Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Exocyst complex component EXO99

Species:

Leishmania mexicana

UniProt:

E9AVF0_LEIMU

TriTrypDb:

LmxM.21.1569

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000145	exocyst	3	1
GO:0005634	nucleus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

E9AVF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVF0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.494
CLV_C14_Caspase3-7	854	858	PF00656	0.324
CLV_MEL_PAP_1	175	181	PF00089	0.360
CLV_NRD_NRD_1	177	179	PF00675	0.306
CLV_NRD_NRD_1	19	21	PF00675	0.619
CLV_NRD_NRD_1	260	262	PF00675	0.548
CLV_NRD_NRD_1	405	407	PF00675	0.743
CLV_NRD_NRD_1	433	435	PF00675	0.536
CLV_NRD_NRD_1	447	449	PF00675	0.258
CLV_NRD_NRD_1	462	464	PF00675	0.371
CLV_NRD_NRD_1	613	615	PF00675	0.565
CLV_NRD_NRD_1	667	669	PF00675	0.518
CLV_NRD_NRD_1	762	764	PF00675	0.500
CLV_NRD_NRD_1	875	877	PF00675	0.432
CLV_NRD_NRD_1	922	924	PF00675	0.655
CLV_PCSK_KEX2_1	177	179	PF00082	0.306
CLV_PCSK_KEX2_1	18	20	PF00082	0.693
CLV_PCSK_KEX2_1	260	262	PF00082	0.564
CLV_PCSK_KEX2_1	447	449	PF00082	0.398
CLV_PCSK_KEX2_1	462	464	PF00082	0.350
CLV_PCSK_KEX2_1	667	669	PF00082	0.481
CLV_PCSK_KEX2_1	922	924	PF00082	0.616
CLV_PCSK_SKI1_1	24	28	PF00082	0.536
CLV_PCSK_SKI1_1	463	467	PF00082	0.515
CLV_PCSK_SKI1_1	584	588	PF00082	0.565
CLV_PCSK_SKI1_1	610	614	PF00082	0.436
CLV_PCSK_SKI1_1	675	679	PF00082	0.472
CLV_PCSK_SKI1_1	727	731	PF00082	0.391
DEG_APCC_DBOX_1	19	27	PF00400	0.639
DEG_APCC_DBOX_1	296	304	PF00400	0.547
DEG_APCC_DBOX_1	583	591	PF00400	0.564
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DEG_SPOP_SBC_1	164	168	PF00917	0.609
DOC_CDC14_PxL_1	391	399	PF14671	0.571
DOC_CYCLIN_RxL_1	459	470	PF00134	0.539
DOC_MAPK_gen_1	763	770	PF00069	0.476
DOC_MAPK_JIP1_4	727	733	PF00069	0.396
DOC_MAPK_MEF2A_6	584	591	PF00069	0.562
DOC_MAPK_NFAT4_5	584	592	PF00069	0.571
DOC_MAPK_RevD_3	600	615	PF00069	0.529
DOC_PP1_RVXF_1	313	319	PF00149	0.495
DOC_PP1_RVXF_1	519	525	PF00149	0.476
DOC_PP1_RVXF_1	620	627	PF00149	0.522
DOC_PP4_FxxP_1	796	799	PF00568	0.494
DOC_SPAK_OSR1_1	795	799	PF12202	0.607
DOC_USP7_MATH_1	12	16	PF00917	0.659
DOC_USP7_MATH_1	128	132	PF00917	0.508
DOC_USP7_MATH_1	164	168	PF00917	0.616
DOC_USP7_MATH_1	249	253	PF00917	0.535
DOC_USP7_MATH_1	550	554	PF00917	0.599
DOC_USP7_MATH_1	647	651	PF00917	0.522
DOC_USP7_MATH_1	82	86	PF00917	0.516
DOC_WW_Pin1_4	137	142	PF00397	0.558
DOC_WW_Pin1_4	157	162	PF00397	0.378
DOC_WW_Pin1_4	214	219	PF00397	0.542
DOC_WW_Pin1_4	63	68	PF00397	0.545
LIG_14-3-3_CanoR_1	156	160	PF00244	0.578
LIG_14-3-3_CanoR_1	635	644	PF00244	0.532
LIG_14-3-3_CanoR_1	646	655	PF00244	0.537
