GBBH-like_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF971), putative

Species:

Leishmania mexicana

UniProt:

E9AVC5_LEIMU

TriTrypDb:

LmxM.21.1410

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVC5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.809
CLV_NRD_NRD_1	155	157	PF00675	0.678
CLV_NRD_NRD_1	193	195	PF00675	0.607
CLV_NRD_NRD_1	357	359	PF00675	0.430
CLV_NRD_NRD_1	414	416	PF00675	0.668
CLV_NRD_NRD_1	422	424	PF00675	0.617
CLV_PCSK_FUR_1	128	132	PF00082	0.679
CLV_PCSK_FUR_1	412	416	PF00082	0.679
CLV_PCSK_KEX2_1	128	130	PF00082	0.810
CLV_PCSK_KEX2_1	155	157	PF00082	0.678
CLV_PCSK_KEX2_1	193	195	PF00082	0.607
CLV_PCSK_KEX2_1	357	359	PF00082	0.430
CLV_PCSK_KEX2_1	414	416	PF00082	0.678
CLV_PCSK_KEX2_1	422	424	PF00082	0.607
CLV_PCSK_PC7_1	418	424	PF00082	0.706
CLV_PCSK_SKI1_1	156	160	PF00082	0.744
CLV_PCSK_SKI1_1	187	191	PF00082	0.586
CLV_PCSK_SKI1_1	272	276	PF00082	0.774
CLV_PCSK_SKI1_1	358	362	PF00082	0.307
CLV_PCSK_SKI1_1	374	378	PF00082	0.369
CLV_PCSK_SKI1_1	428	432	PF00082	0.528
CLV_PCSK_SKI1_1	9	13	PF00082	0.555
CLV_Separin_Metazoa	244	248	PF03568	0.578
CLV_Separin_Metazoa	307	311	PF03568	0.535
DEG_APCC_DBOX_1	309	317	PF00400	0.547
DEG_Nend_UBRbox_3	1	3	PF02207	0.518
DEG_SPOP_SBC_1	157	161	PF00917	0.655
DOC_CKS1_1	309	314	PF01111	0.528
DOC_CKS1_1	338	343	PF01111	0.438
DOC_MAPK_gen_1	229	236	PF00069	0.615
DOC_MAPK_MEF2A_6	91	100	PF00069	0.545
DOC_PP2B_LxvP_1	290	293	PF13499	0.549
DOC_PP4_FxxP_1	236	239	PF00568	0.587
DOC_PP4_FxxP_1	32	35	PF00568	0.540
DOC_USP7_MATH_1	148	152	PF00917	0.568
DOC_USP7_MATH_1	157	161	PF00917	0.589
DOC_USP7_MATH_1	202	206	PF00917	0.701
DOC_USP7_MATH_1	266	270	PF00917	0.720
DOC_USP7_MATH_1	27	31	PF00917	0.494
DOC_USP7_MATH_1	286	290	PF00917	0.566
DOC_USP7_MATH_1	296	300	PF00917	0.748
DOC_USP7_MATH_1	346	350	PF00917	0.454
DOC_USP7_MATH_1	367	371	PF00917	0.496
DOC_USP7_MATH_1	42	46	PF00917	0.514
DOC_USP7_MATH_1	89	93	PF00917	0.563
DOC_WW_Pin1_4	109	114	PF00397	0.556
DOC_WW_Pin1_4	133	138	PF00397	0.787
DOC_WW_Pin1_4	140	145	PF00397	0.698
DOC_WW_Pin1_4	252	257	PF00397	0.615
DOC_WW_Pin1_4	262	267	PF00397	0.635
DOC_WW_Pin1_4	277	282	PF00397	0.533
DOC_WW_Pin1_4	308	313	PF00397	0.718
DOC_WW_Pin1_4	315	320	PF00397	0.747
DOC_WW_Pin1_4	337	342	PF00397	0.630
DOC_WW_Pin1_4	36	41	PF00397	0.552
DOC_WW_Pin1_4	393	398	PF00397	0.501
DOC_WW_Pin1_4	84	89	PF00397	0.733
LIG_14-3-3_CanoR_1	128	138	PF00244	0.646
