F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box-like, putative

Species:

Leishmania mexicana

UniProt:

E9AVF3_LEIMU

TriTrypDb:

LmxM.21.1590

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AVF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.439
CLV_NRD_NRD_1	158	160	PF00675	0.404
CLV_NRD_NRD_1	174	176	PF00675	0.211
CLV_NRD_NRD_1	249	251	PF00675	0.379
CLV_NRD_NRD_1	281	283	PF00675	0.598
CLV_PCSK_FUR_1	172	176	PF00082	0.453
CLV_PCSK_FUR_1	247	251	PF00082	0.451
CLV_PCSK_KEX2_1	158	160	PF00082	0.405
CLV_PCSK_KEX2_1	172	174	PF00082	0.308
CLV_PCSK_KEX2_1	249	251	PF00082	0.412
CLV_PCSK_KEX2_1	37	39	PF00082	0.493
CLV_PCSK_KEX2_1	94	96	PF00082	0.408
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.510
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.408
CLV_PCSK_SKI1_1	147	151	PF00082	0.477
CLV_PCSK_SKI1_1	175	179	PF00082	0.386
CLV_PCSK_SKI1_1	48	52	PF00082	0.362
CLV_Separin_Metazoa	447	451	PF03568	0.631
DEG_APCC_DBOX_1	47	55	PF00400	0.562
DEG_MDM2_SWIB_1	215	223	PF02201	0.447
DEG_MDM2_SWIB_1	286	293	PF02201	0.350
DEG_Nend_Nbox_1	1	3	PF02207	0.725
DEG_SPOP_SBC_1	9	13	PF00917	0.703
DOC_CDC14_PxL_1	239	247	PF14671	0.678
DOC_CYCLIN_RxL_1	247	258	PF00134	0.633
DOC_MAPK_DCC_7	94	104	PF00069	0.668
DOC_MAPK_gen_1	172	180	PF00069	0.546
DOC_MAPK_gen_1	247	256	PF00069	0.598
DOC_MAPK_gen_1	392	400	PF00069	0.555
DOC_MAPK_gen_1	45	54	PF00069	0.535
DOC_MAPK_MEF2A_6	172	180	PF00069	0.537
DOC_MAPK_MEF2A_6	394	402	PF00069	0.559
DOC_MAPK_MEF2A_6	45	54	PF00069	0.562
DOC_PP1_RVXF_1	250	257	PF00149	0.530
DOC_PP2B_LxvP_1	142	145	PF13499	0.660
DOC_PP2B_LxvP_1	336	339	PF13499	0.377
DOC_USP7_MATH_1	143	147	PF00917	0.706
DOC_USP7_MATH_1	347	351	PF00917	0.447
DOC_USP7_UBL2_3	152	156	PF12436	0.653
LIG_14-3-3_CanoR_1	151	155	PF00244	0.694
LIG_14-3-3_CanoR_1	285	289	PF00244	0.377
LIG_14-3-3_CanoR_1	319	327	PF00244	0.687
LIG_14-3-3_CanoR_1	38	47	PF00244	0.652
LIG_14-3-3_CanoR_1	438	448	PF00244	0.622
LIG_APCC_ABBA_1	52	57	PF00400	0.562
LIG_BRCT_BRCA1_1	10	14	PF00533	0.693
LIG_BRCT_BRCA1_1	199	203	PF00533	0.382
LIG_BRCT_BRCA1_1	30	34	PF00533	0.646
LIG_EH1_1	407	415	PF00400	0.402
LIG_FHA_1	209	215	PF00498	0.327
LIG_FHA_1	259	265	PF00498	0.366
LIG_FHA_1	271	277	PF00498	0.282
LIG_FHA_1	292	298	PF00498	0.367
LIG_FHA_1	4	10	PF00498	0.707
LIG_FHA_2	23	29	PF00498	0.626
LIG_GBD_Chelix_1	189	197	PF00786	0.480
LIG_GBD_Chelix_1	396	404	PF00786	0.402
LIG_LIR_Apic_2	306	312	PF02991	0.415
LIG_LIR_Gen_1	284	293	PF02991	0.335
LIG_LIR_Gen_1	329	339	PF02991	0.538
LIG_LIR_Gen_1	350	359	PF02991	0.446
LIG_LIR_Nem_3	163	169	PF02991	0.571
LIG_LIR_Nem_3	212	218	PF02991	0.329
LIG_LIR_Nem_3	284	289	PF02991	0.365
LIG_LIR_Nem_3	329	334	PF02991	0.636
LIG_LIR_Nem_3	350	354	PF02991	0.394
LIG_LIR_Nem_3	386	390	PF02991	0.619
LIG_LIR_Nem_3	416	420	PF02991	0.392
LIG_LIR_Nem_3	64	69	PF02991	0.491
LIG_LIR_Nem_3	78	82	PF02991	0.491
LIG_LYPXL_S_1	99	103	PF13949	0.447
LIG_LYPXL_yS_3	100	103	PF13949	0.598
LIG_NRBOX	380	386	PF00104	0.384
LIG_Pex14_2	215	219	PF04695	0.338
LIG_Pex14_2	286	290	PF04695	0.312
LIG_Pex14_2	342	346	PF04695	0.408
