LeishMANIAdb
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Gnk2-homologous domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Gnk2-homologous domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AVE8_LEIMU
TriTrypDb:
LmxM.21.1568
Length:
146

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVE8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVE8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 139 141 PF00675 0.785
CLV_NRD_NRD_1 20 22 PF00675 0.659
CLV_NRD_NRD_1 29 31 PF00675 0.680
CLV_PCSK_KEX2_1 101 103 PF00082 0.581
CLV_PCSK_KEX2_1 139 141 PF00082 0.762
CLV_PCSK_KEX2_1 20 22 PF00082 0.659
CLV_PCSK_KEX2_1 29 31 PF00082 0.680
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.581
CLV_PCSK_SKI1_1 101 105 PF00082 0.499
DEG_SPOP_SBC_1 52 56 PF00917 0.675
DOC_PP1_RVXF_1 121 128 PF00149 0.543
DOC_USP7_MATH_1 13 17 PF00917 0.703
DOC_USP7_MATH_1 25 29 PF00917 0.559
DOC_USP7_MATH_1 59 63 PF00917 0.723
DOC_WW_Pin1_4 63 68 PF00397 0.701
LIG_14-3-3_CanoR_1 120 126 PF00244 0.535
LIG_LIR_Gen_1 115 125 PF02991 0.482
LIG_LIR_Nem_3 115 121 PF02991 0.478
LIG_SH2_CRK 93 97 PF00017 0.542
LIG_SH3_3 19 25 PF00018 0.761
LIG_SH3_3 3 9 PF00018 0.613
LIG_SH3_3 33 39 PF00018 0.544
LIG_SH3_3 71 77 PF00018 0.647
LIG_TRAF2_1 85 88 PF00917 0.468
MOD_CK2_1 110 116 PF00069 0.512
MOD_GlcNHglycan 112 115 PF01048 0.514
MOD_GlcNHglycan 40 43 PF01048 0.678
MOD_GlcNHglycan 61 64 PF01048 0.650
MOD_GSK3_1 121 128 PF00069 0.550
MOD_GSK3_1 40 47 PF00069 0.665
MOD_GSK3_1 50 57 PF00069 0.721
MOD_GSK3_1 59 66 PF00069 0.649
MOD_NEK2_1 125 130 PF00069 0.396
MOD_NEK2_1 97 102 PF00069 0.519
MOD_PKA_2 138 144 PF00069 0.665
MOD_ProDKin_1 63 69 PF00069 0.696
TRG_ENDOCYTIC_2 93 96 PF00928 0.543
TRG_ER_diArg_1 19 21 PF00400 0.689
TRG_ER_diArg_1 29 31 PF00400 0.604
TRG_Pf-PMV_PEXEL_1 84 88 PF00026 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3J6 Leptomonas seymouri 51% 70%
A0A3Q8IAG5 Leishmania donovani 92% 100%
A0A3R7K8H1 Trypanosoma rangeli 34% 100%
A4HC11 Leishmania braziliensis 74% 99%
A4HZF2 Leishmania infantum 92% 100%
Q4QC31 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS