RNA-binding regulatory protein (Pumilio family),putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding regulatory protein (pumilio family), putative

Species:

Leishmania mexicana

UniProt:

E9AVG4_LEIMU

TriTrypDb:

LmxM.21.1680

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVG4

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.728
CLV_NRD_NRD_1	116	118	PF00675	0.701
CLV_NRD_NRD_1	134	136	PF00675	0.552
CLV_NRD_NRD_1	514	516	PF00675	0.528
CLV_PCSK_KEX2_1	101	103	PF00082	0.728
CLV_PCSK_KEX2_1	136	138	PF00082	0.620
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.639
CLV_PCSK_SKI1_1	314	318	PF00082	0.324
CLV_PCSK_SKI1_1	373	377	PF00082	0.349
DEG_SCF_FBW7_1	278	285	PF00400	0.284
DEG_SCF_FBW7_1	77	83	PF00400	0.463
DEG_SCF_FBW7_1	90	97	PF00400	0.500
DOC_CDC14_PxL_1	414	422	PF14671	0.347
DOC_CKS1_1	48	53	PF01111	0.563
DOC_CKS1_1	77	82	PF01111	0.578
DOC_CKS1_1	91	96	PF01111	0.644
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.746
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.697
DOC_PP2B_LxvP_1	88	91	PF13499	0.762
DOC_PP4_FxxP_1	48	51	PF00568	0.604
DOC_PP4_FxxP_1	522	525	PF00568	0.643
DOC_USP7_MATH_1	403	407	PF00917	0.438
DOC_USP7_MATH_1	80	84	PF00917	0.682
DOC_USP7_UBL2_3	36	40	PF12436	0.723
DOC_USP7_UBL2_3	505	509	PF12436	0.373
DOC_WW_Pin1_4	128	133	PF00397	0.676
DOC_WW_Pin1_4	278	283	PF00397	0.284
DOC_WW_Pin1_4	366	371	PF00397	0.342
DOC_WW_Pin1_4	47	52	PF00397	0.584
DOC_WW_Pin1_4	536	541	PF00397	0.708
DOC_WW_Pin1_4	544	549	PF00397	0.668
DOC_WW_Pin1_4	58	63	PF00397	0.582
DOC_WW_Pin1_4	76	81	PF00397	0.436
DOC_WW_Pin1_4	90	95	PF00397	0.609
LIG_14-3-3_CanoR_1	342	351	PF00244	0.446
LIG_Actin_WH2_2	425	440	PF00022	0.284
LIG_AP2alpha_2	390	392	PF02296	0.284
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BIR_III_4	318	322	PF00653	0.300
LIG_BRCT_BRCA1_1	44	48	PF00533	0.596
LIG_BRCT_BRCA1_1	518	522	PF00533	0.335
LIG_EH1_1	285	293	PF00400	0.284
LIG_FHA_1	125	131	PF00498	0.724
LIG_FHA_1	225	231	PF00498	0.363
LIG_FHA_1	283	289	PF00498	0.278
LIG_FHA_1	299	305	PF00498	0.270
LIG_FHA_1	344	350	PF00498	0.461
LIG_FHA_1	66	72	PF00498	0.689
LIG_FHA_2	2	8	PF00498	0.584
LIG_FHA_2	203	209	PF00498	0.333
LIG_FHA_2	219	225	PF00498	0.319
LIG_FHA_2	295	301	PF00498	0.345
LIG_FHA_2	53	59	PF00498	0.633
LIG_LIR_Apic_2	45	51	PF02991	0.605
LIG_LIR_Apic_2	519	525	PF02991	0.426
LIG_LIR_Gen_1	12	22	PF02991	0.657
LIG_LIR_Gen_1	244	255	PF02991	0.284
LIG_LIR_Gen_1	411	421	PF02991	0.185
LIG_LIR_Gen_1	83	92	PF02991	0.708
LIG_LIR_Nem_3	12	18	PF02991	0.632
LIG_LIR_Nem_3	244	250	PF02991	0.284
LIG_LIR_Nem_3	338	344	PF02991	0.284
LIG_LIR_Nem_3	390	395	PF02991	0.273
LIG_LIR_Nem_3	411	417	PF02991	0.176
LIG_LIR_Nem_3	464	469	PF02991	0.271
LIG_LIR_Nem_3	83	88	PF02991	0.639
LIG_MAD2	435	443	PF02301	0.319
LIG_PCNA_yPIPBox_3	317	329	PF02747	0.270
LIG_PTB_Apo_2	496	503	PF02174	0.371
LIG_PTB_Phospho_1	496	502	PF10480	0.377
LIG_Rb_pABgroove_1	250	258	PF01858	0.284
LIG_SH2_CRK	341	345	PF00017	0.336
LIG_SH2_GRB2like	15	18	PF00017	0.659
LIG_SH2_GRB2like	247	250	PF00017	0.284
LIG_SH2_NCK_1	564	568	PF00017	0.542
LIG_SH2_NCK_1	92	96	PF00017	0.709
LIG_SH2_STAP1	247	251	PF00017	0.284
LIG_SH2_STAP1	502	506	PF00017	0.377
LIG_SH2_STAT3	395	398	PF00017	0.270
LIG_SH2_STAT3	469	472	PF00017	0.270
LIG_SH2_STAT5	214	217	PF00017	0.411
LIG_SH2_STAT5	24	27	PF00017	0.657
LIG_SH2_STAT5	339	342	PF00017	0.442
LIG_SH2_STAT5	395	398	PF00017	0.270
LIG_SH2_STAT5	399	402	PF00017	0.270
LIG_SH2_STAT5	41	44	PF00017	0.608
LIG_SH2_STAT5	469	472	PF00017	0.270
LIG_SH2_STAT5	554	557	PF00017	0.680
LIG_SH2_STAT5	92	95	PF00017	0.723
LIG_SH3_3	267	273	PF00018	0.321
LIG_SH3_3	29	35	PF00018	0.552
LIG_SH3_3	385	391	PF00018	0.333
LIG_SH3_3	489	495	PF00018	0.366
LIG_SH3_3	69	75	PF00018	0.699
LIG_SH3_3	88	94	PF00018	0.597
LIG_SH3_4	36	43	PF00018	0.656
LIG_SUMO_SIM_par_1	276	281	PF11976	0.363
LIG_TRAF2_1	297	300	PF00917	0.248
MOD_CDC14_SPxK_1	61	64	PF00782	0.600
MOD_CDK_SPK_2	366	371	PF00069	0.398
MOD_CDK_SPxK_1	58	64	PF00069	0.687
MOD_CDK_SPxxK_3	128	135	PF00069	0.643
MOD_CDK_SPxxK_3	366	373	PF00069	0.373
MOD_CDK_SPxxK_3	536	543	PF00069	0.727
MOD_CDK_SPxxK_3	94	101	PF00069	0.729
MOD_CK1_1	124	130	PF00069	0.643
MOD_CK1_1	185	191	PF00069	0.561
MOD_CK1_1	49	55	PF00069	0.664
MOD_CK1_1	84	90	PF00069	0.692
MOD_CK2_1	1	7	PF00069	0.662
MOD_CK2_1	293	299	PF00069	0.276
MOD_CK2_1	52	58	PF00069	0.680
MOD_GlcNHglycan	111	114	PF01048	0.700
MOD_GlcNHglycan	179	183	PF01048	0.629
MOD_GlcNHglycan	189	192	PF01048	0.504
MOD_GSK3_1	124	131	PF00069	0.593
MOD_GSK3_1	147	154	PF00069	0.652
MOD_GSK3_1	178	185	PF00069	0.657
MOD_GSK3_1	187	194	PF00069	0.537
MOD_GSK3_1	278	285	PF00069	0.304
MOD_GSK3_1	294	301	PF00069	0.333
MOD_GSK3_1	343	350	PF00069	0.421
MOD_GSK3_1	35	42	PF00069	0.698
MOD_GSK3_1	76	83	PF00069	0.628
MOD_GSK3_1	90	97	PF00069	0.539
MOD_N-GLC_1	107	112	PF02516	0.664
MOD_N-GLC_1	182	187	PF02516	0.619
MOD_N-GLC_1	408	413	PF02516	0.394
MOD_N-GLC_1	81	86	PF02516	0.693
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	107	112	PF00069	0.710
MOD_NEK2_1	291	296	PF00069	0.289
MOD_NEK2_1	67	72	PF00069	0.635
MOD_PIKK_1	165	171	PF00454	0.524
MOD_PIKK_1	185	191	PF00454	0.618
MOD_PIKK_1	42	48	PF00454	0.598
MOD_Plk_1	28	34	PF00069	0.743
MOD_Plk_1	408	414	PF00069	0.439
MOD_Plk_1	81	87	PF00069	0.684
MOD_ProDKin_1	128	134	PF00069	0.675
MOD_ProDKin_1	278	284	PF00069	0.284
MOD_ProDKin_1	366	372	PF00069	0.342
MOD_ProDKin_1	47	53	PF00069	0.582
MOD_ProDKin_1	536	542	PF00069	0.709
MOD_ProDKin_1	544	550	PF00069	0.668
MOD_ProDKin_1	58	64	PF00069	0.584
MOD_ProDKin_1	76	82	PF00069	0.437
MOD_ProDKin_1	90	96	PF00069	0.610
MOD_SUMO_rev_2	110	119	PF00179	0.697
MOD_SUMO_rev_2	402	408	PF00179	0.382
MOD_SUMO_rev_2	7	12	PF00179	0.441
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.492
TRG_ENDOCYTIC_2	15	18	PF00928	0.659
TRG_ENDOCYTIC_2	247	250	PF00928	0.284
TRG_ENDOCYTIC_2	341	344	PF00928	0.322
TRG_ER_diArg_1	198	201	PF00400	0.533
TRG_NLS_Bipartite_1	117	139	PF00514	0.643
TRG_NLS_MonoExtN_4	132	139	PF00514	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC50	Leptomonas seymouri	73%	98%
A0A0S4IY52	Bodo saltans	48%	80%
A0A0S4JMB8	Bodo saltans	32%	81%
A0A1X0NHM5	Trypanosomatidae	57%	100%
A0A3S7WWX7	Leishmania donovani	93%	100%
A0A422N8V0	Trypanosoma rangeli	54%	100%
A4HC32	Leishmania braziliensis	84%	100%
A4HZH4	Leishmania infantum	93%	100%
D0A0Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
P39016	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	66%
Q4QC15	Leishmania major	92%	100%
V5B1W9	Trypanosoma cruzi	53%	100%