LeishMANIAdb
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V-type proton ATPase proteolipid subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
V-type proton ATPase proteolipid subunit
Gene product:
vacuolar ATP synthase, putative
Species:
Leishmania mexicana
UniProt:
E9AVH5_LEIMU
TriTrypDb:
LmxM.21.1790 , LmxM.21.1800
Length:
187

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 20
NetGPI no yes: 0, no: 29
Cellular components
Term Name Level Count
GO:0005774 vacuolar membrane 5 30
GO:0016020 membrane 2 30
GO:0031090 organelle membrane 3 30
GO:0032991 protein-containing complex 1 30
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 30
GO:0033179 proton-transporting V-type ATPase, V0 domain 4 30
GO:0098588 bounding membrane of organelle 4 30
GO:0098796 membrane protein complex 2 30
GO:0110165 cellular anatomical entity 1 30

Expansion

Sequence features

E9AVH5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVH5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 19
GO:0005215 transporter activity 1 30
GO:0008324 monoatomic cation transmembrane transporter activity 4 30
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 30
GO:0015075 monoatomic ion transmembrane transporter activity 3 30
GO:0015078 proton transmembrane transporter activity 5 30
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 30
GO:0015399 primary active transmembrane transporter activity 4 30
GO:0016787 hydrolase activity 2 19
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 30
GO:0022804 active transmembrane transporter activity 3 30
GO:0022853 active monoatomic ion transmembrane transporter activity 4 30
GO:0022857 transmembrane transporter activity 2 30
GO:0022890 inorganic cation transmembrane transporter activity 4 30
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 30
GO:0042626 ATPase-coupled transmembrane transporter activity 2 30
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 30
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 30
GO:0140657 ATP-dependent activity 1 30

