Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AVG0_LEIMU

TriTrypDb:

LmxM.21.1650

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVG0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	15
GO:0006793	phosphorus metabolic process	3	15
GO:0006796	phosphate-containing compound metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009987	cellular process	1	15
GO:0016310	phosphorylation	5	15
GO:0019538	protein metabolic process	3	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0004672	protein kinase activity	3	15
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0016301	kinase activity	4	15
GO:0016740	transferase activity	2	15
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	15
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140096	catalytic activity, acting on a protein	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004713	protein tyrosine kinase activity	4	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.284
CLV_NRD_NRD_1	282	284	PF00675	0.413
CLV_NRD_NRD_1	51	53	PF00675	0.755
CLV_NRD_NRD_1	89	91	PF00675	0.477
CLV_PCSK_KEX2_1	113	115	PF00082	0.622
CLV_PCSK_KEX2_1	89	91	PF00082	0.496
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.622
CLV_PCSK_SKI1_1	17	21	PF00082	0.508
CLV_PCSK_SKI1_1	227	231	PF00082	0.273
CLV_PCSK_SKI1_1	238	242	PF00082	0.275
CLV_PCSK_SKI1_1	304	308	PF00082	0.280
CLV_PCSK_SKI1_1	46	50	PF00082	0.744
CLV_Separin_Metazoa	14	18	PF03568	0.266
DEG_APCC_DBOX_1	263	271	PF00400	0.408
DEG_APCC_DBOX_1	303	311	PF00400	0.341
DOC_MAPK_FxFP_2	446	449	PF00069	0.298
DOC_MAPK_gen_1	11	18	PF00069	0.507
DOC_MAPK_gen_1	191	198	PF00069	0.246
DOC_MAPK_gen_1	360	369	PF00069	0.248
DOC_MAPK_HePTP_8	357	369	PF00069	0.248
DOC_MAPK_MEF2A_6	191	198	PF00069	0.246
DOC_MAPK_MEF2A_6	360	369	PF00069	0.248
DOC_MAPK_MEF2A_6	372	379	PF00069	0.248
DOC_PP4_FxxP_1	446	449	PF00568	0.298
DOC_SPAK_OSR1_1	90	94	PF12202	0.473
DOC_USP7_MATH_1	2	6	PF00917	0.700
DOC_USP7_MATH_1	329	333	PF00917	0.422
DOC_USP7_MATH_1	56	60	PF00917	0.696
DOC_USP7_UBL2_3	46	50	PF12436	0.655
DOC_WW_Pin1_4	78	83	PF00397	0.572
LIG_14-3-3_CanoR_1	17	23	PF00244	0.517
LIG_14-3-3_CanoR_1	224	230	PF00244	0.377
LIG_14-3-3_CanoR_1	304	313	PF00244	0.363
LIG_14-3-3_CanoR_1	424	429	PF00244	0.270
LIG_14-3-3_CanoR_1	471	477	PF00244	0.329
LIG_14-3-3_CanoR_1	52	56	PF00244	0.743
LIG_14-3-3_CanoR_1	66	71	PF00244	0.647
LIG_Actin_WH2_2	295	313	PF00022	0.408
LIG_Actin_WH2_2	465	483	PF00022	0.413
LIG_APCC_ABBA_1	163	168	PF00400	0.443
LIG_BRCT_BRCA1_1	225	229	PF00533	0.298
LIG_Clathr_ClatBox_1	395	399	PF01394	0.338
LIG_Clathr_ClatBox_1	458	462	PF01394	0.338
LIG_eIF4E_1	262	268	PF01652	0.403
LIG_eIF4E_1	439	445	PF01652	0.408
LIG_FHA_1	269	275	PF00498	0.283
LIG_FHA_1	348	354	PF00498	0.289
LIG_FHA_1	384	390	PF00498	0.279
LIG_FHA_2	170	176	PF00498	0.456
LIG_FHA_2	226	232	PF00498	0.284
LIG_FHA_2	383	389	PF00498	0.388
LIG_HCF-1_HBM_1	463	466	PF13415	0.338
LIG_LIR_Apic_2	359	365	PF02991	0.248
LIG_LIR_Gen_1	140	147	PF02991	0.546
LIG_LIR_Gen_1	179	188	PF02991	0.507
LIG_LIR_Gen_1	463	474	PF02991	0.276
LIG_LIR_Nem_3	129	134	PF02991	0.392
