Putative GPI transamidase component GAA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component GAA1, putative

Species:

Leishmania mexicana

UniProt:

E9AVH7_LEIMU

TriTrypDb:

LmxM.21.1810

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008303	caspase complex	5	11
GO:0032991	protein-containing complex	1	11
GO:0042765	GPI-anchor transamidase complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11

Expansion

Sequence features

E9AVH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVH7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016255	attachment of GPI anchor to protein	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.162
CLV_NRD_NRD_1	109	111	PF00675	0.536
CLV_NRD_NRD_1	190	192	PF00675	0.443
CLV_NRD_NRD_1	3	5	PF00675	0.363
CLV_NRD_NRD_1	37	39	PF00675	0.559
CLV_NRD_NRD_1	77	79	PF00675	0.629
CLV_PCSK_FUR_1	188	192	PF00082	0.362
CLV_PCSK_FUR_1	75	79	PF00082	0.590
CLV_PCSK_KEX2_1	108	110	PF00082	0.532
CLV_PCSK_KEX2_1	190	192	PF00082	0.443
CLV_PCSK_KEX2_1	3	5	PF00082	0.388
CLV_PCSK_KEX2_1	77	79	PF00082	0.628
CLV_PCSK_SKI1_1	136	140	PF00082	0.498
CLV_PCSK_SKI1_1	4	8	PF00082	0.399
DEG_APCC_DBOX_1	429	437	PF00400	0.499
DEG_MDM2_SWIB_1	200	207	PF02201	0.303
DEG_Nend_Nbox_1	1	3	PF02207	0.566
DEG_ODPH_VHL_1	17	28	PF01847	0.327
DOC_CDC14_PxL_1	29	37	PF14671	0.385
DOC_CKS1_1	327	332	PF01111	0.327
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.327
DOC_MAPK_DCC_7	315	324	PF00069	0.521
DOC_MAPK_MEF2A_6	136	143	PF00069	0.223
DOC_MAPK_MEF2A_6	16	24	PF00069	0.297
DOC_MAPK_NFAT4_5	136	144	PF00069	0.318
DOC_MAPK_RevD_3	24	39	PF00069	0.327
DOC_MAPK_RevD_3	95	110	PF00069	0.332
DOC_PP1_RVXF_1	1	8	PF00149	0.497
DOC_PP2B_LxvP_1	429	432	PF13499	0.555
DOC_USP7_MATH_1	224	228	PF00917	0.285
DOC_USP7_MATH_1	232	236	PF00917	0.291
DOC_USP7_MATH_1	346	350	PF00917	0.335
DOC_USP7_MATH_1	415	419	PF00917	0.334
DOC_USP7_MATH_1	95	99	PF00917	0.345
DOC_WW_Pin1_4	317	322	PF00397	0.252
DOC_WW_Pin1_4	326	331	PF00397	0.252
DOC_WW_Pin1_4	76	81	PF00397	0.440
LIG_14-3-3_CanoR_1	108	114	PF00244	0.435
LIG_BRCT_BRCA1_1	176	180	PF00533	0.186
LIG_BRCT_BRCA1_1	241	245	PF00533	0.327
LIG_BRCT_BRCA1_1	348	352	PF00533	0.368
LIG_BRCT_BRCA1_1	439	443	PF00533	0.339
LIG_CSL_BTD_1	278	281	PF09270	0.223
LIG_eIF4E_1	134	140	PF01652	0.253
LIG_FHA_1	223	229	PF00498	0.327
LIG_FHA_1	35	41	PF00498	0.477
LIG_FHA_1	58	64	PF00498	0.399
LIG_FHA_2	153	159	PF00498	0.162
LIG_FHA_2	306	312	PF00498	0.260
LIG_GBD_Chelix_1	257	265	PF00786	0.503
LIG_GBD_Chelix_1	374	382	PF00786	0.292
LIG_LIR_Apic_2	125	131	PF02991	0.304
LIG_LIR_Apic_2	60	65	PF02991	0.374
LIG_LIR_Gen_1	252	262	PF02991	0.327
LIG_LIR_Gen_1	275	284	PF02991	0.303
LIG_LIR_Gen_1	320	331	PF02991	0.385
LIG_LIR_Gen_1	349	360	PF02991	0.337
LIG_LIR_Gen_1	370	379	PF02991	0.287
LIG_LIR_Gen_1	440	450	PF02991	0.385
LIG_LIR_Gen_1	457	464	PF02991	0.370
LIG_LIR_Nem_3	116	122	PF02991	0.259
LIG_LIR_Nem_3	197	203	PF02991	0.252
LIG_LIR_Nem_3	252	257	PF02991	0.312
LIG_LIR_Nem_3	275	280	PF02991	0.225
LIG_LIR_Nem_3	283	288	PF02991	0.219
LIG_LIR_Nem_3	306	312	PF02991	0.252
LIG_LIR_Nem_3	320	326	PF02991	0.252
LIG_LIR_Nem_3	349	355	PF02991	0.298
LIG_LIR_Nem_3	370	374	PF02991	0.269
LIG_LIR_Nem_3	440	446	PF02991	0.344
LIG_LYPXL_SIV_4	133	141	PF13949	0.253
LIG_LYPXL_SIV_4	205	213	PF13949	0.253
LIG_NRBOX	354	360	PF00104	0.260
LIG_Pex14_2	200	204	PF04695	0.303
LIG_Pex14_2	352	356	PF04695	0.313
LIG_PTB_Apo_2	87	94	PF02174	0.317
LIG_PTB_Phospho_1	87	93	PF10480	0.355
LIG_SH2_GRB2like	167	170	PF00017	0.253
LIG_SH2_GRB2like	88	91	PF00017	0.252
LIG_SH2_NCK_1	134	138	PF00017	0.318
LIG_SH2_NCK_1	290	294	PF00017	0.223
LIG_SH2_SRC	206	209	PF00017	0.318
LIG_SH2_SRC	290	293	PF00017	0.252
LIG_SH2_SRC	62	65	PF00017	0.364
LIG_SH2_STAP1	134	138	PF00017	0.318
LIG_SH2_STAP1	167	171	PF00017	0.253
LIG_SH2_STAT3	184	187	PF00017	0.253
LIG_SH2_STAT5	120	123	PF00017	0.257
LIG_SH2_STAT5	134	137	PF00017	0.311
LIG_SH2_STAT5	167	170	PF00017	0.383
LIG_SH2_STAT5	184	187	PF00017	0.245
LIG_SH2_STAT5	206	209	PF00017	0.288
LIG_SH2_STAT5	287	290	PF00017	0.318
LIG_SH2_STAT5	41	44	PF00017	0.365
LIG_SH2_STAT5	424	427	PF00017	0.290
LIG_SH2_STAT5	62	65	PF00017	0.334
LIG_SH2_STAT5	88	91	PF00017	0.263
LIG_SH3_3	208	214	PF00018	0.256
LIG_SH3_3	275	281	PF00018	0.223
LIG_SH3_3	444	450	PF00018	0.385
LIG_SH3_3	64	70	PF00018	0.391
LIG_SH3_5	163	167	PF00018	0.253
LIG_SUMO_SIM_par_1	229	237	PF11976	0.235
LIG_SUMO_SIM_par_1	324	329	PF11976	0.357
LIG_TRAF2_1	124	127	PF00917	0.421
LIG_TYR_ITIM	421	426	PF00017	0.385
LIG_UBA3_1	31	39	PF00899	0.372
LIG_WRC_WIRS_1	368	373	PF05994	0.429
LIG_WRC_WIRS_1	443	448	PF05994	0.269
MOD_CAAXbox	461	464	PF01239	0.376
MOD_CK1_1	227	233	PF00069	0.263
MOD_CK1_1	234	240	PF00069	0.270
MOD_CK1_1	303	309	PF00069	0.252
MOD_CK1_1	79	85	PF00069	0.328
MOD_CK2_1	121	127	PF00069	0.389
MOD_CK2_1	152	158	PF00069	0.207
MOD_CK2_1	305	311	PF00069	0.279
MOD_CMANNOS	201	204	PF00535	0.518
MOD_Cter_Amidation	75	78	PF01082	0.559
MOD_GlcNHglycan	239	242	PF01048	0.487
MOD_GlcNHglycan	348	351	PF01048	0.307
MOD_GlcNHglycan	364	367	PF01048	0.278
MOD_GlcNHglycan	418	421	PF01048	0.293
MOD_GlcNHglycan	52	55	PF01048	0.561
MOD_GSK3_1	227	234	PF00069	0.269
MOD_GSK3_1	300	307	PF00069	0.257
MOD_GSK3_1	346	353	PF00069	0.317
MOD_N-GLC_1	122	127	PF02516	0.514
MOD_N-GLC_1	141	146	PF02516	0.470
MOD_NEK2_1	141	146	PF00069	0.323
MOD_NEK2_1	174	179	PF00069	0.186
MOD_NEK2_1	207	212	PF00069	0.326
MOD_NEK2_1	300	305	PF00069	0.267
MOD_NEK2_1	367	372	PF00069	0.513
MOD_NEK2_1	442	447	PF00069	0.288
MOD_PIKK_1	245	251	PF00454	0.232
MOD_PK_1	315	321	PF00069	0.453
MOD_PKA_1	109	115	PF00069	0.300
MOD_PKA_1	190	196	PF00069	0.162
MOD_PKA_2	109	115	PF00069	0.442
MOD_PKA_2	189	195	PF00069	0.367
MOD_PKB_1	188	196	PF00069	0.162
MOD_Plk_1	141	147	PF00069	0.223
MOD_Plk_1	207	213	PF00069	0.318
MOD_Plk_4	142	148	PF00069	0.260
MOD_Plk_4	180	186	PF00069	0.318
MOD_Plk_4	234	240	PF00069	0.286
MOD_Plk_4	273	279	PF00069	0.236
MOD_Plk_4	280	286	PF00069	0.279
MOD_Plk_4	300	306	PF00069	0.182
MOD_Plk_4	396	402	PF00069	0.306
MOD_Plk_4	442	448	PF00069	0.327
MOD_ProDKin_1	317	323	PF00069	0.252
MOD_ProDKin_1	326	332	PF00069	0.252
MOD_ProDKin_1	76	82	PF00069	0.441
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.260
TRG_ENDOCYTIC_2	423	426	PF00928	0.385
TRG_ER_diArg_1	107	110	PF00400	0.333
TRG_ER_diArg_1	188	191	PF00400	0.229
TRG_ER_diArg_1	2	4	PF00400	0.632
TRG_ER_diArg_1	35	38	PF00400	0.357
TRG_ER_diArg_1	74	77	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W7	Leptomonas seymouri	67%	100%
A0A1X0NIY4	Trypanosomatidae	38%	100%
A0A3R7N823	Trypanosoma rangeli	38%	99%
A0A3S7WWY8	Leishmania donovani	94%	100%
A4HLC3	Leishmania braziliensis	83%	100%
A4HZI7	Leishmania infantum	94%	100%
D0A0Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QC02	Leishmania major	94%	100%
V5DID2	Trypanosoma cruzi	37%	96%