LeishMANIAdb
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Palmitoyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Palmitoyltransferase
Gene product:
zinc finger domain-like protein
Species:
Leishmania mexicana
UniProt:
E9AVC4_LEIMU
TriTrypDb:
LmxM.21.1390
Length:
595

Annotations

LeishMANIAdb annotations

Palmitoyltransferase. Leishmaniids have +2 extra TM segments at the N-terminus while all other Kinetoplastids typically only have the 4 core ones.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0031090 organelle membrane 3 1

Expansion

Sequence features

E9AVC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVC4

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 2
GO:0006605 protein targeting 5 2
GO:0006612 protein targeting to membrane 5 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0006810 transport 3 2
GO:0006886 intracellular protein transport 4 2
GO:0006897 endocytosis 5 2
GO:0008104 protein localization 4 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0015031 protein transport 4 2
GO:0016192 vesicle-mediated transport 4 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018198 peptidyl-cysteine modification 6 2
GO:0018230 peptidyl-L-cysteine S-palmitoylation 7 2
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 7 2
GO:0018345 protein palmitoylation 6 2
GO:0019538 protein metabolic process 3 2
GO:0033036 macromolecule localization 2 2
GO:0036211 protein modification process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 2
GO:0043543 protein acylation 5 2
GO:0044238 primary metabolic process 2 2
GO:0045184 establishment of protein localization 3 2
GO:0046907 intracellular transport 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
GO:0051668 localization within membrane 3 2
GO:0070727 cellular macromolecule localization 3 2
GO:0071702 organic substance transport 4 2
GO:0071704 organic substance metabolic process 2 2
GO:0071705 nitrogen compound transport 4 2
GO:0072657 protein localization to membrane 4 2
GO:0090150 establishment of protein localization to membrane 4 2
GO:1901564 organonitrogen compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016409 palmitoyltransferase activity 5 7
GO:0016417 S-acyltransferase activity 5 7
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 7
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 7
GO:0019707 protein-cysteine S-acyltransferase activity 3 7
GO:0140096 catalytic activity, acting on a protein 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.710
CLV_C14_Caspase3-7 228 232 PF00656 0.728
CLV_MEL_PAP_1 552 558 PF00089 0.279
CLV_NRD_NRD_1 13 15 PF00675 0.426
CLV_NRD_NRD_1 250 252 PF00675 0.503
