Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AVD3_LEIMU

TriTrypDb:

LmxM.21.1490

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.537
CLV_C14_Caspase3-7	345	349	PF00656	0.816
CLV_C14_Caspase3-7	460	464	PF00656	0.565
CLV_C14_Caspase3-7	569	573	PF00656	0.864
CLV_NRD_NRD_1	137	139	PF00675	0.739
CLV_NRD_NRD_1	180	182	PF00675	0.674
CLV_NRD_NRD_1	23	25	PF00675	0.683
CLV_NRD_NRD_1	538	540	PF00675	0.578
CLV_NRD_NRD_1	87	89	PF00675	0.566
CLV_PCSK_FUR_1	135	139	PF00082	0.740
CLV_PCSK_KEX2_1	137	139	PF00082	0.743
CLV_PCSK_KEX2_1	180	182	PF00082	0.678
CLV_PCSK_KEX2_1	22	24	PF00082	0.700
CLV_PCSK_KEX2_1	87	89	PF00082	0.566
CLV_PCSK_SKI1_1	137	141	PF00082	0.693
CLV_PCSK_SKI1_1	155	159	PF00082	0.632
CLV_PCSK_SKI1_1	183	187	PF00082	0.822
CLV_PCSK_SKI1_1	268	272	PF00082	0.828
CLV_PCSK_SKI1_1	650	654	PF00082	0.714
DEG_APCC_DBOX_1	154	162	PF00400	0.790
DEG_Nend_UBRbox_3	1	3	PF02207	0.846
DEG_SPOP_SBC_1	324	328	PF00917	0.762
DEG_SPOP_SBC_1	557	561	PF00917	0.652
DEG_SPOP_SBC_1	660	664	PF00917	0.763
DOC_ANK_TNKS_1	384	391	PF00023	0.780
DOC_CKS1_1	118	123	PF01111	0.527
DOC_CKS1_1	14	19	PF01111	0.612
DOC_CYCLIN_RxL_1	132	142	PF00134	0.672
DOC_MAPK_DCC_7	155	163	PF00069	0.790
DOC_MAPK_gen_1	314	324	PF00069	0.557
DOC_MAPK_MEF2A_6	155	163	PF00069	0.790
DOC_MAPK_MEF2A_6	31	39	PF00069	0.612
DOC_PP1_RVXF_1	135	142	PF00149	0.676
DOC_PP2B_LxvP_1	584	587	PF13499	0.657
DOC_PP2B_LxvP_1	613	616	PF13499	0.870
DOC_PP2B_LxvP_1	95	98	PF13499	0.768
DOC_PP4_FxxP_1	114	117	PF00568	0.731
DOC_USP7_MATH_1	127	131	PF00917	0.826
DOC_USP7_MATH_1	227	231	PF00917	0.709
DOC_USP7_MATH_1	270	274	PF00917	0.690
DOC_USP7_MATH_1	443	447	PF00917	0.751
DOC_USP7_MATH_1	494	498	PF00917	0.620
DOC_USP7_MATH_1	522	526	PF00917	0.662
DOC_USP7_MATH_1	557	561	PF00917	0.764
DOC_USP7_MATH_1	635	639	PF00917	0.770
DOC_USP7_MATH_1	660	664	PF00917	0.763
DOC_USP7_MATH_1	8	12	PF00917	0.831
DOC_WW_Pin1_4	104	109	PF00397	0.637
DOC_WW_Pin1_4	117	122	PF00397	0.630
DOC_WW_Pin1_4	13	18	PF00397	0.588
DOC_WW_Pin1_4	171	176	PF00397	0.617
DOC_WW_Pin1_4	200	205	PF00397	0.617
DOC_WW_Pin1_4	236	241	PF00397	0.737
DOC_WW_Pin1_4	30	35	PF00397	0.782
DOC_WW_Pin1_4	331	336	PF00397	0.744
DOC_WW_Pin1_4	475	480	PF00397	0.584
DOC_WW_Pin1_4	503	508	PF00397	0.820
DOC_WW_Pin1_4	534	539	PF00397	0.873
DOC_WW_Pin1_4	547	552	PF00397	0.653
DOC_WW_Pin1_4	559	564	PF00397	0.794
DOC_WW_Pin1_4	57	62	PF00397	0.753
DOC_WW_Pin1_4	582	587	PF00397	0.678
LIG_14-3-3_CanoR_1	137	142	PF00244	0.734
LIG_14-3-3_CanoR_1	187	197	PF00244	0.842
LIG_14-3-3_CanoR_1	444	451	PF00244	0.544
LIG_14-3-3_CanoR_1	534	538	PF00244	0.793
LIG_14-3-3_CanoR_1	6	14	PF00244	0.756
LIG_14-3-3_CanoR_1	620	629	PF00244	0.857
LIG_14-3-3_CanoR_1	650	659	PF00244	0.551
LIG_14-3-3_CanoR_1	81	85	PF00244	0.645
LIG_FHA_1	256	262	PF00498	0.617
LIG_FHA_1	53	59	PF00498	0.702
LIG_FHA_1	542	548	PF00498	0.614
LIG_FHA_2	14	20	PF00498	0.554