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_Nend_UBRbox_1 1 4 PF02207 0.602
DOC_MAPK_DCC_7 71 81 PF00069 0.450
DOC_MAPK_gen_1 146 156 PF00069 0.446
DOC_MAPK_gen_1 71 79 PF00069 0.450
DOC_MAPK_MEF2A_6 146 154 PF00069 0.450
DOC_MAPK_MEF2A_6 74 81 PF00069 0.450
DOC_USP7_MATH_1 19 23 PF00917 0.550
LIG_APCC_ABBA_1 157 162 PF00400 0.300
LIG_BRCT_BRCA1_1 29 33 PF00533 0.360
LIG_LIR_Gen_1 104 114 PF02991 0.390
LIG_LIR_Gen_1 148 159 PF02991 0.451
LIG_LIR_Nem_3 104 110 PF02991 0.398
LIG_LIR_Nem_3 111 116 PF02991 0.366
LIG_MLH1_MIPbox_1 30 34 PF16413 0.356
LIG_SH2_CRK 167 171 PF00017 0.279
LIG_SH2_CRK 88 92 PF00017 0.300
LIG_SH2_SRC 3 6 PF00017 0.645
LIG_SH2_STAT3 144 147 PF00017 0.451
LIG_SH2_STAT5 113 116 PF00017 0.398
MOD_CK1_1 108 114 PF00069 0.380
MOD_GlcNHglycan 100 103 PF01048 0.613
MOD_GlcNHglycan 107 110 PF01048 0.575
MOD_GlcNHglycan 138 142 PF01048 0.292
MOD_GlcNHglycan 30 33 PF01048 0.570
MOD_GlcNHglycan 49 52 PF01048 0.414
MOD_GlcNHglycan 56 59 PF01048 0.244
MOD_GSK3_1 47 54 PF00069 0.332
MOD_N-GLC_1 175 180 PF02516 0.514
MOD_N-GLC_1 98 103 PF02516 0.551
MOD_NEK2_1 175 180 PF00069 0.550
MOD_NEK2_1 33 38 PF00069 0.234
MOD_NEK2_1 90 95 PF00069 0.307
MOD_NEK2_2 10 15 PF00069 0.517
MOD_Plk_1 103 109 PF00069 0.470
MOD_Plk_4 10 16 PF00069 0.638
MOD_Plk_4 90 96 PF00069 0.316
TRG_ENDOCYTIC_2 107 110 PF00928 0.388
TRG_ENDOCYTIC_2 113 116 PF00928 0.378
TRG_ENDOCYTIC_2 167 170 PF00928 0.279
TRG_ENDOCYTIC_2 88 91 PF00928 0.297
TRG_NES_CRM1_1 148 162 PF08389 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3G9 Leptomonas seymouri 29% 83%
A0A0N0P7K0 Leptomonas seymouri 73% 95%
A0A0N1HSG6 Leptomonas seymouri 92% 99%
A0A0N1I3H6 Leptomonas seymouri 63% 100%
A0A0S4IU71 Bodo saltans 86% 100%
A0A0S4JFM4 Bodo saltans 66% 100%
A0A0S4JKG0 Bodo saltans 29% 72%
A0A0S4KKA5 Bodo saltans 73% 96%
A0A1X0NGC8 Trypanosomatidae 68% 100%
A0A1X0NHL5 Trypanosomatidae 90% 98%
A0A1X0NZ73 Trypanosomatidae 72% 100%
A0A1X0P179 Trypanosomatidae 26% 83%
A0A3Q8II19 Leishmania donovani 72% 93%
A0A3Q8II88 Leishmania donovani 27% 83%
A0A3Q8ILV9 Leishmania donovani 65% 100%
A0A3R7MQK8 Trypanosoma rangeli 25% 83%
A0A3R7RFU6 Trypanosoma rangeli 85% 96%
A0A3S7WX01 Leishmania donovani 94% 100%
A0A422N304 Trypanosoma rangeli 72% 94%
A0A422NW00 Trypanosoma rangeli 67% 100%
A2ZBW5 Oryza sativa subsp. indica 56% 100%
A4HCM7 Leishmania braziliensis 63% 100%
A4HGG2 Leishmania braziliensis 75% 100%
A4HIV2 Leishmania braziliensis 30% 100%
A4HLC1 Leishmania braziliensis 93% 100%
A4HZI5 Leishmania infantum 94% 100%
A4I051 Leishmania infantum 65% 100%
A4I3J4 Leishmania infantum 74% 93%
A4I657 Leishmania infantum 27% 83%
C0HLB3 Caenorhabditis elegans 48% 100%
C0HLB4 Caenorhabditis elegans 48% 100%
C0HLB5 Caenorhabditis briggsae 49% 100%
C0HLB6 Caenorhabditis briggsae 49% 100%
C9ZRH7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 83%
D0A0Y8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 89% 98%
D0A7U7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 74%
E9AW14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 100%
E9AZT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 93%
E9B1E0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 83%
G5EDB8 Caenorhabditis elegans 29% 87%
O14046 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 94%
O16110 Aedes aegypti 51% 100%
O18882 Ovis aries 51% 100%
O22552 Vigna radiata var. radiata 55% 100%
O24011 Solanum lycopersicum 55% 100%
P0DH92 Arabidopsis thaliana 55% 100%
P0DH93 Arabidopsis thaliana 55% 100%
P0DH94 Arabidopsis thaliana 55% 100%
P23380 Drosophila melanogaster 53% 100%
P23956 Bos taurus 51% 100%
P23957 Avena sativa 54% 100%
P23968 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 88%
P25515 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 52% 100%
P27449 Homo sapiens 51% 100%
P31403 Manduca sexta 54% 100%
P31413 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 56% 100%
P32842 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 46% 100%
P50515 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 54% 100%
P54642 Dictyostelium discoideum 45% 95%
P55277 Heliothis virescens 55% 100%
P59228 Arabidopsis thaliana 55% 100%
P59229 Arabidopsis thaliana 55% 100%
P63081 Rattus norvegicus 53% 100%
P63082 Mus musculus 53% 100%
P68161 Mesembryanthemum crystallinum 55% 100%
P68162 Beta vulgaris 55% 100%
Q00607 Candida tropicalis 52% 100%
Q03105 Torpedo marmorata 55% 100%
Q0IUB5 Oryza sativa subsp. japonica 56% 100%
Q17046 Ascaris suum 48% 100%
Q21898 Caenorhabditis elegans 51% 100%
Q24808 Entamoeba dispar 47% 100%
Q24810 Entamoeba histolytica 48% 100%
Q26250 Nephrops norvegicus 53% 100%
Q2TA24 Bos taurus 32% 91%
Q40585 Nicotiana tabacum 55% 100%
Q43362 Chrysotila carterae 58% 100%
Q43434 Gossypium hirsutum 55% 100%
Q4Q6S2 Leishmania major 28% 100%
Q4Q8F0 Leishmania major 73% 100%
Q4QBG2 Leishmania major 64% 100%
Q4QC03 Leishmania major 93% 100%
Q6BSB9 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 49% 100%
Q6CT28 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 46% 100%
Q6FUY5 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 47% 100%
Q755G4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 47% 100%
Q91V37 Mus musculus 32% 91%
Q96473 Kalanchoe daigremontiana 55% 100%
Q99437 Homo sapiens 32% 91%
Q9SLA2 Arabidopsis thaliana 31% 100%
Q9SZY7 Arabidopsis thaliana 31% 100%
Q9URZ8 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 100%
Q9Y874 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS