0.760
DOC_WW_Pin1_4	267	272	PF00397	0.815
DOC_WW_Pin1_4	350	355	PF00397	0.565
DOC_WW_Pin1_4	397	402	PF00397	0.492
DOC_WW_Pin1_4	74	79	PF00397	0.542
LIG_14-3-3_CanoR_1	130	139	PF00244	0.700
LIG_14-3-3_CanoR_1	147	151	PF00244	0.495
LIG_14-3-3_CanoR_1	171	179	PF00244	0.719
LIG_14-3-3_CanoR_1	297	303	PF00244	0.534
LIG_BIR_III_4	447	451	PF00653	0.542
LIG_Clathr_ClatBox_1	384	388	PF01394	0.373
LIG_eIF4E_1	68	74	PF01652	0.536
LIG_FHA_1	106	112	PF00498	0.647
LIG_FHA_1	113	119	PF00498	0.716
LIG_FHA_1	163	169	PF00498	0.834
LIG_FHA_1	20	26	PF00498	0.488
LIG_FHA_1	28	34	PF00498	0.453
LIG_FHA_1	419	425	PF00498	0.501
LIG_FHA_1	48	54	PF00498	0.264
LIG_FHA_2	16	22	PF00498	0.581
LIG_FHA_2	381	387	PF00498	0.468
LIG_FHA_2	75	81	PF00498	0.513
LIG_GBD_Chelix_1	32	40	PF00786	0.496
LIG_LIR_Nem_3	2	6	PF02991	0.551
LIG_LIR_Nem_3	67	73	PF02991	0.504
LIG_MYND_1	335	339	PF01753	0.636
LIG_PROFILIN_1	213	219	PF00235	0.557
LIG_SH2_CRK	54	58	PF00017	0.528
LIG_SH2_GRB2like	141	144	PF00017	0.516
LIG_SH2_NCK_1	141	145	PF00017	0.733
LIG_SH2_NCK_1	376	380	PF00017	0.455
LIG_SH2_STAP1	141	145	PF00017	0.733
LIG_SH2_STAP1	411	415	PF00017	0.501
LIG_SH2_STAT3	4	7	PF00017	0.663
LIG_SH2_STAT5	141	144	PF00017	0.633
LIG_SH2_STAT5	64	67	PF00017	0.496
LIG_SH3_1	348	354	PF00018	0.491
LIG_SH3_3	203	209	PF00018	0.814
LIG_SH3_3	210	216	PF00018	0.709
LIG_SH3_3	265	271	PF00018	0.731
LIG_SH3_3	348	354	PF00018	0.491
LIG_SH3_4	338	345	PF00018	0.525
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.495
LIG_SUMO_SIM_anti_2	388	395	PF11976	0.522
LIG_SUMO_SIM_par_1	383	390	PF11976	0.427
LIG_TRAF2_2	261	266	PF00917	0.737
LIG_TYR_ITIM	52	57	PF00017	0.558
LIG_WRC_WIRS_1	36	41	PF05994	0.556
LIG_WW_2	216	219	PF00397	0.493
MOD_CDK_SPK_2	267	272	PF00069	0.813
MOD_CDK_SPxxK_3	350	357	PF00069	0.537
MOD_CK1_1	112	118	PF00069	0.809
MOD_CK1_1	181	187	PF00069	0.767
MOD_CK1_1	200	206	PF00069	0.577
MOD_CK1_1	262	268	PF00069	0.766
MOD_CK1_1	270	276	PF00069	0.772
MOD_CK1_1	277	283	PF00069	0.736
MOD_CK1_1	321	327	PF00069	0.547
MOD_CK1_1	400	406	PF00069	0.560
MOD_CK2_1	147	153	PF00069	0.815
MOD_CK2_1	15	21	PF00069	0.508
MOD_CK2_1	380	386	PF00069	0.455
MOD_GlcNHglycan	122	125	PF01048	0.705
MOD_GlcNHglycan	174	177	PF01048	0.774
MOD_GlcNHglycan	230	233	PF01048	0.692
MOD_GlcNHglycan	257	260	PF01048	0.715
MOD_GlcNHglycan	283	286	PF01048	0.771
MOD_GSK3_1	105	112	PF00069	0.731
MOD_GSK3_1	116	123	PF00069	0.752
MOD_GSK3_1	131	138	PF00069	0.645
MOD_GSK3_1	15	22	PF00069	0.547
MOD_GSK3_1	180	187	PF00069	0.749
MOD_GSK3_1	197	204	PF00069	0.682
MOD_GSK3_1	242	249	PF00069	0.680
MOD_GSK3_1	255	262	PF00069	0.728
MOD_GSK3_1	270	277	PF00069	0.671
MOD_GSK3_1	74	81	PF00069	0.589
MOD_N-GLC_1	131	136	PF02516	0.781
MOD_NEK2_2	298	303	PF00069	0.344
MOD_PIKK_1	186	192	PF00454	0.728
MOD_PIKK_1	246	252	PF00454	0.764
MOD_PIKK_1	259	265	PF00454	0.627
MOD_PIKK_1	290	296	PF00454	0.548
MOD_PIKK_1	78	84	PF00454	0.664
MOD_PKA_1	162	168	PF00069	0.757
MOD_PKA_2	112	118	PF00069	0.811
MOD_PKA_2	146	152	PF00069	0.656
MOD_PKA_2	15	21	PF00069	0.527
MOD_PKA_2	162	168	PF00069	0.820
MOD_Plk_1	319	325	PF00069	0.440
MOD_Plk_1	60	66	PF00069	0.476
MOD_Plk_2-3	380	386	PF00069	0.473
MOD_Plk_4	60	66	PF00069	0.478
MOD_Plk_4	69	75	PF00069	0.432
MOD_ProDKin_1	105	111	PF00069	0.653
MOD_ProDKin_1	116	122	PF00069	0.647
MOD_ProDKin_1	135	141	PF00069	0.574
MOD_ProDKin_1	147	153	PF00069	0.730
MOD_ProDKin_1	207	213	PF00069	0.725
MOD_ProDKin_1	223	229	PF00069	0.563
MOD_ProDKin_1	242	248	PF00069	0.762
MOD_ProDKin_1	267	273	PF00069	0.817
MOD_ProDKin_1	350	356	PF00069	0.558
MOD_ProDKin_1	397	403	PF00069	0.492
MOD_ProDKin_1	74	80	PF00069	0.554
MOD_SUMO_rev_2	447	456	PF00179	0.681
TRG_DiLeu_BaEn_1	380	385	PF01217	0.496
TRG_DiLeu_BaEn_2	34	40	PF01217	0.500
TRG_DiLeu_BaEn_3	412	418	PF01217	0.501
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.539
TRG_ENDOCYTIC_2	411	414	PF00928	0.501
TRG_ENDOCYTIC_2	54	57	PF00928	0.537
TRG_ER_diArg_1	295	297	PF00400	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G1	Leptomonas seymouri	49%	96%
A0A3Q8IB32	Leishmania donovani	87%	100%
A4HC67	Leishmania braziliensis	68%	100%
A4HZP2	Leishmania infantum	87%	100%
C9ZSD2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QBY1	Leishmania major	88%	100%
V5BK86	Trypanosoma cruzi	33%	98%