Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVJ0_LEIMU

TriTrypDb:

LmxM.22.0050

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.600
CLV_C14_Caspase3-7	407	411	PF00656	0.640
CLV_C14_Caspase3-7	413	417	PF00656	0.758
CLV_C14_Caspase3-7	460	464	PF00656	0.443
CLV_NRD_NRD_1	261	263	PF00675	0.603
CLV_NRD_NRD_1	271	273	PF00675	0.536
CLV_NRD_NRD_1	311	313	PF00675	0.425
CLV_NRD_NRD_1	336	338	PF00675	0.583
CLV_NRD_NRD_1	420	422	PF00675	0.597
CLV_PCSK_FUR_1	418	422	PF00082	0.596
CLV_PCSK_KEX2_1	231	233	PF00082	0.578
CLV_PCSK_KEX2_1	261	263	PF00082	0.562
CLV_PCSK_KEX2_1	311	313	PF00082	0.425
CLV_PCSK_KEX2_1	336	338	PF00082	0.583
CLV_PCSK_KEX2_1	354	356	PF00082	0.606
CLV_PCSK_KEX2_1	420	422	PF00082	0.689
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.610
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.554
CLV_PCSK_SKI1_1	420	424	PF00082	0.754
CLV_PCSK_SKI1_1	434	438	PF00082	0.569
CLV_PCSK_SKI1_1	456	460	PF00082	0.548
CLV_Separin_Metazoa	165	169	PF03568	0.424
CLV_Separin_Metazoa	253	257	PF03568	0.459
CLV_Separin_Metazoa	281	285	PF03568	0.381
DEG_APCC_DBOX_1	121	129	PF00400	0.486
DEG_APCC_DBOX_1	402	410	PF00400	0.699
DEG_SPOP_SBC_1	5	9	PF00917	0.692
DOC_MAPK_gen_1	278	285	PF00069	0.528
DOC_PP4_MxPP_1	1	4	PF00568	0.606
DOC_USP7_MATH_1	37	41	PF00917	0.568
DOC_USP7_MATH_1	428	432	PF00917	0.562
DOC_USP7_MATH_1	43	47	PF00917	0.589
DOC_USP7_MATH_1	461	465	PF00917	0.517
DOC_WW_Pin1_4	15	20	PF00397	0.690
DOC_WW_Pin1_4	426	431	PF00397	0.565
LIG_14-3-3_CanoR_1	122	130	PF00244	0.559
LIG_14-3-3_CanoR_1	171	175	PF00244	0.515
LIG_14-3-3_CanoR_1	29	34	PF00244	0.625
LIG_14-3-3_CanoR_1	35	44	PF00244	0.540
LIG_14-3-3_CanoR_1	420	427	PF00244	0.594
LIG_14-3-3_CanoR_1	73	78	PF00244	0.482
LIG_14-3-3_CanoR_1	94	100	PF00244	0.425
LIG_Actin_WH2_2	222	239	PF00022	0.524
LIG_Actin_WH2_2	331	348	PF00022	0.575
LIG_Actin_WH2_2	79	96	PF00022	0.530
LIG_BRCT_BRCA1_1	158	162	PF00533	0.420
LIG_BRCT_BRCA1_1	367	371	PF00533	0.534
LIG_Clathr_ClatBox_1	111	115	PF01394	0.413
LIG_deltaCOP1_diTrp_1	27	33	PF00928	0.615
LIG_EH1_1	105	113	PF00400	0.460
LIG_eIF4E_1	249	255	PF01652	0.297
LIG_FHA_1	118	124	PF00498	0.438
LIG_FHA_1	151	157	PF00498	0.435
LIG_FHA_1	7	13	PF00498	0.669
LIG_FHA_2	302	308	PF00498	0.553
LIG_Integrin_RGD_1	414	416	PF01839	0.543
LIG_LIR_Gen_1	250	257	PF02991	0.489
LIG_LIR_Gen_1	27	37	PF02991	0.527
LIG_LIR_LC3C_4	109	113	PF02991	0.338
LIG_LIR_Nem_3	190	195	PF02991	0.460
LIG_LIR_Nem_3	250	254	PF02991	0.503
LIG_LIR_Nem_3	27	33	PF02991	0.511
LIG_SH2_GRB2like	189	192	PF00017	0.353
LIG_SH2_NCK_1	425	429	PF00017	0.580
LIG_SH2_SRC	68	71	PF00017	0.582
LIG_SH2_STAP1	203	207	PF00017	0.513
LIG_SH2_STAP1	251	255	PF00017	0.462
LIG_SUMO_SIM_anti_2	109	117	PF11976	0.423
LIG_SUMO_SIM_par_1	109	117	PF11976	0.506
LIG_TRAF2_1	239	242	PF00917	0.478
LIG_TRAF2_1	25	28	PF00917	0.585
LIG_TRAF2_1	300	303	PF00917	0.549
LIG_TRAF2_1	328	331	PF00917	0.459
LIG_TRAF2_1	67	70	PF00917	0.550
MOD_CK1_1	457	463	PF00069	0.578
MOD_CK1_1	48	54	PF00069	0.511
MOD_CK2_1	187	193	PF00069	0.548
MOD_CK2_1	22	28	PF00069	0.497
MOD_CK2_1	236	242	PF00069	0.475
MOD_CK2_1	43	49	PF00069	0.596
MOD_CK2_1	96	102	PF00069	0.361
MOD_GlcNHglycan	406	409	PF01048	0.699
MOD_GlcNHglycan	456	459	PF01048	0.608
MOD_GSK3_1	113	120	PF00069	0.284
MOD_GSK3_1	15	22	PF00069	0.635
MOD_GSK3_1	166	173	PF00069	0.470
MOD_GSK3_1	187	194	PF00069	0.459
MOD_GSK3_1	236	243	PF00069	0.489
MOD_GSK3_1	457	464	PF00069	0.592
MOD_NEK2_1	118	123	PF00069	0.483
MOD_NEK2_1	156	161	PF00069	0.483
MOD_NEK2_1	170	175	PF00069	0.384
MOD_NEK2_1	225	230	PF00069	0.480
MOD_NEK2_1	6	11	PF00069	0.725
MOD_PIKK_1	68	74	PF00454	0.542
MOD_PK_1	73	79	PF00069	0.318
MOD_PKA_1	420	426	PF00069	0.683
MOD_PKA_2	170	176	PF00069	0.463
MOD_PKA_2	28	34	PF00069	0.649
MOD_PKA_2	340	346	PF00069	0.496
MOD_PKA_2	404	410	PF00069	0.701
MOD_PKA_2	420	426	PF00069	0.683
MOD_PKA_2	93	99	PF00069	0.533
MOD_PKB_1	299	307	PF00069	0.644
MOD_PKB_1	418	426	PF00069	0.590
MOD_PKB_1	447	455	PF00069	0.601
MOD_Plk_1	301	307	PF00069	0.593
MOD_Plk_1	96	102	PF00069	0.413
MOD_Plk_4	301	307	PF00069	0.604
MOD_Plk_4	73	79	PF00069	0.468
MOD_ProDKin_1	15	21	PF00069	0.696
MOD_ProDKin_1	426	432	PF00069	0.566
MOD_SUMO_for_1	230	233	PF00179	0.470
TRG_DiLeu_BaEn_1	250	255	PF01217	0.460
TRG_DiLeu_BaEn_4	137	143	PF01217	0.459
TRG_ENDOCYTIC_2	189	192	PF00928	0.422
TRG_ENDOCYTIC_2	251	254	PF00928	0.518
TRG_ER_diArg_1	139	142	PF00400	0.502
TRG_ER_diArg_1	246	249	PF00400	0.356
TRG_ER_diArg_1	298	301	PF00400	0.552
TRG_ER_diArg_1	336	338	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S5	Leptomonas seymouri	66%	91%
A0A1X0NTJ5	Trypanosomatidae	31%	78%
A0A3S7WWY1	Leishmania donovani	93%	100%
A0A422N4N0	Trypanosoma rangeli	34%	75%
A4HC57	Leishmania braziliensis	84%	100%
E9AGY5	Leishmania infantum	93%	81%
Q4QBY9	Leishmania major	93%	100%
V5BK97	Trypanosoma cruzi	35%	100%