Pre-mRNA-splicing factor SYF2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVG9_LEIMU

TriTrypDb:

LmxM.21.1730

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.594
CLV_C14_Caspase3-7	98	102	PF00656	0.702
CLV_NRD_NRD_1	11	13	PF00675	0.582
CLV_NRD_NRD_1	130	132	PF00675	0.549
CLV_NRD_NRD_1	25	27	PF00675	0.490
CLV_NRD_NRD_1	66	68	PF00675	0.475
CLV_PCSK_KEX2_1	121	123	PF00082	0.624
CLV_PCSK_KEX2_1	130	132	PF00082	0.525
CLV_PCSK_KEX2_1	27	29	PF00082	0.610
CLV_PCSK_KEX2_1	55	57	PF00082	0.555
CLV_PCSK_KEX2_1	68	70	PF00082	0.425
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.624
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.610
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.555
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.425
CLV_PCSK_SKI1_1	121	125	PF00082	0.653
CLV_PCSK_SKI1_1	151	155	PF00082	0.652
CLV_PCSK_SKI1_1	31	35	PF00082	0.667
DEG_APCC_DBOX_1	150	158	PF00400	0.496
DOC_PP1_RVXF_1	29	36	PF00149	0.662
DOC_PP2B_LxvP_1	123	126	PF13499	0.691
DOC_PP4_FxxP_1	59	62	PF00568	0.491
DOC_USP7_MATH_1	8	12	PF00917	0.647
DOC_USP7_MATH_1	99	103	PF00917	0.745
DOC_USP7_UBL2_3	13	17	PF12436	0.705
DOC_USP7_UBL2_3	132	136	PF12436	0.742
DOC_USP7_UBL2_3	27	31	PF12436	0.545
DOC_USP7_UBL2_3	34	38	PF12436	0.595
DOC_WW_Pin1_4	87	92	PF00397	0.774
DOC_WW_Pin1_4	93	98	PF00397	0.777
LIG_Actin_WH2_2	40	57	PF00022	0.626
LIG_BIR_II_1	1	5	PF00653	0.730
LIG_BRCT_BRCA1_1	10	14	PF00533	0.716
LIG_FHA_1	34	40	PF00498	0.674
LIG_FHA_1	88	94	PF00498	0.750
LIG_FHA_2	1	7	PF00498	0.759
LIG_FHA_2	114	120	PF00498	0.622
LIG_REV1ctd_RIR_1	107	116	PF16727	0.657
LIG_SH3_4	132	139	PF00018	0.658
LIG_TRAF2_1	86	89	PF00917	0.710
LIG_WRC_WIRS_1	163	168	PF05994	0.668
MOD_CK2_1	113	119	PF00069	0.735
MOD_GlcNHglycan	97	100	PF01048	0.630
MOD_GSK3_1	162	169	PF00069	0.673
MOD_GSK3_1	33	40	PF00069	0.638
MOD_GSK3_1	95	102	PF00069	0.644
MOD_NEK2_1	166	171	PF00069	0.670
MOD_Plk_2-3	101	107	PF00069	0.762
MOD_Plk_4	162	168	PF00069	0.672
MOD_ProDKin_1	87	93	PF00069	0.774
MOD_SUMO_rev_2	118	123	PF00179	0.718
MOD_SUMO_rev_2	77	86	PF00179	0.701
TRG_DiLeu_BaEn_1	66	71	PF01217	0.487
TRG_ER_diArg_1	129	131	PF00400	0.537
TRG_ER_diArg_1	56	59	PF00400	0.611
TRG_ER_diArg_1	67	70	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NH88	Trypanosomatidae	34%	97%
A0A3S7WWT3	Leishmania donovani	89%	100%
A0A422N8U7	Trypanosoma rangeli	35%	98%
A4HC37	Leishmania braziliensis	76%	99%
A4HZH9	Leishmania infantum	89%	100%
D0A0Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
Q4QC10	Leishmania major	89%	100%