CLV_NRD_NRD_1 322 324 PF00675 0.348
CLV_NRD_NRD_1 329 331 PF00675 0.296
CLV_NRD_NRD_1 397 399 PF00675 0.546
CLV_NRD_NRD_1 401 403 PF00675 0.520
CLV_NRD_NRD_1 461 463 PF00675 0.213
CLV_NRD_NRD_1 527 529 PF00675 0.479
CLV_NRD_NRD_1 550 552 PF00675 0.403
CLV_PCSK_KEX2_1 13 15 PF00082 0.460
CLV_PCSK_KEX2_1 250 252 PF00082 0.480
CLV_PCSK_KEX2_1 322 324 PF00082 0.356
CLV_PCSK_KEX2_1 329 331 PF00082 0.314
CLV_PCSK_KEX2_1 401 403 PF00082 0.538
CLV_PCSK_KEX2_1 461 463 PF00082 0.321
CLV_PCSK_KEX2_1 479 481 PF00082 0.472
CLV_PCSK_KEX2_1 527 529 PF00082 0.453
CLV_PCSK_KEX2_1 550 552 PF00082 0.403
CLV_PCSK_PC1ET2_1 479 481 PF00082 0.441
CLV_PCSK_SKI1_1 255 259 PF00082 0.570
CLV_PCSK_SKI1_1 329 333 PF00082 0.385
CLV_PCSK_SKI1_1 366 370 PF00082 0.285
CLV_PCSK_SKI1_1 462 466 PF00082 0.348
CLV_PCSK_SKI1_1 516 520 PF00082 0.461
CLV_PCSK_SKI1_1 8 12 PF00082 0.430
DEG_APCC_DBOX_1 13 21 PF00400 0.630
DEG_APCC_DBOX_1 254 262 PF00400 0.655
DEG_APCC_DBOX_1 365 373 PF00400 0.481
DEG_APCC_DBOX_1 510 518 PF00400 0.611
DEG_Nend_UBRbox_2 1 3 PF02207 0.660
DOC_CKS1_1 202 207 PF01111 0.633
DOC_CKS1_1 67 72 PF01111 0.411
DOC_CYCLIN_RxL_1 458 469 PF00134 0.370
DOC_CYCLIN_RxL_1 496 505 PF00134 0.667
DOC_CYCLIN_yCln2_LP_2 423 429 PF00134 0.348
DOC_MAPK_gen_1 311 320 PF00069 0.665
DOC_MAPK_gen_1 550 558 PF00069 0.590
DOC_MAPK_MEF2A_6 307 314 PF00069 0.673
DOC_MAPK_MEF2A_6 440 449 PF00069 0.218
DOC_MAPK_MEF2A_6 551 560 PF00069 0.609
DOC_MAPK_RevD_3 236 251 PF00069 0.689
DOC_PP1_RVXF_1 36 43 PF00149 0.521
DOC_PP1_RVXF_1 497 504 PF00149 0.608
DOC_PP2B_LxvP_1 318 321 PF13499 0.674
DOC_PP2B_LxvP_1 331 334 PF13499 0.451
DOC_PP2B_LxvP_1 423 426 PF13499 0.348
DOC_PP2B_PxIxI_1 215 221 PF00149 0.685
DOC_USP7_MATH_1 470 474 PF00917 0.521
DOC_WW_Pin1_4 142 147 PF00397 0.742
DOC_WW_Pin1_4 167 172 PF00397 0.775
DOC_WW_Pin1_4 186 191 PF00397 0.630
DOC_WW_Pin1_4 201 206 PF00397 0.670
DOC_WW_Pin1_4 407 412 PF00397 0.348
DOC_WW_Pin1_4 490 495 PF00397 0.575
DOC_WW_Pin1_4 66 71 PF00397 0.413
LIG_14-3-3_CanoR_1 172 181 PF00244 0.643
LIG_14-3-3_CanoR_1 263 272 PF00244 0.669
LIG_14-3-3_CanoR_1 285 290 PF00244 0.679
LIG_14-3-3_CanoR_1 440 444 PF00244 0.274
LIG_14-3-3_CanoR_1 544 552 PF00244 0.626
LIG_AP2alpha_1 503 507 PF02296 0.594
LIG_BRCT_BRCA1_1 268 272 PF00533 0.674
LIG_BRCT_BRCA1_1 485 489 PF00533 0.685
LIG_BRCT_BRCA1_1 95 99 PF00533 0.500
LIG_CaM_NSCaTE_8 376 383 PF13499 0.370
LIG_Clathr_ClatBox_1 295 299 PF01394 0.692
LIG_DLG_GKlike_1 250 257 PF00625 0.636
LIG_eIF4E_1 458 464 PF01652 0.407
LIG_eIF4E_1 578 584 PF01652 0.666
LIG_FHA_1 235 241 PF00498 0.767
LIG_FHA_1 35 41 PF00498 0.527
LIG_FHA_1 381 387 PF00498 0.370
LIG_FHA_1 433 439 PF00498 0.348
LIG_FHA_1 440 446 PF00498 0.378
