LeishMANIAdb
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Nodulin-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nodulin-like domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9AVF1_LEIMU
TriTrypDb:
LmxM.21.1570
Length:
614

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 36
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 122
NetGPI no yes: 0, no: 122
Cellular components
Term Name Level Count
GO:0016020 membrane 2 115
GO:0110165 cellular anatomical entity 1 115
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

E9AVF1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVF1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0022857 transmembrane transporter activity 2 54

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 17 19 PF00675 0.343
CLV_NRD_NRD_1 247 249 PF00675 0.300
CLV_NRD_NRD_1 457 459 PF00675 0.413
CLV_NRD_NRD_1 548 550 PF00675 0.530
CLV_NRD_NRD_1 600 602 PF00675 0.415
CLV_PCSK_KEX2_1 17 19 PF00082 0.336
CLV_PCSK_KEX2_1 247 249 PF00082 0.301
CLV_PCSK_KEX2_1 456 458 PF00082 0.365
CLV_PCSK_KEX2_1 600 602 PF00082 0.413
CLV_PCSK_PC7_1 453 459 PF00082 0.369
CLV_PCSK_PC7_1 596 602 PF00082 0.453
CLV_PCSK_SKI1_1 165 169 PF00082 0.371
CLV_PCSK_SKI1_1 437 441 PF00082 0.335
CLV_PCSK_SKI1_1 457 461 PF00082 0.395
CLV_PCSK_SKI1_1 485 489 PF00082 0.527
CLV_PCSK_SKI1_1 537 541 PF00082 0.323
DEG_SCF_FBW7_1 265 271 PF00400 0.165
DOC_CKS1_1 265 270 PF01111 0.174
DOC_CKS1_1 565 570 PF01111 0.384
DOC_CYCLIN_RxL_1 546 556 PF00134 0.367
DOC_CYCLIN_yClb1_LxF_4 535 540 PF00134 0.337
DOC_MAPK_gen_1 155 163 PF00069 0.517
DOC_MAPK_gen_1 222 231 PF00069 0.516
DOC_MAPK_gen_1 453 461 PF00069 0.567
DOC_MAPK_HePTP_8 534 546 PF00069 0.208
DOC_MAPK_MEF2A_6 155 163 PF00069 0.471
DOC_MAPK_MEF2A_6 278 286 PF00069 0.296
DOC_MAPK_MEF2A_6 380 388 PF00069 0.530
DOC_MAPK_MEF2A_6 537 546 PF00069 0.453
DOC_PP1_RVXF_1 435 441 PF00149 0.463
DOC_PP1_RVXF_1 483 490 PF00149 0.401
DOC_PP1_RVXF_1 535 541 PF00149 0.337
DOC_PP2B_LxvP_1 480 483 PF13499 0.415
DOC_PP4_FxxP_1 466 469 PF00568 0.391
DOC_SPAK_OSR1_1 30 34 PF12202 0.518
DOC_USP7_MATH_1 268 272 PF00917 0.445
DOC_USP7_MATH_1 311 315 PF00917 0.534
DOC_WW_Pin1_4 264 269 PF00397 0.308
DOC_WW_Pin1_4 354 359 PF00397 0.770
DOC_WW_Pin1_4 392 397 PF00397 0.449
DOC_WW_Pin1_4 465 470 PF00397 0.379
DOC_WW_Pin1_4 564 569 PF00397 0.404
LIG_14-3-3_CanoR_1 222 231 PF00244 0.548
LIG_14-3-3_CanoR_1 458 467 PF00244 0.455
LIG_APCC_ABBA_1 540 545 PF00400 0.365
LIG_BRCT_BRCA1_1 146 150 PF00533 0.425
LIG_BRCT_BRCA1_1 171 175 PF00533 0.466
LIG_BRCT_BRCA1_1 4 8 PF00533 0.498
LIG_BRCT_BRCA1_1 85 89 PF00533 0.321
LIG_DCNL_PONY_1 1 4 PF03556 0.526
LIG_deltaCOP1_diTrp_1 383 392 PF00928 0.370
LIG_FHA_1 107 113 PF00498 0.293
LIG_FHA_1 141 147 PF00498 0.315
