Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVI1_LEIMU

TriTrypDb:

LmxM.21.1850

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AVI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.438
CLV_C14_Caspase3-7	350	354	PF00656	0.448
CLV_MEL_PAP_1	99	105	PF00089	0.464
CLV_NRD_NRD_1	107	109	PF00675	0.580
CLV_NRD_NRD_1	329	331	PF00675	0.472
CLV_NRD_NRD_1	363	365	PF00675	0.431
CLV_NRD_NRD_1	439	441	PF00675	0.576
CLV_NRD_NRD_1	466	468	PF00675	0.586
CLV_NRD_NRD_1	502	504	PF00675	0.675
CLV_NRD_NRD_1	704	706	PF00675	0.434
CLV_NRD_NRD_1	71	73	PF00675	0.437
CLV_NRD_NRD_1	715	717	PF00675	0.383
CLV_PCSK_FUR_1	197	201	PF00082	0.460
CLV_PCSK_KEX2_1	107	109	PF00082	0.614
CLV_PCSK_KEX2_1	199	201	PF00082	0.454
CLV_PCSK_KEX2_1	329	331	PF00082	0.472
CLV_PCSK_KEX2_1	362	364	PF00082	0.458
CLV_PCSK_KEX2_1	439	441	PF00082	0.562
CLV_PCSK_KEX2_1	466	468	PF00082	0.599
CLV_PCSK_KEX2_1	502	504	PF00082	0.533
CLV_PCSK_KEX2_1	703	705	PF00082	0.487
CLV_PCSK_KEX2_1	715	717	PF00082	0.492
CLV_PCSK_KEX2_1	77	79	PF00082	0.432
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.454
CLV_PCSK_PC1ET2_1	703	705	PF00082	0.487
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.440
CLV_PCSK_PC7_1	435	441	PF00082	0.558
CLV_PCSK_PC7_1	700	706	PF00082	0.381
CLV_PCSK_PC7_1	711	717	PF00082	0.373
CLV_PCSK_SKI1_1	187	191	PF00082	0.582
CLV_PCSK_SKI1_1	224	228	PF00082	0.526
CLV_PCSK_SKI1_1	406	410	PF00082	0.475
CLV_PCSK_SKI1_1	490	494	PF00082	0.631
CLV_PCSK_SKI1_1	624	628	PF00082	0.667
CLV_Separin_Metazoa	621	625	PF03568	0.445
DEG_APCC_DBOX_1	123	131	PF00400	0.524
DEG_SCF_FBW7_1	526	533	PF00400	0.570
DEG_SPOP_SBC_1	483	487	PF00917	0.601
DEG_SPOP_SBC_1	530	534	PF00917	0.521
DOC_ANK_TNKS_1	362	369	PF00023	0.452
DOC_CDC14_PxL_1	304	312	PF14671	0.326
DOC_CKS1_1	527	532	PF01111	0.593
DOC_MAPK_gen_1	124	132	PF00069	0.527
DOC_MAPK_gen_1	502	511	PF00069	0.511
DOC_MAPK_MEF2A_6	502	511	PF00069	0.511
DOC_PP2B_LxvP_1	130	133	PF13499	0.557
DOC_PP2B_LxvP_1	305	308	PF13499	0.327
DOC_USP7_MATH_1	101	105	PF00917	0.534
DOC_USP7_MATH_1	274	278	PF00917	0.511
DOC_USP7_MATH_1	515	519	PF00917	0.550
DOC_USP7_MATH_1	530	534	PF00917	0.681
DOC_USP7_MATH_1	538	542	PF00917	0.622
DOC_USP7_MATH_1	583	587	PF00917	0.517
DOC_USP7_MATH_1	630	634	PF00917	0.594
DOC_USP7_MATH_1	642	646	PF00917	0.581
DOC_USP7_MATH_1	663	667	PF00917	0.637
