RNA polymerase II

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA polymerase II

Gene product:

RNA polymerase II, putative

Species:

Leishmania mexicana

UniProt:

E9AVH0_LEIMU

TriTrypDb:

LmxM.21.1740

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0110165	cellular anatomical entity	1	14
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AVH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVH0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	14
GO:0006396	RNA processing	6	14
GO:0006725	cellular aromatic compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016070	RNA metabolic process	5	14
GO:0031123	RNA 3'-end processing	7	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0043170	macromolecule metabolic process	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0046483	heterocycle metabolic process	3	14
GO:0071076	RNA 3' uridylation	8	14
GO:0071704	organic substance metabolic process	2	14
GO:0090304	nucleic acid metabolic process	4	14
GO:1901360	organic cyclic compound metabolic process	3	14
GO:0006378	mRNA polyadenylation	7	1
GO:0006397	mRNA processing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016779	nucleotidyltransferase activity	4	14
GO:0050265	RNA uridylyltransferase activity	4	14
GO:0070569	uridylyltransferase activity	5	14
GO:0140098	catalytic activity, acting on RNA	3	14
GO:0140640	catalytic activity, acting on a nucleic acid	2	14
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	4
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0070566	adenylyltransferase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.424
CLV_MEL_PAP_1	7	13	PF00089	0.401
CLV_NRD_NRD_1	130	132	PF00675	0.451
CLV_NRD_NRD_1	15	17	PF00675	0.705
CLV_NRD_NRD_1	155	157	PF00675	0.485
CLV_NRD_NRD_1	210	212	PF00675	0.371
CLV_NRD_NRD_1	49	51	PF00675	0.404
CLV_PCSK_KEX2_1	15	17	PF00082	0.731
CLV_PCSK_KEX2_1	210	212	PF00082	0.364
CLV_PCSK_KEX2_1	49	51	PF00082	0.442
CLV_PCSK_SKI1_1	282	286	PF00082	0.421
DEG_APCC_DBOX_1	188	196	PF00400	0.439
DEG_APCC_DBOX_1	48	56	PF00400	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.479
DOC_CKS1_1	291	296	PF01111	0.379
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.393
DOC_MAPK_gen_1	131	139	PF00069	0.456
DOC_MAPK_gen_1	143	151	PF00069	0.302
DOC_MAPK_gen_1	372	378	PF00069	0.435
DOC_MAPK_MEF2A_6	164	171	PF00069	0.362
DOC_MAPK_NFAT4_5	164	172	PF00069	0.385
DOC_PP1_RVXF_1	350	357	PF00149	0.342
DOC_USP7_MATH_1	159	163	PF00917	0.592
DOC_USP7_MATH_1	248	252	PF00917	0.458
DOC_USP7_MATH_1	253	257	PF00917	0.467
DOC_USP7_MATH_1	78	82	PF00917	0.482
DOC_USP7_UBL2_3	160	164	PF12436	0.283
DOC_USP7_UBL2_3	66	70	PF12436	0.535
DOC_WW_Pin1_4	155	160	PF00397	0.286
DOC_WW_Pin1_4	212	217	PF00397	0.336
DOC_WW_Pin1_4	290	295	PF00397	0.373
DOC_WW_Pin1_4	68	73	PF00397	0.635
LIG_14-3-3_CanoR_1	10	15	PF00244	0.505
LIG_14-3-3_CanoR_1	131	141	PF00244	0.443
LIG_14-3-3_CanoR_1	232	238	PF00244	0.485
LIG_14-3-3_CanoR_1	311	318	PF00244	0.384
LIG_14-3-3_CanoR_1	35	42	PF00244	0.398
LIG_Actin_WH2_2	162	177	PF00022	0.393
LIG_AP2alpha_2	343	345	PF02296	0.353
LIG_BRCT_BRCA1_1	123	127	PF00533	0.466
LIG_BRCT_BRCA1_1	161	165	PF00533	0.469
LIG_BRCT_BRCA1_1	352	356	PF00533	0.345
LIG_CtBP_PxDLS_1	359	365	PF00389	0.187
LIG_deltaCOP1_diTrp_1	316	321	PF00928	0.366
LIG_FHA_2	161	167	PF00498	0.311
LIG_FHA_2	250	256	PF00498	0.461
LIG_FHA_2	87	93	PF00498	0.406
LIG_FHA_2	99	105	PF00498	0.433
LIG_LIR_Gen_1	220	227	PF02991	0.294
LIG_LIR_Gen_1	283	291	PF02991	0.288
LIG_LIR_Gen_1	298	306	PF02991	0.289
LIG_LIR_Gen_1	316	325	PF02991	0.437
LIG_LIR_Gen_1	329	339	PF02991	0.247
LIG_LIR_Gen_1	377	382	PF02991	0.398
LIG_LIR_Nem_3	124	130	PF02991	0.414
LIG_LIR_Nem_3	220	226	PF02991	0.295
LIG_LIR_Nem_3	283	288	PF02991	0.295
LIG_LIR_Nem_3	298	302	PF02991	0.294
LIG_LIR_Nem_3	316	321	PF02991	0.442
LIG_LIR_Nem_3	329	334	PF02991	0.269
LIG_LIR_Nem_3	377	382	PF02991	0.398
LIG_LIR_Nem_3	98	102	PF02991	0.357
LIG_NRBOX	51	57	PF00104	0.425
LIG_Pex14_1	213	217	PF04695	0.315
LIG_REV1ctd_RIR_1	354	362	PF16727	0.360
LIG_SH2_CRK	291	295	PF00017	0.467
LIG_SH2_CRK	42	46	PF00017	0.384
LIG_SH2_CRK	79	83	PF00017	0.407
LIG_SH2_STAP1	217	221	PF00017	0.295
LIG_SH2_STAP1	42	46	PF00017	0.471
LIG_SH2_STAT5	154	157	PF00017	0.455
LIG_SH2_STAT5	223	226	PF00017	0.271
LIG_SH2_STAT5	95	98	PF00017	0.452
LIG_SH3_3	341	347	PF00018	0.365
LIG_SH3_3	72	78	PF00018	0.405
LIG_SH3_3	94	100	PF00018	0.416
LIG_SUMO_SIM_anti_2	276	281	PF11976	0.496
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.344
LIG_SUMO_SIM_par_1	302	308	PF11976	0.299
LIG_SUMO_SIM_par_1	337	343	PF11976	0.331
LIG_TRAF2_1	271	274	PF00917	0.362
LIG_TRAF2_1	65	68	PF00917	0.481
LIG_TRAF2_2	271	276	PF00917	0.394
LIG_TYR_ITIM	77	82	PF00017	0.463
LIG_UBA3_1	126	132	PF00899	0.413
LIG_UBA3_1	221	228	PF00899	0.349
MOD_CDK_SPK_2	155	160	PF00069	0.286
MOD_CK1_1	81	87	PF00069	0.431
MOD_CK1_1	98	104	PF00069	0.349
MOD_CK2_1	132	138	PF00069	0.478
MOD_CK2_1	155	161	PF00069	0.508
MOD_CK2_1	233	239	PF00069	0.491
MOD_CK2_1	249	255	PF00069	0.390
MOD_CK2_1	275	281	PF00069	0.272
MOD_CK2_1	98	104	PF00069	0.360
MOD_GlcNHglycan	108	111	PF01048	0.432
MOD_GlcNHglycan	25	28	PF01048	0.599
MOD_GlcNHglycan	31	35	PF01048	0.532
MOD_GlcNHglycan	367	370	PF01048	0.454
MOD_GlcNHglycan	83	86	PF01048	0.377
MOD_GSK3_1	121	128	PF00069	0.369
MOD_GSK3_1	155	162	PF00069	0.425
MOD_GSK3_1	249	256	PF00069	0.427
MOD_GSK3_1	346	353	PF00069	0.449
MOD_GSK3_1	374	381	PF00069	0.371
MOD_GSK3_1	6	13	PF00069	0.485
MOD_N-GLC_1	23	28	PF02516	0.387
MOD_N-GLC_2	4	6	PF02516	0.392
MOD_NEK2_1	165	170	PF00069	0.332
MOD_NEK2_1	174	179	PF00069	0.338
MOD_NEK2_1	227	232	PF00069	0.358
MOD_PIKK_1	240	246	PF00454	0.442
MOD_PIKK_1	35	41	PF00454	0.437
MOD_PKA_2	106	112	PF00069	0.621
MOD_PKA_2	310	316	PF00069	0.480
MOD_PKA_2	9	15	PF00069	0.464
MOD_PKB_1	309	317	PF00069	0.397
MOD_Plk_1	165	171	PF00069	0.283
MOD_Plk_1	258	264	PF00069	0.474
MOD_Plk_1	275	281	PF00069	0.411
MOD_Plk_4	174	180	PF00069	0.329
MOD_Plk_4	217	223	PF00069	0.269
MOD_Plk_4	265	271	PF00069	0.377
MOD_Plk_4	374	380	PF00069	0.425
MOD_Plk_4	78	84	PF00069	0.391
MOD_ProDKin_1	155	161	PF00069	0.288
MOD_ProDKin_1	212	218	PF00069	0.332
MOD_ProDKin_1	290	296	PF00069	0.373
MOD_ProDKin_1	68	74	PF00069	0.615
MOD_SUMO_for_1	371	374	PF00179	0.347
MOD_SUMO_for_1	65	68	PF00179	0.518
MOD_SUMO_rev_2	62	72	PF00179	0.581
TRG_DiLeu_BaEn_1	329	334	PF01217	0.423
TRG_ENDOCYTIC_2	223	226	PF00928	0.270
TRG_ENDOCYTIC_2	42	45	PF00928	0.432
TRG_ENDOCYTIC_2	79	82	PF00928	0.413
TRG_ER_diArg_1	14	16	PF00400	0.731
TRG_ER_diArg_1	145	148	PF00400	0.400
TRG_ER_diArg_1	188	191	PF00400	0.342
TRG_ER_diArg_1	306	309	PF00400	0.418
TRG_ER_diArg_1	49	51	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA71	Leptomonas seymouri	63%	100%
A0A0S4IUE3	Bodo saltans	34%	85%
A0A0S4IXY7	Bodo saltans	21%	100%
A0A1X0NI50	Trypanosomatidae	45%	100%
A0A1X0NT04	Trypanosomatidae	25%	100%
A0A3R7LQY4	Trypanosoma rangeli	26%	100%
A0A3R7M9K0	Trypanosoma rangeli	45%	100%
A0A3S7WWT5	Leishmania donovani	94%	100%
A4HC38	Leishmania braziliensis	82%	100%
A4HZI0	Leishmania infantum	94%	100%
D0A0Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
O13833	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	94%
Q4QC09	Leishmania major	90%	100%
V5B3T6	Trypanosoma cruzi	26%	100%