Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AVE6_LEIMU

TriTrypDb:

LmxM.21.1565

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVE6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.720
CLV_C14_Caspase3-7	695	699	PF00656	0.555
CLV_NRD_NRD_1	122	124	PF00675	0.393
CLV_NRD_NRD_1	276	278	PF00675	0.627
CLV_NRD_NRD_1	294	296	PF00675	0.532
CLV_NRD_NRD_1	300	302	PF00675	0.449
CLV_NRD_NRD_1	332	334	PF00675	0.582
CLV_NRD_NRD_1	340	342	PF00675	0.463
CLV_NRD_NRD_1	352	354	PF00675	0.393
CLV_NRD_NRD_1	364	366	PF00675	0.487
CLV_NRD_NRD_1	400	402	PF00675	0.489
CLV_NRD_NRD_1	440	442	PF00675	0.472
CLV_NRD_NRD_1	493	495	PF00675	0.629
CLV_NRD_NRD_1	513	515	PF00675	0.405
CLV_NRD_NRD_1	519	521	PF00675	0.586
CLV_NRD_NRD_1	589	591	PF00675	0.655
CLV_NRD_NRD_1	660	662	PF00675	0.617
CLV_PCSK_KEX2_1	122	124	PF00082	0.393
CLV_PCSK_KEX2_1	245	247	PF00082	0.360
CLV_PCSK_KEX2_1	276	278	PF00082	0.665
CLV_PCSK_KEX2_1	294	296	PF00082	0.522
CLV_PCSK_KEX2_1	331	333	PF00082	0.584
CLV_PCSK_KEX2_1	340	342	PF00082	0.520
CLV_PCSK_KEX2_1	354	356	PF00082	0.441
CLV_PCSK_KEX2_1	399	401	PF00082	0.482
CLV_PCSK_KEX2_1	440	442	PF00082	0.472
CLV_PCSK_KEX2_1	513	515	PF00082	0.560
CLV_PCSK_KEX2_1	659	661	PF00082	0.549
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.411
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.523
CLV_PCSK_SKI1_1	103	107	PF00082	0.281
CLV_PCSK_SKI1_1	122	126	PF00082	0.313
CLV_PCSK_SKI1_1	127	131	PF00082	0.316
CLV_PCSK_SKI1_1	214	218	PF00082	0.274
CLV_PCSK_SKI1_1	259	263	PF00082	0.437
CLV_PCSK_SKI1_1	354	358	PF00082	0.538
CLV_PCSK_SKI1_1	494	498	PF00082	0.662
CLV_PCSK_SKI1_1	5	9	PF00082	0.240
CLV_PCSK_SKI1_1	521	525	PF00082	0.600
CLV_PCSK_SKI1_1	701	705	PF00082	0.473
CLV_PCSK_SKI1_1	728	732	PF00082	0.373
DEG_APCC_DBOX_1	258	266	PF00400	0.348
DEG_Nend_UBRbox_2	1	3	PF02207	0.417
DEG_SCF_FBW7_1	481	488	PF00400	0.747
DEG_SCF_FBW7_2	632	637	PF00400	0.663
DEG_SPOP_SBC_1	485	489	PF00917	0.660
DOC_CKS1_1	482	487	PF01111	0.752
DOC_MAPK_gen_1	127	136	PF00069	0.266
DOC_MAPK_gen_1	273	282	PF00069	0.654
DOC_MAPK_gen_1	340	350	PF00069	0.478
DOC_MAPK_MEF2A_6	217	225	PF00069	0.167
DOC_MAPK_MEF2A_6	723	731	PF00069	0.403
DOC_MAPK_MEF2A_6	73	80	PF00069	0.298
DOC_PP2B_LxvP_1	570	573	PF13499	0.614
DOC_PP2B_LxvP_1	613	616	PF13499	0.520
DOC_PP4_FxxP_1	709	712	PF00568	0.587
DOC_USP7_MATH_1	247	251	PF00917	0.281
DOC_USP7_MATH_1	486	490	PF00917	0.719
DOC_USP7_MATH_1	548	552	PF00917	0.808
DOC_USP7_MATH_1	565	569	PF00917	0.534
DOC_USP7_MATH_1	696	700	PF00917	0.618
DOC_USP7_MATH_1	712	716	PF00917	0.456
DOC_USP7_MATH_1	791	795	PF00917	0.515
DOC_USP7_MATH_2	42	48	PF00917	0.266
DOC_USP7_UBL2_3	373	377	PF12436	0.633
DOC_USP7_UBL2_3	581	585	PF12436	0.647
DOC_USP7_UBL2_3	8	12	PF12436	0.360
DOC_WW_Pin1_4	163	168	PF00397	0.266
DOC_WW_Pin1_4	481	486	PF00397	0.637
DOC_WW_Pin1_4	494	499	PF00397	0.586
DOC_WW_Pin1_4	544	549	PF00397	0.700
DOC_WW_Pin1_4	604	609	PF00397	0.582
DOC_WW_Pin1_4	630	635	PF00397	0.669
DOC_WW_Pin1_4	649	654	PF00397	0.713
LIG_14-3-3_CanoR_1	154	158	PF00244	0.302
LIG_14-3-3_CanoR_1	233	239	PF00244	0.346
LIG_14-3-3_CanoR_1	246	255	PF00244	0.216
LIG_14-3-3_CanoR_1	276	280	PF00244	0.554
LIG_14-3-3_CanoR_1	788	798	PF00244	0.572
LIG_Actin_WH2_2	145	162	PF00022	0.266
LIG_Actin_WH2_2	204	219	PF00022	0.281
LIG_Actin_WH2_2	28	43	PF00022	0.360
LIG_AP2alpha_1	684	688	PF02296	0.621
LIG_APCC_ABBA_1	727	732	PF00400	0.376
LIG_APCC_ABBAyCdc20_2	122	128	PF00400	0.259
LIG_BRCT_BRCA1_1	505	509	PF00533	0.680
LIG_BRCT_BRCA1_1	554	558	PF00533	0.546
LIG_eIF4E_1	220	226	PF01652	0.167
LIG_EVH1_1	570	574	PF00568	0.593
LIG_FHA_1	129	135	PF00498	0.324
LIG_FHA_1	154	160	PF00498	0.266
LIG_FHA_1	62	68	PF00498	0.266
LIG_FHA_1	706	712	PF00498	0.477
LIG_FHA_1	715	721	PF00498	0.454
LIG_FHA_2	495	501	PF00498	0.621
LIG_FHA_2	536	542	PF00498	0.752
LIG_FHA_2	652	658	PF00498	0.668
LIG_LIR_Apic_2	166	172	PF02991	0.271
LIG_LIR_Apic_2	708	712	PF02991	0.514
LIG_LIR_Gen_1	662	672	PF02991	0.536
LIG_LIR_Gen_1	75	83	PF02991	0.312
LIG_LIR_Nem_3	2	7	PF02991	0.272
LIG_LIR_Nem_3	662	668	PF02991	0.547
LIG_LIR_Nem_3	87	92	PF02991	0.278
LIG_LRP6_Inhibitor_1	253	259	PF00058	0.240
LIG_LYPXL_S_1	219	223	PF13949	0.281
LIG_LYPXL_yS_3	220	223	PF13949	0.266
LIG_MAD2	214	222	PF02301	0.266
LIG_PCNA_yPIPBox_3	209	220	PF02747	0.286
LIG_PDZ_Class_2	795	800	PF00595	0.574
LIG_Pex14_2	15	19	PF04695	0.266
LIG_Pex14_2	684	688	PF04695	0.621
LIG_SH2_CRK	4	8	PF00017	0.332
LIG_SH2_CRK	89	93	PF00017	0.266
LIG_SH2_GRB2like	82	85	PF00017	0.300
LIG_SH2_SRC	66	69	PF00017	0.266
LIG_SH2_SRC	82	85	PF00017	0.266
LIG_SH2_STAP1	227	231	PF00017	0.281
LIG_SH2_STAT5	169	172	PF00017	0.266
LIG_SH2_STAT5	299	302	PF00017	0.428
LIG_SH2_STAT5	491	494	PF00017	0.606
LIG_SH2_STAT5	66	69	PF00017	0.266
LIG_SH3_3	216	222	PF00018	0.342
LIG_SH3_3	412	418	PF00018	0.539
LIG_SH3_3	476	482	PF00018	0.649
LIG_SH3_3	559	565	PF00018	0.653
LIG_SH3_3	568	574	PF00018	0.608
LIG_SH3_3	609	615	PF00018	0.733
LIG_SH3_4	582	589	PF00018	0.606
LIG_SUMO_SIM_par_1	278	284	PF11976	0.551
LIG_TRAF2_1	281	284	PF00917	0.538
LIG_TRAF2_1	349	352	PF00917	0.536
LIG_TRAF2_1	418	421	PF00917	0.427
LIG_TRAF2_1	497	500	PF00917	0.613
LIG_UBA3_1	238	245	PF00899	0.325
LIG_WW_3	480	484	PF00397	0.749
MOD_CK1_1	14	20	PF00069	0.266
MOD_CK1_1	229	235	PF00069	0.307
MOD_CK1_1	278	284	PF00069	0.606
MOD_CK1_1	306	312	PF00069	0.398
MOD_CK1_1	557	563	PF00069	0.808
MOD_CK1_1	596	602	PF00069	0.605
MOD_CK2_1	278	284	PF00069	0.611
MOD_CK2_1	428	434	PF00069	0.561
MOD_CK2_1	494	500	PF00069	0.628
MOD_CK2_1	535	541	PF00069	0.752
MOD_CK2_1	591	597	PF00069	0.588
MOD_CK2_1	649	655	PF00069	0.639
MOD_CK2_1	750	756	PF00069	0.612
MOD_Cter_Amidation	292	295	PF01082	0.360
MOD_GlcNHglycan	16	19	PF01048	0.266
MOD_GlcNHglycan	305	308	PF01048	0.404
MOD_GlcNHglycan	429	433	PF01048	0.530
MOD_GlcNHglycan	46	49	PF01048	0.266
MOD_GlcNHglycan	469	474	PF01048	0.682
MOD_GlcNHglycan	538	541	PF01048	0.690
MOD_GlcNHglycan	714	717	PF01048	0.604
MOD_GlcNHglycan	750	753	PF01048	0.577
MOD_GlcNHglycan	791	794	PF01048	0.629
MOD_GlcNHglycan	795	798	PF01048	0.666
MOD_GSK3_1	159	166	PF00069	0.270
MOD_GSK3_1	225	232	PF00069	0.304
MOD_GSK3_1	481	488	PF00069	0.747
MOD_GSK3_1	490	497	PF00069	0.713
MOD_GSK3_1	531	538	PF00069	0.725
MOD_GSK3_1	544	551	PF00069	0.773
MOD_GSK3_1	552	559	PF00069	0.731
MOD_GSK3_1	572	579	PF00069	0.664
MOD_GSK3_1	591	598	PF00069	0.691
MOD_GSK3_1	789	796	PF00069	0.511
MOD_N-GLC_1	181	186	PF02516	0.266
MOD_N-GLC_1	229	234	PF02516	0.328
MOD_N-GLC_1	247	252	PF02516	0.300
MOD_N-GLC_1	61	66	PF02516	0.266
MOD_N-GLC_1	712	717	PF02516	0.563
MOD_N-GLC_1	748	753	PF02516	0.554
MOD_NEK2_1	114	119	PF00069	0.331
MOD_NEK2_1	147	152	PF00069	0.302
MOD_NEK2_1	159	164	PF00069	0.350
MOD_NEK2_1	203	208	PF00069	0.379
MOD_NEK2_1	225	230	PF00069	0.352
MOD_NEK2_1	234	239	PF00069	0.265
MOD_NEK2_1	54	59	PF00069	0.411
MOD_NEK2_2	451	456	PF00069	0.542
MOD_PIKK_1	107	113	PF00454	0.316