DOC_USP7_MATH_1	689	693	PF00917	0.471
DOC_USP7_UBL2_3	73	77	PF12436	0.352
DOC_WW_Pin1_4	141	146	PF00397	0.594
DOC_WW_Pin1_4	189	194	PF00397	0.575
DOC_WW_Pin1_4	24	29	PF00397	0.565
DOC_WW_Pin1_4	251	256	PF00397	0.537
DOC_WW_Pin1_4	329	334	PF00397	0.582
DOC_WW_Pin1_4	472	477	PF00397	0.486
DOC_WW_Pin1_4	495	500	PF00397	0.668
DOC_WW_Pin1_4	511	516	PF00397	0.519
DOC_WW_Pin1_4	526	531	PF00397	0.531
DOC_WW_Pin1_4	575	580	PF00397	0.624
DOC_WW_Pin1_4	653	658	PF00397	0.646
DOC_WW_Pin1_4	659	664	PF00397	0.684
DOC_WW_Pin1_4	97	102	PF00397	0.514
LIG_14-3-3_CanoR_1	146	155	PF00244	0.517
LIG_14-3-3_CanoR_1	18	26	PF00244	0.651
LIG_14-3-3_CanoR_1	257	265	PF00244	0.488
LIG_14-3-3_CanoR_1	32	38	PF00244	0.580
LIG_14-3-3_CanoR_1	442	448	PF00244	0.361
LIG_14-3-3_CanoR_1	506	510	PF00244	0.592
LIG_14-3-3_CanoR_1	516	521	PF00244	0.594
LIG_14-3-3_CanoR_1	531	535	PF00244	0.561
LIG_14-3-3_CanoR_1	618	626	PF00244	0.440
LIG_14-3-3_CanoR_1	72	81	PF00244	0.592
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BRCT_BRCA1_1	577	581	PF00533	0.671
LIG_BRCT_BRCA1_1	651	655	PF00533	0.496
LIG_FHA_1	142	148	PF00498	0.634
LIG_FHA_1	521	527	PF00498	0.768
LIG_FHA_1	618	624	PF00498	0.550
LIG_FHA_2	654	660	PF00498	0.617
LIG_Integrin_isoDGR_2	570	572	PF01839	0.653
LIG_LIR_Nem_3	170	176	PF02991	0.467
LIG_LYPXL_S_1	581	585	PF13949	0.507
LIG_LYPXL_yS_3	582	585	PF13949	0.504
LIG_MYND_1	381	385	PF01753	0.572
LIG_MYND_1	97	101	PF01753	0.415
LIG_NRBOX	674	680	PF00104	0.511
LIG_NRBOX	708	714	PF00104	0.471
LIG_Pex14_1	295	299	PF04695	0.355
LIG_SH2_PTP2	239	242	PF00017	0.450
LIG_SH2_SRC	239	242	PF00017	0.450
LIG_SH2_STAT5	176	179	PF00017	0.450
LIG_SH2_STAT5	239	242	PF00017	0.450
LIG_SH2_STAT5	298	301	PF00017	0.565
LIG_SH2_STAT5	51	54	PF00017	0.704
LIG_SH2_STAT5	717	720	PF00017	0.395
LIG_SH3_2	252	257	PF14604	0.460
LIG_SH3_3	130	136	PF00018	0.699
LIG_SH3_3	22	28	PF00018	0.568
LIG_SH3_3	249	255	PF00018	0.683
LIG_SH3_3	268	274	PF00018	0.487
LIG_SH3_3	489	495	PF00018	0.482
LIG_SH3_3	504	510	PF00018	0.560
LIG_SH3_3	532	538	PF00018	0.593
LIG_SH3_3	54	60	PF00018	0.498
LIG_SH3_3	644	650	PF00018	0.538
LIG_SH3_3	657	663	PF00018	0.598
LIG_SUMO_SIM_anti_2	674	679	PF11976	0.495
LIG_SUMO_SIM_par_1	128	135	PF11976	0.555
LIG_SxIP_EBH_1	594	603	PF03271	0.560
LIG_TRAF2_1	167	170	PF00917	0.553
