DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA repair protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVJ2_LEIMU

TriTrypDb:

LmxM.22.0070

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000110	nucleotide-excision repair factor 1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070522	ERCC4-ERCC1 complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AVJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVJ2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000710	meiotic mismatch repair	4	1
GO:0006296	obsolete nucleotide-excision repair, DNA incision, 5'-to lesion	7	1
GO:0006298	mismatch repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0009314	response to radiation	3	1
GO:0009411	response to UV	5	1
GO:0009416	response to light stimulus	4	1
GO:0009628	response to abiotic stimulus	2	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	1
GO:0034644	cellular response to UV	6	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0070914	UV-damage excision repair	6	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071482	cellular response to light stimulus	5	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.523
CLV_NRD_NRD_1	175	177	PF00675	0.559
CLV_NRD_NRD_1	198	200	PF00675	0.579
CLV_NRD_NRD_1	24	26	PF00675	0.565
CLV_NRD_NRD_1	270	272	PF00675	0.691
CLV_NRD_NRD_1	278	280	PF00675	0.540
CLV_PCSK_FUR_1	22	26	PF00082	0.562
CLV_PCSK_KEX2_1	24	26	PF00082	0.565
CLV_PCSK_KEX2_1	269	271	PF00082	0.669
CLV_PCSK_KEX2_1	278	280	PF00082	0.576
DEG_Nend_UBRbox_3	1	3	PF02207	0.492
DEG_SCF_FBW7_1	208	215	PF00400	0.640
DEG_SCF_TRCP1_1	87	93	PF00400	0.429
DOC_CKS1_1	209	214	PF01111	0.638
DOC_MAPK_gen_1	22	31	PF00069	0.594
DOC_MAPK_HePTP_8	82	94	PF00069	0.398
DOC_MAPK_MEF2A_6	22	31	PF00069	0.594
DOC_MAPK_MEF2A_6	59	68	PF00069	0.594
DOC_MAPK_MEF2A_6	74	83	PF00069	0.416
DOC_MAPK_MEF2A_6	85	94	PF00069	0.511
DOC_PP1_RVXF_1	94	100	PF00149	0.489
DOC_PP4_FxxP_1	209	212	PF00568	0.620
DOC_USP7_MATH_1	132	136	PF00917	0.523
DOC_USP7_MATH_1	183	187	PF00917	0.517
DOC_USP7_MATH_1	227	231	PF00917	0.595
DOC_USP7_MATH_1	238	242	PF00917	0.683
DOC_USP7_MATH_2	254	260	PF00917	0.620
DOC_WW_Pin1_4	158	163	PF00397	0.522
DOC_WW_Pin1_4	208	213	PF00397	0.628
LIG_14-3-3_CanoR_1	176	184	PF00244	0.624
LIG_14-3-3_CanoR_1	270	280	PF00244	0.648
LIG_BRCT_BRCA1_1	134	138	PF00533	0.651
LIG_FHA_1	1	7	PF00498	0.549
LIG_FHA_1	159	165	PF00498	0.491
LIG_FHA_1	209	215	PF00498	0.591
LIG_FHA_1	253	259	PF00498	0.809
LIG_FHA_2	132	138	PF00498	0.641
LIG_FHA_2	164	170	PF00498	0.460
LIG_LIR_Gen_1	189	197	PF02991	0.465
LIG_LIR_Gen_1	46	57	PF02991	0.499
LIG_LIR_Gen_1	98	107	PF02991	0.506
LIG_LIR_Nem_3	189	194	PF02991	0.529
LIG_LIR_Nem_3	234	239	PF02991	0.459
LIG_LIR_Nem_3	46	52	PF02991	0.464
LIG_LIR_Nem_3	98	102	PF02991	0.505
LIG_PCNA_yPIPBox_3	210	224	PF02747	0.610
LIG_Pex14_2	209	213	PF04695	0.577
LIG_Pex14_2	232	236	PF04695	0.449
LIG_SH2_STAT5	124	127	PF00017	0.485
LIG_SH2_STAT5	49	52	PF00017	0.448
LIG_SUMO_SIM_par_1	111	117	PF11976	0.547
LIG_SUMO_SIM_par_1	151	156	PF11976	0.415
LIG_SUMO_SIM_par_1	3	10	PF11976	0.466
LIG_TYR_ITIM	47	52	PF00017	0.332
LIG_WRC_WIRS_1	220	225	PF05994	0.652
MOD_CK1_1	131	137	PF00069	0.509
MOD_CK1_1	186	192	PF00069	0.590
MOD_CK1_1	231	237	PF00069	0.703
MOD_CK1_1	259	265	PF00069	0.712
MOD_CK1_1	42	48	PF00069	0.544
MOD_CK1_1	7	13	PF00069	0.475
MOD_CK2_1	131	137	PF00069	0.589
MOD_CK2_1	186	192	PF00069	0.595
MOD_CK2_1	85	91	PF00069	0.608
MOD_Cter_Amidation	197	200	PF01082	0.431
MOD_Cter_Amidation	267	270	PF01082	0.712
MOD_GlcNHglycan	130	133	PF01048	0.511
MOD_GlcNHglycan	273	276	PF01048	0.662
MOD_GlcNHglycan	41	44	PF01048	0.443
MOD_GlcNHglycan	87	90	PF01048	0.524
MOD_GSK3_1	124	131	PF00069	0.403
MOD_GSK3_1	132	139	PF00069	0.545
MOD_GSK3_1	208	215	PF00069	0.522
MOD_GSK3_1	227	234	PF00069	0.471
MOD_GSK3_1	244	251	PF00069	0.777
MOD_GSK3_1	252	259	PF00069	0.691
MOD_GSK3_1	38	45	PF00069	0.445
MOD_NEK2_1	128	133	PF00069	0.407
MOD_NEK2_1	213	218	PF00069	0.607
MOD_PIKK_1	156	162	PF00454	0.498
MOD_PIKK_1	213	219	PF00454	0.589
MOD_PK_1	176	182	PF00069	0.549
MOD_PKA_1	176	182	PF00069	0.538
MOD_PKA_2	175	181	PF00069	0.624
MOD_PKA_2	252	258	PF00069	0.804
MOD_PKB_1	269	277	PF00069	0.608
MOD_Plk_1	228	234	PF00069	0.740
MOD_Plk_1	90	96	PF00069	0.518
MOD_Plk_2-3	256	262	PF00069	0.718
MOD_Plk_4	219	225	PF00069	0.683
MOD_Plk_4	43	49	PF00069	0.537
MOD_Plk_4	60	66	PF00069	0.315
MOD_Plk_4	95	101	PF00069	0.487
MOD_ProDKin_1	158	164	PF00069	0.513
MOD_ProDKin_1	208	214	PF00069	0.634
TRG_ENDOCYTIC_2	49	52	PF00928	0.484
TRG_ER_diArg_1	21	24	PF00400	0.489
TRG_ER_diArg_1	269	271	PF00400	0.696
TRG_ER_diArg_1	278	280	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V1	Leptomonas seymouri	59%	100%
A0A1X0NUS6	Trypanosomatidae	30%	100%
A0A3Q8IC77	Leishmania donovani	90%	100%
A0A3S5IQI3	Trypanosoma rangeli	32%	100%
A4HC59	Leishmania braziliensis	77%	100%
E9AGY7	Leishmania infantum	91%	73%
Q4QBY7	Leishmania major	91%	100%