LIG_14-3-3_CanoR_1	14	19	PF00244	0.540
LIG_14-3-3_CanoR_1	155	163	PF00244	0.589
LIG_14-3-3_CanoR_1	200	210	PF00244	0.563
LIG_14-3-3_CanoR_1	22	27	PF00244	0.502
LIG_14-3-3_CanoR_1	247	252	PF00244	0.735
LIG_14-3-3_CanoR_1	272	277	PF00244	0.772
LIG_14-3-3_CanoR_1	44	50	PF00244	0.604
LIG_Actin_WH2_2	359	376	PF00022	0.630
LIG_BH_BH3_1	155	171	PF00452	0.719
LIG_BRCT_BRCA1_1	24	28	PF00533	0.498
LIG_CSL_BTD_1	181	184	PF09270	0.464
LIG_FHA_1	157	163	PF00498	0.590
LIG_FHA_1	273	279	PF00498	0.751
LIG_FHA_1	327	333	PF00498	0.462
LIG_FHA_1	361	367	PF00498	0.573
LIG_FHA_2	102	108	PF00498	0.534
LIG_FHA_2	15	21	PF00498	0.541
LIG_FHA_2	235	241	PF00498	0.467
LIG_FHA_2	262	268	PF00498	0.651
LIG_LIR_Apic_2	235	239	PF02991	0.588
LIG_LIR_Apic_2	30	35	PF02991	0.517
LIG_LIR_Gen_1	17	23	PF02991	0.518
LIG_LIR_Gen_1	230	239	PF02991	0.610
LIG_LIR_Gen_1	334	341	PF02991	0.438
LIG_LIR_Gen_1	387	394	PF02991	0.630
LIG_LIR_Gen_1	426	437	PF02991	0.528
LIG_LIR_Nem_3	17	21	PF02991	0.544
LIG_LIR_Nem_3	230	236	PF02991	0.618
LIG_LIR_Nem_3	25	31	PF02991	0.493
LIG_LIR_Nem_3	334	338	PF02991	0.438
LIG_LIR_Nem_3	387	393	PF02991	0.630
LIG_Pex14_2	28	32	PF04695	0.521
LIG_SH2_STAP1	371	375	PF00017	0.630
LIG_SH2_STAP1	386	390	PF00017	0.457
LIG_SH2_STAP1	429	433	PF00017	0.653
LIG_SH2_STAT5	233	236	PF00017	0.600
LIG_SH2_STAT5	335	338	PF00017	0.630
LIG_SH2_STAT5	339	342	PF00017	0.515
LIG_SH2_STAT5	390	393	PF00017	0.615
LIG_SH2_STAT5	407	410	PF00017	0.339
LIG_SH3_3	132	138	PF00018	0.558
LIG_SH3_3	178	184	PF00018	0.533
LIG_SH3_3	186	192	PF00018	0.702
LIG_SH3_3	255	261	PF00018	0.710
LIG_SH3_3	275	281	PF00018	0.653
LIG_SH3_3	28	34	PF00018	0.523
LIG_SH3_3	316	322	PF00018	0.737
LIG_SH3_3	335	341	PF00018	0.436
LIG_SUMO_SIM_anti_2	240	247	PF11976	0.542
LIG_SUMO_SIM_par_1	34	39	PF11976	0.548
LIG_TRFH_1	140	144	PF08558	0.719
LIG_WW_3	419	423	PF00397	0.442
MOD_CDC14_SPxK_1	265	268	PF00782	0.590
MOD_CDK_SPxK_1	262	268	PF00069	0.586
MOD_CDK_SPxxK_3	109	116	PF00069	0.562
MOD_CDK_SPxxK_3	393	400	PF00069	0.498
MOD_CDK_SPxxK_3	84	91	PF00069	0.726
MOD_CK1_1	161	167	PF00069	0.595
MOD_CK1_1	169	175	PF00069	0.595
MOD_CK1_1	280	286	PF00069	0.613
MOD_CK1_1	396	402	PF00069	0.532
MOD_CK1_1	45	51	PF00069	0.600
MOD_CK2_1	202	208	PF00069	0.695
MOD_CK2_1	234	240	PF00069	0.459
MOD_CK2_1	261	267	PF00069	0.644
MOD_CK2_1	48	54	PF00069	0.621
MOD_Cter_Amidation	355	358	PF01082	0.430
MOD_DYRK1A_RPxSP_1	337	341	PF00069	0.630
MOD_GlcNHglycan	109	112	PF01048	0.557
MOD_GlcNHglycan	150	153	PF01048	0.659
MOD_GlcNHglycan	282	285	PF01048	0.630
MOD_GlcNHglycan	298	301	PF01048	0.596
MOD_GlcNHglycan	322	325	PF01048	0.667
MOD_GlcNHglycan	381	384	PF01048	0.335
MOD_GSK3_1	129	136	PF00069	0.656
MOD_GSK3_1	157	164	PF00069	0.644
MOD_GSK3_1	252	259	PF00069	0.690
MOD_GSK3_1	262	269	PF00069	0.812
MOD_GSK3_1	272	279	PF00069	0.646
MOD_GSK3_1	375	382	PF00069	0.487
MOD_GSK3_1	392	399	PF00069	0.438
MOD_GSK3_1	44	51	PF00069	0.615
MOD_N-GLC_1	202	207	PF02516	0.698
MOD_NEK2_1	100	105	PF00069	0.577
MOD_NEK2_1	158	163	PF00069	0.729
MOD_NEK2_1	166	171	PF00069	0.551
MOD_NEK2_1	177	182	PF00069	0.505
MOD_NEK2_2	212	217	PF00069	0.410
MOD_PIKK_1	172	178	PF00454	0.549
MOD_PIKK_1	54	60	PF00454	0.593
MOD_PK_1	423	429	PF00069	0.568
MOD_PKA_1	129	135	PF00069	0.813
MOD_PKA_1	414	420	PF00069	0.675
MOD_PKA_2	129	135	PF00069	0.658
MOD_PKA_2	21	27	PF00069	0.510
MOD_PKA_2	414	420	PF00069	0.675
MOD_PKA_2	45	51	PF00069	0.608
MOD_PKB_1	412	420	PF00069	0.677
MOD_Plk_1	202	208	PF00069	0.565
MOD_Plk_1	234	240	PF00069	0.572
MOD_Plk_4	101	107	PF00069	0.479
MOD_Plk_4	158	164	PF00069	0.591
MOD_Plk_4	177	183	PF00069	0.668
MOD_Plk_4	27	33	PF00069	0.576
MOD_ProDKin_1	109	115	PF00069	0.558
MOD_ProDKin_1	133	139	PF00069	0.783
MOD_ProDKin_1	140	146	PF00069	0.697
MOD_ProDKin_1	252	258	PF00069	0.619
MOD_ProDKin_1	262	268	PF00069	0.637
MOD_ProDKin_1	277	283	PF00069	0.573
MOD_ProDKin_1	308	314	PF00069	0.716
MOD_ProDKin_1	315	321	PF00069	0.738
MOD_ProDKin_1	337	343	PF00069	0.630
MOD_ProDKin_1	36	42	PF00069	0.550
MOD_ProDKin_1	393	399	PF00069	0.500
MOD_ProDKin_1	84	90	PF00069	0.729
MOD_SUMO_rev_2	180	189	PF00179	0.724
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.546
TRG_ENDOCYTIC_2	233	236	PF00928	0.600
TRG_ENDOCYTIC_2	335	338	PF00928	0.433
TRG_ENDOCYTIC_2	388	391	PF00928	0.630
TRG_ENDOCYTIC_2	401	404	PF00928	0.609
TRG_ENDOCYTIC_2	429	432	PF00928	0.520
TRG_ER_diArg_1	127	130	PF00400	0.804
TRG_ER_diArg_1	155	157	PF00400	0.678
TRG_ER_diArg_1	192	194	PF00400	0.600
TRG_ER_diArg_1	216	219	PF00400	0.682
TRG_ER_diArg_1	327	330	PF00400	0.611
TRG_ER_diArg_1	411	414	PF00400	0.652
TRG_ER_diArg_1	421	423	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAY8	Leishmania donovani	81%	100%
A4HBZ0	Leishmania braziliensis	71%	96%
A4HZD8	Leishmania infantum	80%	94%
Q4QC54	Leishmania major	81%	100%