TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVD1_LEIMU

TriTrypDb:

LmxM.21.1470

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.336
CLV_NRD_NRD_1	223	225	PF00675	0.435
CLV_NRD_NRD_1	231	233	PF00675	0.396
CLV_NRD_NRD_1	252	254	PF00675	0.298
CLV_PCSK_KEX2_1	145	147	PF00082	0.341
CLV_PCSK_KEX2_1	231	233	PF00082	0.417
CLV_PCSK_KEX2_1	252	254	PF00082	0.299
CLV_PCSK_SKI1_1	146	150	PF00082	0.428
DEG_APCC_DBOX_1	145	153	PF00400	0.409
DOC_MAPK_gen_1	252	261	PF00069	0.288
DOC_PP1_RVXF_1	119	126	PF00149	0.475
DOC_PP1_RVXF_1	223	230	PF00149	0.328
DOC_USP7_MATH_1	14	18	PF00917	0.428
DOC_USP7_MATH_1	74	78	PF00917	0.385
LIG_14-3-3_CanoR_1	145	149	PF00244	0.362
LIG_14-3-3_CanoR_1	224	230	PF00244	0.435
LIG_Actin_WH2_2	132	147	PF00022	0.514
LIG_Actin_WH2_2	20	37	PF00022	0.416
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_BIR_III_4	235	239	PF00653	0.497
LIG_Clathr_ClatBox_1	49	53	PF01394	0.339
LIG_FHA_1	19	25	PF00498	0.398
LIG_FHA_2	180	186	PF00498	0.493
LIG_LIR_Gen_1	193	203	PF02991	0.418
LIG_LIR_Nem_3	193	199	PF02991	0.424
LIG_LIR_Nem_3	209	213	PF02991	0.397
LIG_LIR_Nem_3	96	101	PF02991	0.416
LIG_Rb_LxCxE_1	47	66	PF01857	0.478
LIG_SH2_SRC	64	67	PF00017	0.496
LIG_SH2_STAP1	64	68	PF00017	0.442
LIG_SH2_STAT5	226	229	PF00017	0.337
LIG_SUMO_SIM_par_1	256	262	PF11976	0.487
LIG_UBA3_1	245	254	PF00899	0.414
LIG_WRC_WIRS_1	207	212	PF05994	0.405
MOD_CK1_1	147	153	PF00069	0.362
MOD_CK2_1	179	185	PF00069	0.474
MOD_CK2_1	79	85	PF00069	0.453
MOD_Cter_Amidation	269	272	PF01082	0.425
MOD_GlcNHglycan	109	112	PF01048	0.345
MOD_GlcNHglycan	131	134	PF01048	0.495
MOD_GlcNHglycan	16	19	PF01048	0.529
MOD_GSK3_1	14	21	PF00069	0.494
MOD_GSK3_1	154	161	PF00069	0.475
MOD_NEK2_1	144	149	PF00069	0.340
MOD_NEK2_1	152	157	PF00069	0.324
MOD_NEK2_1	52	57	PF00069	0.360
MOD_NEK2_1	79	84	PF00069	0.459
MOD_NEK2_2	219	224	PF00069	0.465
MOD_PIKK_1	214	220	PF00454	0.403
MOD_PIKK_1	52	58	PF00454	0.346
MOD_PKA_2	14	20	PF00069	0.492
MOD_PKA_2	144	150	PF00069	0.335
MOD_PKA_2	74	80	PF00069	0.502
MOD_Plk_4	179	185	PF00069	0.417
MOD_Plk_4	74	80	PF00069	0.429
MOD_SUMO_rev_2	127	133	PF00179	0.392
MOD_SUMO_rev_2	168	175	PF00179	0.416
MOD_SUMO_rev_2	76	84	PF00179	0.551
TRG_DiLeu_BaEn_1	114	119	PF01217	0.471
TRG_DiLeu_BaEn_2	93	99	PF01217	0.381
TRG_ER_diArg_1	144	146	PF00400	0.351
TRG_NES_CRM1_1	94	106	PF08389	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVJ3	Leptomonas seymouri	71%	73%
A0A0S4JQG6	Bodo saltans	41%	76%
A0A1X0PAZ2	Trypanosomatidae	48%	87%
A0A3Q8IE15	Leishmania donovani	92%	100%
A0A3R7KWQ9	Trypanosoma rangeli	50%	87%
A4HC18	Leishmania braziliensis	86%	100%
A4HZE4	Leishmania infantum	93%	100%
C9ZMM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	85%
Q4QC48	Leishmania major	90%	100%
V5BFW6	Trypanosoma cruzi	50%	87%