DUF5745 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVD2_LEIMU

TriTrypDb:

LmxM.21.1480

Length:

819

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	7
GO:0005813	centrosome	3	7
GO:0005815	microtubule organizing center	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AVD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	529	533	PF00656	0.689
CLV_C14_Caspase3-7	545	549	PF00656	0.424
CLV_C14_Caspase3-7	566	570	PF00656	0.530
CLV_C14_Caspase3-7	612	616	PF00656	0.602
CLV_C14_Caspase3-7	94	98	PF00656	0.626
CLV_NRD_NRD_1	238	240	PF00675	0.457
CLV_NRD_NRD_1	479	481	PF00675	0.717
CLV_NRD_NRD_1	517	519	PF00675	0.814
CLV_NRD_NRD_1	552	554	PF00675	0.604
CLV_NRD_NRD_1	583	585	PF00675	0.679
CLV_NRD_NRD_1	705	707	PF00675	0.475
CLV_NRD_NRD_1	735	737	PF00675	0.426
CLV_NRD_NRD_1	797	799	PF00675	0.444
CLV_NRD_NRD_1	87	89	PF00675	0.727
CLV_PCSK_FUR_1	703	707	PF00082	0.462
CLV_PCSK_KEX2_1	237	239	PF00082	0.453
CLV_PCSK_KEX2_1	479	481	PF00082	0.717
CLV_PCSK_KEX2_1	517	519	PF00082	0.726
CLV_PCSK_KEX2_1	552	554	PF00082	0.588
CLV_PCSK_KEX2_1	583	585	PF00082	0.679
CLV_PCSK_KEX2_1	608	610	PF00082	0.723
CLV_PCSK_KEX2_1	705	707	PF00082	0.480
CLV_PCSK_KEX2_1	735	737	PF00082	0.435
CLV_PCSK_KEX2_1	792	794	PF00082	0.432
CLV_PCSK_KEX2_1	797	799	PF00082	0.450
CLV_PCSK_KEX2_1	87	89	PF00082	0.714
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.453
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.710
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.416
CLV_PCSK_PC7_1	701	707	PF00082	0.459
CLV_PCSK_PC7_1	793	799	PF00082	0.417
CLV_PCSK_SKI1_1	609	613	PF00082	0.678
CLV_PCSK_SKI1_1	664	668	PF00082	0.618
CLV_PCSK_SKI1_1	724	728	PF00082	0.412
CLV_PCSK_SKI1_1	783	787	PF00082	0.310
CLV_Separin_Metazoa	802	806	PF03568	0.523
DEG_SPOP_SBC_1	304	308	PF00917	0.564
DEG_SPOP_SBC_1	335	339	PF00917	0.617
DEG_SPOP_SBC_1	37	41	PF00917	0.711
DEG_SPOP_SBC_1	48	52	PF00917	0.610
DOC_CKS1_1	43	48	PF01111	0.625
DOC_CYCLIN_RxL_1	780	790	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.639
DOC_MAPK_gen_1	237	246	PF00069	0.428
DOC_MAPK_gen_1	724	733	PF00069	0.440
DOC_MAPK_MEF2A_6	237	246	PF00069	0.428
DOC_MAPK_MEF2A_6	274	282	PF00069	0.386
DOC_PP4_FxxP_1	373	376	PF00568	0.676
DOC_PP4_MxPP_1	353	356	PF00568	0.615
DOC_USP7_MATH_1	102	106	PF00917	0.475
DOC_USP7_MATH_1	107	111	PF00917	0.486
DOC_USP7_MATH_1	148	152	PF00917	0.616
DOC_USP7_MATH_1	154	158	PF00917	0.606
DOC_USP7_MATH_1	304	308	PF00917	0.489
DOC_USP7_MATH_1	37	41	PF00917	0.734
DOC_USP7_MATH_1	491	495	PF00917	0.708
DOC_USP7_MATH_1	632	636	PF00917	0.592
DOC_USP7_MATH_1	69	73	PF00917	0.630
DOC_USP7_MATH_1	76	80	PF00917	0.555
DOC_USP7_MATH_1	82	86	PF00917	0.605
DOC_USP7_MATH_1	93	97	PF00917	0.570
DOC_WW_Pin1_4	138	143	PF00397	0.562
DOC_WW_Pin1_4	228	233	PF00397	0.477
DOC_WW_Pin1_4	28	33	PF00397	0.610
DOC_WW_Pin1_4	351	356	PF00397	0.478
DOC_WW_Pin1_4	39	44	PF00397	0.626
DOC_WW_Pin1_4	418	423	PF00397	0.689
DOC_WW_Pin1_4	497	502	PF00397	0.640
DOC_WW_Pin1_4	510	515	PF00397	0.709
DOC_WW_Pin1_4	516	521	PF00397	0.585
DOC_WW_Pin1_4	561	566	PF00397	0.663
DOC_WW_Pin1_4	587	592	PF00397	0.557
DOC_WW_Pin1_4	645	650	PF00397	0.651
LIG_14-3-3_CanoR_1	206	216	PF00244	0.380
LIG_14-3-3_CanoR_1	583	592	PF00244	0.605
LIG_14-3-3_CanoR_1	652	657	PF00244	0.565
LIG_14-3-3_CanoR_1	68	74	PF00244	0.539
LIG_14-3-3_CanoR_1	686	693	PF00244	0.533
LIG_14-3-3_CanoR_1	768	772	PF00244	0.432
LIG_BIR_III_4	315	319	PF00653	0.593
LIG_BRCT_BRCA1_1	14	18	PF00533	0.505
LIG_BRCT_BRCA1_1	209	213	PF00533	0.373
LIG_CaM_IQ_9	693	708	PF13499	0.451
LIG_EVH1_1	159	163	PF00568	0.507
LIG_EVH1_2	591	595	PF00568	0.520
LIG_FHA_1	142	148	PF00498	0.550
LIG_FHA_1	434	440	PF00498	0.553
LIG_FHA_1	768	774	PF00498	0.425
LIG_FHA_2	169	175	PF00498	0.638
LIG_FHA_2	527	533	PF00498	0.604
LIG_FHA_2	564	570	PF00498	0.523
LIG_FHA_2	610	616	PF00498	0.805
LIG_FHA_2	658	664	PF00498	0.532
LIG_FHA_2	723	729	PF00498	0.468
LIG_FHA_2	748	754	PF00498	0.412
LIG_FHA_2	797	803	PF00498	0.415
LIG_LIR_Gen_1	193	202	PF02991	0.446
LIG_LIR_Gen_1	210	221	PF02991	0.373
LIG_LIR_Nem_3	193	197	PF02991	0.423
LIG_LIR_Nem_3	209	215	PF02991	0.374
LIG_LIR_Nem_3	339	345	PF02991	0.661
LIG_LIR_Nem_3	441	447	PF02991	0.549
LIG_MLH1_MIPbox_1	209	213	PF16413	0.373
LIG_MYND_1	160	164	PF01753	0.528
LIG_PCNA_PIPBox_1	374	383	PF02747	0.488
LIG_PDZ_Class_2	814	819	PF00595	0.434
LIG_PTB_Apo_2	443	450	PF02174	0.533
LIG_PTB_Phospho_1	443	449	PF10480	0.530
LIG_REV1ctd_RIR_1	664	670	PF16727	0.571
LIG_SH2_CRK	217	221	PF00017	0.381
LIG_SH2_CRK	321	325	PF00017	0.512
LIG_SH2_CRK	342	346	PF00017	0.660
LIG_SH2_CRK	444	448	PF00017	0.550
LIG_SH2_CRK	748	752	PF00017	0.433
LIG_SH2_NCK_1	342	346	PF00017	0.604
LIG_SH2_PTP2	381	384	PF00017	0.565
LIG_SH2_SRC	342	345	PF00017	0.658
LIG_SH2_SRC	428	431	PF00017	0.619
LIG_SH2_STAP1	708	712	PF00017	0.455
LIG_SH2_STAP1	748	752	PF00017	0.433
LIG_SH2_STAP1	777	781	PF00017	0.401
LIG_SH2_STAP1	806	810	PF00017	0.419
LIG_SH2_STAT3	371	374	PF00017	0.574
LIG_SH2_STAT3	4	7	PF00017	0.690
LIG_SH2_STAT3	708	711	PF00017	0.463
LIG_SH2_STAT5	381	384	PF00017	0.565
LIG_SH2_STAT5	428	431	PF00017	0.619
LIG_SH2_STAT5	665	668	PF00017	0.618
LIG_SH2_STAT5	692	695	PF00017	0.441
LIG_SH3_1	381	387	PF00018	0.559
LIG_SH3_3	13	19	PF00018	0.632
LIG_SH3_3	131	137	PF00018	0.638
LIG_SH3_3	150	156	PF00018	0.539
LIG_SH3_3	157	163	PF00018	0.754
LIG_SH3_3	349	355	PF00018	0.666
LIG_SH3_3	381	387	PF00018	0.592
LIG_SH3_3	40	46	PF00018	0.634
LIG_SH3_3	445	451	PF00018	0.644
LIG_SH3_3	591	597	PF00018	0.635
LIG_SH3_3	651	657	PF00018	0.726
LIG_SH3_3	70	76	PF00018	0.650
LIG_SUMO_SIM_par_1	242	247	PF11976	0.418
LIG_TRAF2_1	171	174	PF00917	0.626
LIG_TRAF2_1	455	458	PF00917	0.695
LIG_TRAF2_1	620	623	PF00917	0.678
LIG_TRAF2_1	660	663	PF00917	0.531
LIG_TYR_ITIM	215	220	PF00017	0.376
LIG_WRC_WIRS_1	191	196	PF05994	0.406
LIG_WW_2	160	163	PF00397	0.529
MOD_CDK_SPxxK_3	497	504	PF00069	0.506
MOD_CDK_SPxxK_3	510	517	PF00069	0.716
MOD_CDK_SPxxK_3	645	652	PF00069	0.592
MOD_CK1_1	105	111	PF00069	0.474
MOD_CK1_1	231	237	PF00069	0.476
MOD_CK1_1	363	369	PF00069	0.565
MOD_CK1_1	39	45	PF00069	0.637
MOD_CK1_1	421	427	PF00069	0.609
MOD_CK1_1	47	53	PF00069	0.651
MOD_CK1_1	494	500	PF00069	0.622
MOD_CK1_1	563	569	PF00069	0.573
MOD_CK1_1	71	77	PF00069	0.775
MOD_CK1_1	722	728	PF00069	0.396
MOD_CK1_1	767	773	PF00069	0.427
MOD_CK2_1	168	174	PF00069	0.641
MOD_CK2_1	49	55	PF00069	0.653
MOD_CK2_1	510	516	PF00069	0.712
MOD_CK2_1	568	574	PF00069	0.667
MOD_CK2_1	657	663	PF00069	0.533
MOD_CK2_1	679	685	PF00069	0.500
MOD_CK2_1	715	721	PF00069	0.457
MOD_CK2_1	722	728	PF00069	0.439
MOD_CK2_1	747	753	PF00069	0.412
MOD_CK2_1	796	802	PF00069	0.412
MOD_GlcNHglycan	107	110	PF01048	0.455
MOD_GlcNHglycan	126	129	PF01048	0.647
MOD_GlcNHglycan	150	153	PF01048	0.628
MOD_GlcNHglycan	307	310	PF01048	0.545
MOD_GlcNHglycan	338	341	PF01048	0.608
MOD_GlcNHglycan	362	365	PF01048	0.661
MOD_GlcNHglycan	367	370	PF01048	0.679
MOD_GlcNHglycan	393	396	PF01048	0.634
MOD_GlcNHglycan	400	404	PF01048	0.594
MOD_GlcNHglycan	410	413	PF01048	0.590
MOD_GlcNHglycan	462	465	PF01048	0.695
MOD_GlcNHglycan	497	500	PF01048	0.626
MOD_GlcNHglycan	51	54	PF01048	0.656
MOD_GlcNHglycan	510	513	PF01048	0.673
MOD_GlcNHglycan	609	612	PF01048	0.583
MOD_GlcNHglycan	615	618	PF01048	0.622
MOD_GlcNHglycan	626	629	PF01048	0.604
MOD_GlcNHglycan	688	691	PF01048	0.534
MOD_GlcNHglycan	712	715	PF01048	0.448
MOD_GlcNHglycan	73	76	PF01048	0.739
MOD_GlcNHglycan	78	81	PF01048	0.664
MOD_GlcNHglycan	808	813	PF01048	0.407
MOD_GlcNHglycan	88	91	PF01048	0.767
MOD_GlcNHglycan	93	96	PF01048	0.535
MOD_GSK3_1	165	172	PF00069	0.541
MOD_GSK3_1	193	200	PF00069	0.543
MOD_GSK3_1	38	45	PF00069	0.678
MOD_GSK3_1	429	436	PF00069	0.593
MOD_GSK3_1	456	463	PF00069	0.681
MOD_GSK3_1	47	54	PF00069	0.769
MOD_GSK3_1	491	498	PF00069	0.626
MOD_GSK3_1	559	566	PF00069	0.618
MOD_GSK3_1	583	590	PF00069	0.627
MOD_GSK3_1	603	610	PF00069	0.507
MOD_GSK3_1	715	722	PF00069	0.428
MOD_GSK3_1	792	799	PF00069	0.384
MOD_GSK3_1	82	89	PF00069	0.786
MOD_LATS_1	581	587	PF00433	0.537
MOD_N-GLC_2	389	391	PF02516	0.540
MOD_NEK2_1	22	27	PF00069	0.493
MOD_NEK2_1	221	226	PF00069	0.446
MOD_NEK2_1	303	308	PF00069	0.658
MOD_NEK2_1	429	434	PF00069	0.602
MOD_NEK2_1	49	54	PF00069	0.657
MOD_NEK2_1	495	500	PF00069	0.632
MOD_NEK2_1	5	10	PF00069	0.623
MOD_NEK2_1	502	507	PF00069	0.637
MOD_NEK2_1	715	720	PF00069	0.459
MOD_NEK2_1	781	786	PF00069	0.413
MOD_NEK2_1	83	88	PF00069	0.531
MOD_NEK2_2	107	112	PF00069	0.600
MOD_NEK2_2	208	213	PF00069	0.371
MOD_NEK2_2	468	473	PF00069	0.703
MOD_PIKK_1	154	160	PF00454	0.645
MOD_PIKK_1	474	480	PF00454	0.712
MOD_PIKK_1	5	11	PF00454	0.604
MOD_PIKK_1	526	532	PF00454	0.584
MOD_PIKK_1	632	638	PF00454	0.657
MOD_PIKK_1	707	713	PF00454	0.459
MOD_PK_1	201	207	PF00069	0.419
MOD_PKA_1	583	589	PF00069	0.616
MOD_PKA_1	792	798	PF00069	0.332
MOD_PKA_2	200	206	PF00069	0.516
MOD_PKA_2	583	589	PF00069	0.626
MOD_PKA_2	679	685	PF00069	0.500
MOD_PKA_2	715	721	PF00069	0.457
MOD_PKA_2	767	773	PF00069	0.427
MOD_PKA_2	792	798	PF00069	0.409
MOD_PKA_2	86	92	PF00069	0.735
MOD_Plk_1	221	227	PF00069	0.444
MOD_Plk_1	429	435	PF00069	0.599
MOD_Plk_1	808	814	PF00069	0.408
MOD_Plk_4	130	136	PF00069	0.662
MOD_Plk_4	208	214	PF00069	0.400
MOD_Plk_4	22	28	PF00069	0.556
MOD_Plk_4	429	435	PF00069	0.629
MOD_Plk_4	747	753	PF00069	0.412
MOD_ProDKin_1	138	144	PF00069	0.566
MOD_ProDKin_1	228	234	PF00069	0.474
MOD_ProDKin_1	28	34	PF00069	0.614
MOD_ProDKin_1	351	357	PF00069	0.482
MOD_ProDKin_1	39	45	PF00069	0.627
MOD_ProDKin_1	418	424	PF00069	0.688
MOD_ProDKin_1	497	503	PF00069	0.640
MOD_ProDKin_1	510	516	PF00069	0.710
MOD_ProDKin_1	561	567	PF00069	0.662
MOD_ProDKin_1	587	593	PF00069	0.558
MOD_ProDKin_1	645	651	PF00069	0.652
MOD_SUMO_for_1	791	794	PF00179	0.438
MOD_SUMO_rev_2	676	684	PF00179	0.485
MOD_SUMO_rev_2	722	731	PF00179	0.459
TRG_DiLeu_BaEn_4	262	268	PF01217	0.420
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.370
TRG_ENDOCYTIC_2	217	220	PF00928	0.382
TRG_ENDOCYTIC_2	342	345	PF00928	0.577
TRG_ENDOCYTIC_2	444	447	PF00928	0.551
TRG_ENDOCYTIC_2	748	751	PF00928	0.436
TRG_ER_diArg_1	503	506	PF00400	0.518
TRG_ER_diArg_1	552	555	PF00400	0.609
TRG_ER_diArg_1	700	703	PF00400	0.453
TRG_ER_diArg_1	704	706	PF00400	0.468
TRG_ER_diArg_1	734	736	PF00400	0.438
TRG_NES_CRM1_1	270	285	PF08389	0.418
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC22	Leptomonas seymouri	52%	87%
A0A3Q8IB84	Leishmania donovani	88%	100%
A4HBZ6	Leishmania braziliensis	76%	99%
A4HZE5	Leishmania infantum	88%	93%
Q4QC47	Leishmania major	87%	100%