LIG_14-3-3_CanoR_1	775	783	PF00244	0.426
LIG_14-3-3_CanoR_1	884	893	PF00244	0.473
LIG_BIR_III_4	439	443	PF00653	0.501
LIG_BRCT_BRCA1_1	135	139	PF00533	0.382
LIG_BRCT_BRCA1_1	253	257	PF00533	0.530
LIG_Clathr_ClatBox_1	76	80	PF01394	0.420
LIG_deltaCOP1_diTrp_1	107	114	PF00928	0.490
LIG_FHA_1	101	107	PF00498	0.432
LIG_FHA_1	180	186	PF00498	0.499
LIG_FHA_1	288	294	PF00498	0.395
LIG_FHA_1	33	39	PF00498	0.498
LIG_FHA_1	517	523	PF00498	0.472
LIG_FHA_1	536	542	PF00498	0.433
LIG_FHA_1	679	685	PF00498	0.243
LIG_FHA_1	69	75	PF00498	0.560
LIG_FHA_1	782	788	PF00498	0.574
LIG_FHA_1	814	820	PF00498	0.482
LIG_FHA_1	90	96	PF00498	0.487
LIG_FHA_2	363	369	PF00498	0.545
LIG_FHA_2	424	430	PF00498	0.668
LIG_FHA_2	583	589	PF00498	0.594
LIG_FHA_2	705	711	PF00498	0.265
LIG_FHA_2	808	814	PF00498	0.510
LIG_FHA_2	883	889	PF00498	0.566
LIG_LIR_Apic_2	793	799	PF02991	0.509
LIG_LIR_Gen_1	451	460	PF02991	0.394
LIG_LIR_Gen_1	516	524	PF02991	0.436
LIG_LIR_Gen_1	621	631	PF02991	0.543
LIG_LIR_Gen_1	639	649	PF02991	0.563
LIG_LIR_Gen_1	739	750	PF02991	0.399
LIG_LIR_Gen_1	754	762	PF02991	0.433
LIG_LIR_Gen_1	811	821	PF02991	0.402
LIG_LIR_Gen_1	914	925	PF02991	0.482
LIG_LIR_Gen_1	92	98	PF02991	0.268
LIG_LIR_Nem_3	273	277	PF02991	0.353
LIG_LIR_Nem_3	451	456	PF02991	0.390
LIG_LIR_Nem_3	488	492	PF02991	0.519
LIG_LIR_Nem_3	516	520	PF02991	0.442
LIG_LIR_Nem_3	621	626	PF02991	0.526
LIG_LIR_Nem_3	639	645	PF02991	0.581
LIG_LIR_Nem_3	696	701	PF02991	0.443
LIG_LIR_Nem_3	739	745	PF02991	0.412
LIG_LIR_Nem_3	754	759	PF02991	0.441
LIG_LIR_Nem_3	811	817	PF02991	0.403
LIG_LIR_Nem_3	857	862	PF02991	0.441
LIG_LIR_Nem_3	914	920	PF02991	0.445
LIG_NRBOX	22	28	PF00104	0.514
LIG_PCNA_yPIPBox_3	350	361	PF02747	0.354
LIG_PCNA_yPIPBox_3	562	571	PF02747	0.457
LIG_Pex14_2	669	673	PF04695	0.557
LIG_PTAP_UEV_1	160	165	PF05743	0.664
LIG_SH2_CRK	353	357	PF00017	0.404
LIG_SH2_CRK	453	457	PF00017	0.459
LIG_SH2_CRK	642	646	PF00017	0.529
LIG_SH2_NCK_1	11	15	PF00017	0.616
LIG_SH2_SRC	752	755	PF00017	0.514
LIG_SH2_STAP1	237	241	PF00017	0.547
LIG_SH2_STAP1	294	298	PF00017	0.456
LIG_SH2_STAT3	298	301	PF00017	0.527
LIG_SH2_STAT5	193	196	PF00017	0.478
LIG_SH2_STAT5	445	448	PF00017	0.457
LIG_SH2_STAT5	742	745	PF00017	0.513
LIG_SH2_STAT5	752	755	PF00017	0.528
LIG_SH2_STAT5	878	881	PF00017	0.538
LIG_SH3_3	158	164	PF00018	0.587
LIG_SH3_3	273	279	PF00018	0.420
LIG_SH3_3	418	424	PF00018	0.738
LIG_SH3_3	479	485	PF00018	0.531
LIG_SH3_5	485	489	PF00018	0.445
LIG_SUMO_SIM_anti_2	238	246	PF11976	0.533
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.429
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.566
LIG_SUMO_SIM_anti_2	700	707	PF11976	0.519
LIG_SUMO_SIM_anti_2	813	819	PF11976	0.419
LIG_SUMO_SIM_par_1	280	285	PF11976	0.403
LIG_SUMO_SIM_par_1	287	295	PF11976	0.364
LIG_SUMO_SIM_par_1	536	542	PF11976	0.505
LIG_SUMO_SIM_par_1	579	585	PF11976	0.599
LIG_SUMO_SIM_par_1	597	604	PF11976	0.359
LIG_SUMO_SIM_par_1	908	915	PF11976	0.515
LIG_TRAF2_1	427	430	PF00917	0.626
LIG_TRAF2_1	651	654	PF00917	0.523
LIG_TRAF2_1	707	710	PF00917	0.478
LIG_TRAF2_2	209	214	PF00917	0.320
LIG_TYR_ITIM	640	645	PF00017	0.555
LIG_Vh1_VBS_1	776	794	PF01044	0.460
LIG_WRC_WIRS_1	742	747	PF05994	0.395
LIG_WRC_WIRS_1	883	888	PF05994	0.559
MOD_CK1_1	155	161	PF00069	0.630
MOD_CK1_1	180	186	PF00069	0.545
MOD_CK1_1	287	293	PF00069	0.400
MOD_CK1_1	331	337	PF00069	0.487
MOD_CK1_1	4	10	PF00069	0.482
MOD_CK1_1	413	419	PF00069	0.746
MOD_CK1_1	516	522	PF00069	0.551
MOD_CK1_1	533	539	PF00069	0.377
MOD_CK1_1	582	588	PF00069	0.513
MOD_CK2_1	101	107	PF00069	0.423
MOD_CK2_1	128	134	PF00069	0.411
MOD_CK2_1	145	151	PF00069	0.424
MOD_CK2_1	423	429	PF00069	0.655
MOD_CK2_1	704	710	PF00069	0.381
MOD_CK2_1	807	813	PF00069	0.495
MOD_CK2_1	847	853	PF00069	0.496
MOD_CK2_1	882	888	PF00069	0.522
MOD_GlcNHglycan	134	138	PF01048	0.442
MOD_GlcNHglycan	161	164	PF01048	0.686
MOD_GlcNHglycan	227	230	PF01048	0.462
MOD_GlcNHglycan	233	236	PF01048	0.372
MOD_GlcNHglycan	247	250	PF01048	0.452
MOD_GlcNHglycan	408	411	PF01048	0.718
MOD_GlcNHglycan	412	415	PF01048	0.749
MOD_GlcNHglycan	418	421	PF01048	0.689
MOD_GlcNHglycan	48	51	PF01048	0.498
MOD_GlcNHglycan	649	652	PF01048	0.549
MOD_GlcNHglycan	71	74	PF01048	0.431
MOD_GlcNHglycan	777	780	PF01048	0.438
MOD_GlcNHglycan	849	852	PF01048	0.457
MOD_GlcNHglycan	895	899	PF01048	0.635
MOD_GSK3_1	128	135	PF00069	0.432
MOD_GSK3_1	155	162	PF00069	0.590
MOD_GSK3_1	165	172	PF00069	0.446
MOD_GSK3_1	227	234	PF00069	0.389
MOD_GSK3_1	245	252	PF00069	0.278
MOD_GSK3_1	324	331	PF00069	0.497
MOD_GSK3_1	360	367	PF00069	0.508
MOD_GSK3_1	406	413	PF00069	0.773
MOD_GSK3_1	529	536	PF00069	0.511
MOD_GSK3_1	550	557	PF00069	0.606
MOD_GSK3_1	626	633	PF00069	0.445
MOD_GSK3_1	700	707	PF00069	0.260
MOD_GSK3_1	737	744	PF00069	0.418
MOD_GSK3_1	790	797	PF00069	0.486
MOD_GSK3_1	804	811	PF00069	0.384
MOD_GSK3_1	878	885	PF00069	0.524
MOD_NEK2_1	1	6	PF00069	0.558
MOD_NEK2_1	114	119	PF00069	0.384
MOD_NEK2_1	145	150	PF00069	0.467
MOD_NEK2_1	169	174	PF00069	0.452
MOD_NEK2_1	243	248	PF00069	0.526
MOD_NEK2_1	325	330	PF00069	0.450
MOD_NEK2_1	33	38	PF00069	0.554
MOD_NEK2_1	360	365	PF00069	0.412
MOD_NEK2_1	380	385	PF00069	0.220
MOD_NEK2_1	46	51	PF00069	0.421
MOD_NEK2_1	529	534	PF00069	0.430
MOD_NEK2_1	535	540	PF00069	0.383
MOD_NEK2_1	61	66	PF00069	0.358
MOD_NEK2_1	626	631	PF00069	0.509
MOD_NEK2_1	68	73	PF00069	0.457
MOD_NEK2_1	746	751	PF00069	0.460
MOD_NEK2_1	790	795	PF00069	0.579
MOD_NEK2_1	894	899	PF00069	0.460
MOD_NEK2_2	128	133	PF00069	0.548
MOD_NEK2_2	879	884	PF00069	0.517
MOD_OFUCOSY	125	132	PF10250	0.506
MOD_PIKK_1	626	632	PF00454	0.588
MOD_PIKK_1	683	689	PF00454	0.497
MOD_PKA_1	177	183	PF00069	0.291
MOD_PKA_1	406	412	PF00069	0.714
MOD_PKA_2	132	138	PF00069	0.508
MOD_PKA_2	155	161	PF00069	0.689
MOD_PKA_2	177	183	PF00069	0.369
MOD_PKA_2	794	800	PF00069	0.577
MOD_PKB_1	543	551	PF00069	0.570
MOD_Plk_1	1	7	PF00069	0.518
MOD_Plk_1	188	194	PF00069	0.466
MOD_Plk_1	237	243	PF00069	0.541
MOD_Plk_1	378	384	PF00069	0.384
MOD_Plk_1	791	797	PF00069	0.572
MOD_Plk_1	804	810	PF00069	0.458
MOD_Plk_2-3	554	560	PF00069	0.545
MOD_Plk_2-3	601	607	PF00069	0.388
MOD_Plk_4	1	7	PF00069	0.583
MOD_Plk_4	165	171	PF00069	0.459
MOD_Plk_4	180	186	PF00069	0.401
MOD_Plk_4	188	194	PF00069	0.401
MOD_Plk_4	227	233	PF00069	0.392
MOD_Plk_4	237	243	PF00069	0.397
MOD_Plk_4	741	747	PF00069	0.398
MOD_Plk_4	813	819	PF00069	0.481
MOD_ProDKin_1	137	143	PF00069	0.556
MOD_ProDKin_1	157	163	PF00069	0.372
MOD_ProDKin_1	214	220	PF00069	0.529
MOD_ProDKin_1	63	69	PF00069	0.557
MOD_SUMO_rev_2	402	409	PF00179	0.696
MOD_SUMO_rev_2	96	104	PF00179	0.510
TRG_DiLeu_BaEn_2	109	115	PF01217	0.490
TRG_DiLeu_BaEn_2	618	624	PF01217	0.405
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.473
TRG_DiLeu_BaLyEn_6	607	612	PF01217	0.548
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.454
TRG_ENDOCYTIC_2	453	456	PF00928	0.418
TRG_ENDOCYTIC_2	489	492	PF00928	0.435
TRG_ENDOCYTIC_2	517	520	PF00928	0.518
TRG_ENDOCYTIC_2	642	645	PF00928	0.555
TRG_ENDOCYTIC_2	674	677	PF00928	0.505
TRG_ENDOCYTIC_2	698	701	PF00928	0.434
TRG_ENDOCYTIC_2	742	745	PF00928	0.402
TRG_ER_diArg_1	119	122	PF00400	0.388
TRG_ER_diArg_1	17	20	PF00400	0.683
TRG_ER_diArg_1	177	179	PF00400	0.306
TRG_ER_diArg_1	314	317	PF00400	0.501
TRG_ER_diArg_1	446	448	PF00400	0.405
TRG_ER_diArg_1	462	464	PF00400	0.353
TRG_ER_diArg_1	667	669	PF00400	0.580
TRG_ER_diArg_1	91	94	PF00400	0.500
TRG_NES_CRM1_1	474	488	PF08389	0.526
TRG_NES_CRM1_1	813	826	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	569	574	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU1	Leptomonas seymouri	72%	100%
A0A1X0NJ82	Trypanosomatidae	44%	100%
A0A3S7WWR2	Leishmania donovani	94%	100%
A0A422N8B4	Trypanosoma rangeli	43%	100%
A4HC13	Leishmania braziliensis	85%	100%
A4HZF4	Leishmania infantum	94%	100%
D0A113	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QC29	Leishmania major	94%	100%
V5B1W3	Trypanosoma cruzi	44%	100%