Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVG2_LEIMU

TriTrypDb:

LmxM.21.1670

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.467
CLV_PCSK_KEX2_1	26	28	PF00082	0.445
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.445
CLV_PCSK_PC7_1	22	28	PF00082	0.336
CLV_PCSK_SKI1_1	121	125	PF00082	0.217
CLV_PCSK_SKI1_1	22	26	PF00082	0.442
CLV_PCSK_SKI1_1	339	343	PF00082	0.459
CLV_PCSK_SKI1_1	357	361	PF00082	0.251
CLV_PCSK_SKI1_1	397	401	PF00082	0.434
CLV_PCSK_SKI1_1	85	89	PF00082	0.421
CLV_Separin_Metazoa	221	225	PF03568	0.307
DEG_APCC_DBOX_1	356	364	PF00400	0.417
DEG_MDM2_SWIB_1	169	177	PF02201	0.377
DEG_Nend_UBRbox_2	1	3	PF02207	0.438
DOC_CKS1_1	31	36	PF01111	0.483
DOC_CYCLIN_RxL_1	394	405	PF00134	0.383
DOC_MAPK_MEF2A_6	316	324	PF00069	0.425
DOC_PP1_RVXF_1	83	90	PF00149	0.415
DOC_PP4_FxxP_1	77	80	PF00568	0.429
DOC_USP7_MATH_1	110	114	PF00917	0.535
DOC_USP7_MATH_1	157	161	PF00917	0.513
DOC_USP7_MATH_1	210	214	PF00917	0.462
DOC_USP7_MATH_1	256	260	PF00917	0.470
DOC_USP7_MATH_1	395	399	PF00917	0.528
DOC_USP7_MATH_1	431	435	PF00917	0.570
DOC_WW_Pin1_4	30	35	PF00397	0.453
DOC_WW_Pin1_4	309	314	PF00397	0.451
DOC_WW_Pin1_4	326	331	PF00397	0.233
DOC_WW_Pin1_4	348	353	PF00397	0.485
DOC_WW_Pin1_4	87	92	PF00397	0.237
LIG_14-3-3_CanoR_1	216	221	PF00244	0.400
LIG_14-3-3_CanoR_1	307	313	PF00244	0.400
LIG_14-3-3_CanoR_1	316	321	PF00244	0.344
LIG_14-3-3_CanoR_1	409	414	PF00244	0.470
LIG_Actin_WH2_2	301	318	PF00022	0.428
LIG_BRCT_BRCA1_1	228	232	PF00533	0.360
LIG_deltaCOP1_diTrp_1	171	179	PF00928	0.386
LIG_FHA_1	172	178	PF00498	0.354
LIG_FHA_1	206	212	PF00498	0.419
LIG_FHA_1	217	223	PF00498	0.391
LIG_FHA_1	23	29	PF00498	0.510
LIG_FHA_1	273	279	PF00498	0.526
LIG_FHA_1	294	300	PF00498	0.511
LIG_FHA_1	301	307	PF00498	0.517
LIG_FHA_1	317	323	PF00498	0.260
LIG_FHA_1	336	342	PF00498	0.242
LIG_FHA_1	45	51	PF00498	0.423
LIG_FHA_2	163	169	PF00498	0.254
LIG_FHA_2	348	354	PF00498	0.411
LIG_FHA_2	400	406	PF00498	0.504
LIG_FHA_2	410	416	PF00498	0.499
LIG_LIR_Apic_2	74	80	PF02991	0.419
LIG_LIR_Gen_1	171	181	PF02991	0.452
LIG_LIR_Gen_1	229	238	PF02991	0.360
LIG_LIR_Gen_1	276	286	PF02991	0.338
LIG_LIR_Gen_1	64	73	PF02991	0.337
LIG_LIR_Nem_3	118	123	PF02991	0.386
LIG_LIR_Nem_3	171	176	PF02991	0.461
LIG_LIR_Nem_3	229	235	PF02991	0.329
LIG_LIR_Nem_3	276	282	PF02991	0.348
LIG_LIR_Nem_3	64	69	PF02991	0.378
LIG_NRBOX	27	33	PF00104	0.479
LIG_PCNA_APIM_2	96	102	PF02747	0.202
LIG_PCNA_yPIPBox_3	62	71	PF02747	0.345
LIG_Pex14_2	169	173	PF04695	0.387
LIG_Pex14_2	95	99	PF04695	0.434
LIG_Rb_pABgroove_1	147	155	PF01858	0.326
LIG_REV1ctd_RIR_1	334	343	PF16727	0.466
LIG_SH2_CRK	120	124	PF00017	0.284
LIG_SH2_NCK_1	198	202	PF00017	0.320
LIG_SH2_STAT5	198	201	PF00017	0.320
LIG_SH2_STAT5	234	237	PF00017	0.376
LIG_SH3_3	206	212	PF00018	0.407
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.437
LIG_SUMO_SIM_anti_2	434	441	PF11976	0.584
LIG_SUMO_SIM_par_1	207	213	PF11976	0.430
LIG_TRAF2_1	389	392	PF00917	0.400
LIG_TYR_ITSM	116	123	PF00017	0.288
LIG_WRC_WIRS_1	185	190	PF05994	0.272
MOD_CDK_SPxxK_3	309	316	PF00069	0.374
MOD_CK1_1	113	119	PF00069	0.396
MOD_CK1_1	284	290	PF00069	0.448
MOD_CK1_1	309	315	PF00069	0.455
MOD_CK1_1	325	331	PF00069	0.265
MOD_CK1_1	335	341	PF00069	0.316
MOD_CK1_1	383	389	PF00069	0.461
MOD_CK1_1	435	441	PF00069	0.610
MOD_CK2_1	270	276	PF00069	0.290
MOD_CK2_1	399	405	PF00069	0.476
MOD_CK2_1	409	415	PF00069	0.502
MOD_GlcNHglycan	102	105	PF01048	0.438
MOD_GlcNHglycan	159	162	PF01048	0.462
MOD_GlcNHglycan	201	204	PF01048	0.333
MOD_GlcNHglycan	212	215	PF01048	0.389
MOD_GlcNHglycan	271	275	PF01048	0.519
MOD_GlcNHglycan	283	286	PF01048	0.479
MOD_GlcNHglycan	386	389	PF01048	0.536
MOD_GlcNHglycan	434	437	PF01048	0.585
MOD_GSK3_1	106	113	PF00069	0.439
MOD_GSK3_1	18	25	PF00069	0.448
MOD_GSK3_1	281	288	PF00069	0.384
MOD_GSK3_1	307	314	PF00069	0.526
MOD_GSK3_1	322	329	PF00069	0.276
MOD_GSK3_1	380	387	PF00069	0.359
MOD_GSK3_1	395	402	PF00069	0.381
MOD_GSK3_1	431	438	PF00069	0.579
MOD_GSK3_1	8	15	PF00069	0.350
MOD_N-GLC_1	11	16	PF02516	0.455
MOD_N-GLC_1	162	167	PF02516	0.546
MOD_N-GLC_1	196	201	PF02516	0.508
MOD_N-GLC_1	332	337	PF02516	0.354
MOD_NEK2_1	115	120	PF00069	0.345
MOD_NEK2_1	135	140	PF00069	0.222
MOD_NEK2_1	281	286	PF00069	0.500
MOD_NEK2_1	308	313	PF00069	0.443
MOD_NEK2_1	315	320	PF00069	0.338
MOD_NEK2_1	322	327	PF00069	0.278
MOD_NEK2_1	332	337	PF00069	0.265
MOD_NEK2_1	369	374	PF00069	0.418
MOD_NEK2_1	384	389	PF00069	0.288
MOD_NEK2_1	399	404	PF00069	0.402
MOD_NEK2_1	408	413	PF00069	0.492
MOD_NEK2_2	395	400	PF00069	0.368
MOD_PIKK_1	285	291	PF00454	0.386
MOD_PIKK_1	419	425	PF00454	0.467
MOD_PIKK_1	75	81	PF00454	0.427
MOD_PK_1	237	243	PF00069	0.426
MOD_PKA_2	306	312	PF00069	0.468
MOD_PKA_2	315	321	PF00069	0.355
MOD_PKA_2	408	414	PF00069	0.441
MOD_PKA_2	419	425	PF00069	0.354
MOD_Plk_1	162	168	PF00069	0.549
MOD_Plk_1	181	187	PF00069	0.242
MOD_Plk_1	196	202	PF00069	0.447
MOD_Plk_1	226	232	PF00069	0.494
MOD_Plk_1	332	338	PF00069	0.448
MOD_Plk_2-3	162	168	PF00069	0.228
MOD_Plk_4	172	178	PF00069	0.361
MOD_Plk_4	257	263	PF00069	0.428
MOD_Plk_4	322	328	PF00069	0.336
MOD_Plk_4	332	338	PF00069	0.323
MOD_Plk_4	380	386	PF00069	0.340
MOD_Plk_4	435	441	PF00069	0.591
MOD_ProDKin_1	30	36	PF00069	0.455
MOD_ProDKin_1	309	315	PF00069	0.443
MOD_ProDKin_1	326	332	PF00069	0.231
MOD_ProDKin_1	348	354	PF00069	0.485
MOD_ProDKin_1	87	93	PF00069	0.230
MOD_SUMO_rev_2	156	166	PF00179	0.483
MOD_SUMO_rev_2	81	87	PF00179	0.404
TRG_DiLeu_BaEn_2	130	136	PF01217	0.458
TRG_DiLeu_LyEn_5	189	194	PF01217	0.429
TRG_ENDOCYTIC_2	120	123	PF00928	0.278
TRG_ER_diArg_1	215	218	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III8	Leptomonas seymouri	58%	100%
A0A1X0NJ75	Trypanosomatidae	35%	100%
A0A3Q8IC10	Leishmania donovani	91%	100%
A0A3S5IQQ3	Trypanosoma rangeli	33%	100%
A4HC29	Leishmania braziliensis	81%	100%
A4HZH2	Leishmania infantum	92%	100%
D0A102	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QC17	Leishmania major	91%	100%
V5BRG3	Trypanosoma cruzi	33%	100%