Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVD0_LEIMU

TriTrypDb:

LmxM.21.1460

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.584
CLV_C14_Caspase3-7	355	359	PF00656	0.673
CLV_NRD_NRD_1	129	131	PF00675	0.632
CLV_NRD_NRD_1	20	22	PF00675	0.562
CLV_NRD_NRD_1	390	392	PF00675	0.671
CLV_NRD_NRD_1	423	425	PF00675	0.678
CLV_NRD_NRD_1	450	452	PF00675	0.830
CLV_NRD_NRD_1	537	539	PF00675	0.690
CLV_NRD_NRD_1	614	616	PF00675	0.570
CLV_NRD_NRD_1	665	667	PF00675	0.580
CLV_NRD_NRD_1	673	675	PF00675	0.442
CLV_PCSK_FUR_1	535	539	PF00082	0.682
CLV_PCSK_KEX2_1	129	131	PF00082	0.673
CLV_PCSK_KEX2_1	19	21	PF00082	0.572
CLV_PCSK_KEX2_1	390	392	PF00082	0.671
CLV_PCSK_KEX2_1	423	425	PF00082	0.678
CLV_PCSK_KEX2_1	450	452	PF00082	0.836
CLV_PCSK_KEX2_1	534	536	PF00082	0.676
CLV_PCSK_KEX2_1	537	539	PF00082	0.667
CLV_PCSK_KEX2_1	580	582	PF00082	0.611
CLV_PCSK_KEX2_1	614	616	PF00082	0.577
CLV_PCSK_KEX2_1	631	633	PF00082	0.540
CLV_PCSK_KEX2_1	665	667	PF00082	0.580
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.676
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.611
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.673
CLV_PCSK_SKI1_1	141	145	PF00082	0.641
CLV_PCSK_SKI1_1	438	442	PF00082	0.690
CLV_PCSK_SKI1_1	554	558	PF00082	0.675
CLV_PCSK_SKI1_1	665	669	PF00082	0.565
CLV_PCSK_SKI1_1	675	679	PF00082	0.620
DEG_APCC_DBOX_1	613	621	PF00400	0.608
DEG_APCC_DBOX_1	664	672	PF00400	0.561
DEG_Nend_UBRbox_2	1	3	PF02207	0.528
DEG_SPOP_SBC_1	286	290	PF00917	0.663
DEG_SPOP_SBC_1	303	307	PF00917	0.519
DEG_SPOP_SBC_1	39	43	PF00917	0.611
DEG_SPOP_SBC_1	401	405	PF00917	0.580
DEG_SPOP_SBC_1	600	604	PF00917	0.676
DOC_CKS1_1	167	172	PF01111	0.608
DOC_CKS1_1	218	223	PF01111	0.549
DOC_CKS1_1	347	352	PF01111	0.723
DOC_CYCLIN_RxL_1	551	561	PF00134	0.653
DOC_CYCLIN_RxL_1	612	622	PF00134	0.560
DOC_MAPK_FxFP_2	196	199	PF00069	0.706
DOC_MAPK_FxFP_2	265	268	PF00069	0.478
DOC_MAPK_gen_1	438	447	PF00069	0.681
DOC_PP2B_LxvP_1	224	227	PF13499	0.680
DOC_PP2B_LxvP_1	266	269	PF13499	0.599
DOC_PP2B_LxvP_1	557	560	PF13499	0.615
DOC_PP4_FxxP_1	196	199	PF00568	0.706
DOC_PP4_FxxP_1	230	233	PF00568	0.679
DOC_PP4_FxxP_1	265	268	PF00568	0.478
DOC_USP7_MATH_1	172	176	PF00917	0.603
DOC_USP7_MATH_1	219	223	PF00917	0.758
DOC_USP7_MATH_1	225	229	PF00917	0.710
DOC_USP7_MATH_1	238	242	PF00917	0.498
DOC_USP7_MATH_1	286	290	PF00917	0.709
DOC_USP7_MATH_1	303	307	PF00917	0.521
DOC_USP7_MATH_1	315	319	PF00917	0.559
DOC_USP7_MATH_1	333	337	PF00917	0.691
DOC_USP7_MATH_1	343	347	PF00917	0.606
DOC_USP7_MATH_1	352	356	PF00917	0.524
DOC_USP7_MATH_1	389	393	PF00917	0.669