LIG_Pex14_2	383	387	PF04695	0.447
LIG_Pex14_2	430	434	PF04695	0.361
LIG_RPA_C_Fungi	433	445	PF08784	0.476
LIG_SH2_CRK	112	116	PF00017	0.598
LIG_SH2_CRK	167	171	PF00017	0.507
LIG_SH2_NCK_1	112	116	PF00017	0.620
LIG_SH2_PTP2	309	312	PF00017	0.467
LIG_SH2_PTP2	364	367	PF00017	0.429
LIG_SH2_STAP1	305	309	PF00017	0.404
LIG_SH2_STAT5	169	172	PF00017	0.436
LIG_SH2_STAT5	222	225	PF00017	0.349
LIG_SH2_STAT5	305	308	PF00017	0.330
LIG_SH2_STAT5	309	312	PF00017	0.454
LIG_SH2_STAT5	356	359	PF00017	0.459
LIG_SH2_STAT5	364	367	PF00017	0.355
LIG_SH2_STAT5	439	442	PF00017	0.472
LIG_SH2_STAT5	91	94	PF00017	0.518
LIG_SH3_3	135	141	PF00018	0.676
LIG_SH3_3	266	272	PF00018	0.324
LIG_SH3_3	95	101	PF00018	0.483
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.389
LIG_SUMO_SIM_par_1	293	298	PF11976	0.447
LIG_SUMO_SIM_par_1	370	375	PF11976	0.358
LIG_TYR_ITIM	134	139	PF00017	0.712
LIG_TYR_ITIM	98	103	PF00017	0.496
LIG_UBA3_1	244	252	PF00899	0.494
LIG_UBA3_1	274	283	PF00899	0.529
LIG_WRC_WIRS_1	296	301	PF05994	0.447
LIG_WRC_WIRS_1	348	353	PF05994	0.188
MOD_CK1_1	13	19	PF00069	0.586
MOD_CK1_1	258	264	PF00069	0.410
MOD_CK1_1	30	36	PF00069	0.536
MOD_CK2_1	17	23	PF00069	0.734
MOD_CK2_1	38	44	PF00069	0.626
MOD_Cter_Amidation	280	283	PF01082	0.514
MOD_GlcNHglycan	257	260	PF01048	0.355
MOD_GlcNHglycan	27	33	PF01048	0.622
MOD_GlcNHglycan	442	445	PF01048	0.484
MOD_GSK3_1	291	298	PF00069	0.369
MOD_GSK3_1	9	16	PF00069	0.543
MOD_N-GLC_1	209	214	PF02516	0.475
MOD_N-GLC_2	457	459	PF02516	0.556
MOD_NEK2_1	10	15	PF00069	0.608
MOD_NEK2_1	180	185	PF00069	0.334
MOD_NEK2_1	191	196	PF00069	0.214
MOD_NEK2_1	208	213	PF00069	0.500
MOD_NEK2_1	448	453	PF00069	0.516
MOD_PIKK_1	113	119	PF00454	0.643
MOD_PIKK_1	160	166	PF00454	0.612
MOD_PKA_2	150	156	PF00069	0.636
MOD_PKA_2	160	166	PF00069	0.532
MOD_PKA_2	284	290	PF00069	0.517
MOD_Plk_1	209	215	PF00069	0.439
MOD_Plk_4	14	20	PF00069	0.650
MOD_Plk_4	182	188	PF00069	0.357
MOD_Plk_4	209	215	PF00069	0.376
MOD_Plk_4	258	264	PF00069	0.378
MOD_Plk_4	270	276	PF00069	0.276
MOD_Plk_4	30	36	PF00069	0.579
MOD_Plk_4	303	309	PF00069	0.416
TRG_DiLeu_BaEn_2	328	334	PF01217	0.603
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.637
TRG_DiLeu_LyEn_5	240	245	PF01217	0.543
TRG_ENDOCYTIC_2	100	103	PF00928	0.517
TRG_ENDOCYTIC_2	112	115	PF00928	0.534
TRG_ENDOCYTIC_2	136	139	PF00928	0.713
TRG_ENDOCYTIC_2	167	170	PF00928	0.430
TRG_ENDOCYTIC_2	222	225	PF00928	0.333
TRG_ENDOCYTIC_2	305	308	PF00928	0.355
TRG_ENDOCYTIC_2	364	367	PF00928	0.355
TRG_ER_diArg_1	122	125	PF00400	0.568
TRG_ER_diArg_1	157	159	PF00400	0.542
TRG_ER_diArg_1	172	175	PF00400	0.385
TRG_ER_diArg_1	246	249	PF00400	0.488
TRG_NES_CRM1_1	316	329	PF08389	0.608
TRG_NES_CRM1_1	44	57	PF08389	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVU0	Leptomonas seymouri	77%	99%
A0A0S4JHL9	Bodo saltans	29%	69%
A0A1X0NI23	Trypanosomatidae	51%	100%
A0A3Q8IAZ7	Leishmania donovani	97%	99%
A0A422N8A5	Trypanosoma rangeli	48%	100%
A4HC20	Leishmania braziliensis	86%	100%
A4HZJ5	Leishmania infantum	97%	99%
D0A112	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
Q4QC26	Leishmania major	94%	100%