CLN3 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CLN3 protein

Gene product:

Batten disease-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVI5_LEIMU

TriTrypDb:

LmxM.22.0010

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	13
GO:0016020	membrane	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AVI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVI5

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006885	regulation of pH	8	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	1
GO:0030641	regulation of cellular pH	7	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051453	regulation of intracellular pH	8	1
GO:0055067	obsolete monovalent inorganic cation homeostasis	7	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0098771	inorganic ion homeostasis	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.559
CLV_C14_Caspase3-7	401	405	PF00656	0.354
CLV_C14_Caspase3-7	586	590	PF00656	0.564
CLV_MEL_PAP_1	129	135	PF00089	0.316
CLV_NRD_NRD_1	254	256	PF00675	0.283
CLV_NRD_NRD_1	354	356	PF00675	0.379
CLV_NRD_NRD_1	605	607	PF00675	0.434
CLV_PCSK_FUR_1	54	58	PF00082	0.439
CLV_PCSK_KEX2_1	266	268	PF00082	0.270
CLV_PCSK_KEX2_1	354	356	PF00082	0.310
CLV_PCSK_KEX2_1	500	502	PF00082	0.374
CLV_PCSK_KEX2_1	56	58	PF00082	0.442
CLV_PCSK_KEX2_1	605	607	PF00082	0.342
CLV_PCSK_KEX2_1	67	69	PF00082	0.355
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.270
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.374
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.435
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.312
CLV_PCSK_PC7_1	262	268	PF00082	0.237
CLV_PCSK_SKI1_1	255	259	PF00082	0.338
DEG_APCC_DBOX_1	426	434	PF00400	0.459
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DOC_CKS1_1	155	160	PF01111	0.312
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.367
DOC_MAPK_gen_1	266	272	PF00069	0.470
DOC_MAPK_gen_1	466	474	PF00069	0.340
DOC_MAPK_gen_1	605	612	PF00069	0.549
DOC_MAPK_MEF2A_6	12	19	PF00069	0.615
DOC_MAPK_MEF2A_6	358	366	PF00069	0.523
DOC_MAPK_MEF2A_6	427	435	PF00069	0.459
DOC_MAPK_MEF2A_6	466	474	PF00069	0.322
DOC_MAPK_MEF2A_6	72	79	PF00069	0.516
DOC_PP2B_LxvP_1	390	393	PF13499	0.367
DOC_PP4_FxxP_1	155	158	PF00568	0.376
DOC_USP7_MATH_1	143	147	PF00917	0.330
DOC_USP7_MATH_1	203	207	PF00917	0.402
DOC_USP7_MATH_1	325	329	PF00917	0.552
DOC_USP7_MATH_1	531	535	PF00917	0.724
DOC_USP7_MATH_1	562	566	PF00917	0.723
DOC_USP7_MATH_1	94	98	PF00917	0.359
DOC_USP7_UBL2_3	462	466	PF12436	0.283
DOC_USP7_UBL2_3	551	555	PF12436	0.779
DOC_WW_Pin1_4	154	159	PF00397	0.312
DOC_WW_Pin1_4	250	255	PF00397	0.284
DOC_WW_Pin1_4	345	350	PF00397	0.540
LIG_14-3-3_CanoR_1	132	136	PF00244	0.492
LIG_14-3-3_CanoR_1	138	144	PF00244	0.305
LIG_14-3-3_CanoR_1	22	28	PF00244	0.612
LIG_14-3-3_CanoR_1	427	431	PF00244	0.459
LIG_14-3-3_CanoR_1	501	506	PF00244	0.581
LIG_14-3-3_CanoR_1	72	76	PF00244	0.493
LIG_Actin_WH2_2	622	639	PF00022	0.445
LIG_BRCT_BRCA1_1	215	219	PF00533	0.320
LIG_deltaCOP1_diTrp_1	399	407	PF00928	0.311
LIG_EH1_1	302	310	PF00400	0.470
LIG_eIF4E_1	102	108	PF01652	0.316
LIG_eIF4E_1	419	425	PF01652	0.325
LIG_FHA_1	230	236	PF00498	0.343
LIG_FHA_1	616	622	PF00498	0.360
LIG_FHA_2	181	187	PF00498	0.399
LIG_FHA_2	22	28	PF00498	0.645
LIG_FHA_2	502	508	PF00498	0.560
LIG_FHA_2	582	588	PF00498	0.662
LIG_FHA_2	623	629	PF00498	0.445
LIG_GBD_Chelix_1	169	177	PF00786	0.376
LIG_LIR_Apic_2	154	158	PF02991	0.376
LIG_LIR_Apic_2	395	400	PF02991	0.373
LIG_LIR_Gen_1	112	121	PF02991	0.305
LIG_LIR_Gen_1	166	176	PF02991	0.347
LIG_LIR_Gen_1	473	482	PF02991	0.358
LIG_LIR_Gen_1	490	499	PF02991	0.209
LIG_LIR_Gen_1	74	83	PF02991	0.376
LIG_LIR_Nem_3	112	116	PF02991	0.305
LIG_LIR_Nem_3	216	222	PF02991	0.297
LIG_LIR_Nem_3	370	376	PF02991	0.386
LIG_LIR_Nem_3	473	477	PF02991	0.358
LIG_LIR_Nem_3	490	494	PF02991	0.209
LIG_NRBOX	143	149	PF00104	0.459
LIG_Pex14_1	113	117	PF04695	0.344
LIG_Pex14_1	402	406	PF04695	0.367
LIG_Pex14_1	78	82	PF04695	0.376
LIG_Pex14_2	117	121	PF04695	0.418
LIG_Pex14_2	151	155	PF04695	0.448
LIG_Pex14_2	417	421	PF04695	0.188
LIG_Pex14_2	82	86	PF04695	0.381
LIG_PTB_Apo_2	490	497	PF02174	0.309
LIG_PTB_Apo_2	70	77	PF02174	0.570
LIG_PTB_Apo_2	82	89	PF02174	0.242
LIG_PTB_Phospho_1	490	496	PF10480	0.325
LIG_PTB_Phospho_1	82	88	PF10480	0.306
LIG_Rb_LxCxE_1	268	288	PF01857	0.483
LIG_SH2_CRK	162	166	PF00017	0.224
LIG_SH2_CRK	616	620	PF00017	0.321
LIG_SH2_CRK	88	92	PF00017	0.309
LIG_SH2_GRB2like	491	494	PF00017	0.297
LIG_SH2_NCK_1	162	166	PF00017	0.224
LIG_SH2_NCK_1	616	620	PF00017	0.306
LIG_SH2_PTP2	437	440	PF00017	0.344
LIG_SH2_PTP2	491	494	PF00017	0.297
LIG_SH2_SRC	491	494	PF00017	0.326
LIG_SH2_STAP1	303	307	PF00017	0.539
LIG_SH2_STAP1	386	390	PF00017	0.309
LIG_SH2_STAT3	386	389	PF00017	0.297
LIG_SH2_STAT5	273	276	PF00017	0.563
LIG_SH2_STAT5	382	385	PF00017	0.309
LIG_SH2_STAT5	397	400	PF00017	0.259
LIG_SH2_STAT5	412	415	PF00017	0.448
LIG_SH2_STAT5	437	440	PF00017	0.344
LIG_SH2_STAT5	460	463	PF00017	0.367
LIG_SH2_STAT5	491	494	PF00017	0.297
LIG_SH2_STAT5	496	499	PF00017	0.459
LIG_SH2_STAT5	517	520	PF00017	0.668
LIG_SH2_STAT5	88	91	PF00017	0.323
LIG_SH3_3	232	238	PF00018	0.412
LIG_SH3_3	319	325	PF00018	0.537
LIG_SH3_3	430	436	PF00018	0.567
LIG_SUMO_SIM_anti_2	428	434	PF11976	0.516
LIG_SUMO_SIM_anti_2	625	632	PF11976	0.319
LIG_SUMO_SIM_par_1	106	112	PF11976	0.409
LIG_SUMO_SIM_par_1	174	180	PF11976	0.484
LIG_SUMO_SIM_par_1	295	300	PF11976	0.514
LIG_TRAF2_1	328	331	PF00917	0.457
LIG_TRAF2_1	48	51	PF00917	0.717
LIG_TRAF2_1	584	587	PF00917	0.612
LIG_TYR_ITIM	435	440	PF00017	0.493
LIG_TYR_ITIM	494	499	PF00017	0.479
LIG_UBA3_1	248	256	PF00899	0.330
LIG_WRC_WIRS_1	152	157	PF05994	0.325
MOD_CDC14_SPxK_1	253	256	PF00782	0.516
MOD_CDK_SPK_2	250	255	PF00069	0.330
MOD_CDK_SPxK_1	250	256	PF00069	0.376
MOD_CDK_SPxxK_3	154	161	PF00069	0.229
MOD_CK1_1	154	160	PF00069	0.433
MOD_CK1_1	205	211	PF00069	0.317
MOD_CK1_1	426	432	PF00069	0.471
MOD_CK2_1	180	186	PF00069	0.313
MOD_CK2_1	325	331	PF00069	0.519
MOD_CK2_1	44	50	PF00069	0.734
MOD_CK2_1	501	507	PF00069	0.492
MOD_CK2_1	581	587	PF00069	0.635
MOD_CK2_1	94	100	PF00069	0.367
MOD_Cter_Amidation	264	267	PF01082	0.270
MOD_GlcNHglycan	165	168	PF01048	0.557
MOD_GlcNHglycan	205	208	PF01048	0.309
MOD_GlcNHglycan	210	213	PF01048	0.299
MOD_GlcNHglycan	223	226	PF01048	0.459
MOD_GlcNHglycan	299	302	PF01048	0.237
MOD_GlcNHglycan	326	330	PF01048	0.330
MOD_GlcNHglycan	524	528	PF01048	0.470
MOD_GlcNHglycan	92	95	PF01048	0.328
MOD_GSK3_1	18	25	PF00069	0.792
MOD_GSK3_1	180	187	PF00069	0.335
MOD_GSK3_1	221	228	PF00069	0.330
MOD_GSK3_1	229	236	PF00069	0.319
MOD_GSK3_1	45	52	PF00069	0.708
MOD_GSK3_1	460	467	PF00069	0.377
MOD_GSK3_1	562	569	PF00069	0.758
MOD_GSK3_1	615	622	PF00069	0.325
MOD_GSK3_1	90	97	PF00069	0.410
MOD_N-GLC_1	163	168	PF02516	0.597
MOD_N-GLC_1	35	40	PF02516	0.440
MOD_NEK2_1	128	133	PF00069	0.379
MOD_NEK2_1	142	147	PF00069	0.288
MOD_NEK2_1	151	156	PF00069	0.249
MOD_NEK2_1	177	182	PF00069	0.367
MOD_NEK2_1	220	225	PF00069	0.305
MOD_NEK2_1	233	238	PF00069	0.278
MOD_NEK2_1	258	263	PF00069	0.573
MOD_NEK2_1	367	372	PF00069	0.586
MOD_NEK2_1	499	504	PF00069	0.503
MOD_NEK2_1	615	620	PF00069	0.329
MOD_NEK2_1	629	634	PF00069	0.340
MOD_NEK2_1	636	641	PF00069	0.377
MOD_NEK2_1	66	71	PF00069	0.611
MOD_NEK2_1	90	95	PF00069	0.317
MOD_PIKK_1	225	231	PF00454	0.340
MOD_PIKK_1	573	579	PF00454	0.578
MOD_PIKK_1	581	587	PF00454	0.559
MOD_PKA_1	500	506	PF00069	0.601
MOD_PKA_2	131	137	PF00069	0.482
MOD_PKA_2	21	27	PF00069	0.611
MOD_PKA_2	426	432	PF00069	0.475
MOD_PKA_2	500	506	PF00069	0.516
MOD_PKA_2	71	77	PF00069	0.534
MOD_PKB_1	506	514	PF00069	0.461
MOD_Plk_1	163	169	PF00069	0.401
MOD_Plk_1	35	41	PF00069	0.608
MOD_Plk_1	557	563	PF00069	0.616
MOD_Plk_2-3	45	51	PF00069	0.594
MOD_Plk_4	143	149	PF00069	0.334
MOD_Plk_4	184	190	PF00069	0.348
MOD_Plk_4	196	202	PF00069	0.479
MOD_Plk_4	213	219	PF00069	0.268
MOD_Plk_4	229	235	PF00069	0.287
MOD_Plk_4	35	41	PF00069	0.608
MOD_Plk_4	367	373	PF00069	0.532
MOD_Plk_4	408	414	PF00069	0.272
MOD_Plk_4	426	432	PF00069	0.430
MOD_Plk_4	470	476	PF00069	0.337
MOD_Plk_4	487	493	PF00069	0.265
MOD_Plk_4	622	628	PF00069	0.315
MOD_Plk_4	631	637	PF00069	0.455
MOD_Plk_4	71	77	PF00069	0.541
MOD_ProDKin_1	154	160	PF00069	0.312
MOD_ProDKin_1	250	256	PF00069	0.284
MOD_ProDKin_1	345	351	PF00069	0.540
MOD_SUMO_for_1	550	553	PF00179	0.699
MOD_SUMO_rev_2	298	308	PF00179	0.470
TRG_DiLeu_BaEn_4	330	336	PF01217	0.516
TRG_ENDOCYTIC_2	162	165	PF00928	0.224
TRG_ENDOCYTIC_2	437	440	PF00928	0.344
TRG_ENDOCYTIC_2	491	494	PF00928	0.304
TRG_ENDOCYTIC_2	496	499	PF00928	0.466
TRG_ENDOCYTIC_2	616	619	PF00928	0.328
TRG_ENDOCYTIC_2	88	91	PF00928	0.308
TRG_ER_diArg_1	353	355	PF00400	0.579
TRG_ER_diArg_1	604	606	PF00400	0.525
TRG_NLS_MonoExtC_3	536	542	PF00514	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N3	Leptomonas seymouri	46%	88%
A0A0S4IMH8	Bodo saltans	40%	100%
A0A1X0NL65	Trypanosomatidae	39%	100%
A0A1X0NM99	Trypanosomatidae	41%	100%
A0A3Q8IBB0	Leishmania donovani	90%	100%
A0A3R7MV96	Trypanosoma rangeli	40%	100%
A4HC54	Leishmania braziliensis	79%	100%
A4HT21	Leishmania infantum	90%	100%
C9ZTE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QBZ3	Leishmania major	89%	100%
Q7SC45	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
V5DU41	Trypanosoma cruzi	41%	100%