LIG_TRAF2_1	317	320	PF00917	0.422
LIG_TRAF2_1	476	479	PF00917	0.610
LIG_WRC_WIRS_1	209	214	PF05994	0.438
LIG_WRC_WIRS_1	310	315	PF05994	0.479
MOD_CDC14_SPxK_1	254	257	PF00782	0.458
MOD_CDC14_SPxK_1	332	335	PF00782	0.510
MOD_CDK_SPK_2	141	146	PF00069	0.594
MOD_CDK_SPK_2	511	516	PF00069	0.671
MOD_CDK_SPK_2	526	531	PF00069	0.542
MOD_CDK_SPK_2	97	102	PF00069	0.514
MOD_CDK_SPxK_1	251	257	PF00069	0.454
MOD_CDK_SPxK_1	329	335	PF00069	0.513
MOD_CDK_SPxxK_3	495	502	PF00069	0.558
MOD_CK1_1	109	115	PF00069	0.736
MOD_CK1_1	148	154	PF00069	0.507
MOD_CK1_1	27	33	PF00069	0.625
MOD_CK1_1	277	283	PF00069	0.431
MOD_CK1_1	375	381	PF00069	0.535
MOD_CK1_1	519	525	PF00069	0.631
MOD_CK1_1	533	539	PF00069	0.597
MOD_CK1_1	558	564	PF00069	0.631
MOD_CK1_1	641	647	PF00069	0.644
MOD_CK2_1	276	282	PF00069	0.492
MOD_CK2_1	331	337	PF00069	0.493
MOD_CK2_1	472	478	PF00069	0.748
MOD_DYRK1A_RPxSP_1	531	535	PF00069	0.632
MOD_GlcNHglycan	103	106	PF01048	0.625
MOD_GlcNHglycan	108	111	PF01048	0.769
MOD_GlcNHglycan	118	122	PF01048	0.499
MOD_GlcNHglycan	228	231	PF01048	0.572
MOD_GlcNHglycan	276	279	PF01048	0.483
MOD_GlcNHglycan	29	32	PF01048	0.632
MOD_GlcNHglycan	369	373	PF01048	0.719
MOD_GlcNHglycan	386	389	PF01048	0.409
MOD_GlcNHglycan	468	471	PF01048	0.616
MOD_GlcNHglycan	511	514	PF01048	0.710
MOD_GlcNHglycan	541	544	PF01048	0.714
MOD_GlcNHglycan	566	569	PF01048	0.667
MOD_GlcNHglycan	573	576	PF01048	0.664
MOD_GlcNHglycan	586	589	PF01048	0.481
MOD_GlcNHglycan	640	643	PF01048	0.618
MOD_GlcNHglycan	691	694	PF01048	0.528
MOD_GlcNHglycan	74	77	PF01048	0.511
MOD_GSK3_1	13	20	PF00069	0.630
MOD_GSK3_1	141	148	PF00069	0.592
MOD_GSK3_1	247	254	PF00069	0.525
MOD_GSK3_1	273	280	PF00069	0.474
MOD_GSK3_1	329	336	PF00069	0.655
MOD_GSK3_1	348	355	PF00069	0.469
MOD_GSK3_1	368	375	PF00069	0.550
MOD_GSK3_1	482	489	PF00069	0.577
MOD_GSK3_1	505	512	PF00069	0.615
MOD_GSK3_1	51	58	PF00069	0.479
MOD_GSK3_1	515	522	PF00069	0.593
MOD_GSK3_1	526	533	PF00069	0.593
MOD_GSK3_1	551	558	PF00069	0.797
MOD_GSK3_1	571	578	PF00069	0.605
MOD_GSK3_1	597	604	PF00069	0.567
MOD_GSK3_1	630	637	PF00069	0.599
MOD_GSK3_1	638	645	PF00069	0.652
MOD_GSK3_1	649	656	PF00069	0.655
MOD_GSK3_1	659	666	PF00069	0.549
MOD_GSK3_1	91	98	PF00069	0.583
MOD_N-GLC_1	663	668	PF02516	0.486
MOD_NEK2_1	443	448	PF00069	0.358
MOD_NEK2_2	51	56	PF00069	0.500
MOD_NEK2_2	630	635	PF00069	0.597
MOD_NEK2_2	650	655	PF00069	0.550
MOD_NEK2_2	91	96	PF00069	0.580
MOD_PIKK_1	13	19	PF00454	0.582
MOD_PIKK_1	414	420	PF00454	0.458
MOD_PIKK_1	634	640	PF00454	0.625
MOD_PIKK_1	642	648	PF00454	0.639
MOD_PIKK_1	663	669	PF00454	0.604
MOD_PK_1	516	522	PF00069	0.560
MOD_PKA_1	466	472	PF00069	0.558
MOD_PKA_1	72	78	PF00069	0.389
MOD_PKA_2	101	107	PF00069	0.594
MOD_PKA_2	116	122	PF00069	0.550
MOD_PKA_2	145	151	PF00069	0.534
MOD_PKA_2	17	23	PF00069	0.724
MOD_PKA_2	247	253	PF00069	0.521
MOD_PKA_2	466	472	PF00069	0.558
MOD_PKA_2	505	511	PF00069	0.590
MOD_PKA_2	515	521	PF00069	0.580
MOD_PKA_2	530	536	PF00069	0.578
MOD_PKA_2	55	61	PF00069	0.656
MOD_PKA_2	551	557	PF00069	0.602
MOD_PKA_2	571	577	PF00069	0.549
MOD_PKA_2	617	623	PF00069	0.472
MOD_PKA_2	634	640	PF00069	0.491
MOD_Plk_1	336	342	PF00069	0.407
MOD_Plk_1	352	358	PF00069	0.423
MOD_Plk_1	375	381	PF00069	0.463
MOD_Plk_1	91	97	PF00069	0.582
MOD_Plk_2-3	208	214	PF00069	0.440
MOD_Plk_2-3	426	432	PF00069	0.496
MOD_Plk_4	323	329	PF00069	0.409
MOD_Plk_4	352	358	PF00069	0.613
MOD_ProDKin_1	141	147	PF00069	0.587
MOD_ProDKin_1	189	195	PF00069	0.572
MOD_ProDKin_1	24	30	PF00069	0.564
MOD_ProDKin_1	251	257	PF00069	0.541
MOD_ProDKin_1	329	335	PF00069	0.577
MOD_ProDKin_1	472	478	PF00069	0.489
MOD_ProDKin_1	495	501	PF00069	0.669
MOD_ProDKin_1	511	517	PF00069	0.519
MOD_ProDKin_1	526	532	PF00069	0.531
MOD_ProDKin_1	575	581	PF00069	0.626
MOD_ProDKin_1	653	659	PF00069	0.646
MOD_ProDKin_1	97	103	PF00069	0.515
MOD_SUMO_for_1	76	79	PF00179	0.506
MOD_SUMO_for_1	83	86	PF00179	0.493
TRG_DiLeu_BaEn_1	708	713	PF01217	0.468
TRG_DiLeu_LyEn_5	708	713	PF01217	0.468
TRG_ENDOCYTIC_2	582	585	PF00928	0.504
TRG_ER_diArg_1	106	108	PF00400	0.651
TRG_ER_diArg_1	178	181	PF00400	0.347
TRG_ER_diArg_1	328	330	PF00400	0.453
TRG_ER_diArg_1	361	364	PF00400	0.446
TRG_ER_diArg_1	439	442	PF00400	0.564
TRG_ER_diArg_1	501	503	PF00400	0.525
TRG_ER_diArg_1	704	707	PF00400	0.433
TRG_ER_diArg_1	714	716	PF00400	0.382
TRG_NES_CRM1_1	122	135	PF08389	0.560
TRG_NLS_MonoExtC_3	702	707	PF00514	0.377
TRG_NLS_MonoExtN_4	700	707	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRK6	Leptomonas seymouri	42%	77%
A0A3Q8IC18	Leishmania donovani	86%	100%
A4HLC7	Leishmania braziliensis	69%	100%
A4HZJ1	Leishmania infantum	86%	72%
Q4QBZ8	Leishmania major	86%	100%