Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVE4_LEIMU

TriTrypDb:

LmxM.21.1561

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.706
CLV_NRD_NRD_1	222	224	PF00675	0.736
CLV_PCSK_KEX2_1	185	187	PF00082	0.803
CLV_PCSK_KEX2_1	222	224	PF00082	0.736
CLV_PCSK_KEX2_1	277	279	PF00082	0.725
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.725
CLV_PCSK_SKI1_1	2	6	PF00082	0.773
CLV_PCSK_SKI1_1	244	248	PF00082	0.531
DEG_Nend_UBRbox_1	1	4	PF02207	0.785
DEG_SCF_FBW7_2	4	11	PF00400	0.745
DEG_SPOP_SBC_1	16	20	PF00917	0.769
DEG_SPOP_SBC_1	214	218	PF00917	0.748
DEG_SPOP_SBC_1	23	27	PF00917	0.676
DEG_SPOP_SBC_1	62	66	PF00917	0.497
DOC_ANK_TNKS_1	178	185	PF00023	0.717
DOC_CKS1_1	198	203	PF01111	0.685
DOC_CYCLIN_RxL_1	244	255	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.553
DOC_MAPK_gen_1	244	253	PF00069	0.536
DOC_MAPK_MEF2A_6	244	253	PF00069	0.536
DOC_PP4_FxxP_1	306	309	PF00568	0.822
DOC_PP4_FxxP_1	356	359	PF00568	0.564
DOC_SPAK_OSR1_1	321	325	PF12202	0.630
DOC_USP7_MATH_1	174	178	PF00917	0.664
DOC_USP7_MATH_1	192	196	PF00917	0.779
DOC_USP7_MATH_1	22	26	PF00917	0.801
DOC_USP7_MATH_1	287	291	PF00917	0.716
DOC_USP7_MATH_1	297	301	PF00917	0.776
DOC_USP7_MATH_1	317	321	PF00917	0.704
DOC_USP7_MATH_1	376	380	PF00917	0.749
DOC_USP7_MATH_1	41	45	PF00917	0.509
DOC_USP7_MATH_1	62	66	PF00917	0.730
DOC_USP7_UBL2_3	2	6	PF12436	0.773
DOC_WW_Pin1_4	170	175	PF00397	0.658
DOC_WW_Pin1_4	197	202	PF00397	0.670
DOC_WW_Pin1_4	208	213	PF00397	0.736
DOC_WW_Pin1_4	215	220	PF00397	0.741
DOC_WW_Pin1_4	272	277	PF00397	0.697
DOC_WW_Pin1_4	283	288	PF00397	0.717
DOC_WW_Pin1_4	311	316	PF00397	0.650
DOC_WW_Pin1_4	397	402	PF00397	0.711
DOC_WW_Pin1_4	4	9	PF00397	0.763
DOC_WW_Pin1_4	89	94	PF00397	0.697
LIG_14-3-3_CanoR_1	185	192	PF00244	0.691
LIG_14-3-3_CanoR_1	278	287	PF00244	0.823
LIG_14-3-3_CanoR_1	321	330	PF00244	0.598
LIG_14-3-3_CanoR_1	394	402	PF00244	0.761
LIG_14-3-3_CanoR_1	405	409	PF00244	0.606
LIG_14-3-3_CanoR_1	46	50	PF00244	0.710
LIG_Actin_WH2_2	68	85	PF00022	0.716
LIG_APCC_ABBA_1	74	79	PF00400	0.730
LIG_BIR_III_2	273	277	PF00653	0.727
LIG_CSL_BTD_1	198	201	PF09270	0.674
LIG_FHA_1	127	133	PF00498	0.506
LIG_FHA_1	152	158	PF00498	0.556
LIG_FHA_1	279	285	PF00498	0.644
LIG_FHA_2	338	344	PF00498	0.738
LIG_HCF-1_HBM_1	123	126	PF13415	0.557
LIG_LIR_Gen_1	103	114	PF02991	0.594
LIG_LIR_Gen_1	255	264	PF02991	0.545
LIG_LIR_Nem_3	103	109	PF02991	0.606
LIG_LIR_Nem_3	255	261	PF02991	0.494
LIG_NRBOX	144	150	PF00104	0.528
LIG_NRBOX	412	418	PF00104	0.583
LIG_SH2_CRK	106	110	PF00017	0.565
LIG_SH2_STAT3	131	134	PF00017	0.535
LIG_SH2_STAT3	415	418	PF00017	0.637
LIG_SH2_STAT5	106	109	PF00017	0.566
LIG_SH2_STAT5	131	134	PF00017	0.513
LIG_SH2_STAT5	415	418	PF00017	0.606
LIG_SH3_3	177	183	PF00018	0.733
LIG_SH3_3	195	201	PF00018	0.677
LIG_SH3_3	265	271	PF00018	0.646
LIG_SH3_3	281	287	PF00018	0.719
LIG_SH3_3	302	308	PF00018	0.724
LIG_SH3_3	91	97	PF00018	0.740
LIG_TRFH_1	72	76	PF08558	0.735
MOD_CDC14_SPxK_1	275	278	PF00782	0.715
MOD_CDK_SPK_2	272	277	PF00069	0.697
MOD_CDK_SPK_2	4	9	PF00069	0.763
MOD_CDK_SPxK_1	272	278	PF00069	0.700
MOD_CDK_SPxxK_3	215	222	PF00069	0.843
MOD_CK1_1	207	213	PF00069	0.655
MOD_CK1_1	280	286	PF00069	0.749
MOD_CK1_1	320	326	PF00069	0.669
MOD_CK1_1	357	363	PF00069	0.821
MOD_CK1_1	369	375	PF00069	0.622
MOD_CK1_1	44	50	PF00069	0.579
MOD_CK1_1	63	69	PF00069	0.475
MOD_CK1_1	92	98	PF00069	0.644
MOD_CK2_1	320	326	PF00069	0.625
MOD_Cter_Amidation	183	186	PF01082	0.795
MOD_GlcNHglycan	174	177	PF01048	0.756
MOD_GlcNHglycan	194	197	PF01048	0.662
MOD_GlcNHglycan	206	209	PF01048	0.736
MOD_GlcNHglycan	289	292	PF01048	0.681
MOD_GlcNHglycan	299	302	PF01048	0.687
MOD_GlcNHglycan	363	366	PF01048	0.755
MOD_GlcNHglycan	368	371	PF01048	0.712
MOD_GlcNHglycan	390	393	PF01048	0.766
MOD_GlcNHglycan	395	398	PF01048	0.790
MOD_GlcNHglycan	65	68	PF01048	0.698
MOD_GlcNHglycan	89	92	PF01048	0.686
MOD_GSK3_1	11	18	PF00069	0.764
MOD_GSK3_1	140	147	PF00069	0.524
MOD_GSK3_1	170	177	PF00069	0.644
MOD_GSK3_1	204	211	PF00069	0.698
MOD_GSK3_1	213	220	PF00069	0.656
MOD_GSK3_1	24	31	PF00069	0.664
MOD_GSK3_1	283	290	PF00069	0.738
MOD_GSK3_1	357	364	PF00069	0.761
MOD_GSK3_1	388	395	PF00069	0.724
MOD_GSK3_1	41	48	PF00069	0.820
MOD_GSK3_1	58	65	PF00069	0.539
MOD_GSK3_1	85	92	PF00069	0.720
MOD_GSK3_1	96	103	PF00069	0.526
MOD_N-GLC_1	126	131	PF02516	0.527
MOD_N-GLC_1	192	197	PF02516	0.780
MOD_N-GLC_1	214	219	PF02516	0.689
MOD_N-GLC_1	251	256	PF02516	0.586
MOD_N-GLC_1	28	33	PF02516	0.752
MOD_N-GLC_1	36	41	PF02516	0.827
MOD_NEK2_1	204	209	PF00069	0.722
MOD_NEK2_1	251	256	PF00069	0.656
MOD_NEK2_1	361	366	PF00069	0.783
MOD_NEK2_1	416	421	PF00069	0.605
MOD_NEK2_2	126	131	PF00069	0.527
MOD_PIKK_1	376	382	PF00454	0.744
MOD_PIKK_1	41	47	PF00454	0.652
MOD_PIKK_1	92	98	PF00454	0.696
MOD_PKA_1	185	191	PF00069	0.800
MOD_PKA_1	277	283	PF00069	0.828
MOD_PKA_2	185	191	PF00069	0.730
MOD_PKA_2	204	210	PF00069	0.495
MOD_PKA_2	277	283	PF00069	0.800
MOD_PKA_2	320	326	PF00069	0.625
MOD_PKA_2	361	367	PF00069	0.828
MOD_PKA_2	393	399	PF00069	0.752
MOD_PKA_2	404	410	PF00069	0.788
MOD_PKA_2	45	51	PF00069	0.755
MOD_Plk_1	100	106	PF00069	0.528
MOD_Plk_1	126	132	PF00069	0.528
MOD_Plk_1	376	382	PF00069	0.750
MOD_Plk_2-3	409	415	PF00069	0.619
MOD_Plk_4	104	110	PF00069	0.574
MOD_Plk_4	11	17	PF00069	0.709
MOD_Plk_4	140	146	PF00069	0.523
MOD_Plk_4	152	158	PF00069	0.556
MOD_Plk_4	280	286	PF00069	0.597
MOD_Plk_4	308	314	PF00069	0.785
MOD_ProDKin_1	170	176	PF00069	0.662
MOD_ProDKin_1	197	203	PF00069	0.676
MOD_ProDKin_1	208	214	PF00069	0.736
MOD_ProDKin_1	215	221	PF00069	0.741
MOD_ProDKin_1	272	278	PF00069	0.700
MOD_ProDKin_1	283	289	PF00069	0.718
MOD_ProDKin_1	311	317	PF00069	0.647
MOD_ProDKin_1	397	403	PF00069	0.711
MOD_ProDKin_1	4	10	PF00069	0.763
MOD_ProDKin_1	89	95	PF00069	0.695
TRG_DiLeu_BaEn_1	11	16	PF01217	0.716
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.696
TRG_ENDOCYTIC_2	106	109	PF00928	0.566
TRG_ENDOCYTIC_2	258	261	PF00928	0.501
TRG_ER_diArg_1	160	163	PF00400	0.558
TRG_ER_diArg_1	185	187	PF00400	0.687
TRG_ER_diArg_1	222	225	PF00400	0.735
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K6	Leptomonas seymouri	58%	100%
A0A3S7WWV7	Leishmania donovani	92%	97%
A4HC07	Leishmania braziliensis	82%	100%
A4HZG3	Leishmania infantum	92%	97%
Q4QC35	Leishmania major	92%	100%