V-type proton ATPase proteolipid subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase, putative

Species:

Leishmania mexicana

UniProt:

E9AVH5_LEIMU

TriTrypDb:

LmxM.21.1790 , LmxM.21.1800

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 20
NetGPI	no	yes: 0, no: 29

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Cellular components
Term	Name	Level	Count
GO:0005774	vacuolar membrane	5	30
GO:0016020	membrane	2	30
GO:0031090	organelle membrane	3	30
GO:0032991	protein-containing complex	1	30
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	30
GO:0033179	proton-transporting V-type ATPase, V0 domain	4	30
GO:0098588	bounding membrane of organelle	4	30
GO:0098796	membrane protein complex	2	30
GO:0110165	cellular anatomical entity	1	30

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Expansion

Sequence features

E9AVH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVH5

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0005215	transporter activity	1	30
GO:0008324	monoatomic cation transmembrane transporter activity	4	30
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	30
GO:0015075	monoatomic ion transmembrane transporter activity	3	30
GO:0015078	proton transmembrane transporter activity	5	30
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	30
GO:0015399	primary active transmembrane transporter activity	4	30
GO:0016787	hydrolase activity	2	19
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	30

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_1	1	4	PF02207	0.602
DOC_MAPK_DCC_7	71	81	PF00069	0.450
DOC_MAPK_gen_1	146	156	PF00069	0.446
DOC_MAPK_gen_1	71	79	PF00069	0.450
DOC_MAPK_MEF2A_6	146	154	PF00069	0.450
DOC_MAPK_MEF2A_6	74	81	PF00069	0.450
DOC_USP7_MATH_1	19	23	PF00917	0.550
LIG_APCC_ABBA_1	157	162	PF00400	0.300
LIG_BRCT_BRCA1_1	29	33	PF00533	0.360
LIG_LIR_Gen_1	104	114	PF02991	0.390

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G9	Leptomonas seymouri	29%	83%
A0A0N0P7K0	Leptomonas seymouri	73%	95%
A0A0N1HSG6	Leptomonas seymouri	92%	99%
A0A0N1I3H6	Leptomonas seymouri	63%	100%
A0A0S4IU71	Bodo saltans	86%	100%
A0A0S4JFM4	Bodo saltans	66%	100%
A0A0S4JKG0	Bodo saltans	29%	72%
A0A0S4KKA5	Bodo saltans	73%	96%
A0A1X0NGC8	Trypanosomatidae	68%	100%
A0A1X0NHL5	Trypanosomatidae	90%	98%

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