Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AVI4_LEIMU

TriTrypDb:

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AVI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVI4

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016570	histone modification	5	1
GO:0016575	histone deacetylation	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0098732	macromolecule deacylation	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004407	histone deacetylase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1
GO:0033558	protein lysine deacetylase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	676	680	PF00656	0.446
CLV_NRD_NRD_1	153	155	PF00675	0.274
CLV_NRD_NRD_1	23	25	PF00675	0.510
CLV_NRD_NRD_1	310	312	PF00675	0.479
CLV_NRD_NRD_1	373	375	PF00675	0.573
CLV_NRD_NRD_1	631	633	PF00675	0.606
CLV_PCSK_KEX2_1	153	155	PF00082	0.274
CLV_PCSK_KEX2_1	23	25	PF00082	0.542
CLV_PCSK_KEX2_1	3	5	PF00082	0.631
CLV_PCSK_KEX2_1	319	321	PF00082	0.641
CLV_PCSK_KEX2_1	373	375	PF00082	0.561
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.631
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.641
CLV_PCSK_SKI1_1	145	149	PF00082	0.336
CLV_PCSK_SKI1_1	207	211	PF00082	0.347
CLV_PCSK_SKI1_1	583	587	PF00082	0.242
DEG_APCC_DBOX_1	518	526	PF00400	0.580
DEG_SCF_FBW7_1	48	55	PF00400	0.684
DEG_SPOP_SBC_1	406	410	PF00917	0.647
DEG_SPOP_SBC_1	417	421	PF00917	0.659
DEG_SPOP_SBC_1	425	429	PF00917	0.602
DEG_SPOP_SBC_1	72	76	PF00917	0.634
DOC_ANK_TNKS_1	176	183	PF00023	0.496
DOC_CKS1_1	49	54	PF01111	0.677
DOC_CYCLIN_RxL_1	580	589	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	46	49	PF00134	0.624
DOC_MAPK_DCC_7	264	273	PF00069	0.367
DOC_MAPK_gen_1	516	525	PF00069	0.496
DOC_MAPK_MEF2A_6	264	273	PF00069	0.367
DOC_MAPK_MEF2A_6	516	524	PF00069	0.442
DOC_PIKK_1	330	337	PF02985	0.694
DOC_PP2B_LxvP_1	46	49	PF13499	0.731
DOC_PP2B_PxIxI_1	268	274	PF00149	0.536
DOC_USP7_MATH_1	354	358	PF00917	0.633
DOC_USP7_MATH_1	360	364	PF00917	0.689
DOC_USP7_MATH_1	366	370	PF00917	0.507
DOC_USP7_MATH_1	406	410	PF00917	0.643
DOC_USP7_MATH_1	417	421	PF00917	0.666
DOC_USP7_MATH_1	57	61	PF00917	0.695
DOC_USP7_MATH_1	575	579	PF00917	0.442
DOC_USP7_MATH_1	65	69	PF00917	0.690
DOC_USP7_MATH_1	71	75	PF00917	0.657
DOC_USP7_MATH_2	686	692	PF00917	0.433
DOC_WW_Pin1_4	108	113	PF00397	0.528
DOC_WW_Pin1_4	421	426	PF00397	0.591
DOC_WW_Pin1_4	449	454	PF00397	0.803
DOC_WW_Pin1_4	48	53	PF00397	0.651
DOC_WW_Pin1_4	540	545	PF00397	0.455
DOC_WW_Pin1_4	84	89	PF00397	0.654
LIG_14-3-3_CanoR_1	122	128	PF00244	0.451
LIG_14-3-3_CanoR_1	311	321	PF00244	0.632
LIG_14-3-3_CanoR_1	632	638	PF00244	0.506
LIG_BRCT_BRCA1_1	525	529	PF00533	0.442
LIG_Clathr_ClatBox_1	399	403	PF01394	0.608
LIG_EH1_1	547	555	PF00400	0.536
LIG_eIF4E_1	548	554	PF01652	0.536
LIG_FHA_1	282	288	PF00498	0.442
LIG_FHA_1	433	439	PF00498	0.638
LIG_FHA_1	442	448	PF00498	0.574
LIG_FHA_1	468	474	PF00498	0.455
LIG_FHA_1	49	55	PF00498	0.450
LIG_FHA_1	96	102	PF00498	0.393
LIG_FHA_2	325	331	PF00498	0.716
LIG_FHA_2	456	462	PF00498	0.664
LIG_FHA_2	692	698	PF00498	0.439
LIG_FHA_2	74	80	PF00498	0.639
LIG_IRF3_LxIS_1	292	298	PF10401	0.536
LIG_LIR_Apic_2	116	120	PF02991	0.282
LIG_LIR_Apic_2	286	292	PF02991	0.439
LIG_LIR_Apic_2	85	89	PF02991	0.565
LIG_LIR_Gen_1	215	224	PF02991	0.473
LIG_LIR_Gen_1	380	388	PF02991	0.521
LIG_LIR_Gen_1	500	511	PF02991	0.442
LIG_LIR_LC3C_4	559	563	PF02991	0.367
LIG_LIR_Nem_3	168	173	PF02991	0.494
LIG_LIR_Nem_3	215	221	PF02991	0.473
LIG_LIR_Nem_3	380	384	PF02991	0.538
LIG_LIR_Nem_3	500	506	PF02991	0.443
LIG_MYND_1	40	44	PF01753	0.728
LIG_MYND_1	48	52	PF01753	0.647
LIG_MYND_1	640	644	PF01753	0.439
LIG_NRBOX	336	342	PF00104	0.593
LIG_NRP_CendR_1	699	701	PF00754	0.456
LIG_SH2_CRK	239	243	PF00017	0.536
LIG_SH2_CRK	381	385	PF00017	0.604
LIG_SH2_GRB2like	381	384	PF00017	0.421
LIG_SH2_NCK_1	117	121	PF00017	0.264
LIG_SH2_NCK_1	239	243	PF00017	0.536
LIG_SH2_NCK_1	289	293	PF00017	0.442
LIG_SH2_SRC	289	292	PF00017	0.442
LIG_SH2_STAP1	102	106	PF00017	0.355
LIG_SH2_STAP1	381	385	PF00017	0.486
LIG_SH2_STAT5	28	31	PF00017	0.482
LIG_SH2_STAT5	503	506	PF00017	0.442
LIG_SH2_STAT5	548	551	PF00017	0.442
LIG_SH2_STAT5	683	686	PF00017	0.433
LIG_SH3_3	218	224	PF00018	0.473
LIG_SH3_3	34	40	PF00018	0.577
LIG_SH3_3	343	349	PF00018	0.602
LIG_SH3_3	46	52	PF00018	0.526
LIG_SH3_3	507	513	PF00018	0.456
LIG_SUMO_SIM_anti_2	293	298	PF11976	0.442
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.496
LIG_SUMO_SIM_par_1	270	275	PF11976	0.498
LIG_SUMO_SIM_par_1	293	298	PF11976	0.442
LIG_SUMO_SIM_par_1	349	355	PF11976	0.482
LIG_SUMO_SIM_par_1	521	526	PF11976	0.504
LIG_SUMO_SIM_par_1	561	566	PF11976	0.443
LIG_TRAF2_1	460	463	PF00917	0.676
LIG_TYR_ITIM	379	384	PF00017	0.538
LIG_TYR_ITIM	501	506	PF00017	0.442
LIG_WRC_WIRS_1	690	695	PF05994	0.445
LIG_WW_3	261	265	PF00397	0.367
LIG_WW_3	267	271	PF00397	0.362
MOD_CDK_SPxxK_3	449	456	PF00069	0.618
MOD_CK1_1	18	24	PF00069	0.625
MOD_CK1_1	188	194	PF00069	0.501
MOD_CK1_1	325	331	PF00069	0.757
MOD_CK1_1	408	414	PF00069	0.595
MOD_CK1_1	415	421	PF00069	0.584
MOD_CK1_1	424	430	PF00069	0.588
MOD_CK1_1	589	595	PF00069	0.330
MOD_CK1_1	59	65	PF00069	0.649
MOD_CK1_1	622	628	PF00069	0.524
MOD_CK1_1	691	697	PF00069	0.446
MOD_CK2_1	324	330	PF00069	0.687
MOD_CK2_1	349	355	PF00069	0.622
MOD_CK2_1	445	451	PF00069	0.602
MOD_CK2_1	455	461	PF00069	0.573
MOD_Cter_Amidation	21	24	PF01082	0.600
MOD_Cter_Amidation	371	374	PF01082	0.706
MOD_Cter_Amidation	630	633	PF01082	0.433
MOD_GlcNHglycan	178	181	PF01048	0.166
MOD_GlcNHglycan	20	23	PF01048	0.615
MOD_GlcNHglycan	210	213	PF01048	0.349
MOD_GlcNHglycan	314	317	PF01048	0.732
MOD_GlcNHglycan	341	344	PF01048	0.636
MOD_GlcNHglycan	415	418	PF01048	0.636
MOD_GlcNHglycan	421	424	PF01048	0.641
MOD_GlcNHglycan	428	431	PF01048	0.744
MOD_GlcNHglycan	481	484	PF01048	0.166
MOD_GlcNHglycan	530	533	PF01048	0.239
MOD_GlcNHglycan	544	547	PF01048	0.249
MOD_GlcNHglycan	587	591	PF01048	0.440
MOD_GlcNHglycan	59	62	PF01048	0.600
MOD_GlcNHglycan	67	70	PF01048	0.609
MOD_GlcNHglycan	694	697	PF01048	0.446
MOD_GSK3_1	185	192	PF00069	0.527
MOD_GSK3_1	208	215	PF00069	0.554
MOD_GSK3_1	405	412	PF00069	0.576
MOD_GSK3_1	413	420	PF00069	0.574
MOD_GSK3_1	421	428	PF00069	0.540
MOD_GSK3_1	441	448	PF00069	0.638
MOD_GSK3_1	48	55	PF00069	0.610
MOD_GSK3_1	536	543	PF00069	0.446
MOD_GSK3_1	585	592	PF00069	0.266
MOD_GSK3_1	67	74	PF00069	0.463
MOD_GSK3_1	688	695	PF00069	0.442
MOD_N-GLC_1	412	417	PF02516	0.809
MOD_N-GLC_1	432	437	PF02516	0.703
MOD_N-GLC_1	556	561	PF02516	0.211
MOD_N-GLC_1	663	668	PF02516	0.489
MOD_NEK2_1	295	300	PF00069	0.536
MOD_NEK2_1	536	541	PF00069	0.436
MOD_NEK2_1	56	61	PF00069	0.507
MOD_NEK2_1	585	590	PF00069	0.377
MOD_NEK2_2	283	288	PF00069	0.439
MOD_NEK2_2	619	624	PF00069	0.475
MOD_PIKK_1	263	269	PF00454	0.410
MOD_PIKK_1	622	628	PF00454	0.547
MOD_PKA_1	311	317	PF00069	0.616
MOD_PKA_2	176	182	PF00069	0.427
MOD_PKA_2	263	269	PF00069	0.451
MOD_PKA_2	42	48	PF00069	0.690
MOD_PKA_2	455	461	PF00069	0.610
MOD_Plk_1	102	108	PF00069	0.494
MOD_Plk_1	15	21	PF00069	0.640
MOD_Plk_1	556	562	PF00069	0.367
MOD_Plk_1	673	679	PF00069	0.457
MOD_Plk_4	102	108	PF00069	0.480
MOD_Plk_4	283	289	PF00069	0.441
MOD_Plk_4	290	296	PF00069	0.443
MOD_Plk_4	42	48	PF00069	0.655
MOD_ProDKin_1	108	114	PF00069	0.537
MOD_ProDKin_1	421	427	PF00069	0.590
MOD_ProDKin_1	449	455	PF00069	0.666
MOD_ProDKin_1	48	54	PF00069	0.654
MOD_ProDKin_1	540	546	PF00069	0.455
MOD_ProDKin_1	84	90	PF00069	0.654
MOD_SUMO_rev_2	607	616	PF00179	0.491
TRG_DiLeu_BaEn_1	502	507	PF01217	0.496
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.744
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.623
TRG_ENDOCYTIC_2	239	242	PF00928	0.536
TRG_ENDOCYTIC_2	381	384	PF00928	0.526
TRG_ENDOCYTIC_2	503	506	PF00928	0.442
TRG_ENDOCYTIC_2	547	550	PF00928	0.427
TRG_ER_diArg_1	152	154	PF00400	0.470
TRG_ER_diArg_1	23	25	PF00400	0.600
TRG_ER_diArg_1	373	376	PF00400	0.635
TRG_ER_diArg_1	698	701	PF00400	0.441
TRG_NES_CRM1_1	162	174	PF08389	0.508
TRG_NLS_MonoExtN_4	2	7	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R2	Leptomonas seymouri	60%	100%
A0A1X0NJV3	Trypanosomatidae	47%	100%
A0A3S7WWW4	Leishmania donovani	91%	100%
A0A422N700	Trypanosoma rangeli	48%	100%
A4HLD0	Leishmania braziliensis	80%	100%
A4HTR2	Leishmania infantum	91%	100%
C9ZIZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QBZ5	Leishmania major	91%	100%
V5BFA4	Trypanosoma cruzi	47%	100%