LIG_LIR_Nem_3	140	144	PF02991	0.469
LIG_LIR_Nem_3	179	183	PF02991	0.463
LIG_LIR_Nem_3	259	263	PF02991	0.289
LIG_LIR_Nem_3	463	469	PF02991	0.263
LIG_LIR_Nem_3	68	73	PF02991	0.721
LIG_PCNA_yPIPBox_3	298	307	PF02747	0.338
LIG_PCNA_yPIPBox_3	9	20	PF02747	0.424
LIG_Rb_pABgroove_1	114	122	PF01858	0.429
LIG_SH2_SRC	279	282	PF00017	0.408
LIG_SH2_STAP1	281	285	PF00017	0.311
LIG_SH2_STAT3	147	150	PF00017	0.521
LIG_SH2_STAT3	210	213	PF00017	0.451
LIG_SH2_STAT5	131	134	PF00017	0.413
LIG_SH2_STAT5	260	263	PF00017	0.300
LIG_SH2_STAT5	293	296	PF00017	0.270
LIG_SH2_STAT5	356	359	PF00017	0.270
LIG_SH2_STAT5	429	432	PF00017	0.317
LIG_SH2_STAT5	466	469	PF00017	0.285
LIG_SH3_3	191	197	PF00018	0.447
LIG_SH3_3	408	414	PF00018	0.311
LIG_SH3_3	446	452	PF00018	0.349
LIG_SH3_3	76	82	PF00018	0.652
LIG_SH3_5	118	122	PF00018	0.412
LIG_SUMO_SIM_anti_2	265	272	PF11976	0.338
LIG_SUMO_SIM_par_1	265	272	PF11976	0.374
LIG_SUMO_SIM_par_1	339	346	PF11976	0.371
MOD_CK1_1	140	146	PF00069	0.539
MOD_CK1_1	40	46	PF00069	0.524
MOD_CK1_1	400	406	PF00069	0.343
MOD_CK1_1	407	413	PF00069	0.288
MOD_CK1_1	59	65	PF00069	0.613
MOD_CK1_1	69	75	PF00069	0.665
MOD_CK2_1	169	175	PF00069	0.429
MOD_CK2_1	382	388	PF00069	0.388
MOD_Cter_Amidation	50	53	PF01082	0.720
MOD_GlcNHglycan	4	7	PF01048	0.600
MOD_GlcNHglycan	482	485	PF01048	0.353
MOD_GSK3_1	199	206	PF00069	0.326
MOD_GSK3_1	343	350	PF00069	0.284
MOD_GSK3_1	352	359	PF00069	0.257
MOD_GSK3_1	378	385	PF00069	0.408
MOD_GSK3_1	400	407	PF00069	0.408
MOD_GSK3_1	424	431	PF00069	0.437
MOD_GSK3_1	491	498	PF00069	0.391
MOD_GSK3_1	56	63	PF00069	0.612
MOD_GSK3_1	65	72	PF00069	0.563
MOD_GSK3_1	74	81	PF00069	0.491
MOD_N-GLC_1	424	429	PF02516	0.338
MOD_NEK2_1	203	208	PF00069	0.354
MOD_NEK2_1	312	317	PF00069	0.310
MOD_NEK2_1	343	348	PF00069	0.302
MOD_NEK2_1	349	354	PF00069	0.316
MOD_NEK2_1	382	387	PF00069	0.355
MOD_NEK2_1	404	409	PF00069	0.316
MOD_NEK2_1	428	433	PF00069	0.343
MOD_NEK2_1	493	498	PF00069	0.374
MOD_NEK2_1	83	88	PF00069	0.551
MOD_NEK2_1	91	96	PF00069	0.449
MOD_PIKK_1	84	90	PF00454	0.555
MOD_PKA_2	223	229	PF00069	0.272
MOD_PKA_2	37	43	PF00069	0.616
MOD_PKA_2	423	429	PF00069	0.280
MOD_PKA_2	480	486	PF00069	0.269
MOD_PKA_2	51	57	PF00069	0.675
MOD_PKA_2	65	71	PF00069	0.426
MOD_Plk_1	424	430	PF00069	0.338
MOD_Plk_4	137	143	PF00069	0.475
MOD_Plk_4	225	231	PF00069	0.338
MOD_Plk_4	352	358	PF00069	0.269
MOD_Plk_4	390	396	PF00069	0.388
MOD_Plk_4	400	406	PF00069	0.308
MOD_Plk_4	424	430	PF00069	0.383
MOD_ProDKin_1	78	84	PF00069	0.562
MOD_SUMO_for_1	323	326	PF00179	0.248
MOD_SUMO_rev_2	174	180	PF00179	0.464
MOD_SUMO_rev_2	332	341	PF00179	0.273
TRG_DiLeu_BaEn_1	265	270	PF01217	0.338
TRG_DiLeu_BaEn_1	440	445	PF01217	0.321
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.338
TRG_ENDOCYTIC_2	260	263	PF00928	0.285
TRG_ENDOCYTIC_2	293	296	PF00928	0.270
TRG_ENDOCYTIC_2	466	469	PF00928	0.285
TRG_ER_diArg_1	89	91	PF00400	0.464
TRG_NES_CRM1_1	265	276	PF08389	0.202
TRG_NLS_MonoExtC_3	48	53	PF00514	0.658
TRG_NLS_MonoExtN_4	46	53	PF00514	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D6	Leptomonas seymouri	34%	69%
A0A0N1IJ52	Leptomonas seymouri	64%	99%
A0A0N1PBM1	Leptomonas seymouri	31%	68%
A0A0S4IIU2	Bodo saltans	32%	100%
A0A0S4IUF2	Bodo saltans	32%	91%
A0A0S4IVF2	Bodo saltans	25%	100%
A0A0S4IYY9	Bodo saltans	25%	100%
A0A0S4J343	Bodo saltans	45%	89%
A0A0S4J8J4	Bodo saltans	25%	100%
A0A0S4JUY0	Bodo saltans	26%	84%
A0A0S4JZV2	Bodo saltans	26%	100%
A0A1X0NHA6	Trypanosomatidae	48%	95%
A0A1X0NQT9	Trypanosomatidae	27%	100%
A0A1X0P3K5	Trypanosomatidae	34%	100%
A0A3Q8IC55	Leishmania donovani	96%	100%
A0A3Q8ITZ9	Leishmania donovani	26%	100%
A0A3R7KRM5	Trypanosoma rangeli	35%	74%
A0A3R7MWP2	Trypanosoma rangeli	25%	100%
A0A3S5H6C8	Leishmania donovani	26%	100%
A0A3S5H7N7	Leishmania donovani	25%	100%
A0A3S7WQK7	Leishmania donovani	26%	100%
A0A3S7WR45	Leishmania donovani	28%	100%
A0A3S7WTA3	Leishmania donovani	32%	67%
A0A3S7X9D1	Leishmania donovani	29%	87%
A0A422N7C9	Trypanosoma rangeli	25%	80%
A0A422N878	Trypanosoma rangeli	48%	95%
A4H5L7	Leishmania braziliensis	26%	100%
A4H641	Leishmania braziliensis	29%	100%
A4HA94	Leishmania braziliensis	25%	100%
A4HC27	Leishmania braziliensis	88%	100%
A4HIM5	Leishmania braziliensis	25%	100%
A4HLJ9	Leishmania braziliensis	27%	100%
A4HMK7	Leishmania braziliensis	31%	87%
A4HTV4	Leishmania infantum	26%	100%
A4HTV5	Leishmania infantum	26%	100%
A4HUG1	Leishmania infantum	28%	100%
A4HWB5	Leishmania infantum	32%	67%
A4HZH0	Leishmania infantum	96%	100%
A4I5X0	Leishmania infantum	25%	100%
A4I910	Leishmania infantum	26%	100%
A4IB86	Leishmania infantum	29%	87%
B0Y4X4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	28%	100%
D0A105	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AF07	Leishmania major	30%	87%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AQ15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	67%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	87%
G4N374	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	28%	100%
O13352	Magnaporthe oryzae	28%	100%
O35492	Mus musculus	27%	78%
P40417	Drosophila melanogaster	27%	100%
P49760	Homo sapiens	26%	100%
P49761	Homo sapiens	28%	78%
P51566	Arabidopsis thaliana	27%	100%
P51567	Arabidopsis thaliana	29%	100%
P51568	Arabidopsis thaliana	26%	100%
Q00772	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q07538	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q10156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	72%
Q39011	Arabidopsis thaliana	26%	100%
Q3SX21	Bos taurus	28%	100%
Q4Q449	Leishmania major	26%	100%
Q4Q701	Leishmania major	26%	100%
Q4QC19	Leishmania major	95%	100%
Q4QFG6	Leishmania major	32%	96%
Q4QHG6	Leishmania major	28%	100%
Q4QHY3	Leishmania major	25%	100%
Q4QHY4	Leishmania major	25%	100%
Q4WQR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	100%
Q5U4C9	Mus musculus	33%	83%
Q5VP69	Oryza sativa subsp. japonica	27%	100%
Q60EZ2	Oryza sativa subsp. japonica	27%	100%
Q63117	Rattus norvegicus	28%	100%
Q8SQZ4	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q92630	Homo sapiens	33%	83%
Q9P6P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	93%
V5AWK7	Trypanosoma cruzi	33%	73%
V5B8U8	Trypanosoma cruzi	24%	100%
V5DIC3	Trypanosoma cruzi	47%	83%