DOC_USP7_MATH_1	401	405	PF00917	0.584
DOC_USP7_MATH_1	475	479	PF00917	0.457
DOC_USP7_MATH_1	585	589	PF00917	0.653
DOC_USP7_MATH_1	590	594	PF00917	0.686
DOC_USP7_MATH_1	600	604	PF00917	0.629
DOC_USP7_MATH_1	648	652	PF00917	0.659
DOC_USP7_MATH_1	73	77	PF00917	0.575
DOC_WW_Pin1_4	166	171	PF00397	0.607
DOC_WW_Pin1_4	217	222	PF00397	0.659
DOC_WW_Pin1_4	277	282	PF00397	0.618
DOC_WW_Pin1_4	346	351	PF00397	0.803
DOC_WW_Pin1_4	433	438	PF00397	0.549
DOC_WW_Pin1_4	511	516	PF00397	0.628
DOC_WW_Pin1_4	562	567	PF00397	0.631
DOC_WW_Pin1_4	581	586	PF00397	0.646
DOC_WW_Pin1_4	636	641	PF00397	0.623
LIG_14-3-3_CanoR_1	100	106	PF00244	0.581
LIG_14-3-3_CanoR_1	141	146	PF00244	0.607
LIG_14-3-3_CanoR_1	368	377	PF00244	0.640
LIG_14-3-3_CanoR_1	37	45	PF00244	0.639
LIG_14-3-3_CanoR_1	380	384	PF00244	0.568
LIG_14-3-3_CanoR_1	390	394	PF00244	0.657
LIG_14-3-3_CanoR_1	412	417	PF00244	0.720
LIG_14-3-3_CanoR_1	474	480	PF00244	0.518
LIG_14-3-3_CanoR_1	52	60	PF00244	0.587
LIG_14-3-3_CanoR_1	535	541	PF00244	0.685
LIG_Actin_WH2_2	42	57	PF00022	0.540
LIG_APCC_ABBA_1	463	468	PF00400	0.622
LIG_BIR_III_4	358	362	PF00653	0.720
LIG_BRCT_BRCA1_1	371	375	PF00533	0.520
LIG_BRCT_BRCA1_1	663	667	PF00533	0.442
LIG_CSL_BTD_1	159	162	PF09270	0.573
LIG_EVH1_1	230	234	PF00568	0.679
LIG_EVH1_1	267	271	PF00568	0.614
LIG_EVH1_2	273	277	PF00568	0.630
LIG_FHA_1	442	448	PF00498	0.795
LIG_FHA_1	571	577	PF00498	0.608
LIG_FHA_1	637	643	PF00498	0.718
LIG_FHA_1	644	650	PF00498	0.631
LIG_FHA_1	652	658	PF00498	0.573
LIG_FHA_2	218	224	PF00498	0.545
LIG_FHA_2	524	530	PF00498	0.709
LIG_FHA_2	654	660	PF00498	0.643
LIG_HCF-1_HBM_1	498	501	PF13415	0.566
LIG_Integrin_RGD_1	356	358	PF01839	0.664
LIG_LIR_Apic_2	217	221	PF02991	0.685
LIG_LIR_Apic_2	228	233	PF02991	0.559
LIG_LIR_Gen_1	473	483	PF02991	0.624
LIG_LIR_Gen_1	506	515	PF02991	0.572
LIG_LIR_Gen_1	621	630	PF02991	0.738
LIG_LIR_Gen_1	664	671	PF02991	0.428
LIG_LIR_Nem_3	473	479	PF02991	0.636
LIG_LIR_Nem_3	498	504	PF02991	0.629
LIG_LIR_Nem_3	506	511	PF02991	0.525
LIG_LIR_Nem_3	621	627	PF02991	0.733
LIG_LIR_Nem_3	664	670	PF02991	0.432
LIG_MYND_1	264	268	PF01753	0.611
LIG_PDZ_Class_1	677	682	PF00595	0.579
LIG_PROFILIN_1	268	274	PF00235	0.617
LIG_SH2_CRK	167	171	PF00017	0.719
LIG_SH2_CRK	278	282	PF00017	0.622
LIG_SH2_CRK	476	480	PF00017	0.503
LIG_SH2_CRK	501	505	PF00017	0.575
LIG_SH2_NCK_1	329	333	PF00017	0.529
LIG_SH2_NCK_1	476	480	PF00017	0.442
LIG_SH2_NCK_1	508	512	PF00017	0.418
LIG_SH2_SRC	329	332	PF00017	0.531
LIG_SH2_SRC	508	511	PF00017	0.599
LIG_SH2_STAP1	181	185	PF00017	0.713
LIG_SH2_STAP1	329	333	PF00017	0.577
LIG_SH2_STAP1	508	512	PF00017	0.600
