Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function, DUF607, putative

Species:

Leishmania mexicana

UniProt:

E9AVG5_LEIMU

TriTrypDb:

LmxM.21.1690

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1

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Expansion

Sequence features

E9AVG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVG5

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006851	mitochondrial calcium ion transmembrane transport	4	1
GO:0006873	intracellular monoatomic ion homeostasis	4	12
GO:0006874	intracellular calcium ion homeostasis	7	12
GO:0006875	obsolete intracellular metal ion homeostasis	6	12
GO:0009987	cellular process	1	12
GO:0019725	cellular homeostasis	2	12

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005261	monoatomic cation channel activity	5	12
GO:0005262	calcium channel activity	6	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015085	calcium ion transmembrane transporter activity	6	12
GO:0015267	channel activity	4	12
GO:0015291	secondary active transmembrane transporter activity	4	12
GO:0015292	uniporter activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.258
CLV_NRD_NRD_1	7	9	PF00675	0.398
CLV_PCSK_KEX2_1	125	127	PF00082	0.263
CLV_PCSK_KEX2_1	59	61	PF00082	0.377
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.377
CLV_PCSK_SKI1_1	214	218	PF00082	0.397
CLV_PCSK_SKI1_1	22	26	PF00082	0.333
CLV_PCSK_SKI1_1	27	31	PF00082	0.252
CLV_PCSK_SKI1_1	59	63	PF00082	0.352
CLV_PCSK_SKI1_1	8	12	PF00082	0.380

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P418	Leptomonas seymouri	60%	89%
A0A0S4IYH5	Bodo saltans	35%	100%
A0A1X0NHK2	Trypanosomatidae	42%	93%
A0A3Q8IFA5	Leishmania donovani	95%	100%
A0A422N8V4	Trypanosoma rangeli	36%	96%
A4HC33	Leishmania braziliensis	84%	100%
A4HZH5	Leishmania infantum	95%	100%
D0A0Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
Q4QC14	Leishmania major	97%	100%
V5DIC7	Trypanosoma cruzi	43%	84%

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