SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVI9_LEIMU

TriTrypDb:

LmxM.22.0040

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.365
CLV_C14_Caspase3-7	178	182	PF00656	0.451
CLV_C14_Caspase3-7	37	41	PF00656	0.405
CLV_NRD_NRD_1	222	224	PF00675	0.324
CLV_PCSK_KEX2_1	222	224	PF00082	0.324
DEG_Nend_Nbox_1	1	3	PF02207	0.382
DOC_CDC14_PxL_1	44	52	PF14671	0.442
DOC_MAPK_FxFP_2	255	258	PF00069	0.482
DOC_MAPK_gen_1	222	229	PF00069	0.482
DOC_MAPK_MEF2A_6	155	162	PF00069	0.464
DOC_PP1_RVXF_1	270	276	PF00149	0.463
DOC_PP4_FxxP_1	186	189	PF00568	0.462
DOC_PP4_FxxP_1	255	258	PF00568	0.482
DOC_PP4_FxxP_1	281	284	PF00568	0.452
DOC_USP7_MATH_1	140	144	PF00917	0.451
DOC_USP7_MATH_1	171	175	PF00917	0.495
DOC_WW_Pin1_4	101	106	PF00397	0.536
DOC_WW_Pin1_4	51	56	PF00397	0.337
DOC_WW_Pin1_4	58	63	PF00397	0.329
LIG_14-3-3_CanoR_1	72	77	PF00244	0.413
LIG_14-3-3_CanoR_1	82	86	PF00244	0.338
LIG_APCC_ABBA_1	207	212	PF00400	0.499
LIG_CaM_NSCaTE_8	63	70	PF13499	0.397
LIG_FHA_1	122	128	PF00498	0.396
LIG_FHA_1	212	218	PF00498	0.521
LIG_FHA_1	244	250	PF00498	0.486
LIG_FHA_1	71	77	PF00498	0.489
LIG_FHA_2	134	140	PF00498	0.412
LIG_FHA_2	35	41	PF00498	0.413
LIG_FHA_2	73	79	PF00498	0.423
LIG_LIR_Apic_2	183	189	PF02991	0.479
LIG_LIR_Apic_2	253	258	PF02991	0.482
LIG_LIR_Gen_1	92	102	PF02991	0.314
LIG_LIR_LC3C_4	143	146	PF02991	0.451
LIG_LIR_Nem_3	254	260	PF02991	0.434
LIG_LIR_Nem_3	277	282	PF02991	0.405
LIG_LIR_Nem_3	92	98	PF02991	0.375
LIG_LYPXL_yS_3	257	260	PF13949	0.451
LIG_MYND_1	189	193	PF01753	0.449
LIG_PCNA_TLS_4	103	110	PF02747	0.513
LIG_PDZ_Class_3	282	287	PF00595	0.428
LIG_Pex14_1	275	279	PF04695	0.313
LIG_SH2_CRK	19	23	PF00017	0.406
LIG_SH2_PTP2	259	262	PF00017	0.578
LIG_SH2_SRC	19	22	PF00017	0.397
LIG_SH2_SRC	259	262	PF00017	0.409
LIG_SH2_STAP1	269	273	PF00017	0.478
LIG_SH2_STAP1	85	89	PF00017	0.474
LIG_SH2_STAT3	109	112	PF00017	0.584
LIG_SH2_STAT5	109	112	PF00017	0.470
LIG_SH2_STAT5	21	24	PF00017	0.426
LIG_SH2_STAT5	259	262	PF00017	0.464
LIG_SH2_STAT5	49	52	PF00017	0.437
LIG_SH2_STAT5	74	77	PF00017	0.418
LIG_SH3_3	174	180	PF00018	0.453
LIG_SH3_3	99	105	PF00018	0.513
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.430
LIG_TRAF2_1	105	108	PF00917	0.365
LIG_TRAF2_1	75	78	PF00917	0.491
LIG_TYR_ITIM	17	22	PF00017	0.385
LIG_UBA3_1	229	235	PF00899	0.482
MOD_CK2_1	101	107	PF00069	0.531
MOD_CK2_1	72	78	PF00069	0.485
MOD_GlcNHglycan	5	8	PF01048	0.375
MOD_GSK3_1	129	136	PF00069	0.412
MOD_GSK3_1	89	96	PF00069	0.363
MOD_N-GLC_1	205	210	PF02516	0.302
MOD_NEK2_1	211	216	PF00069	0.488
MOD_NEK2_1	268	273	PF00069	0.371
MOD_NEK2_2	205	210	PF00069	0.493
MOD_NEK2_2	34	39	PF00069	0.369
MOD_NEK2_2	90	95	PF00069	0.351
MOD_PKA_1	222	228	PF00069	0.539
MOD_PKA_2	222	228	PF00069	0.470
MOD_PKA_2	243	249	PF00069	0.492
MOD_PKA_2	81	87	PF00069	0.504
MOD_Plk_1	151	157	PF00069	0.493
MOD_Plk_1	205	211	PF00069	0.517
MOD_Plk_1	253	259	PF00069	0.531
MOD_Plk_4	140	146	PF00069	0.477
MOD_Plk_4	187	193	PF00069	0.531
MOD_Plk_4	205	211	PF00069	0.418
MOD_Plk_4	90	96	PF00069	0.293
MOD_ProDKin_1	101	107	PF00069	0.536
MOD_ProDKin_1	51	57	PF00069	0.339
MOD_ProDKin_1	58	64	PF00069	0.322
TRG_DiLeu_BaEn_1	42	47	PF01217	0.315
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.531
TRG_ENDOCYTIC_2	19	22	PF00928	0.459
TRG_ENDOCYTIC_2	257	260	PF00928	0.445
TRG_ER_diArg_1	221	223	PF00400	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZC8	Leptomonas seymouri	65%	82%
A0A1X0NT21	Trypanosomatidae	41%	100%
A0A3R7M657	Trypanosoma rangeli	40%	100%
A0A3S7WWX4	Leishmania donovani	95%	100%
A4HC56	Leishmania braziliensis	85%	100%
C9ZSB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGY4	Leishmania infantum	96%	100%
Q4QBZ0	Leishmania major	94%	100%
V5BB74	Trypanosoma cruzi	39%	99%