TRAF3-interacting protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding protein MIP-T3, putative

Species:

Leishmania mexicana

UniProt:

E9AVE7_LEIMU

TriTrypDb:

LmxM.21.1566

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVE7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0065007	biological regulation	1	1
GO:0070507	regulation of microtubule cytoskeleton organization	5	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0008017	microtubule binding	5	6
GO:0008092	cytoskeletal protein binding	3	6
GO:0015631	tubulin binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.630
CLV_C14_Caspase3-7	55	59	PF00656	0.582
CLV_NRD_NRD_1	125	127	PF00675	0.659
CLV_NRD_NRD_1	167	169	PF00675	0.729
CLV_NRD_NRD_1	174	176	PF00675	0.657
CLV_NRD_NRD_1	216	218	PF00675	0.826
CLV_NRD_NRD_1	237	239	PF00675	0.797
CLV_NRD_NRD_1	426	428	PF00675	0.382
CLV_PCSK_FUR_1	164	168	PF00082	0.662
CLV_PCSK_FUR_1	172	176	PF00082	0.600
CLV_PCSK_KEX2_1	166	168	PF00082	0.724
CLV_PCSK_KEX2_1	172	174	PF00082	0.676
CLV_PCSK_KEX2_1	180	182	PF00082	0.616
CLV_PCSK_KEX2_1	215	217	PF00082	0.819
CLV_PCSK_KEX2_1	223	225	PF00082	0.818
CLV_PCSK_KEX2_1	271	273	PF00082	0.780
CLV_PCSK_KEX2_1	323	325	PF00082	0.382
CLV_PCSK_KEX2_1	426	428	PF00082	0.382
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.672
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.510
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.765
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.773
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.382
CLV_PCSK_PC7_1	168	174	PF00082	0.662
CLV_PCSK_PC7_1	219	225	PF00082	0.770
CLV_PCSK_SKI1_1	224	228	PF00082	0.601
CLV_PCSK_SKI1_1	312	316	PF00082	0.392
CLV_PCSK_SKI1_1	65	69	PF00082	0.429
CLV_PCSK_SKI1_1	90	94	PF00082	0.329
DEG_APCC_DBOX_1	376	384	PF00400	0.582
DEG_Nend_UBRbox_2	1	3	PF02207	0.594
DEG_SPOP_SBC_1	142	146	PF00917	0.617
DOC_MAPK_gen_1	65	71	PF00069	0.582
DOC_MAPK_RevD_3	309	324	PF00069	0.582
DOC_PP1_RVXF_1	66	72	PF00149	0.582
DOC_USP7_MATH_1	115	119	PF00917	0.560
DOC_USP7_MATH_1	142	146	PF00917	0.779
DOC_USP7_MATH_1	233	237	PF00917	0.816
DOC_USP7_UBL2_3	20	24	PF12436	0.535
DOC_USP7_UBL2_3	61	65	PF12436	0.582
DOC_WW_Pin1_4	341	346	PF00397	0.535
LIG_14-3-3_CanoR_1	426	433	PF00244	0.582
LIG_Actin_WH2_2	444	460	PF00022	0.582
LIG_BIR_III_2	259	263	PF00653	0.753
LIG_FHA_1	20	26	PF00498	0.582
LIG_FHA_1	225	231	PF00498	0.716
LIG_FHA_1	245	251	PF00498	0.764
LIG_FHA_1	300	306	PF00498	0.733
LIG_FHA_1	403	409	PF00498	0.603
LIG_FHA_1	452	458	PF00498	0.582
LIG_FHA_2	158	164	PF00498	0.674
LIG_FHA_2	195	201	PF00498	0.734
LIG_FHA_2	275	281	PF00498	0.707
LIG_FHA_2	6	12	PF00498	0.582
LIG_LIR_Gen_1	105	115	PF02991	0.582
LIG_LIR_Gen_1	285	294	PF02991	0.685
LIG_LIR_Nem_3	105	110	PF02991	0.582
LIG_LIR_Nem_3	285	290	PF02991	0.681
LIG_PCNA_yPIPBox_3	7	16	PF02747	0.658
LIG_SH2_STAT5	33	36	PF00017	0.582
LIG_SH3_1	238	244	PF00018	0.764
LIG_SH3_3	238	244	PF00018	0.877
LIG_TRAF2_1	156	159	PF00917	0.701
LIG_TRAF2_1	160	163	PF00917	0.653
LIG_TRAF2_1	197	200	PF00917	0.787
LIG_TRAF2_1	432	435	PF00917	0.582
LIG_TRAF2_1	96	99	PF00917	0.679
LIG_WRC_WIRS_1	38	43	PF05994	0.551
LIG_WW_3	240	244	PF00397	0.903
MOD_CK1_1	355	361	PF00069	0.571
MOD_CK2_1	143	149	PF00069	0.788
MOD_CK2_1	157	163	PF00069	0.596
MOD_CK2_1	194	200	PF00069	0.809
MOD_CK2_1	274	280	PF00069	0.715
MOD_CK2_1	429	435	PF00069	0.582
MOD_CK2_1	5	11	PF00069	0.582
MOD_Cter_Amidation	269	272	PF01082	0.769
MOD_GlcNHglycan	117	120	PF01048	0.631
MOD_GlcNHglycan	209	212	PF01048	0.836
MOD_GlcNHglycan	235	238	PF01048	0.847
MOD_GlcNHglycan	58	61	PF01048	0.366
MOD_GSK3_1	194	201	PF00069	0.807
MOD_GSK3_1	229	236	PF00069	0.764
MOD_GSK3_1	351	358	PF00069	0.582
MOD_GSK3_1	37	44	PF00069	0.563
MOD_NEK2_1	41	46	PF00069	0.657
MOD_NEK2_1	457	462	PF00069	0.573
MOD_NEK2_1	471	476	PF00069	0.483
MOD_PIKK_1	5	11	PF00454	0.582
MOD_PKA_1	426	432	PF00069	0.582
MOD_PKA_2	426	432	PF00069	0.582
MOD_PKA_2	457	463	PF00069	0.582
MOD_Plk_1	429	435	PF00069	0.582
MOD_Plk_2-3	276	282	PF00069	0.746
MOD_Plk_4	37	43	PF00069	0.610
MOD_Plk_4	457	463	PF00069	0.582
MOD_Plk_4	471	477	PF00069	0.483
MOD_ProDKin_1	341	347	PF00069	0.535
MOD_SUMO_rev_2	292	299	PF00179	0.681
MOD_SUMO_rev_2	307	314	PF00179	0.617
MOD_SUMO_rev_2	58	67	PF00179	0.582
TRG_ER_diArg_1	172	175	PF00400	0.710
TRG_ER_diArg_1	215	217	PF00400	0.730
TRG_NES_CRM1_1	399	414	PF08389	0.582
TRG_NLS_MonoExtC_3	270	276	PF00514	0.768
TRG_NLS_MonoExtN_4	268	275	PF00514	0.767
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWV8	Leishmania donovani	90%	100%
A4HC10	Leishmania braziliensis	77%	99%
A4HZM1	Leishmania infantum	90%	100%
Q4QC32	Leishmania major	89%	100%