LIG_SH2_STAT5	493	496	PF00017	0.584
LIG_SH2_STAT5	79	82	PF00017	0.588
LIG_SH3_1	267	273	PF00018	0.621
LIG_SH3_1	278	284	PF00018	0.557
LIG_SH3_1	91	97	PF00018	0.545
LIG_SH3_2	582	587	PF14604	0.535
LIG_SH3_3	132	138	PF00018	0.634
LIG_SH3_3	156	162	PF00018	0.580
LIG_SH3_3	228	234	PF00018	0.680
LIG_SH3_3	250	256	PF00018	0.630
LIG_SH3_3	265	271	PF00018	0.499
LIG_SH3_3	278	284	PF00018	0.575
LIG_SH3_3	33	39	PF00018	0.592
LIG_SH3_3	337	343	PF00018	0.705
LIG_SH3_3	344	350	PF00018	0.641
LIG_SH3_3	569	575	PF00018	0.683
LIG_SH3_3	579	585	PF00018	0.617
LIG_SH3_3	594	600	PF00018	0.574
LIG_SH3_3	91	97	PF00018	0.697
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.562
LIG_SUMO_SIM_par_1	348	355	PF11976	0.606
LIG_TRAF2_1	527	530	PF00917	0.529
LIG_WRC_WIRS_1	393	398	PF05994	0.604
LIG_WW_1	164	167	PF00397	0.595
LIG_WW_3	232	236	PF00397	0.495
MOD_CDC14_SPxK_1	514	517	PF00782	0.644
MOD_CDC14_SPxK_1	584	587	PF00782	0.538
MOD_CDK_SPK_2	433	438	PF00069	0.540
MOD_CDK_SPxK_1	511	517	PF00069	0.633
MOD_CDK_SPxK_1	581	587	PF00069	0.538
MOD_CK1_1	108	114	PF00069	0.606
MOD_CK1_1	117	123	PF00069	0.598
MOD_CK1_1	125	131	PF00069	0.573
MOD_CK1_1	13	19	PF00069	0.606
MOD_CK1_1	211	217	PF00069	0.697
MOD_CK1_1	289	295	PF00069	0.721
MOD_CK1_1	296	302	PF00069	0.614
MOD_CK1_1	304	310	PF00069	0.564
MOD_CK1_1	346	352	PF00069	0.732
MOD_CK1_1	369	375	PF00069	0.748
MOD_CK1_1	392	398	PF00069	0.756
MOD_CK1_1	400	406	PF00069	0.749
MOD_CK1_1	407	413	PF00069	0.597
MOD_CK1_1	41	47	PF00069	0.721
MOD_CK1_1	428	434	PF00069	0.740
MOD_CK1_1	478	484	PF00069	0.562
MOD_CK1_1	50	56	PF00069	0.688
MOD_CK1_1	565	571	PF00069	0.725
MOD_CK1_1	58	64	PF00069	0.603
MOD_CK1_1	602	608	PF00069	0.692
MOD_CK1_1	609	615	PF00069	0.571
MOD_CK1_1	651	657	PF00069	0.584
MOD_CK1_1	77	83	PF00069	0.734
MOD_CK2_1	211	217	PF00069	0.665
MOD_CK2_1	240	246	PF00069	0.625
MOD_CK2_1	485	491	PF00069	0.609
MOD_CK2_1	503	509	PF00069	0.388
MOD_CK2_1	523	529	PF00069	0.548
MOD_CK2_1	590	596	PF00069	0.680
MOD_CK2_1	601	607	PF00069	0.573
MOD_DYRK1A_RPxSP_1	562	566	PF00069	0.545
MOD_DYRK1A_RPxSP_1	581	585	PF00069	0.642
MOD_GlcNHglycan	124	127	PF01048	0.644
MOD_GlcNHglycan	21	24	PF01048	0.561
MOD_GlcNHglycan	212	216	PF01048	0.724
MOD_GlcNHglycan	240	243	PF01048	0.689
MOD_GlcNHglycan	289	292	PF01048	0.718
MOD_GlcNHglycan	309	312	PF01048	0.761
MOD_GlcNHglycan	372	375	PF01048	0.752
MOD_GlcNHglycan	396	399	PF01048	0.761
MOD_GlcNHglycan	4	7	PF01048	0.534
MOD_GlcNHglycan	406	409	PF01048	0.579
MOD_GlcNHglycan	428	431	PF01048	0.720
MOD_GlcNHglycan	46	49	PF01048	0.659
MOD_GlcNHglycan	487	490	PF01048	0.676
MOD_GlcNHglycan	55	58	PF01048	0.645
MOD_GlcNHglycan	587	590	PF01048	0.838
MOD_GlcNHglycan	592	595	PF01048	0.779
MOD_GlcNHglycan	60	63	PF01048	0.604
MOD_GlcNHglycan	607	611	PF01048	0.471
MOD_GlcNHglycan	679	682	PF01048	0.773
MOD_GSK3_1	111	118	PF00069	0.555
MOD_GSK3_1	121	128	PF00069	0.576
MOD_GSK3_1	137	144	PF00069	0.625
MOD_GSK3_1	185	192	PF00069	0.511
MOD_GSK3_1	285	292	PF00069	0.707
MOD_GSK3_1	293	300	PF00069	0.615
MOD_GSK3_1	303	310	PF00069	0.664
MOD_GSK3_1	366	373	PF00069	0.734
MOD_GSK3_1	37	44	PF00069	0.734
MOD_GSK3_1	392	399	PF00069	0.703
MOD_GSK3_1	400	407	PF00069	0.738
MOD_GSK3_1	408	415	PF00069	0.622
MOD_GSK3_1	426	433	PF00069	0.644
MOD_GSK3_1	541	548	PF00069	0.733
MOD_GSK3_1	570	577	PF00069	0.619
MOD_GSK3_1	581	588	PF00069	0.707
MOD_GSK3_1	595	602	PF00069	0.586
MOD_GSK3_1	605	612	PF00069	0.562
MOD_GSK3_1	649	656	PF00069	0.651
MOD_GSK3_1	71	78	PF00069	0.580
MOD_GSK3_1	96	103	PF00069	0.607
MOD_NEK2_1	12	17	PF00069	0.685
MOD_NEK2_1	396	401	PF00069	0.711
MOD_NEK2_1	601	606	PF00069	0.667
MOD_NEK2_1	619	624	PF00069	0.529
MOD_NEK2_1	661	666	PF00069	0.527
MOD_NEK2_1	677	682	PF00069	0.639
MOD_PIKK_1	47	53	PF00454	0.697
MOD_PIKK_1	548	554	PF00454	0.550
MOD_PIKK_1	619	625	PF00454	0.651
MOD_PK_1	366	372	PF00069	0.656
MOD_PKA_1	19	25	PF00069	0.558
MOD_PKA_2	111	117	PF00069	0.627
MOD_PKA_2	121	127	PF00069	0.566
MOD_PKA_2	19	25	PF00069	0.558
MOD_PKA_2	307	313	PF00069	0.731
MOD_PKA_2	379	385	PF00069	0.591
MOD_PKA_2	389	395	PF00069	0.656
MOD_PKA_2	408	414	PF00069	0.702
MOD_PKA_2	449	455	PF00069	0.674
MOD_PKA_2	516	522	PF00069	0.532
MOD_PKA_2	536	542	PF00069	0.673
MOD_PKA_2	545	551	PF00069	0.640
MOD_Plk_2-3	27	33	PF00069	0.564
MOD_Plk_4	225	231	PF00069	0.566
MOD_Plk_4	27	33	PF00069	0.612
MOD_ProDKin_1	166	172	PF00069	0.606
MOD_ProDKin_1	217	223	PF00069	0.653
MOD_ProDKin_1	277	283	PF00069	0.618
MOD_ProDKin_1	346	352	PF00069	0.804
MOD_ProDKin_1	433	439	PF00069	0.552
MOD_ProDKin_1	511	517	PF00069	0.633
MOD_ProDKin_1	562	568	PF00069	0.634
MOD_ProDKin_1	581	587	PF00069	0.650
MOD_ProDKin_1	636	642	PF00069	0.627
TRG_ENDOCYTIC_2	476	479	PF00928	0.519
TRG_ENDOCYTIC_2	501	504	PF00928	0.633
TRG_ENDOCYTIC_2	508	511	PF00928	0.545
TRG_ER_diArg_1	19	21	PF00400	0.570
TRG_ER_diArg_1	423	425	PF00400	0.754
TRG_ER_diArg_1	449	451	PF00400	0.791
TRG_ER_diArg_1	504	507	PF00400	0.565
TRG_ER_diArg_1	535	538	PF00400	0.681
TRG_ER_diArg_1	613	615	PF00400	0.609
TRG_ER_diArg_1	665	667	PF00400	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWP6	Leishmania donovani	83%	100%
A4HC17	Leishmania braziliensis	60%	100%
A4HZE3	Leishmania infantum	82%	100%
Q4QC49	Leishmania major	81%	100%