LIG_FHA_1 233 239 PF00498 0.484
LIG_FHA_1 256 262 PF00498 0.306
LIG_FHA_1 265 271 PF00498 0.337
LIG_FHA_1 405 411 PF00498 0.335
LIG_FHA_1 419 425 PF00498 0.284
LIG_FHA_1 460 466 PF00498 0.314
LIG_FHA_1 47 53 PF00498 0.353
LIG_FHA_1 524 530 PF00498 0.299
LIG_FHA_1 565 571 PF00498 0.314
LIG_FHA_1 71 77 PF00498 0.342
LIG_FHA_1 94 100 PF00498 0.420
LIG_FHA_2 146 152 PF00498 0.374
LIG_FHA_2 344 350 PF00498 0.781
LIG_FHA_2 372 378 PF00498 0.573
LIG_FHA_2 553 559 PF00498 0.250
LIG_FHA_2 606 612 PF00498 0.605
LIG_GBD_Chelix_1 287 295 PF00786 0.343
LIG_LIR_Gen_1 128 137 PF02991 0.342
LIG_LIR_Gen_1 147 154 PF02991 0.490
LIG_LIR_Gen_1 172 183 PF02991 0.414
LIG_LIR_Gen_1 330 341 PF02991 0.708
LIG_LIR_Gen_1 383 392 PF02991 0.329
LIG_LIR_Gen_1 5 16 PF02991 0.630
LIG_LIR_Gen_1 510 521 PF02991 0.555
LIG_LIR_Gen_1 524 533 PF02991 0.356
LIG_LIR_Gen_1 86 95 PF02991 0.457
LIG_LIR_Nem_3 128 134 PF02991 0.304
LIG_LIR_Nem_3 147 153 PF02991 0.507
LIG_LIR_Nem_3 172 178 PF02991 0.334
LIG_LIR_Nem_3 240 246 PF02991 0.581
LIG_LIR_Nem_3 330 336 PF02991 0.694
LIG_LIR_Nem_3 383 388 PF02991 0.311
LIG_LIR_Nem_3 426 431 PF02991 0.345
LIG_LIR_Nem_3 49 53 PF02991 0.366
LIG_LIR_Nem_3 5 11 PF02991 0.649
LIG_LIR_Nem_3 510 516 PF02991 0.581
LIG_LIR_Nem_3 86 92 PF02991 0.415
LIG_PALB2_WD40_1 3 11 PF16756 0.459
LIG_PCNA_yPIPBox_3 536 550 PF02747 0.423
LIG_Pex14_2 193 197 PF04695 0.356
LIG_Pex14_2 509 513 PF04695 0.558
LIG_Pex14_2 85 89 PF04695 0.422
LIG_PTB_Apo_2 515 522 PF02174 0.580
LIG_PTB_Phospho_1 515 521 PF10480 0.408
LIG_SH2_CRK 131 135 PF00017 0.265
LIG_SH2_CRK 253 257 PF00017 0.381
LIG_SH2_CRK 333 337 PF00017 0.642
LIG_SH2_GRB2like 215 218 PF00017 0.408
LIG_SH2_NCK_1 325 329 PF00017 0.477
LIG_SH2_NCK_1 333 337 PF00017 0.505
LIG_SH2_SRC 13 16 PF00017 0.409
LIG_SH2_STAP1 239 243 PF00017 0.614
LIG_SH2_STAP1 253 257 PF00017 0.399
LIG_SH2_STAP1 425 429 PF00017 0.387
LIG_SH2_STAP1 48 52 PF00017 0.342
LIG_SH2_STAP1 53 57 PF00017 0.189
LIG_SH2_STAP1 590 594 PF00017 0.551
LIG_SH2_STAT3 53 56 PF00017 0.259
LIG_SH2_STAT5 13 16 PF00017 0.568
LIG_SH2_STAT5 145 148 PF00017 0.386
LIG_SH2_STAT5 192 195 PF00017 0.309
LIG_SH2_STAT5 272 275 PF00017 0.367
LIG_SH2_STAT5 378 381 PF00017 0.535
LIG_SH2_STAT5 425 428 PF00017 0.298
LIG_SH2_STAT5 446 449 PF00017 0.546
LIG_SH2_STAT5 48 51 PF00017 0.337
LIG_SH2_STAT5 491 494 PF00017 0.318
LIG_SH2_STAT5 495 498 PF00017 0.317
LIG_SH2_STAT5 53 56 PF00017 0.322
LIG_SH2_STAT5 543 546 PF00017 0.293
LIG_SH3_1 365 371 PF00018 0.590
LIG_SH3_3 262 268 PF00018 0.309
LIG_SH3_3 365 371 PF00018 0.584
LIG_SH3_3 41 47 PF00018 0.470
LIG_SUMO_SIM_anti_2 205 212 PF11976 0.382
LIG_SUMO_SIM_anti_2 227 233 PF11976 0.587
LIG_SUMO_SIM_anti_2 526 531 PF11976 0.271
LIG_TRAF2_1 225 228 PF00917 0.475
