DUF393 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVC6_LEIMU

TriTrypDb:

LmxM.21.1420

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AVC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.617
CLV_NRD_NRD_1	230	232	PF00675	0.501
CLV_NRD_NRD_1	255	257	PF00675	0.629
CLV_NRD_NRD_1	52	54	PF00675	0.582
CLV_NRD_NRD_1	82	84	PF00675	0.533
CLV_PCSK_FUR_1	253	257	PF00082	0.619
CLV_PCSK_KEX2_1	229	231	PF00082	0.494
CLV_PCSK_KEX2_1	255	257	PF00082	0.579
CLV_PCSK_KEX2_1	82	84	PF00082	0.533
CLV_PCSK_PC7_1	225	231	PF00082	0.565
CLV_PCSK_SKI1_1	143	147	PF00082	0.674
CLV_PCSK_SKI1_1	156	160	PF00082	0.561
CLV_PCSK_SKI1_1	18	22	PF00082	0.604
CLV_PCSK_SKI1_1	200	204	PF00082	0.526
CLV_PCSK_SKI1_1	35	39	PF00082	0.554
CLV_PCSK_SKI1_1	82	86	PF00082	0.555
DEG_SPOP_SBC_1	158	162	PF00917	0.586
DEG_SPOP_SBC_1	89	93	PF00917	0.595
DOC_AGCK_PIF_1	45	50	PF00069	0.566
DOC_CYCLIN_RxL_1	15	24	PF00134	0.553
DOC_PP1_RVXF_1	65	71	PF00149	0.598
DOC_PP1_RVXF_1	80	87	PF00149	0.551
DOC_PP2B_LxvP_1	106	109	PF13499	0.664
DOC_USP7_MATH_1	158	162	PF00917	0.665
DOC_USP7_MATH_1	89	93	PF00917	0.652
LIG_14-3-3_CanoR_1	260	267	PF00244	0.684
LIG_14-3-3_CanoR_1	40	45	PF00244	0.545
LIG_14-3-3_CanoR_1	96	106	PF00244	0.610
LIG_APCC_ABBA_1	115	120	PF00400	0.528
LIG_APCC_ABBA_1	194	199	PF00400	0.612
LIG_APCC_ABBAyCdc20_2	193	199	PF00400	0.603
LIG_CaM_IQ_9	27	42	PF13499	0.548
LIG_Clathr_ClatBox_1	116	120	PF01394	0.508
LIG_Clathr_ClatBox_1	20	24	PF01394	0.478
LIG_CtBP_PxDLS_1	111	115	PF00389	0.551
LIG_deltaCOP1_diTrp_1	254	259	PF00928	0.620
LIG_DLG_GKlike_1	40	47	PF00625	0.487
LIG_FHA_1	178	184	PF00498	0.452
LIG_FHA_1	201	207	PF00498	0.465
LIG_FHA_1	50	56	PF00498	0.511
LIG_FHA_2	142	148	PF00498	0.574
LIG_LIR_Gen_1	185	196	PF02991	0.498
LIG_LIR_Gen_1	39	50	PF02991	0.525
LIG_LIR_Gen_1	7	17	PF02991	0.570
LIG_LIR_Nem_3	205	210	PF02991	0.557
LIG_LIR_Nem_3	39	45	PF02991	0.532
LIG_LIR_Nem_3	7	12	PF02991	0.517
LIG_Pex14_1	222	226	PF04695	0.570
LIG_Pex14_2	44	48	PF04695	0.557
LIG_PTB_Apo_2	217	224	PF02174	0.486
LIG_REV1ctd_RIR_1	83	92	PF16727	0.631
LIG_SH2_CRK	211	215	PF00017	0.468
LIG_SH2_CRK	9	13	PF00017	0.499
LIG_SH2_STAP1	99	103	PF00017	0.438
LIG_SH2_STAT5	188	191	PF00017	0.586
LIG_SH2_STAT5	211	214	PF00017	0.507
LIG_SH2_STAT5	226	229	PF00017	0.407
LIG_SH2_STAT5	36	39	PF00017	0.506
LIG_SH2_STAT5	69	72	PF00017	0.620
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.544
MOD_CK1_1	161	167	PF00069	0.632
MOD_CK1_1	168	174	PF00069	0.598
MOD_CK1_1	263	269	PF00069	0.608
MOD_CK1_1	43	49	PF00069	0.518
MOD_CK1_1	72	78	PF00069	0.503
MOD_CK1_1	90	96	PF00069	0.557
MOD_CK2_1	141	147	PF00069	0.674
MOD_GlcNHglycan	92	95	PF01048	0.669
MOD_GlcNHglycan	99	102	PF01048	0.666
MOD_GSK3_1	121	128	PF00069	0.490
MOD_GSK3_1	156	163	PF00069	0.643
MOD_GSK3_1	165	172	PF00069	0.537
MOD_GSK3_1	182	189	PF00069	0.568
MOD_GSK3_1	88	95	PF00069	0.669
MOD_N-GLC_1	186	191	PF02516	0.628
MOD_N-GLC_1	40	45	PF02516	0.530
MOD_NEK2_1	182	187	PF00069	0.514
MOD_NEK2_1	202	207	PF00069	0.293
MOD_NEK2_1	4	9	PF00069	0.506
MOD_PIKK_1	11	17	PF00454	0.623
MOD_PIKK_1	121	127	PF00454	0.577
MOD_PKA_2	4	10	PF00069	0.523
MOD_PKA_2	87	93	PF00069	0.518
MOD_PKA_2	95	101	PF00069	0.594
MOD_Plk_1	141	147	PF00069	0.616
MOD_Plk_1	186	192	PF00069	0.572
MOD_Plk_1	40	46	PF00069	0.528
MOD_Plk_2-3	141	147	PF00069	0.636
MOD_Plk_4	125	131	PF00069	0.491
MOD_SUMO_rev_2	141	151	PF00179	0.490
TRG_DiLeu_BaEn_1	112	117	PF01217	0.586
TRG_DiLeu_BaEn_1	179	184	PF01217	0.392
TRG_ENDOCYTIC_2	188	191	PF00928	0.519
TRG_ENDOCYTIC_2	211	214	PF00928	0.455
TRG_ENDOCYTIC_2	9	12	PF00928	0.489
TRG_ER_diArg_1	229	231	PF00400	0.467
TRG_ER_diArg_1	255	257	PF00400	0.587
TRG_ER_diArg_1	33	36	PF00400	0.625
TRG_ER_diArg_1	65	68	PF00400	0.684
TRG_ER_diArg_1	81	83	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V9	Leptomonas seymouri	62%	98%
A0A0S4IH77	Bodo saltans	29%	100%
A0A1X0NHE8	Trypanosomatidae	42%	100%
A0A3S7WWT7	Leishmania donovani	90%	100%
A4HBY9	Leishmania braziliensis	80%	100%
A4HZD9	Leishmania infantum	91%	100%
D0A146	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QC53	Leishmania major	92%	100%
V5B1U8	Trypanosoma cruzi	38%	100%