Pheromone-regulated membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVE0_LEIMU

TriTrypDb:

LmxM.21.1560

Length:

543

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AVE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	454	458	PF00656	0.608
CLV_C14_Caspase3-7	468	472	PF00656	0.602
CLV_MEL_PAP_1	408	414	PF00089	0.470
CLV_NRD_NRD_1	142	144	PF00675	0.347
CLV_NRD_NRD_1	310	312	PF00675	0.455
CLV_NRD_NRD_1	337	339	PF00675	0.640
CLV_NRD_NRD_1	512	514	PF00675	0.468
CLV_NRD_NRD_1	79	81	PF00675	0.606
CLV_PCSK_KEX2_1	235	237	PF00082	0.454
CLV_PCSK_KEX2_1	310	312	PF00082	0.455
CLV_PCSK_KEX2_1	336	338	PF00082	0.545
CLV_PCSK_KEX2_1	512	514	PF00082	0.468
CLV_PCSK_KEX2_1	79	81	PF00082	0.606
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.425
CLV_PCSK_SKI1_1	102	106	PF00082	0.483
CLV_PCSK_SKI1_1	232	236	PF00082	0.388
CLV_PCSK_SKI1_1	380	384	PF00082	0.491
CLV_PCSK_SKI1_1	80	84	PF00082	0.639
DEG_APCC_DBOX_1	432	440	PF00400	0.690
DEG_SPOP_SBC_1	330	334	PF00917	0.754
DOC_CKS1_1	14	19	PF01111	0.620
DOC_CKS1_1	381	386	PF01111	0.687
DOC_CYCLIN_yClb1_LxF_4	123	128	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.392
DOC_MAPK_gen_1	223	231	PF00069	0.586
DOC_MAPK_MEF2A_6	223	231	PF00069	0.598
DOC_PP1_RVXF_1	123	129	PF00149	0.535
DOC_PP2B_LxvP_1	358	361	PF13499	0.620
DOC_PP2B_LxvP_1	524	527	PF13499	0.696
DOC_PP2B_LxvP_1	64	67	PF13499	0.399
DOC_USP7_MATH_1	259	263	PF00917	0.690
DOC_USP7_MATH_1	330	334	PF00917	0.754
DOC_USP7_MATH_1	376	380	PF00917	0.699
DOC_USP7_MATH_1	46	50	PF00917	0.352
DOC_USP7_MATH_1	516	520	PF00917	0.717
DOC_WW_Pin1_4	13	18	PF00397	0.639
DOC_WW_Pin1_4	281	286	PF00397	0.714
DOC_WW_Pin1_4	356	361	PF00397	0.704
DOC_WW_Pin1_4	380	385	PF00397	0.691
DOC_WW_Pin1_4	498	503	PF00397	0.670
DOC_WW_Pin1_4	525	530	PF00397	0.697
LIG_14-3-3_CanoR_1	24	29	PF00244	0.535
LIG_14-3-3_CanoR_1	279	284	PF00244	0.693
LIG_14-3-3_CanoR_1	316	324	PF00244	0.621
LIG_14-3-3_CanoR_1	327	335	PF00244	0.674
LIG_14-3-3_CanoR_1	336	345	PF00244	0.791
LIG_Actin_WH2_2	448	463	PF00022	0.666
LIG_APCC_ABBA_1	193	198	PF00400	0.338
LIG_BRCT_BRCA1_1	185	189	PF00533	0.543
LIG_BRCT_BRCA1_1	52	56	PF00533	0.353
LIG_deltaCOP1_diTrp_1	19	28	PF00928	0.588
LIG_EVH1_2	352	356	PF00568	0.666
LIG_FHA_1	130	136	PF00498	0.507
LIG_FHA_1	147	153	PF00498	0.183
LIG_FHA_1	160	166	PF00498	0.244
LIG_FHA_1	171	177	PF00498	0.343
LIG_FHA_1	195	201	PF00498	0.294
LIG_FHA_1	25	31	PF00498	0.535
LIG_FHA_1	381	387	PF00498	0.686
LIG_FHA_1	489	495	PF00498	0.698
LIG_FHA_1	56	62	PF00498	0.374
LIG_FHA_2	14	20	PF00498	0.560
LIG_FHA_2	146	152	PF00498	0.315
LIG_FHA_2	466	472	PF00498	0.614
LIG_FHA_2	534	540	PF00498	0.707
LIG_GBD_Chelix_1	30	38	PF00786	0.315
LIG_LIR_Gen_1	134	142	PF02991	0.567
LIG_LIR_Gen_1	148	157	PF02991	0.379
LIG_LIR_Gen_1	19	30	PF02991	0.509
LIG_LIR_Gen_1	388	398	PF02991	0.742
LIG_LIR_Nem_3	134	140	PF02991	0.563
LIG_LIR_Nem_3	148	153	PF02991	0.386
LIG_LIR_Nem_3	19	25	PF02991	0.509
LIG_LIR_Nem_3	246	251	PF02991	0.588
LIG_LIR_Nem_3	27	31	PF02991	0.389
LIG_LIR_Nem_3	388	393	PF02991	0.743
LIG_PDZ_Class_2	538	543	PF00595	0.725
LIG_PTB_Apo_2	103	110	PF02174	0.315
LIG_PTB_Apo_2	210	217	PF02174	0.315
LIG_PTB_Apo_2	384	391	PF02174	0.660
LIG_PTB_Apo_2	51	58	PF02174	0.335
LIG_PTB_Apo_2	83	90	PF02174	0.346
LIG_PTB_Phospho_1	103	109	PF10480	0.315
LIG_PTB_Phospho_1	384	390	PF10480	0.660
LIG_PTB_Phospho_1	83	89	PF10480	0.370
LIG_SH2_CRK	137	141	PF00017	0.552
LIG_SH2_CRK	190	194	PF00017	0.403
LIG_SH2_NCK_1	190	194	PF00017	0.443
LIG_SH2_NCK_1	390	394	PF00017	0.742
LIG_SH2_SRC	109	112	PF00017	0.383
LIG_SH2_SRC	203	206	PF00017	0.345
LIG_SH2_STAP1	196	200	PF00017	0.288
LIG_SH2_STAT5	109	112	PF00017	0.362
LIG_SH2_STAT5	175	178	PF00017	0.338
LIG_SH2_STAT5	196	199	PF00017	0.333
LIG_SH2_STAT5	203	206	PF00017	0.351
LIG_SH2_STAT5	467	470	PF00017	0.613
LIG_SH2_STAT5	68	71	PF00017	0.334
LIG_SH2_STAT5	98	101	PF00017	0.329
LIG_SH3_3	375	381	PF00018	0.737
LIG_SH3_3	390	396	PF00018	0.683
LIG_SH3_3	499	505	PF00018	0.690
LIG_SH3_3	523	529	PF00018	0.699
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.395
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.395
LIG_SUMO_SIM_par_1	151	158	PF11976	0.402
LIG_TRFH_1	356	360	PF08558	0.622
LIG_TYR_ITIM	135	140	PF00017	0.551
LIG_WRC_WIRS_1	156	161	PF05994	0.311
LIG_WRC_WIRS_1	25	30	PF05994	0.436
LIG_WW_1	505	508	PF00397	0.649
MOD_CDK_SPxxK_3	13	20	PF00069	0.623
MOD_CK1_1	182	188	PF00069	0.328
MOD_CK1_1	329	335	PF00069	0.661
MOD_CK1_1	428	434	PF00069	0.693
MOD_CK1_1	487	493	PF00069	0.693
MOD_CK1_1	55	61	PF00069	0.349
MOD_CK2_1	13	19	PF00069	0.567
MOD_CK2_1	145	151	PF00069	0.485
MOD_CK2_1	293	299	PF00069	0.655
MOD_CK2_1	336	342	PF00069	0.756
MOD_CK2_1	482	488	PF00069	0.716
MOD_DYRK1A_RPxSP_1	380	384	PF00069	0.691
MOD_GlcNHglycan	120	123	PF01048	0.373
MOD_GlcNHglycan	185	188	PF01048	0.636
MOD_GlcNHglycan	295	298	PF01048	0.497
MOD_GlcNHglycan	328	331	PF01048	0.457
MOD_GlcNHglycan	422	425	PF01048	0.503
MOD_GlcNHglycan	430	433	PF01048	0.493
MOD_GlcNHglycan	484	487	PF01048	0.512
MOD_GlcNHglycan	508	511	PF01048	0.510
MOD_GSK3_1	155	162	PF00069	0.345
MOD_GSK3_1	170	177	PF00069	0.334
MOD_GSK3_1	179	186	PF00069	0.426
MOD_GSK3_1	199	206	PF00069	0.292
MOD_GSK3_1	20	27	PF00069	0.587
MOD_GSK3_1	255	262	PF00069	0.688
MOD_GSK3_1	326	333	PF00069	0.708
MOD_GSK3_1	376	383	PF00069	0.695
MOD_GSK3_1	46	53	PF00069	0.330
MOD_GSK3_1	463	470	PF00069	0.614
MOD_GSK3_1	484	491	PF00069	0.691
MOD_GSK3_1	533	540	PF00069	0.708
MOD_GSK3_1	56	63	PF00069	0.352
MOD_LATS_1	314	320	PF00433	0.625
MOD_N-GLC_1	219	224	PF02516	0.366
MOD_N-GLC_1	75	80	PF02516	0.529
MOD_NEK2_1	155	160	PF00069	0.340
MOD_NEK2_1	189	194	PF00069	0.451
MOD_NEK2_1	199	204	PF00069	0.294
MOD_NEK2_1	345	350	PF00069	0.677
MOD_NEK2_1	52	57	PF00069	0.332
MOD_PIKK_1	347	353	PF00454	0.625
MOD_PKA_1	336	342	PF00069	0.756
MOD_PKA_2	278	284	PF00069	0.648
MOD_PKA_2	326	332	PF00069	0.692
MOD_PKA_2	336	342	PF00069	0.699
MOD_PKB_1	336	344	PF00069	0.759
MOD_Plk_1	456	462	PF00069	0.684
MOD_Plk_1	537	543	PF00069	0.706
MOD_Plk_4	155	161	PF00069	0.368
MOD_Plk_4	199	205	PF00069	0.387
MOD_Plk_4	207	213	PF00069	0.457
MOD_Plk_4	24	30	PF00069	0.593
MOD_Plk_4	36	42	PF00069	0.427
MOD_Plk_4	52	58	PF00069	0.287
MOD_ProDKin_1	13	19	PF00069	0.632
MOD_ProDKin_1	281	287	PF00069	0.713
MOD_ProDKin_1	356	362	PF00069	0.705
MOD_ProDKin_1	380	386	PF00069	0.689
MOD_ProDKin_1	498	504	PF00069	0.668
MOD_ProDKin_1	525	531	PF00069	0.699
MOD_SUMO_rev_2	239	244	PF00179	0.534
MOD_SUMO_rev_2	339	348	PF00179	0.729
MOD_SUMO_rev_2	452	458	PF00179	0.665
TRG_ENDOCYTIC_2	137	140	PF00928	0.555
TRG_ENDOCYTIC_2	190	193	PF00928	0.397
TRG_ENDOCYTIC_2	196	199	PF00928	0.338
TRG_ENDOCYTIC_2	248	251	PF00928	0.605
TRG_ENDOCYTIC_2	390	393	PF00928	0.741
TRG_ER_diArg_1	309	311	PF00400	0.627
TRG_ER_diArg_1	335	338	PF00400	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA63	Leptomonas seymouri	53%	93%
A0A3S5H7A1	Leishmania donovani	88%	100%
A4HC03	Leishmania braziliensis	66%	94%
A4HZG0	Leishmania infantum	87%	100%
Q4QC39	Leishmania major	85%	97%