LeishMANIAdb
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Rad60-SLD_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Rad60-SLD_2 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AVF6_LEIMU
TriTrypDb:
LmxM.21.1610
Length:
159

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AVF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVF6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 89 91 PF00675 0.261
CLV_PCSK_SKI1_1 67 71 PF00082 0.362
CLV_PCSK_SKI1_1 7 11 PF00082 0.359
DEG_Nend_UBRbox_2 1 3 PF02207 0.541
DOC_MAPK_MEF2A_6 110 117 PF00069 0.320
DOC_USP7_MATH_1 127 131 PF00917 0.383
DOC_USP7_MATH_1 13 17 PF00917 0.570
DOC_USP7_UBL2_3 131 135 PF12436 0.376
DOC_WW_Pin1_4 122 127 PF00397 0.271
LIG_Actin_WH2_2 54 72 PF00022 0.302
LIG_FHA_1 80 86 PF00498 0.392
LIG_FHA_2 136 142 PF00498 0.747
LIG_FHA_2 35 41 PF00498 0.430
LIG_FHA_2 84 90 PF00498 0.372
LIG_Pex14_2 46 50 PF04695 0.411
LIG_SH2_STAT5 8 11 PF00017 0.480
MOD_CAAXbox 156 159 PF01239 0.543
MOD_CK1_1 134 140 PF00069 0.544
MOD_CK1_1 16 22 PF00069 0.585
MOD_CK1_1 96 102 PF00069 0.360
MOD_CK2_1 122 128 PF00069 0.398
MOD_CK2_1 135 141 PF00069 0.497
MOD_CK2_1 34 40 PF00069 0.356
MOD_CK2_1 83 89 PF00069 0.320
MOD_GlcNHglycan 18 21 PF01048 0.437
MOD_GlcNHglycan 63 66 PF01048 0.401
MOD_GSK3_1 105 112 PF00069 0.396
MOD_GSK3_1 127 134 PF00069 0.288
MOD_GSK3_1 79 86 PF00069 0.314
MOD_N-GLC_2 33 35 PF02516 0.382
MOD_PIKK_1 105 111 PF00454 0.325
MOD_PKA_1 151 157 PF00069 0.630
MOD_PKA_2 59 65 PF00069 0.360
MOD_Plk_1 35 41 PF00069 0.356
MOD_Plk_4 109 115 PF00069 0.346
MOD_ProDKin_1 122 128 PF00069 0.271
MOD_SUMO_rev_2 48 57 PF00179 0.337
MOD_SUMO_rev_2 88 92 PF00179 0.429
TRG_ER_diArg_1 3 6 PF00400 0.376
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.387

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2H2 Leptomonas seymouri 49% 99%
A0A0S4JTL1 Bodo saltans 36% 100%
A0A1X0NHK7 Trypanosomatidae 37% 100%
A0A3Q8IB92 Leishmania donovani 86% 99%
A0A3R7RFJ8 Trypanosoma rangeli 32% 100%
A4HC23 Leishmania braziliensis 61% 100%
A4HZG6 Leishmania infantum 86% 99%
D0A109 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
Q4QC23 Leishmania major 81% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS