PEROXIDASE_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxidase, putative

Species:

Leishmania mexicana

UniProt:

E9AVE9_LEIMU

TriTrypDb:

LmxM.21.1567

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AVE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVE9

PDB structure(s): 5via_A

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	17
GO:0006979	response to oxidative stress	3	17
GO:0009987	cellular process	1	17
GO:0033554	cellular response to stress	3	17
GO:0034599	cellular response to oxidative stress	4	17
GO:0042221	response to chemical	2	17
GO:0050896	response to stimulus	1	17
GO:0051716	cellular response to stimulus	2	17
GO:0062197	cellular response to chemical stress	4	17
GO:0070887	cellular response to chemical stimulus	3	17
GO:0000302	response to reactive oxygen species	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0042743	hydrogen peroxide metabolic process	4	1
GO:0042744	hydrogen peroxide catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0072593	reactive oxygen species metabolic process	3	1
GO:1901700	response to oxygen-containing compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004601	peroxidase activity	2	17
GO:0005488	binding	1	17
GO:0016209	antioxidant activity	1	17
GO:0016491	oxidoreductase activity	2	17
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	17
GO:0020037	heme binding	4	17
GO:0046906	tetrapyrrole binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:1901363	heterocyclic compound binding	2	17
GO:0016688	L-ascorbate peroxidase activity	3	3
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.464
CLV_NRD_NRD_1	94	96	PF00675	0.447
CLV_PCSK_KEX2_1	170	172	PF00082	0.478
CLV_PCSK_KEX2_1	226	228	PF00082	0.495
CLV_PCSK_KEX2_1	281	283	PF00082	0.445
CLV_PCSK_KEX2_1	330	332	PF00082	0.519
CLV_PCSK_KEX2_1	94	96	PF00082	0.447
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.504
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.483
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.424
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.519
CLV_PCSK_SKI1_1	227	231	PF00082	0.441
CLV_PCSK_SKI1_1	86	90	PF00082	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SPOP_SBC_1	128	132	PF00917	0.197
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.313
DOC_MAPK_gen_1	295	304	PF00069	0.201
DOC_PP1_RVXF_1	84	90	PF00149	0.221
DOC_PP4_FxxP_1	182	185	PF00568	0.197
DOC_PP4_FxxP_1	2	5	PF00568	0.611
DOC_USP7_MATH_1	128	132	PF00917	0.346
DOC_USP7_MATH_1	174	178	PF00917	0.318
DOC_USP7_MATH_1	20	24	PF00917	0.576
DOC_USP7_MATH_1	204	208	PF00917	0.232
DOC_USP7_MATH_1	81	85	PF00917	0.255
DOC_USP7_UBL2_3	274	278	PF12436	0.229
DOC_USP7_UBL2_3	3	7	PF12436	0.541
DOC_USP7_UBL2_3	56	60	PF12436	0.361
LIG_14-3-3_CanoR_1	333	338	PF00244	0.333
LIG_APCC_ABBA_1	332	337	PF00400	0.388
LIG_deltaCOP1_diTrp_1	156	160	PF00928	0.212
LIG_deltaCOP1_diTrp_1	309	317	PF00928	0.263
LIG_FHA_1	130	136	PF00498	0.273
LIG_FHA_1	28	34	PF00498	0.543
LIG_FHA_1	320	326	PF00498	0.260
LIG_FHA_2	100	106	PF00498	0.294
LIG_FHA_2	193	199	PF00498	0.238
LIG_FHA_2	296	302	PF00498	0.298
LIG_IBAR_NPY_1	19	21	PF08397	0.606
LIG_LIR_Gen_1	23	32	PF02991	0.525
LIG_LIR_Gen_1	319	329	PF02991	0.256
LIG_LIR_LC3C_4	301	304	PF02991	0.209
LIG_LIR_Nem_3	23	27	PF02991	0.554
LIG_LIR_Nem_3	242	248	PF02991	0.254