LIG_FHA_1 466 472 PF00498 0.566
LIG_FHA_1 51 57 PF00498 0.271
LIG_FHA_1 578 584 PF00498 0.666
LIG_FHA_2 182 188 PF00498 0.771
LIG_FHA_2 292 298 PF00498 0.736
LIG_FHA_2 345 351 PF00498 0.521
LIG_FHA_2 467 473 PF00498 0.551
LIG_FHA_2 507 513 PF00498 0.649
LIG_HP1_1 74 78 PF01393 0.275
LIG_Integrin_RGD_1 225 227 PF01839 0.528
LIG_LIR_Apic_2 111 115 PF02991 0.711
LIG_LIR_Apic_2 490 494 PF02991 0.573
LIG_LIR_Gen_1 454 464 PF02991 0.407
LIG_LIR_Gen_1 53 60 PF02991 0.407
LIG_LIR_Gen_1 580 589 PF02991 0.676
LIG_LIR_Gen_1 72 83 PF02991 0.321
LIG_LIR_Nem_3 212 218 PF02991 0.749
LIG_LIR_Nem_3 269 275 PF02991 0.571
LIG_LIR_Nem_3 383 388 PF02991 0.407
LIG_LIR_Nem_3 454 459 PF02991 0.407
LIG_LIR_Nem_3 53 57 PF02991 0.407
LIG_LIR_Nem_3 563 568 PF02991 0.616
LIG_LIR_Nem_3 580 584 PF02991 0.563
LIG_LIR_Nem_3 72 78 PF02991 0.348
LIG_LIR_Nem_3 86 90 PF02991 0.262
LIG_LYPXL_SIV_4 426 434 PF13949 0.348
LIG_NRBOX 291 297 PF00104 0.692
LIG_NRBOX 77 83 PF00104 0.370
LIG_Pex14_1 561 565 PF04695 0.600
LIG_Pex14_2 29 33 PF04695 0.631
LIG_Pex14_2 503 507 PF04695 0.682
LIG_SH2_CRK 112 116 PF00017 0.703
LIG_SH2_CRK 388 392 PF00017 0.530
LIG_SH2_CRK 491 495 PF00017 0.633
LIG_SH2_GRB2like 458 461 PF00017 0.407
LIG_SH2_GRB2like 90 93 PF00017 0.407
LIG_SH2_PTP2 75 78 PF00017 0.370
LIG_SH2_STAT3 9 12 PF00017 0.590
LIG_SH2_STAT5 110 113 PF00017 0.695
LIG_SH2_STAT5 16 19 PF00017 0.630
LIG_SH2_STAT5 324 327 PF00017 0.548
LIG_SH2_STAT5 367 370 PF00017 0.407
LIG_SH2_STAT5 390 393 PF00017 0.348
LIG_SH2_STAT5 437 440 PF00017 0.370
LIG_SH2_STAT5 458 461 PF00017 0.407
LIG_SH2_STAT5 475 478 PF00017 0.520
LIG_SH2_STAT5 75 78 PF00017 0.471
LIG_SH2_STAT5 90 93 PF00017 0.341
LIG_SH3_3 175 181 PF00018 0.760
LIG_SH3_3 189 195 PF00018 0.691
LIG_SH3_3 202 208 PF00018 0.666
LIG_SH3_3 280 286 PF00018 0.687
LIG_SH3_3 423 429 PF00018 0.348
LIG_SH3_3 573 579 PF00018 0.681
LIG_SUMO_SIM_par_1 293 299 PF11976 0.689
LIG_SUMO_SIM_par_1 80 86 PF11976 0.256
LIG_TYR_ITIM 386 391 PF00017 0.370
LIG_TYR_ITIM 73 78 PF00017 0.407
LIG_WRC_WIRS_1 30 35 PF05994 0.531
LIG_WRC_WIRS_1 51 56 PF05994 0.407
LIG_WRC_WIRS_1 565 570 PF05994 0.525
LIG_WRC_WIRS_1 578 583 PF05994 0.447
LIG_WRC_WIRS_1 84 89 PF05994 0.407
LIG_WW_1 107 110 PF00397 0.609
LIG_WW_3 308 312 PF00397 0.588
MOD_CDC14_SPxK_1 410 413 PF00782 0.407
MOD_CDK_SPK_2 167 172 PF00069 0.593
MOD_CDK_SPK_2 188 193 PF00069 0.633
MOD_CDK_SPxK_1 407 413 PF00069 0.407
MOD_CDK_SPxxK_3 186 193 PF00069 0.541
MOD_CK1_1 128 134 PF00069 0.745
MOD_CK1_1 253 259 PF00069 0.646
MOD_CK1_1 291 297 PF00069 0.496
MOD_CK1_1 32 38 PF00069 0.357
MOD_CK2_1 291 297 PF00069 0.655
MOD_CK2_1 466 472 PF00069 0.434
MOD_CMANNOS 373 376 PF00535 0.407
MOD_GlcNHglycan 132 136 PF01048 0.617
