LeishMANIAdb
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DIOX_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DIOX_N domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9AVI7_LEIMU
TriTrypDb:
LmxM.22.0020
Length:
144

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVI7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVI7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 133 135 PF00675 0.543
CLV_NRD_NRD_1 82 84 PF00675 0.630
CLV_NRD_NRD_1 86 88 PF00675 0.583
CLV_PCSK_KEX2_1 133 135 PF00082 0.543
CLV_PCSK_KEX2_1 88 90 PF00082 0.673
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.640
CLV_PCSK_SKI1_1 134 138 PF00082 0.520
DOC_CYCLIN_yCln2_LP_2 109 112 PF00134 0.627
DOC_MAPK_gen_1 83 93 PF00069 0.572
DOC_MAPK_MEF2A_6 18 26 PF00069 0.523
DOC_PP2B_LxvP_1 109 112 PF13499 0.552
DOC_PP4_FxxP_1 108 111 PF00568 0.758
DOC_PP4_FxxP_1 127 130 PF00568 0.465
DOC_USP7_MATH_1 30 34 PF00917 0.593
DOC_USP7_UBL2_3 84 88 PF12436 0.550
DOC_WW_Pin1_4 25 30 PF00397 0.572
DOC_WW_Pin1_4 94 99 PF00397 0.608
LIG_14-3-3_CanoR_1 40 46 PF00244 0.538
LIG_BIR_II_1 1 5 PF00653 0.709
LIG_FHA_1 130 136 PF00498 0.556
LIG_FHA_1 21 27 PF00498 0.509
LIG_LIR_Apic_2 106 111 PF02991 0.557
LIG_LIR_Nem_3 33 38 PF02991 0.517
LIG_LIR_Nem_3 75 81 PF02991 0.518
LIG_LYPXL_SIV_4 37 45 PF13949 0.536
LIG_SH2_CRK 38 42 PF00017 0.463
LIG_SH2_STAP1 78 82 PF00017 0.562
LIG_SH2_STAT3 49 52 PF00017 0.551
LIG_SH2_STAT5 49 52 PF00017 0.589
LIG_SH2_STAT5 81 84 PF00017 0.527
LIG_SH3_2 7 12 PF14604 0.483
LIG_SH3_3 4 10 PF00018 0.560
LIG_SH3_3 79 85 PF00018 0.562
LIG_SH3_4 84 91 PF00018 0.618
LIG_SUMO_SIM_par_1 22 28 PF11976 0.554
LIG_TYR_ITIM 36 41 PF00017 0.471
LIG_WW_3 140 144 PF00397 0.509
MOD_CK1_1 28 34 PF00069 0.689
MOD_GSK3_1 125 132 PF00069 0.628
MOD_GSK3_1 68 75 PF00069 0.548
MOD_PIKK_1 60 66 PF00454 0.541
MOD_PKA_1 83 89 PF00069 0.626
MOD_PKA_2 68 74 PF00069 0.580
MOD_Plk_4 73 79 PF00069 0.503
MOD_ProDKin_1 25 31 PF00069 0.570
MOD_ProDKin_1 94 100 PF00069 0.610
TRG_ENDOCYTIC_2 38 41 PF00928 0.469
TRG_ER_diArg_1 133 135 PF00400 0.541
TRG_NLS_MonoExtN_4 84 91 PF00514 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HS75 Leptomonas seymouri 80% 99%
A0A1X0NT17 Trypanosomatidae 54% 100%
A0A3S7WWV6 Leishmania donovani 90% 100%
A0A422MUD0 Trypanosoma rangeli 46% 100%
A4HC53 Leishmania braziliensis 85% 100%
E9AGY2 Leishmania infantum 90% 100%
Q4QBZ2 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS