Vitamin B6 photo-protection and homoeostasis-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis, putative

Species:

Leishmania mexicana

UniProt:

E9AVD7_LEIMU

TriTrypDb:

LmxM.21.1530

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AVD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.722
CLV_C14_Caspase3-7	586	590	PF00656	0.702
CLV_C14_Caspase3-7	622	626	PF00656	0.749
CLV_NRD_NRD_1	256	258	PF00675	0.418
CLV_NRD_NRD_1	360	362	PF00675	0.448
CLV_NRD_NRD_1	391	393	PF00675	0.453
CLV_NRD_NRD_1	488	490	PF00675	0.605
CLV_NRD_NRD_1	542	544	PF00675	0.536
CLV_NRD_NRD_1	62	64	PF00675	0.341
CLV_PCSK_FUR_1	439	443	PF00082	0.460
CLV_PCSK_FUR_1	540	544	PF00082	0.529
CLV_PCSK_KEX2_1	256	258	PF00082	0.418
CLV_PCSK_KEX2_1	360	362	PF00082	0.448
CLV_PCSK_KEX2_1	441	443	PF00082	0.486
CLV_PCSK_KEX2_1	488	490	PF00082	0.544
CLV_PCSK_KEX2_1	542	544	PF00082	0.536
CLV_PCSK_KEX2_1	613	615	PF00082	0.553
CLV_PCSK_KEX2_1	62	64	PF00082	0.342
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.486
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.453
CLV_PCSK_PC7_1	58	64	PF00082	0.410
CLV_PCSK_SKI1_1	108	112	PF00082	0.305
CLV_PCSK_SKI1_1	188	192	PF00082	0.410
CLV_PCSK_SKI1_1	228	232	PF00082	0.314
CLV_PCSK_SKI1_1	511	515	PF00082	0.486
CLV_PCSK_SKI1_1	58	62	PF00082	0.362
CLV_PCSK_SKI1_1	63	67	PF00082	0.401
CLV_PCSK_SKI1_1	70	74	PF00082	0.320
CLV_PCSK_SKI1_1	99	103	PF00082	0.372
DEG_APCC_DBOX_1	107	115	PF00400	0.542
DEG_APCC_DBOX_1	57	65	PF00400	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SCF_FBW7_1	47	54	PF00400	0.702
DEG_SCF_TRCP1_1	312	317	PF00400	0.744
DOC_CDC14_PxL_1	335	343	PF14671	0.658
DOC_CKS1_1	388	393	PF01111	0.543
DOC_CKS1_1	48	53	PF01111	0.771
DOC_CYCLIN_RxL_1	331	340	PF00134	0.704
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.542
DOC_MAPK_gen_1	256	262	PF00069	0.218
DOC_MAPK_gen_1	310	318	PF00069	0.735
DOC_MAPK_gen_1	506	514	PF00069	0.712
DOC_MAPK_MEF2A_6	108	116	PF00069	0.542
DOC_MAPK_RevD_3	428	442	PF00069	0.766
DOC_PP1_RVXF_1	288	294	PF00149	0.542
DOC_PP1_RVXF_1	509	515	PF00149	0.685
DOC_PP2B_LxvP_1	286	289	PF13499	0.542
DOC_PP2B_LxvP_1	336	339	PF13499	0.662
DOC_PP2B_PxIxI_1	433	439	PF00149	0.573
DOC_USP7_MATH_1	199	203	PF00917	0.608
DOC_USP7_MATH_1	252	256	PF00917	0.410
DOC_USP7_MATH_1	264	268	PF00917	0.309
DOC_USP7_MATH_1	347	351	PF00917	0.679
DOC_USP7_MATH_1	403	407	PF00917	0.665
DOC_USP7_MATH_1	474	478	PF00917	0.634
DOC_USP7_MATH_1	51	55	PF00917	0.717
DOC_USP7_MATH_1	582	586	PF00917	0.771
DOC_USP7_MATH_1	619	623	PF00917	0.653
DOC_USP7_MATH_1	633	637	PF00917	0.806
DOC_WW_Pin1_4	174	179	PF00397	0.418
DOC_WW_Pin1_4	322	327	PF00397	0.666
DOC_WW_Pin1_4	387	392	PF00397	0.591
DOC_WW_Pin1_4	41	46	PF00397	0.758
DOC_WW_Pin1_4	47	52	PF00397	0.747
DOC_WW_Pin1_4	470	475	PF00397	0.796
DOC_WW_Pin1_4	590	595	PF00397	0.749
DOC_WW_Pin1_4	599	604	PF00397	0.677
LIG_14-3-3_CanoR_1	155	160	PF00244	0.542
LIG_14-3-3_CanoR_1	209	218	PF00244	0.542
LIG_14-3-3_CanoR_1	456	460	PF00244	0.562
LIG_14-3-3_CanoR_1	62	72	PF00244	0.610
LIG_BRCT_BRCA1_1	140	144	PF00533	0.542
LIG_BRCT_BRCA1_1	347	351	PF00533	0.725
LIG_CSL_BTD_1	178	181	PF09270	0.610
LIG_EH1_1	406	414	PF00400	0.498
LIG_FHA_1	100	106	PF00498	0.380
LIG_FHA_1	156	162	PF00498	0.610
LIG_FHA_1	365	371	PF00498	0.648
LIG_FHA_1	417	423	PF00498	0.688
LIG_FHA_1	605	611	PF00498	0.793
LIG_FHA_1	667	673	PF00498	0.669
LIG_FHA_1	80	86	PF00498	0.542
LIG_FHA_2	64	70	PF00498	0.610
LIG_FHA_2	652	658	PF00498	0.671
LIG_LIR_Gen_1	141	152	PF02991	0.515
LIG_LIR_Gen_1	158	166	PF02991	0.595
LIG_LIR_Gen_1	350	359	PF02991	0.718
LIG_LIR_Gen_1	419	428	PF02991	0.646
LIG_LIR_Gen_1	596	603	PF02991	0.604
LIG_LIR_Gen_1	636	645	PF02991	0.562
LIG_LIR_Gen_1	666	675	PF02991	0.679
LIG_LIR_Nem_3	141	147	PF02991	0.542
LIG_LIR_Nem_3	158	162	PF02991	0.542
LIG_LIR_Nem_3	296	301	PF02991	0.584
LIG_LIR_Nem_3	350	355	PF02991	0.665
LIG_LIR_Nem_3	417	423	PF02991	0.620
LIG_LIR_Nem_3	596	600	PF02991	0.603
LIG_LIR_Nem_3	636	640	PF02991	0.621
LIG_LIR_Nem_3	666	671	PF02991	0.674
LIG_LYPXL_S_1	640	644	PF13949	0.309
LIG_NRBOX	657	663	PF00104	0.622
LIG_Pex14_1	527	531	PF04695	0.581
LIG_Pex14_2	212	216	PF04695	0.542
LIG_PTB_Apo_2	662	669	PF02174	0.662
LIG_PTB_Phospho_1	662	668	PF10480	0.663
LIG_REV1ctd_RIR_1	32	40	PF16727	0.593
LIG_SH2_CRK	275	279	PF00017	0.542
LIG_SH2_CRK	352	356	PF00017	0.718
LIG_SH2_CRK	362	366	PF00017	0.727
LIG_SH2_CRK	536	540	PF00017	0.691
LIG_SH2_CRK	637	641	PF00017	0.631
LIG_SH2_CRK	668	672	PF00017	0.662
LIG_SH2_NCK_1	352	356	PF00017	0.622
LIG_SH2_NCK_1	592	596	PF00017	0.591
LIG_SH2_PTP2	249	252	PF00017	0.361
LIG_SH2_PTP2	421	424	PF00017	0.681
LIG_SH2_PTP2	615	618	PF00017	0.597
LIG_SH2_STAP1	30	34	PF00017	0.591
LIG_SH2_STAP1	352	356	PF00017	0.622
LIG_SH2_STAP1	637	641	PF00017	0.535
LIG_SH2_STAP1	668	672	PF00017	0.634
LIG_SH2_STAT5	249	252	PF00017	0.361
LIG_SH2_STAT5	299	302	PF00017	0.471
LIG_SH2_STAT5	362	365	PF00017	0.668
LIG_SH2_STAT5	421	424	PF00017	0.635
LIG_SH2_STAT5	5	8	PF00017	0.758
LIG_SH2_STAT5	529	532	PF00017	0.585
LIG_SH2_STAT5	569	572	PF00017	0.515
LIG_SH2_STAT5	615	618	PF00017	0.597
LIG_SH2_STAT5	668	671	PF00017	0.664
LIG_SH3_3	175	181	PF00018	0.542
LIG_SH3_3	341	347	PF00018	0.696
LIG_SH3_3	39	45	PF00018	0.815
LIG_SH3_3	419	425	PF00018	0.580
LIG_SH3_3	468	474	PF00018	0.665
LIG_SH3_3	509	515	PF00018	0.713
LIG_SH3_3	588	594	PF00018	0.679
LIG_SUMO_SIM_anti_2	333	340	PF11976	0.646
LIG_SUMO_SIM_par_1	171	177	PF11976	0.568
LIG_SUMO_SIM_par_1	320	325	PF11976	0.614
LIG_SUMO_SIM_par_1	333	340	PF11976	0.640
LIG_TYR_ITIM	521	526	PF00017	0.598
LIG_Vh1_VBS_1	251	269	PF01044	0.218
MOD_CDK_SPK_2	322	327	PF00069	0.666
MOD_CDK_SPK_2	387	392	PF00069	0.545
MOD_CDK_SPxK_1	387	393	PF00069	0.544
MOD_CK1_1	126	132	PF00069	0.509
MOD_CK1_1	325	331	PF00069	0.658
MOD_CK1_1	470	476	PF00069	0.621
MOD_CK1_1	49	55	PF00069	0.740
MOD_CK1_1	545	551	PF00069	0.579
MOD_CK1_1	585	591	PF00069	0.811
MOD_CK1_1	602	608	PF00069	0.715
MOD_CK1_1	79	85	PF00069	0.610
MOD_CK1_1	9	15	PF00069	0.527
MOD_CK2_1	590	596	PF00069	0.628
MOD_CK2_1	63	69	PF00069	0.610
MOD_CK2_1	651	657	PF00069	0.657
MOD_CK2_1	77	83	PF00069	0.449
MOD_Cter_Amidation	486	489	PF01082	0.547
MOD_GlcNHglycan	168	171	PF01048	0.218
MOD_GlcNHglycan	266	269	PF01048	0.368
MOD_GlcNHglycan	312	315	PF01048	0.544
MOD_GlcNHglycan	327	330	PF01048	0.283
MOD_GlcNHglycan	401	404	PF01048	0.447
MOD_GlcNHglycan	476	479	PF01048	0.540
MOD_GlcNHglycan	55	58	PF01048	0.567
MOD_GSK3_1	122	129	PF00069	0.542
MOD_GSK3_1	306	313	PF00069	0.709
MOD_GSK3_1	347	354	PF00069	0.737
MOD_GSK3_1	399	406	PF00069	0.669
MOD_GSK3_1	43	50	PF00069	0.753
MOD_GSK3_1	470	477	PF00069	0.792
MOD_GSK3_1	598	605	PF00069	0.674
MOD_GSK3_1	629	636	PF00069	0.777
MOD_GSK3_1	99	106	PF00069	0.550
MOD_N-GLC_1	205	210	PF02516	0.314
MOD_N-GLC_1	559	564	PF02516	0.602
MOD_N-GLC_1	99	104	PF02516	0.410
MOD_NEK2_1	123	128	PF00069	0.519
MOD_NEK2_1	138	143	PF00069	0.581
MOD_NEK2_1	306	311	PF00069	0.691
MOD_NEK2_1	351	356	PF00069	0.722
MOD_NEK2_1	490	495	PF00069	0.595
MOD_NEK2_1	651	656	PF00069	0.666
MOD_NEK2_2	347	352	PF00069	0.745
MOD_NEK2_2	366	371	PF00069	0.515
MOD_PIKK_1	210	216	PF00454	0.476
MOD_PKA_1	310	316	PF00069	0.734
MOD_PKA_1	542	548	PF00069	0.559
MOD_PKA_2	455	461	PF00069	0.749
MOD_PKA_2	542	548	PF00069	0.559
MOD_PKA_2	651	657	PF00069	0.657
MOD_PKB_1	540	548	PF00069	0.552
MOD_Plk_1	416	422	PF00069	0.593
MOD_Plk_1	559	565	PF00069	0.798
MOD_Plk_4	126	132	PF00069	0.542
MOD_Plk_4	138	144	PF00069	0.542
MOD_Plk_4	192	198	PF00069	0.528
MOD_Plk_4	314	320	PF00069	0.561
MOD_Plk_4	347	353	PF00069	0.738
MOD_Plk_4	416	422	PF00069	0.627
MOD_Plk_4	542	548	PF00069	0.559
MOD_Plk_4	667	673	PF00069	0.669
MOD_ProDKin_1	174	180	PF00069	0.418
MOD_ProDKin_1	322	328	PF00069	0.665
MOD_ProDKin_1	387	393	PF00069	0.591
MOD_ProDKin_1	41	47	PF00069	0.758
MOD_ProDKin_1	470	476	PF00069	0.794
MOD_ProDKin_1	590	596	PF00069	0.748
MOD_ProDKin_1	599	605	PF00069	0.678
TRG_DiLeu_BaEn_1	37	42	PF01217	0.802
TRG_DiLeu_BaEn_1	657	662	PF01217	0.623
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.619
TRG_ENDOCYTIC_2	275	278	PF00928	0.542
TRG_ENDOCYTIC_2	298	301	PF00928	0.656
TRG_ENDOCYTIC_2	352	355	PF00928	0.668
TRG_ENDOCYTIC_2	356	359	PF00928	0.638
TRG_ENDOCYTIC_2	420	423	PF00928	0.608
TRG_ENDOCYTIC_2	523	526	PF00928	0.553
TRG_ENDOCYTIC_2	531	534	PF00928	0.526
TRG_ENDOCYTIC_2	536	539	PF00928	0.455
TRG_ENDOCYTIC_2	637	640	PF00928	0.650
TRG_ENDOCYTIC_2	641	644	PF00928	0.565
TRG_ENDOCYTIC_2	668	671	PF00928	0.664
TRG_ER_diArg_1	256	258	PF00400	0.218
TRG_ER_diArg_1	359	361	PF00400	0.636
TRG_ER_diArg_1	488	490	PF00400	0.619
TRG_ER_diArg_1	539	542	PF00400	0.665
TRG_ER_diArg_1	61	63	PF00400	0.544
TRG_NES_CRM1_1	643	657	PF08389	0.570
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W6	Leptomonas seymouri	53%	98%
A0A3S7WWW0	Leishmania donovani	85%	100%
A4HZF0	Leishmania infantum	85%	100%
Q4QC42	Leishmania major	82%	100%