MOD_PIKK_1	128	134	PF00454	0.266
MOD_PIKK_1	247	253	PF00454	0.300
MOD_PIKK_1	503	509	PF00454	0.656
MOD_PIKK_1	531	537	PF00454	0.548
MOD_PK_1	591	597	PF00069	0.489
MOD_PKA_1	581	587	PF00069	0.491
MOD_PKA_2	153	159	PF00069	0.308
MOD_PKA_2	275	281	PF00069	0.631
MOD_PKA_2	44	50	PF00069	0.272
MOD_PKA_2	451	457	PF00069	0.650
MOD_PKA_2	679	685	PF00069	0.492
MOD_Plk_1	194	200	PF00069	0.266
MOD_Plk_1	229	235	PF00069	0.352
MOD_Plk_1	247	253	PF00069	0.189
MOD_Plk_1	591	597	PF00069	0.489
MOD_Plk_1	61	67	PF00069	0.274
MOD_Plk_1	628	634	PF00069	0.595
MOD_Plk_1	697	703	PF00069	0.582
MOD_Plk_4	114	120	PF00069	0.331
MOD_Plk_4	148	154	PF00069	0.301
MOD_Plk_4	234	240	PF00069	0.318
MOD_Plk_4	451	457	PF00069	0.588
MOD_Plk_4	667	673	PF00069	0.561
MOD_Plk_4	72	78	PF00069	0.300
MOD_ProDKin_1	163	169	PF00069	0.266
MOD_ProDKin_1	481	487	PF00069	0.637
MOD_ProDKin_1	494	500	PF00069	0.580
MOD_ProDKin_1	544	550	PF00069	0.693
MOD_ProDKin_1	604	610	PF00069	0.577
MOD_ProDKin_1	630	636	PF00069	0.670
MOD_ProDKin_1	649	655	PF00069	0.711
MOD_SUMO_rev_2	347	356	PF00179	0.562
MOD_SUMO_rev_2	575	584	PF00179	0.610
MOD_SUMO_rev_2	68	75	PF00179	0.331
MOD_SUMO_rev_2	699	709	PF00179	0.667
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.411
TRG_ENDOCYTIC_2	220	223	PF00928	0.266
TRG_ENDOCYTIC_2	4	7	PF00928	0.272
TRG_ENDOCYTIC_2	436	439	PF00928	0.486
TRG_ENDOCYTIC_2	665	668	PF00928	0.523
TRG_ENDOCYTIC_2	744	747	PF00928	0.404
TRG_ENDOCYTIC_2	89	92	PF00928	0.296
TRG_ER_diArg_1	122	124	PF00400	0.393
TRG_ER_diArg_1	331	333	PF00400	0.587
TRG_ER_diArg_1	340	342	PF00400	0.568
TRG_ER_diArg_1	399	401	PF00400	0.502
TRG_ER_diArg_1	439	441	PF00400	0.480
TRG_ER_diArg_1	512	514	PF00400	0.545
TRG_ER_diArg_1	659	661	PF00400	0.679
TRG_NES_CRM1_1	260	275	PF08389	0.469
TRG_NES_CRM1_1	718	732	PF08389	0.406
TRG_NLS_MonoExtC_3	519	525	PF00514	0.444
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W7	Leptomonas seymouri	64%	100%
A0A0S4JKY4	Bodo saltans	45%	100%
A0A1X0NHD4	Trypanosomatidae	48%	100%
A0A3Q8IBZ9	Leishmania donovani	93%	100%
A0A3R7M6Z7	Trypanosoma rangeli	46%	100%
A4HC09	Leishmania braziliensis	81%	100%
A4HZM2	Leishmania infantum	93%	100%
D0A118	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QC33	Leishmania major	91%	100%
V5BLW4	Trypanosoma cruzi	48%	100%