LIG_FHA_2	166	172	PF00498	0.506
LIG_FHA_2	254	260	PF00498	0.629
LIG_FHA_2	275	281	PF00498	0.530
LIG_FHA_2	296	302	PF00498	0.704
LIG_LIR_Apic_2	445	451	PF02991	0.834
LIG_MYND_1	99	103	PF01753	0.834
LIG_SH2_CRK	251	255	PF00017	0.517
LIG_SH2_PTP2	448	451	PF00017	0.726
LIG_SH2_PTP2	511	514	PF00017	0.828
LIG_SH2_SRC	439	442	PF00017	0.533
LIG_SH2_SRC	448	451	PF00017	0.803
LIG_SH2_STAT3	362	365	PF00017	0.705
LIG_SH2_STAT5	439	442	PF00017	0.747
LIG_SH2_STAT5	448	451	PF00017	0.589
LIG_SH2_STAT5	511	514	PF00017	0.828
LIG_SH2_STAT5	518	521	PF00017	0.713
LIG_SH3_2	17	22	PF14604	0.634
LIG_SH3_3	11	17	PF00018	0.654
LIG_SH3_3	115	121	PF00018	0.650
LIG_SH3_3	156	162	PF00018	0.787
LIG_SH3_3	232	238	PF00018	0.532
LIG_SH3_3	283	289	PF00018	0.743
LIG_SH3_3	301	307	PF00018	0.722
LIG_SH3_3	354	360	PF00018	0.644
LIG_SH3_3	378	384	PF00018	0.547
LIG_SH3_3	535	541	PF00018	0.705
LIG_SH3_3	545	551	PF00018	0.721
LIG_SH3_3	55	61	PF00018	0.633
LIG_SH3_3	560	566	PF00018	0.863
LIG_SH3_3	583	589	PF00018	0.689
LIG_SH3_3	600	606	PF00018	0.624
LIG_SH3_3	608	614	PF00018	0.682
LIG_SUMO_SIM_anti_2	205	210	PF11976	0.600
LIG_SUMO_SIM_par_1	122	131	PF11976	0.754
LIG_SUMO_SIM_par_1	33	38	PF11976	0.530
LIG_SUMO_SIM_par_1	512	517	PF11976	0.827
LIG_TRAF2_1	316	319	PF00917	0.749
LIG_TRAF2_1	425	428	PF00917	0.622
LIG_TYR_ITIM	249	254	PF00017	0.522
LIG_WW_2	586	589	PF00397	0.532
LIG_WW_3	97	101	PF00397	0.842
MOD_CDC14_SPxK_1	537	540	PF00782	0.867
MOD_CDC14_SPxK_1	60	63	PF00782	0.748
MOD_CDK_SPK_2	534	539	PF00069	0.581
MOD_CDK_SPK_2	547	552	PF00069	0.551
MOD_CDK_SPK_2	559	564	PF00069	0.697
MOD_CDK_SPxK_1	534	540	PF00069	0.871
MOD_CDK_SPxK_1	57	63	PF00069	0.752
MOD_CK1_1	153	159	PF00069	0.775
MOD_CK1_1	198	204	PF00069	0.740
MOD_CK1_1	274	280	PF00069	0.574
MOD_CK1_1	327	333	PF00069	0.847
MOD_CK1_1	41	47	PF00069	0.782
MOD_CK1_1	478	484	PF00069	0.763
MOD_CK1_1	525	531	PF00069	0.825
MOD_CK1_1	550	556	PF00069	0.869
MOD_CK1_1	559	565	PF00069	0.650
MOD_CK1_1	59	65	PF00069	0.604
MOD_CK1_1	618	624	PF00069	0.862
MOD_CK1_1	662	668	PF00069	0.818
MOD_CK2_1	165	171	PF00069	0.503
MOD_CK2_1	253	259	PF00069	0.627
MOD_CK2_1	313	319	PF00069	0.746
MOD_CK2_1	398	404	PF00069	0.661
MOD_CK2_1	635	641	PF00069	0.571
MOD_DYRK1A_RPxSP_1	534	538	PF00069	0.793
MOD_GlcNHglycan	152	155	PF01048	0.799
MOD_GlcNHglycan	197	200	PF01048	0.733
MOD_GlcNHglycan	243	246	PF01048	0.698
MOD_GlcNHglycan	292	295	PF01048	0.859
MOD_GlcNHglycan	304	307	PF01048	0.543
MOD_GlcNHglycan	318	322	PF01048	0.654
MOD_GlcNHglycan	41	44	PF01048	0.724
MOD_GlcNHglycan	418	421	PF01048	0.543
MOD_GlcNHglycan	468	471	PF01048	0.660
MOD_GlcNHglycan	483	486	PF01048	0.801
MOD_GlcNHglycan	494	497	PF01048	0.618
MOD_GlcNHglycan	520	523	PF01048	0.805
MOD_GlcNHglycan	528	531	PF01048	0.794
MOD_GlcNHglycan	555	558	PF01048	0.777
MOD_GlcNHglycan	568	571	PF01048	0.705
MOD_GlcNHglycan	607	610	PF01048	0.868
MOD_GlcNHglycan	644	647	PF01048	0.680
MOD_GlcNHglycan	665	668	PF01048	0.848
MOD_GSK3_1	146	153	PF00069	0.675
MOD_GSK3_1	161	168	PF00069	0.580
MOD_GSK3_1	179	186	PF00069	0.763
MOD_GSK3_1	189	196	PF00069	0.762
MOD_GSK3_1	270	277	PF00069	0.534
MOD_GSK3_1	313	320	PF00069	0.687
MOD_GSK3_1	323	330	PF00069	0.839
MOD_GSK3_1	412	419	PF00069	0.732
MOD_GSK3_1	462	469	PF00069	0.632
MOD_GSK3_1	481	488	PF00069	0.737
MOD_GSK3_1	499	506	PF00069	0.621
MOD_GSK3_1	518	525	PF00069	0.592
MOD_GSK3_1	52	59	PF00069	0.716
MOD_GSK3_1	529	536	PF00069	0.660
MOD_GSK3_1	553	560	PF00069	0.736
MOD_GSK3_1	616	623	PF00069	0.804
MOD_GSK3_1	659	666	PF00069	0.839
MOD_N-GLC_2	405	407	PF02516	0.652
MOD_NEK2_1	139	144	PF00069	0.745
MOD_NEK2_1	39	44	PF00069	0.766
MOD_NEK2_1	412	417	PF00069	0.700
MOD_NEK2_1	651	656	PF00069	0.664
MOD_NEK2_1	659	664	PF00069	0.840
MOD_NEK2_1	72	77	PF00069	0.745
MOD_NEK2_2	494	499	PF00069	0.622
MOD_PIKK_1	253	259	PF00454	0.724
MOD_PIKK_1	271	277	PF00454	0.516
MOD_PIKK_1	370	376	PF00454	0.706
MOD_PIKK_1	462	468	PF00454	0.566
MOD_PIKK_1	529	535	PF00454	0.871
MOD_PIKK_1	541	547	PF00454	0.628
MOD_PKA_1	137	143	PF00069	0.654
MOD_PKA_2	137	143	PF00069	0.654
MOD_PKA_2	179	185	PF00069	0.826
MOD_PKA_2	313	319	PF00069	0.712
MOD_PKA_2	443	449	PF00069	0.649
MOD_PKA_2	488	494	PF00069	0.706
MOD_PKA_2	525	531	PF00069	0.854
MOD_PKA_2	533	539	PF00069	0.709
MOD_PKA_2	80	86	PF00069	0.666
MOD_PKB_1	135	143	PF00069	0.655
MOD_PKB_1	648	656	PF00069	0.554
MOD_Plk_1	227	233	PF00069	0.642
MOD_Plk_1	271	277	PF00069	0.744
MOD_Plk_4	162	168	PF00069	0.654
MOD_Plk_4	398	404	PF00069	0.647
MOD_Plk_4	494	500	PF00069	0.621
MOD_Plk_4	624	630	PF00069	0.774
MOD_ProDKin_1	104	110	PF00069	0.637
MOD_ProDKin_1	117	123	PF00069	0.632
MOD_ProDKin_1	13	19	PF00069	0.588
MOD_ProDKin_1	171	177	PF00069	0.616
MOD_ProDKin_1	200	206	PF00069	0.617
MOD_ProDKin_1	236	242	PF00069	0.738
MOD_ProDKin_1	30	36	PF00069	0.780
MOD_ProDKin_1	331	337	PF00069	0.745
MOD_ProDKin_1	475	481	PF00069	0.588
MOD_ProDKin_1	503	509	PF00069	0.820
MOD_ProDKin_1	534	540	PF00069	0.871
MOD_ProDKin_1	547	553	PF00069	0.652
MOD_ProDKin_1	559	565	PF00069	0.790
MOD_ProDKin_1	57	63	PF00069	0.752
MOD_ProDKin_1	582	588	PF00069	0.681
MOD_SUMO_for_1	217	220	PF00179	0.736
MOD_SUMO_for_1	296	299	PF00179	0.547
TRG_DiLeu_BaEn_1	299	304	PF01217	0.620
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.789
TRG_ENDOCYTIC_2	251	254	PF00928	0.521
TRG_ENDOCYTIC_2	511	514	PF00928	0.828
TRG_ER_diArg_1	134	137	PF00400	0.735
TRG_ER_diArg_1	179	181	PF00400	0.835
TRG_ER_diArg_1	22	24	PF00400	0.700
TRG_ER_diArg_1	648	651	PF00400	0.646
TRG_ER_diArg_1	86	88	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.780
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.822

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWS0	Leishmania donovani	78%	100%
A4HBZ7	Leishmania braziliensis	56%	99%
A4HZE6	Leishmania infantum	79%	100%
Q4QC46	Leishmania major	80%	99%