MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVG3_LEIMU

TriTrypDb:

LmxM.21.1675

Length:

149

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVG3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	68	70	PF00675	0.461
CLV_PCSK_KEX2_1	41	43	PF00082	0.451
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.451
CLV_PCSK_SKI1_1	56	60	PF00082	0.638
CLV_PCSK_SKI1_1	70	74	PF00082	0.478
DEG_Nend_UBRbox_2	1	3	PF02207	0.514
DOC_CKS1_1	52	57	PF01111	0.444
DOC_MAPK_gen_1	41	48	PF00069	0.477
DOC_MAPK_gen_1	69	75	PF00069	0.480
DOC_PP4_FxxP_1	106	109	PF00568	0.445
DOC_USP7_MATH_1	83	87	PF00917	0.603
DOC_WW_Pin1_4	51	56	PF00397	0.439
LIG_14-3-3_CanoR_1	35	39	PF00244	0.405
LIG_14-3-3_CanoR_1	42	47	PF00244	0.445
LIG_14-3-3_CanoR_1	69	75	PF00244	0.604
LIG_FHA_2	57	63	PF00498	0.580
LIG_LIR_Gen_1	96	101	PF02991	0.429
LIG_LIR_Nem_3	96	100	PF02991	0.417
LIG_SH2_CRK	97	101	PF00017	0.427
LIG_SH2_STAT3	137	140	PF00017	0.518
LIG_SH2_STAT5	116	119	PF00017	0.373
LIG_SH2_STAT5	137	140	PF00017	0.518
LIG_SH2_STAT5	97	100	PF00017	0.411
LIG_SH3_3	75	81	PF00018	0.601
MOD_CDK_SPK_2	51	56	PF00069	0.437
MOD_CDK_SPxK_1	51	57	PF00069	0.440
MOD_CK2_1	13	19	PF00069	0.459
MOD_CK2_1	34	40	PF00069	0.362
MOD_CK2_1	71	77	PF00069	0.608
MOD_GlcNHglycan	117	120	PF01048	0.549
MOD_GlcNHglycan	85	88	PF01048	0.717
MOD_GSK3_1	47	54	PF00069	0.420
MOD_N-GLC_1	83	88	PF02516	0.707
MOD_NEK2_1	13	18	PF00069	0.462
MOD_NEK2_1	99	104	PF00069	0.440
MOD_PKA_1	41	47	PF00069	0.468
MOD_PKA_1	56	62	PF00069	0.433
MOD_PKA_2	34	40	PF00069	0.406
MOD_PKA_2	41	47	PF00069	0.441
MOD_PKA_2	68	74	PF00069	0.597
MOD_Plk_4	34	40	PF00069	0.362
MOD_Plk_4	89	95	PF00069	0.435
MOD_ProDKin_1	51	57	PF00069	0.441
TRG_ENDOCYTIC_2	97	100	PF00928	0.423
TRG_ER_diArg_1	124	127	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU38	Leptomonas seymouri	39%	97%
A0A3Q8IAH7	Leishmania donovani	89%	99%
A0A422N8B7	Trypanosoma rangeli	33%	100%
A4HC30	Leishmania braziliensis	66%	100%
A4HZH3	Leishmania infantum	88%	99%
Q4QC16	Leishmania major	89%	100%