LIG_TRAF2_1 555 558 PF00917 0.348
LIG_TYR_ITIM 251 256 PF00017 0.379
LIG_UBA3_1 478 485 PF00899 0.380
LIG_WRC_WIRS_1 513 518 PF05994 0.578
MOD_CK1_1 271 277 PF00069 0.335
MOD_CK1_1 357 363 PF00069 0.760
MOD_CK1_1 406 412 PF00069 0.344
MOD_CK1_1 418 424 PF00069 0.341
MOD_CK1_1 69 75 PF00069 0.330
MOD_CK2_1 145 151 PF00069 0.423
MOD_CK2_1 222 228 PF00069 0.503
MOD_CK2_1 311 317 PF00069 0.473
MOD_CK2_1 552 558 PF00069 0.252
MOD_CK2_1 605 611 PF00069 0.599
MOD_Cter_Amidation 454 457 PF01082 0.418
MOD_GlcNHglycan 116 119 PF01048 0.534
MOD_GlcNHglycan 137 140 PF01048 0.354
MOD_GlcNHglycan 205 208 PF01048 0.365
MOD_GlcNHglycan 224 227 PF01048 0.292
MOD_GlcNHglycan 453 456 PF01048 0.445
MOD_GlcNHglycan 62 66 PF01048 0.510
MOD_GSK3_1 140 147 PF00069 0.358
MOD_GSK3_1 165 172 PF00069 0.345
MOD_GSK3_1 199 206 PF00069 0.303
MOD_GSK3_1 2 9 PF00069 0.648
MOD_GSK3_1 264 271 PF00069 0.361
MOD_GSK3_1 357 364 PF00069 0.753
MOD_GSK3_1 399 406 PF00069 0.427
MOD_GSK3_1 42 49 PF00069 0.325
MOD_GSK3_1 512 519 PF00069 0.546
MOD_GSK3_1 66 73 PF00069 0.269
MOD_LATS_1 449 455 PF00433 0.493
MOD_N-GLC_1 403 408 PF02516 0.560
MOD_N-GLC_1 521 526 PF02516 0.440
MOD_N-GLC_1 559 564 PF02516 0.538
MOD_NEK2_1 112 117 PF00069 0.303
MOD_NEK2_1 140 145 PF00069 0.345
MOD_NEK2_1 170 175 PF00069 0.397
MOD_NEK2_1 178 183 PF00069 0.326
MOD_NEK2_1 2 7 PF00069 0.660
MOD_NEK2_1 232 237 PF00069 0.504
MOD_NEK2_1 431 436 PF00069 0.296
MOD_NEK2_1 507 512 PF00069 0.389
MOD_NEK2_1 516 521 PF00069 0.589
MOD_NEK2_1 52 57 PF00069 0.336
MOD_NEK2_1 523 528 PF00069 0.354
MOD_NEK2_1 551 556 PF00069 0.383
MOD_NEK2_1 61 66 PF00069 0.344
MOD_NEK2_1 78 83 PF00069 0.243
MOD_NEK2_2 125 130 PF00069 0.298
MOD_NEK2_2 145 150 PF00069 0.444
MOD_PIKK_1 52 58 PF00454 0.295
MOD_PIKK_1 553 559 PF00454 0.386
MOD_PIKK_1 6 12 PF00454 0.613
MOD_PKA_2 232 238 PF00069 0.531
MOD_PKB_1 220 228 PF00069 0.580
MOD_Plk_1 141 147 PF00069 0.323
MOD_Plk_1 348 354 PF00069 0.776
MOD_Plk_1 521 527 PF00069 0.440
MOD_Plk_1 559 565 PF00069 0.304
MOD_Plk_1 66 72 PF00069 0.263
MOD_Plk_4 141 147 PF00069 0.332
MOD_Plk_4 170 176 PF00069 0.370
MOD_Plk_4 178 184 PF00069 0.436
MOD_Plk_4 255 261 PF00069 0.317
MOD_Plk_4 268 274 PF00069 0.447
MOD_Plk_4 286 292 PF00069 0.347
MOD_Plk_4 371 377 PF00069 0.559
MOD_Plk_4 516 522 PF00069 0.539
MOD_ProDKin_1 264 270 PF00069 0.308
MOD_ProDKin_1 354 360 PF00069 0.769
MOD_ProDKin_1 392 398 PF00069 0.449
MOD_ProDKin_1 465 471 PF00069 0.379
MOD_ProDKin_1 564 570 PF00069 0.386
TRG_DiLeu_BaEn_1 227 232 PF01217 0.539
TRG_DiLeu_BaEn_4 227 233 PF01217 0.539
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.607
TRG_DiLeu_BaLyEn_6 534 539 PF01217 0.301
TRG_ENDOCYTIC_2 131 134 PF00928 0.284
TRG_ENDOCYTIC_2 253 256 PF00928 0.358
