Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVC8_LEIMU

TriTrypDb:

LmxM.21.1440

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.483
CLV_NRD_NRD_1	125	127	PF00675	0.339
CLV_PCSK_FUR_1	123	127	PF00082	0.429
CLV_PCSK_KEX2_1	125	127	PF00082	0.401
CLV_Separin_Metazoa	150	154	PF03568	0.366
DOC_USP7_MATH_1	119	123	PF00917	0.427
DOC_USP7_MATH_1	19	23	PF00917	0.261
DOC_USP7_UBL2_3	38	42	PF12436	0.399
LIG_14-3-3_CanoR_1	128	134	PF00244	0.345
LIG_14-3-3_CanoR_1	164	169	PF00244	0.434
LIG_14-3-3_CanoR_1	3	10	PF00244	0.412
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_FHA_1	137	143	PF00498	0.305
LIG_FHA_1	29	35	PF00498	0.283
LIG_FHA_1	45	51	PF00498	0.373
LIG_FHA_1	5	11	PF00498	0.198
LIG_FHA_2	132	138	PF00498	0.410
LIG_FHA_2	145	151	PF00498	0.237
LIG_FHA_2	181	187	PF00498	0.341
LIG_FHA_2	4	10	PF00498	0.295
LIG_LIR_Apic_2	102	108	PF02991	0.329
LIG_LIR_Apic_2	204	208	PF02991	0.330
LIG_LIR_Apic_2	81	85	PF02991	0.335
LIG_LIR_Gen_1	154	163	PF02991	0.386
LIG_LIR_Gen_1	165	175	PF02991	0.360
LIG_LIR_Gen_1	17	28	PF02991	0.325
LIG_LIR_Gen_1	194	203	PF02991	0.347
LIG_LIR_Nem_3	154	159	PF02991	0.328
LIG_LIR_Nem_3	165	171	PF02991	0.294
LIG_LIR_Nem_3	17	23	PF02991	0.323
LIG_LIR_Nem_3	194	199	PF02991	0.353
LIG_NRBOX	147	153	PF00104	0.431
LIG_PDZ_Class_1	216	221	PF00595	0.436
LIG_SH2_CRK	82	86	PF00017	0.351
LIG_SH2_GRB2like	213	216	PF00017	0.419
LIG_SH2_PTP2	20	23	PF00017	0.339
LIG_SH2_SRC	105	108	PF00017	0.362
LIG_SH2_SRC	115	118	PF00017	0.275
LIG_SH2_SRC	206	209	PF00017	0.286
LIG_SH2_STAT5	115	118	PF00017	0.307
LIG_SH2_STAT5	156	159	PF00017	0.315
LIG_SH2_STAT5	166	169	PF00017	0.292
LIG_SH2_STAT5	20	23	PF00017	0.303
LIG_SH2_STAT5	206	209	PF00017	0.286
LIG_SH2_STAT5	5	8	PF00017	0.358
LIG_SH3_3	87	93	PF00018	0.365
LIG_SH3_4	48	55	PF00018	0.422
LIG_SUMO_SIM_par_1	26	32	PF11976	0.291
LIG_TRAF2_1	147	150	PF00917	0.368
MOD_CK2_1	131	137	PF00069	0.397
MOD_CK2_1	144	150	PF00069	0.289
MOD_CK2_1	3	9	PF00069	0.303
MOD_GlcNHglycan	76	79	PF01048	0.480
MOD_GSK3_1	131	138	PF00069	0.432
MOD_GSK3_1	74	81	PF00069	0.356
MOD_LATS_1	162	168	PF00433	0.437
MOD_NEK2_1	178	183	PF00069	0.431
MOD_NEK2_1	28	33	PF00069	0.261
MOD_PK_1	155	161	PF00069	0.396
MOD_PKB_1	153	161	PF00069	0.383
MOD_Plk_1	135	141	PF00069	0.355
MOD_Plk_1	144	150	PF00069	0.331
MOD_Plk_1	28	34	PF00069	0.323
MOD_Plk_1	56	62	PF00069	0.308
MOD_Plk_2-3	136	142	PF00069	0.386
MOD_Plk_2-3	192	198	PF00069	0.480
MOD_Plk_4	164	170	PF00069	0.356
MOD_Plk_4	29	35	PF00069	0.288
MOD_Plk_4	91	97	PF00069	0.356
TRG_ENDOCYTIC_2	156	159	PF00928	0.358
TRG_ENDOCYTIC_2	166	169	PF00928	0.335
TRG_ENDOCYTIC_2	20	23	PF00928	0.339
TRG_ENDOCYTIC_2	37	40	PF00928	0.384
TRG_ER_diArg_1	123	126	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G7	Leptomonas seymouri	85%	100%
A0A0S4IWY2	Bodo saltans	60%	100%
A0A1X0NJA6	Trypanosomatidae	64%	99%
A0A3R7MUY6	Trypanosoma rangeli	62%	100%
A0A3S7WWT8	Leishmania donovani	97%	100%
A4HC15	Leishmania braziliensis	94%	100%
A4HZE1	Leishmania infantum	97%	100%
D0A144	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q0IHR1	Xenopus tropicalis	45%	100%
Q4QC51	Leishmania major	97%	100%
Q567I9	Danio rerio	45%	100%
Q5NCY3	Mus musculus	44%	97%
Q5PPR6	Xenopus laevis	46%	100%
Q5R4Q5	Pongo abelii	45%	97%
Q6P9G0	Homo sapiens	44%	97%