LIG_LIR_Nem_3	298	302	PF02991	0.238
LIG_LIR_Nem_3	30	34	PF02991	0.327
LIG_LIR_Nem_3	326	332	PF02991	0.280
LIG_Pex14_1	313	317	PF04695	0.252
LIG_Pex14_2	317	321	PF04695	0.262
LIG_PTB_Apo_2	145	152	PF02174	0.300
LIG_PTB_Apo_2	228	235	PF02174	0.247
LIG_PTB_Phospho_1	145	151	PF10480	0.300
LIG_PTB_Phospho_1	228	234	PF10480	0.234
LIG_SH2_CRK	235	239	PF00017	0.247
LIG_SH2_GRB2like	146	149	PF00017	0.300
LIG_SH2_NCK_1	335	339	PF00017	0.396
LIG_SH2_SRC	146	149	PF00017	0.300
LIG_SH2_STAP1	151	155	PF00017	0.368
LIG_SH2_STAT5	122	125	PF00017	0.365
LIG_SH2_STAT5	146	149	PF00017	0.311
LIG_SH2_STAT5	228	231	PF00017	0.285
LIG_SH2_STAT5	270	273	PF00017	0.276
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.233
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.136
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.298
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.257
LIG_SUMO_SIM_par_1	48	55	PF11976	0.340
LIG_TRAF2_1	308	311	PF00917	0.377
MOD_CK1_1	183	189	PF00069	0.300
MOD_CK1_1	319	325	PF00069	0.249
MOD_CK2_1	127	133	PF00069	0.367
MOD_CK2_1	192	198	PF00069	0.242
MOD_CK2_1	204	210	PF00069	0.258
MOD_CK2_1	213	219	PF00069	0.258
MOD_CK2_1	295	301	PF00069	0.346
MOD_CK2_1	99	105	PF00069	0.274
MOD_Cter_Amidation	10	13	PF01082	0.492
MOD_Cter_Amidation	224	227	PF01082	0.513
MOD_GlcNHglycan	213	218	PF01048	0.430
MOD_GlcNHglycan	318	321	PF01048	0.459
MOD_GlcNHglycan	68	71	PF01048	0.554
MOD_GSK3_1	123	130	PF00069	0.313
MOD_GSK3_1	246	253	PF00069	0.365
MOD_GSK3_1	333	340	PF00069	0.343
MOD_GSK3_1	99	106	PF00069	0.223
MOD_LATS_1	178	184	PF00433	0.136
MOD_N-GLC_1	162	167	PF02516	0.404
MOD_N-GLC_1	27	32	PF02516	0.220
MOD_N-GLC_1	295	300	PF02516	0.429
MOD_NEK2_1	123	128	PF00069	0.313
MOD_NEK2_1	324	329	PF00069	0.266
MOD_NEK2_1	80	85	PF00069	0.285
MOD_NEK2_2	81	86	PF00069	0.266
MOD_PIKK_1	250	256	PF00454	0.317
MOD_PK_1	180	186	PF00069	0.294
MOD_PKA_1	12	18	PF00069	0.661
MOD_PKB_1	331	339	PF00069	0.395
MOD_Plk_1	27	33	PF00069	0.420
MOD_Plk_1	295	301	PF00069	0.255
MOD_Plk_4	183	189	PF00069	0.206
MOD_Plk_4	27	33	PF00069	0.523
MOD_SUMO_rev_2	51	57	PF00179	0.403
TRG_DiLeu_BaEn_1	198	203	PF01217	0.229
TRG_ENDOCYTIC_2	151	154	PF00928	0.311
TRG_ENDOCYTIC_2	234	237	PF00928	0.236
TRG_ER_diArg_1	331	334	PF00400	0.333
TRG_NLS_MonoExtC_3	329	334	PF00514	0.339
TRG_NLS_MonoExtN_4	278	284	PF00514	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y9	Leptomonas seymouri	80%	84%
A0A0N0P6I0	Leptomonas seymouri	27%	100%
A0A0S4JPM4	Bodo saltans	47%	68%
A0A1X0NHV6	Trypanosomatidae	55%	93%
A0A1X0P9U7	Trypanosomatidae	28%	100%
A0A3S7WWR4	Leishmania donovani	96%	100%
A0A422N895	Trypanosoma rangeli	56%	90%
A4HAD2	Leishmania braziliensis	25%	100%
A4HC12	Leishmania braziliensis	88%	100%
A4HZF3	Leishmania infantum	96%	100%
A4I9H5	Leishmania infantum	25%	100%
D0A114	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	91%
E9B4H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
H6V7N3	Leishmania donovani	25%	100%
Q4Q3K2	Leishmania major	25%	100%
Q4QC30	Leishmania major	91%	100%
Q6C0Z6	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	100%
Q6CAB5	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q6CW24	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	99%
Q9FE01	Oryza sativa subsp. japonica	24%	100%
V5BHD3	Trypanosoma cruzi	55%	100%
V5BM56	Trypanosoma cruzi	25%	100%