Proteasome subunit alpha type

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome subunit alpha type-5, putative

Species:

Leishmania mexicana

UniProt:

E9AVH9_LEIMU

TriTrypDb:

LmxM.21.1830

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	11
GO:0005829	cytosol	2	1
GO:0005839	proteasome core complex	3	1
GO:0019773	proteasome core complex, alpha-subunit complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12

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Expansion

Sequence features

E9AVH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVH9

PDB structure(s): 6qm7_E , 6qm7_S , 6qm8_E , 6qm8_S , 6tcz_e , 6td5_e

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	119	125	PF00089	0.195
CLV_NRD_NRD_1	129	131	PF00675	0.255
CLV_PCSK_KEX2_1	129	131	PF00082	0.308
CLV_PCSK_KEX2_1	52	54	PF00082	0.243
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.308
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.243
CLV_PCSK_SKI1_1	187	191	PF00082	0.243
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DOC_CKS1_1	229	234	PF01111	0.386
DOC_CKS1_1	40	45	PF01111	0.453

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	93%	100%
A0A0N0P4E6	Leptomonas seymouri	32%	100%
A0A0N0P7F8	Leptomonas seymouri	20%	81%
A0A0N1HVL0	Leptomonas seymouri	28%	96%
A0A0N1I173	Leptomonas seymouri	42%	100%
A0A0N1I278	Leptomonas seymouri	36%	99%
A0A0N1I2E0	Leptomonas seymouri	27%	98%
A0A0N1ILS9	Leptomonas seymouri	37%	92%
A0A0N1PBJ3	Leptomonas seymouri	38%	86%
A0A0S4INC9	Bodo saltans	30%	100%

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