Peroxisomal membrane protein PEX14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxin 14, putative

Species:

Leishmania mexicana

UniProt:

E9AVI0_LEIMU

TriTrypDb:

LmxM.21.1840

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	7
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	7
GO:0031903	microbody membrane	5	7
GO:0042579	microbody	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0098588	bounding membrane of organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0032991	protein-containing complex	1	1
GO:1990351	transporter complex	2	1
GO:1990429	peroxisomal importomer complex	3	1

Expansion

Sequence features

E9AVI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVI0

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	7
GO:0009987	cellular process	1	7
GO:0016560	protein import into peroxisome matrix, docking	5	7
GO:0033036	macromolecule localization	2	7
GO:0051179	localization	1	7
GO:0051641	cellular localization	2	7
GO:0070727	cellular macromolecule localization	3	7

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.601
CLV_C14_Caspase3-7	26	30	PF00656	0.477
CLV_NRD_NRD_1	182	184	PF00675	0.557
CLV_NRD_NRD_1	268	270	PF00675	0.451
CLV_PCSK_KEX2_1	182	184	PF00082	0.557
CLV_PCSK_SKI1_1	262	266	PF00082	0.438
CLV_PCSK_SKI1_1	39	43	PF00082	0.205
CLV_PCSK_SKI1_1	56	60	PF00082	0.304
CLV_PCSK_SKI1_1	77	81	PF00082	0.423
DOC_ANK_TNKS_1	152	159	PF00023	0.449
DOC_MAPK_gen_1	269	277	PF00069	0.442
DOC_MAPK_MEF2A_6	104	112	PF00069	0.493
DOC_PP2B_LxvP_1	13	16	PF13499	0.600
DOC_PP2B_LxvP_1	137	140	PF13499	0.442
DOC_PP2B_LxvP_1	223	226	PF13499	0.564
DOC_USP7_MATH_1	23	27	PF00917	0.454
DOC_USP7_MATH_1	237	241	PF00917	0.548
DOC_USP7_MATH_1	440	444	PF00917	0.534
DOC_USP7_MATH_1	50	54	PF00917	0.328
DOC_USP7_MATH_1	9	13	PF00917	0.606
DOC_USP7_UBL2_3	184	188	PF12436	0.571
DOC_WW_Pin1_4	103	108	PF00397	0.623
DOC_WW_Pin1_4	121	126	PF00397	0.523
DOC_WW_Pin1_4	174	179	PF00397	0.472
DOC_WW_Pin1_4	213	218	PF00397	0.666
DOC_WW_Pin1_4	240	245	PF00397	0.531
DOC_WW_Pin1_4	345	350	PF00397	0.597
DOC_WW_Pin1_4	370	375	PF00397	0.567
DOC_WW_Pin1_4	408	413	PF00397	0.728
DOC_WW_Pin1_4	416	421	PF00397	0.609
DOC_WW_Pin1_4	450	455	PF00397	0.681
DOC_WW_Pin1_4	46	51	PF00397	0.318
LIG_14-3-3_CanoR_1	145	151	PF00244	0.616
LIG_14-3-3_CanoR_1	182	191	PF00244	0.618
LIG_14-3-3_CanoR_1	295	303	PF00244	0.456
LIG_14-3-3_CanoR_1	356	360	PF00244	0.543
LIG_14-3-3_CanoR_1	77	84	PF00244	0.554
LIG_BRCT_BRCA1_1	331	335	PF00533	0.651
LIG_EVH1_1	137	141	PF00568	0.444
LIG_EVH1_1	223	227	PF00568	0.555
LIG_FHA_1	128	134	PF00498	0.740
LIG_FHA_1	246	252	PF00498	0.475
LIG_FHA_1	295	301	PF00498	0.457
LIG_FHA_1	359	365	PF00498	0.500
LIG_FHA_1	423	429	PF00498	0.559
LIG_FHA_2	254	260	PF00498	0.431
LIG_FHA_2	338	344	PF00498	0.618
LIG_FHA_2	428	434	PF00498	0.616
LIG_LIR_Gen_1	430	439	PF02991	0.494
LIG_LIR_Gen_1	69	79	PF02991	0.294
LIG_LIR_Nem_3	132	137	PF02991	0.715
LIG_LIR_Nem_3	149	155	PF02991	0.500
LIG_LIR_Nem_3	168	173	PF02991	0.355
LIG_LIR_Nem_3	332	338	PF02991	0.655
LIG_LIR_Nem_3	430	434	PF02991	0.495
LIG_LIR_Nem_3	69	75	PF02991	0.205
LIG_MLH1_MIPbox_1	331	335	PF16413	0.651
LIG_MYND_1	135	139	PF01753	0.455
LIG_PTAP_UEV_1	423	428	PF05743	0.494
LIG_SH2_SRC	136	139	PF00017	0.452
LIG_SH2_STAP1	129	133	PF00017	0.564
LIG_SH2_STAT5	129	132	PF00017	0.631
LIG_SH2_STAT5	136	139	PF00017	0.553
LIG_SH2_STAT5	334	337	PF00017	0.656
LIG_SH3_3	132	138	PF00018	0.653
LIG_SH3_3	17	23	PF00018	0.538
LIG_SH3_3	221	227	PF00018	0.579
LIG_SH3_3	3	9	PF00018	0.579
LIG_SH3_3	325	331	PF00018	0.595
LIG_SH3_3	363	369	PF00018	0.622
LIG_SH3_3	421	427	PF00018	0.594
LIG_SH3_3	84	90	PF00018	0.516
LIG_WRC_WIRS_1	428	433	PF05994	0.498
MOD_CDK_SPxK_1	213	219	PF00069	0.620
MOD_CDK_SPxxK_3	349	356	PF00069	0.509
MOD_CK1_1	206	212	PF00069	0.679
MOD_CK1_1	240	246	PF00069	0.523
MOD_CK1_1	315	321	PF00069	0.448
MOD_CK1_1	337	343	PF00069	0.640
MOD_CK1_1	358	364	PF00069	0.580
MOD_CK2_1	174	180	PF00069	0.520
MOD_CK2_1	204	210	PF00069	0.621
MOD_CK2_1	21	27	PF00069	0.734
MOD_CK2_1	337	343	PF00069	0.616
MOD_CK2_1	427	433	PF00069	0.660
MOD_CK2_1	46	52	PF00069	0.304
MOD_GlcNHglycan	167	170	PF01048	0.474
MOD_GlcNHglycan	206	209	PF01048	0.641
MOD_GlcNHglycan	239	242	PF01048	0.573
MOD_GlcNHglycan	277	280	PF01048	0.431
MOD_GlcNHglycan	313	317	PF01048	0.488
MOD_GlcNHglycan	35	38	PF01048	0.292
MOD_GlcNHglycan	357	360	PF01048	0.613
MOD_GlcNHglycan	442	445	PF01048	0.581
MOD_GSK3_1	204	211	PF00069	0.580
MOD_GSK3_1	315	322	PF00069	0.430
MOD_GSK3_1	330	337	PF00069	0.711
MOD_GSK3_1	345	352	PF00069	0.516
MOD_GSK3_1	355	362	PF00069	0.580
MOD_GSK3_1	370	377	PF00069	0.530
MOD_GSK3_1	434	441	PF00069	0.504
MOD_GSK3_1	46	53	PF00069	0.319
MOD_GSK3_1	99	106	PF00069	0.656
MOD_N-GLC_1	203	208	PF02516	0.567
MOD_NEK2_1	275	280	PF00069	0.430
MOD_NEK2_2	129	134	PF00069	0.540
MOD_PIKK_1	127	133	PF00454	0.563
MOD_PIKK_1	294	300	PF00454	0.459
MOD_PIKK_1	319	325	PF00454	0.632
MOD_PIKK_1	50	56	PF00454	0.304
MOD_PK_1	83	89	PF00069	0.451
MOD_PKA_1	182	188	PF00069	0.566
MOD_PKA_2	144	150	PF00069	0.586
MOD_PKA_2	182	188	PF00069	0.566
MOD_PKA_2	294	300	PF00069	0.459
MOD_PKA_2	355	361	PF00069	0.545
MOD_Plk_1	30	36	PF00069	0.347
MOD_Plk_1	374	380	PF00069	0.584
MOD_Plk_4	129	135	PF00069	0.589
MOD_Plk_4	330	336	PF00069	0.622
MOD_Plk_4	434	440	PF00069	0.491
MOD_ProDKin_1	103	109	PF00069	0.619
MOD_ProDKin_1	121	127	PF00069	0.518
MOD_ProDKin_1	174	180	PF00069	0.479
MOD_ProDKin_1	213	219	PF00069	0.671
MOD_ProDKin_1	240	246	PF00069	0.523
MOD_ProDKin_1	345	351	PF00069	0.599
MOD_ProDKin_1	370	376	PF00069	0.570
MOD_ProDKin_1	408	414	PF00069	0.732
MOD_ProDKin_1	416	422	PF00069	0.608
MOD_ProDKin_1	450	456	PF00069	0.681
MOD_ProDKin_1	46	52	PF00069	0.318
MOD_SUMO_rev_2	180	189	PF00179	0.561
MOD_SUMO_rev_2	249	254	PF00179	0.463
MOD_SUMO_rev_2	257	264	PF00179	0.461
TRG_DiLeu_BaEn_4	249	255	PF01217	0.477
TRG_ENDOCYTIC_2	170	173	PF00928	0.429
TRG_ER_diArg_1	181	183	PF00400	0.546
TRG_ER_diArg_1	198	201	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA53	Leptomonas seymouri	60%	94%
A0A3S7WWU5	Leishmania donovani	85%	99%
A4HLC6	Leishmania braziliensis	70%	100%
A4HZJ0	Leishmania infantum	85%	99%
Q4QBZ9	Leishmania major	85%	100%