TRG_ENDOCYTIC_2 333 336 PF00928 0.501
TRG_ENDOCYTIC_2 425 428 PF00928 0.317
TRG_ENDOCYTIC_2 543 546 PF00928 0.347
TRG_ENDOCYTIC_2 590 593 PF00928 0.526
TRG_ER_diArg_1 154 157 PF00400 0.558
TRG_ER_diArg_1 219 222 PF00400 0.572
TRG_ER_diArg_1 246 248 PF00400 0.509
TRG_ER_diArg_1 456 458 PF00400 0.572
TRG_ER_diArg_1 600 602 PF00400 0.623
TRG_Pf-PMV_PEXEL_1 236 240 PF00026 0.363

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G0 Leptomonas seymouri 26% 97%
A0A0N1HT40 Leptomonas seymouri 28% 100%
A0A0N1HZC2 Leptomonas seymouri 42% 98%
A0A0N1IKC5 Leptomonas seymouri 30% 100%
A0A0N1PAX2 Leptomonas seymouri 56% 100%
A0A0N1PB63 Leptomonas seymouri 52% 93%
A0A0N1PD04 Leptomonas seymouri 22% 96%
A0A0N1PFR4 Leptomonas seymouri 26% 93%
A0A0S4JR45 Bodo saltans 25% 100%
A0A1X0NKK0 Trypanosomatidae 49% 100%
A0A1X0NL32 Trypanosomatidae 28% 98%
A0A1X0NM09 Trypanosomatidae 49% 100%
A0A1X0NRW5 Trypanosomatidae 24% 88%
A0A1X0NV13 Trypanosomatidae 29% 94%
A0A1X0NV19 Trypanosomatidae 30% 100%
A0A1X0NV27 Trypanosomatidae 30% 100%
A0A1X0NVH8 Trypanosomatidae 26% 93%
A0A1X0NVM7 Trypanosomatidae 29% 95%
A0A1X0NWQ1 Trypanosomatidae 25% 96%
A0A1X0NZE6 Trypanosomatidae 27% 100%
A0A1X0NZU2 Trypanosomatidae 26% 95%
A0A1X0NZU5 Trypanosomatidae 27% 100%
A0A1X0NZW1 Trypanosomatidae 27% 100%
A0A1X0P0M7 Trypanosomatidae 26% 100%
A0A381MMW5 Leishmania infantum 27% 94%
A0A3Q8I7Y9 Leishmania donovani 29% 100%
A0A3Q8IEC4 Leishmania donovani 27% 95%
A0A3Q8IF95 Leishmania donovani 88% 97%
A0A3Q8IIT5 Leishmania donovani 25% 91%
A0A3Q8ISY9 Leishmania donovani 26% 97%
A0A3R7JSQ9 Trypanosoma rangeli 27% 100%
A0A3R7KKN8 Trypanosoma rangeli 26% 100%
A0A3R7MAQ7 Trypanosoma rangeli 23% 87%
A0A3R7N3S6 Trypanosoma rangeli 22% 95%
A0A3R7N415 Trypanosoma rangeli 29% 100%
A0A3R7N921 Trypanosoma rangeli 30% 100%
A0A3R7R443 Trypanosoma rangeli 27% 100%
A0A3S7WRJ4 Leishmania donovani 29% 96%
A0A3S7WRJ5 Leishmania donovani 29% 88%
A0A3S7WRL4 Leishmania donovani 29% 99%
A0A3S7WRS3 Leishmania donovani 21% 98%
A0A3S7WSR4 Leishmania donovani 29% 100%
A0A3S7WWU1 Leishmania donovani 51% 92%
A0A3S7X2G0 Leishmania donovani 27% 94%
A0A3S7X2K5 Leishmania donovani 25% 100%
A0A3S7XB11 Leishmania donovani 43% 100%
A0A422MSE4 Trypanosoma rangeli 30% 100%
A0A422MSP6 Trypanosoma rangeli 26% 100%
A0A422MST9 Trypanosoma rangeli 27% 100%
A0A422MU68 Trypanosoma rangeli 48% 100%
A4H6J0 Leishmania braziliensis 28% 100%
A4H6J1 Leishmania braziliensis 30% 100%
A4H6J3 Leishmania braziliensis 28% 100%
A4H6Q5 Leishmania braziliensis 21% 100%
A4HC19 Leishmania braziliensis 50% 100%
A4HHG2 Leishmania braziliensis 24% 91%
A4HHG3 Leishmania braziliensis 26% 100%
A4HHG4 Leishmania braziliensis 26% 100%
A4HJW3 Leishmania braziliensis 27% 100%