MOD_GlcNHglycan 266 269 PF01048 0.579
MOD_GlcNHglycan 585 588 PF01048 0.719
MOD_GSK3_1 127 134 PF00069 0.681
MOD_GSK3_1 148 155 PF00069 0.561
MOD_GSK3_1 161 168 PF00069 0.566
MOD_GSK3_1 182 189 PF00069 0.690
MOD_GSK3_1 197 204 PF00069 0.548
MOD_GSK3_1 262 269 PF00069 0.623
MOD_GSK3_1 28 35 PF00069 0.521
MOD_GSK3_1 376 383 PF00069 0.407
MOD_GSK3_1 466 473 PF00069 0.370
MOD_GSK3_1 483 490 PF00069 0.498
MOD_GSK3_1 560 567 PF00069 0.565
MOD_GSK3_1 65 72 PF00069 0.455
MOD_GSK3_1 93 100 PF00069 0.442
MOD_N-GLC_1 33 38 PF02516 0.507
MOD_N-GLC_1 466 471 PF02516 0.407
MOD_N-GLC_1 487 492 PF02516 0.445
MOD_N-GLC_2 343 345 PF02516 0.341
MOD_N-GLC_2 357 359 PF02516 0.407
MOD_NEK2_1 20 25 PF00069 0.382
MOD_NEK2_1 264 269 PF00069 0.498
MOD_NEK2_1 29 34 PF00069 0.473
MOD_NEK2_1 380 385 PF00069 0.407
MOD_NEK2_1 433 438 PF00069 0.407
MOD_NEK2_1 451 456 PF00069 0.220
MOD_NEK2_1 465 470 PF00069 0.231
MOD_NEK2_1 506 511 PF00069 0.471
MOD_NEK2_1 94 99 PF00069 0.540
MOD_NEK2_2 470 475 PF00069 0.370
MOD_PIKK_1 149 155 PF00454 0.659
MOD_PIKK_1 161 167 PF00454 0.562
MOD_PKA_1 250 256 PF00069 0.538
MOD_PKA_2 250 256 PF00069 0.636
MOD_PKA_2 262 268 PF00069 0.463
MOD_PKA_2 439 445 PF00069 0.274
MOD_PKA_2 543 549 PF00069 0.410
MOD_Plk_1 182 188 PF00069 0.735
MOD_Plk_1 226 232 PF00069 0.506
MOD_Plk_1 466 472 PF00069 0.407
MOD_Plk_1 487 493 PF00069 0.470
MOD_Plk_4 153 159 PF00069 0.664
MOD_Plk_4 291 297 PF00069 0.590
MOD_Plk_4 376 382 PF00069 0.407
MOD_Plk_4 433 439 PF00069 0.389
MOD_Plk_4 451 457 PF00069 0.239
MOD_Plk_4 470 476 PF00069 0.487
MOD_ProDKin_1 142 148 PF00069 0.677
MOD_ProDKin_1 167 173 PF00069 0.722
MOD_ProDKin_1 186 192 PF00069 0.522
MOD_ProDKin_1 201 207 PF00069 0.578
MOD_ProDKin_1 407 413 PF00069 0.407
MOD_ProDKin_1 490 496 PF00069 0.440
MOD_ProDKin_1 66 72 PF00069 0.494
TRG_DiLeu_BaLyEn_6 205 210 PF01217 0.523
TRG_DiLeu_LyEn_5 588 593 PF01217 0.613
TRG_ENDOCYTIC_2 367 370 PF00928 0.407
TRG_ENDOCYTIC_2 388 391 PF00928 0.530
TRG_ENDOCYTIC_2 578 581 PF00928 0.603
TRG_ENDOCYTIC_2 75 78 PF00928 0.407
TRG_ER_diArg_1 310 313 PF00400 0.693
TRG_ER_diArg_1 321 323 PF00400 0.352
TRG_ER_diArg_1 329 331 PF00400 0.235
TRG_ER_diArg_1 400 402 PF00400 0.396
TRG_ER_diArg_1 461 463 PF00400 0.218
TRG_ER_diArg_1 550 552 PF00400 0.524
TRG_NLS_MonoExtC_3 397 402 PF00514 0.313
TRG_Pf-PMV_PEXEL_1 401 406 PF00026 0.407
TRG_Pf-PMV_PEXEL_1 461 466 PF00026 0.218
TRG_Pf-PMV_PEXEL_1 550 554 PF00026 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IAF5 Leishmania donovani 88% 84%
A4HC51 Leishmania braziliensis 68% 100%
A4HZD7 Leishmania infantum 88% 100%
Q4QC55 Leishmania major 87% 100%
Q4QC56 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS