Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVF9_LEIMU

TriTrypDb:

LmxM.21.1640

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVF9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.648
CLV_PCSK_KEX2_1	12	14	PF00082	0.673
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.673
CLV_PCSK_SKI1_1	13	17	PF00082	0.648
CLV_PCSK_SKI1_1	208	212	PF00082	0.541
CLV_PCSK_SKI1_1	6	10	PF00082	0.742
CLV_PCSK_SKI1_1	80	84	PF00082	0.438
CLV_PCSK_SKI1_1	99	103	PF00082	0.435
DEG_APCC_DBOX_1	207	215	PF00400	0.428
DEG_APCC_DBOX_1	79	87	PF00400	0.454
DOC_CDC14_PxL_1	195	203	PF14671	0.582
DOC_CYCLIN_RxL_1	11	22	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	197	200	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.538
DOC_MAPK_gen_1	12	18	PF00069	0.536
DOC_MAPK_MEF2A_6	28	36	PF00069	0.450
DOC_MAPK_RevD_3	1	14	PF00069	0.520
DOC_PP1_RVXF_1	59	66	PF00149	0.536
DOC_PP2B_LxvP_1	197	200	PF13499	0.596
DOC_USP7_MATH_1	200	204	PF00917	0.626
DOC_USP7_MATH_1	210	214	PF00917	0.546
DOC_USP7_MATH_1	220	224	PF00917	0.381
DOC_USP7_MATH_2	88	94	PF00917	0.578
LIG_14-3-3_CanoR_1	190	198	PF00244	0.658
LIG_14-3-3_CanoR_1	61	66	PF00244	0.630
LIG_14-3-3_CanoR_1	99	105	PF00244	0.333
LIG_BIR_III_2	193	197	PF00653	0.569
LIG_BIR_III_4	146	150	PF00653	0.465
LIG_deltaCOP1_diTrp_1	163	170	PF00928	0.442
LIG_deltaCOP1_diTrp_1	175	180	PF00928	0.496
LIG_FHA_1	112	118	PF00498	0.523
LIG_FHA_1	119	125	PF00498	0.503
LIG_FHA_1	190	196	PF00498	0.463
LIG_FHA_1	219	225	PF00498	0.561
LIG_FHA_1	25	31	PF00498	0.645
LIG_FHA_1	43	49	PF00498	0.427
LIG_FHA_1	57	63	PF00498	0.462
LIG_FHA_2	17	23	PF00498	0.666
LIG_LIR_Gen_1	175	184	PF02991	0.508
LIG_LIR_Gen_1	50	58	PF02991	0.553
LIG_LIR_Gen_1	98	109	PF02991	0.455
LIG_LIR_Nem_3	137	143	PF02991	0.546
LIG_LIR_Nem_3	154	160	PF02991	0.545
LIG_LIR_Nem_3	169	173	PF02991	0.625
LIG_LIR_Nem_3	175	180	PF02991	0.582
LIG_LIR_Nem_3	50	55	PF02991	0.492
LIG_LIR_Nem_3	77	82	PF02991	0.430
LIG_LIR_Nem_3	98	104	PF02991	0.446
LIG_LYPXL_S_1	156	160	PF13949	0.535
LIG_LYPXL_yS_3	157	160	PF13949	0.534
LIG_MYND_1	196	200	PF01753	0.588
LIG_PCNA_yPIPBox_3	127	140	PF02747	0.618
LIG_PDZ_Class_1	226	231	PF00595	0.666
LIG_SH2_CRK	52	56	PF00017	0.529
LIG_SH2_STAP1	42	46	PF00017	0.630
LIG_SH2_STAP1	52	56	PF00017	0.403
LIG_SH2_STAP1	96	100	PF00017	0.581
LIG_SH2_STAT5	218	221	PF00017	0.603
LIG_SH3_3	152	158	PF00018	0.480
LIG_SH3_3	193	199	PF00018	0.680
LIG_SH3_3	43	49	PF00018	0.607
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.492
LIG_SUMO_SIM_par_1	120	125	PF11976	0.573
LIG_SUMO_SIM_par_1	182	189	PF11976	0.403
LIG_SUMO_SIM_par_1	44	50	PF11976	0.504
LIG_TYR_ITIM	155	160	PF00017	0.380
LIG_WRC_WIRS_1	62	67	PF05994	0.551
MOD_CK1_1	111	117	PF00069	0.516
MOD_CK1_1	166	172	PF00069	0.526
MOD_CK1_1	185	191	PF00069	0.569
MOD_CK1_1	44	50	PF00069	0.636
MOD_CK2_1	131	137	PF00069	0.657
MOD_GlcNHglycan	52	55	PF01048	0.544
MOD_GlcNHglycan	92	95	PF01048	0.344
MOD_GSK3_1	185	192	PF00069	0.514
MOD_GSK3_1	216	223	PF00069	0.633
MOD_GSK3_1	22	29	PF00069	0.681
MOD_GSK3_1	99	106	PF00069	0.475
MOD_LATS_1	129	135	PF00433	0.687
MOD_NEK2_1	100	105	PF00069	0.506
MOD_NEK2_1	16	21	PF00069	0.506
MOD_NEK2_1	226	231	PF00069	0.629
MOD_PIKK_1	163	169	PF00454	0.448
MOD_PKA_2	189	195	PF00069	0.501
MOD_PKA_2	72	78	PF00069	0.481
MOD_Plk_4	47	53	PF00069	0.520
MOD_SUMO_rev_2	144	150	PF00179	0.646
TRG_DiLeu_BaEn_1	81	86	PF01217	0.489
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.555
TRG_ENDOCYTIC_2	157	160	PF00928	0.623
TRG_ENDOCYTIC_2	52	55	PF00928	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NI68	Trypanosomatidae	32%	73%
A0A3S5H7A2	Leishmania donovani	90%	100%
A0A422N8A3	Trypanosoma rangeli	33%	78%
A4HC26	Leishmania braziliensis	73%	100%
A4HZG9	Leishmania infantum	89%	100%
D0A106	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	76%
Q4QC20	Leishmania major	84%	100%
V5B1W6	Trypanosoma cruzi	33%	77%