A4HPE2 Leishmania braziliensis 45% 100%
A4HUX5 Leishmania infantum 29% 96%
A4HUX6 Leishmania infantum 28% 88%
A4HUX7 Leishmania infantum 30% 99%
A4HUX8 Leishmania infantum 29% 100%
A4HV40 Leishmania infantum 21% 98%
A4HZF5 Leishmania infantum 88% 97%
A4HZJ4 Leishmania infantum 51% 92%
A4I4L2 Leishmania infantum 25% 91%
A4I7C5 Leishmania infantum 26% 97%
A4ICI3 Leishmania infantum 43% 100%
C9ZL97 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
C9ZL98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZL99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZLA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZLA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
C9ZTR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZTR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZTR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
C9ZTR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZTR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZTS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZUT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0A7H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0AAQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 90%
E8NHE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AE01 Leishmania major 26% 100%
E9AE09 Leishmania major 25% 91%
E9AE10 Leishmania major 25% 91%
E9AE11 Leishmania major 26% 100%
E9AGK5 Leishmania infantum 29% 100%
E9AHJ0 Leishmania infantum 27% 95%
E9AHJ1 Leishmania infantum 25% 100%
E9ALS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ALS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 91%
E9ANL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ANL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ANL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ANS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9APJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AT53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 99%
E9AVF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 93%
E9B2B8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 97%
Q4Q1E4 Leishmania major 42% 100%
Q4Q5T8 Leishmania major 26% 100%
Q4QC27 Leishmania major 50% 100%
Q4QC28 Leishmania major 85% 98%
Q4QFY5 Leishmania major 30% 100%
Q4QGU8 Leishmania major 20% 100%
Q4QH10 Leishmania major 29% 99%
Q4QH11 Leishmania major 29% 96%
Q4QH12 Leishmania major 29% 96%
Q4QH13 Leishmania major 29% 96%
Q4QH14 Leishmania major 28% 100%
Q4QH15 Leishmania major 29% 100%
V5B647 Trypanosoma cruzi 28% 97%
V5B983 Trypanosoma cruzi 28% 100%
V5BBB1 Trypanosoma cruzi 27% 100%
V5BFV8 Trypanosoma cruzi 27% 92%
V5BQY6 Trypanosoma cruzi 25% 87%
V5BVP0 Trypanosoma cruzi 26% 100%
V5DT25 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS