GST_C_6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 19

Species:

Leishmania mexicana

UniProt:

E9AVE3_LEIMU

TriTrypDb:

LmxM.21.1558

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVE3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.545
CLV_C14_Caspase3-7	43	47	PF00656	0.574
CLV_NRD_NRD_1	140	142	PF00675	0.369
CLV_NRD_NRD_1	208	210	PF00675	0.337
CLV_NRD_NRD_1	261	263	PF00675	0.407
CLV_NRD_NRD_1	278	280	PF00675	0.436
CLV_PCSK_KEX2_1	140	142	PF00082	0.469
CLV_PCSK_KEX2_1	261	263	PF00082	0.375
CLV_PCSK_KEX2_1	278	280	PF00082	0.413
CLV_PCSK_KEX2_1	90	92	PF00082	0.367
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.346
CLV_PCSK_SKI1_1	210	214	PF00082	0.364
CLV_PCSK_SKI1_1	279	283	PF00082	0.459
CLV_Separin_Metazoa	177	181	PF03568	0.531
DOC_MAPK_MEF2A_6	48	56	PF00069	0.495
DOC_PP2B_LxvP_1	19	22	PF13499	0.492
DOC_USP7_MATH_1	239	243	PF00917	0.446
DOC_USP7_MATH_1	58	62	PF00917	0.606
DOC_USP7_MATH_1	68	72	PF00917	0.652
DOC_WW_Pin1_4	54	59	PF00397	0.618
DOC_WW_Pin1_4	70	75	PF00397	0.740
LIG_14-3-3_CanoR_1	140	144	PF00244	0.596
LIG_14-3-3_CanoR_1	180	186	PF00244	0.560
LIG_14-3-3_CanoR_1	209	217	PF00244	0.636
LIG_14-3-3_CanoR_1	318	323	PF00244	0.572
LIG_14-3-3_CterR_2	371	373	PF00244	0.378
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	329	333	PF00533	0.335
LIG_EH_1	165	169	PF12763	0.535
LIG_eIF4E_1	265	271	PF01652	0.414
LIG_FHA_1	286	292	PF00498	0.685
LIG_FHA_2	229	235	PF00498	0.608
LIG_FHA_2	41	47	PF00498	0.517
LIG_IRF3_LxIS_1	52	57	PF10401	0.499
LIG_LIR_Gen_1	199	208	PF02991	0.578
LIG_LIR_Gen_1	325	336	PF02991	0.323
LIG_LIR_Gen_1	95	106	PF02991	0.530
LIG_LIR_Nem_3	10	15	PF02991	0.543
LIG_LIR_Nem_3	199	205	PF02991	0.577
LIG_LIR_Nem_3	321	327	PF02991	0.305
LIG_LIR_Nem_3	330	336	PF02991	0.291
LIG_LIR_Nem_3	95	101	PF02991	0.550
LIG_MLH1_MIPbox_1	329	333	PF16413	0.335
LIG_NRBOX	340	346	PF00104	0.542
LIG_Pex14_1	324	328	PF04695	0.355
LIG_Pex14_2	126	130	PF04695	0.538
LIG_PTB_Apo_2	163	170	PF02174	0.539
LIG_SH2_CRK	265	269	PF00017	0.422
LIG_SH2_NCK_1	238	242	PF00017	0.446
LIG_SH2_NCK_1	265	269	PF00017	0.422
LIG_SH2_NCK_1	42	46	PF00017	0.574
LIG_SH2_SRC	232	235	PF00017	0.536
LIG_SH2_SRC	273	276	PF00017	0.491
LIG_SH2_STAT5	232	235	PF00017	0.556
LIG_SH2_STAT5	273	276	PF00017	0.469
LIG_SH2_STAT5	289	292	PF00017	0.537
LIG_SH2_STAT5	332	335	PF00017	0.280
LIG_SH2_STAT5	42	45	PF00017	0.551
LIG_SUMO_SIM_par_1	339	347	PF11976	0.491
LIG_TRFH_1	289	293	PF08558	0.637
LIG_UBA3_1	85	90	PF00899	0.530
LIG_WRC_WIRS_1	147	152	PF05994	0.604
MOD_CDC14_SPxK_1	73	76	PF00782	0.542
MOD_CDK_SPxK_1	70	76	PF00069	0.545
MOD_CK1_1	184	190	PF00069	0.615
MOD_CK1_1	228	234	PF00069	0.556
MOD_CK1_1	61	67	PF00069	0.656
MOD_CK2_1	146	152	PF00069	0.619
MOD_GlcNHglycan	170	173	PF01048	0.422
MOD_GlcNHglycan	213	216	PF01048	0.376
MOD_GlcNHglycan	285	288	PF01048	0.381
MOD_GlcNHglycan	315	318	PF01048	0.448
MOD_GlcNHglycan	63	66	PF01048	0.453
MOD_GlcNHglycan	95	98	PF01048	0.419
MOD_GSK3_1	204	211	PF00069	0.558
MOD_GSK3_1	224	231	PF00069	0.448
MOD_GSK3_1	318	325	PF00069	0.466
MOD_GSK3_1	50	57	PF00069	0.524
MOD_GSK3_1	66	73	PF00069	0.570
MOD_GSK3_1	93	100	PF00069	0.595
MOD_NEK2_1	154	159	PF00069	0.528
MOD_NEK2_1	168	173	PF00069	0.529
MOD_NEK2_1	208	213	PF00069	0.548
MOD_NEK2_1	224	229	PF00069	0.573
MOD_NEK2_1	322	327	PF00069	0.325
MOD_NEK2_1	52	57	PF00069	0.623
MOD_PKA_2	139	145	PF00069	0.570
MOD_PKA_2	154	160	PF00069	0.461
MOD_PKA_2	208	214	PF00069	0.531
MOD_PKA_2	228	234	PF00069	0.406
MOD_PKA_2	40	46	PF00069	0.595
MOD_Plk_1	50	56	PF00069	0.641
MOD_Plk_4	146	152	PF00069	0.538
MOD_Plk_4	228	234	PF00069	0.502
MOD_Plk_4	240	246	PF00069	0.423
MOD_Plk_4	30	36	PF00069	0.583
MOD_Plk_4	318	324	PF00069	0.506
MOD_Plk_4	327	333	PF00069	0.386
MOD_Plk_4	7	13	PF00069	0.526
MOD_ProDKin_1	54	60	PF00069	0.621
MOD_ProDKin_1	70	76	PF00069	0.739
MOD_SUMO_for_1	77	80	PF00179	0.569
MOD_SUMO_rev_2	142	148	PF00179	0.583
TRG_AP2beta_CARGO_1	199	209	PF09066	0.529
TRG_ENDOCYTIC_2	127	130	PF00928	0.574
TRG_ENDOCYTIC_2	332	335	PF00928	0.300
TRG_ER_diArg_1	139	141	PF00400	0.654
TRG_ER_diArg_1	261	263	PF00400	0.608
TRG_ER_diArg_1	277	279	PF00400	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X3	Leptomonas seymouri	55%	100%
A0A1X0NHP3	Trypanosomatidae	36%	100%
A0A3R7N7N1	Trypanosoma rangeli	33%	100%
A0A3S7WWQ5	Leishmania donovani	93%	83%
A4HC06	Leishmania braziliensis	76%	100%
A4HZF6	Leishmania infantum	93%	83%
D0A124	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QC36	Leishmania major	91%	100%
V5BLW0	Trypanosoma cruzi	30%	100%