RSN1_7TM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVC3_LEIMU

TriTrypDb:

LmxM.21.1380

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AVC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.461
CLV_NRD_NRD_1	172	174	PF00675	0.442
CLV_NRD_NRD_1	180	182	PF00675	0.431
CLV_PCSK_KEX2_1	104	106	PF00082	0.461
CLV_PCSK_KEX2_1	171	173	PF00082	0.449
DEG_APCC_DBOX_1	256	264	PF00400	0.705
DEG_APCC_DBOX_1	56	64	PF00400	0.266
DEG_APCC_DBOX_1	88	96	PF00400	0.525
DEG_Nend_Nbox_1	1	3	PF02207	0.506
DEG_SPOP_SBC_1	296	300	PF00917	0.637
DOC_CDC14_PxL_1	17	25	PF14671	0.326
DOC_MAPK_gen_1	178	186	PF00069	0.590
DOC_MAPK_gen_1	55	64	PF00069	0.263
DOC_MAPK_HePTP_8	54	66	PF00069	0.188
DOC_MAPK_MEF2A_6	55	64	PF00069	0.263
DOC_MAPK_NFAT4_5	55	63	PF00069	0.284
DOC_MAPK_RevD_3	90	105	PF00069	0.593
DOC_PP1_RVXF_1	147	154	PF00149	0.597
DOC_PP1_RVXF_1	79	86	PF00149	0.530
DOC_PP2B_LxvP_1	62	65	PF13499	0.243
DOC_PP4_FxxP_1	227	230	PF00568	0.630
DOC_USP7_MATH_1	134	138	PF00917	0.658
DOC_USP7_MATH_1	296	300	PF00917	0.772
DOC_USP7_MATH_1	303	307	PF00917	0.650
DOC_USP7_MATH_1	32	36	PF00917	0.374
DOC_USP7_UBL2_3	178	182	PF12436	0.656
DOC_USP7_UBL2_3	218	222	PF12436	0.586
DOC_WW_Pin1_4	136	141	PF00397	0.564
DOC_WW_Pin1_4	226	231	PF00397	0.613
DOC_WW_Pin1_4	274	279	PF00397	0.764
DOC_WW_Pin1_4	48	53	PF00397	0.353
LIG_14-3-3_CanoR_1	162	168	PF00244	0.602
LIG_14-3-3_CanoR_1	176	181	PF00244	0.598
LIG_14-3-3_CanoR_1	257	263	PF00244	0.714
LIG_14-3-3_CanoR_1	328	336	PF00244	0.697
LIG_14-3-3_CanoR_1	98	102	PF00244	0.612
LIG_Actin_WH2_2	83	100	PF00022	0.571
LIG_BRCT_BRCA1_1	149	153	PF00533	0.594
LIG_BRCT_BRCA1_1	187	191	PF00533	0.628
LIG_DCNL_PONY_1	1	4	PF03556	0.444
LIG_deltaCOP1_diTrp_1	183	191	PF00928	0.706
LIG_FHA_1	215	221	PF00498	0.590
LIG_FHA_1	39	45	PF00498	0.455
LIG_FHA_1	49	55	PF00498	0.374
LIG_FHA_1	94	100	PF00498	0.580
LIG_FHA_2	322	328	PF00498	0.627
LIG_Integrin_RGD_1	319	321	PF01839	0.378
LIG_LIR_Gen_1	188	197	PF02991	0.613
LIG_LIR_Nem_3	188	194	PF02991	0.574
LIG_LIR_Nem_3	313	318	PF02991	0.684
LIG_LIR_Nem_3	324	329	PF02991	0.633
LIG_NRBOX	57	63	PF00104	0.243
LIG_PTB_Apo_2	24	31	PF02174	0.329
LIG_PTB_Phospho_1	24	30	PF10480	0.330
LIG_SH2_CRK	80	84	PF00017	0.569
LIG_SH2_STAT5	24	27	PF00017	0.376
LIG_SH2_STAT5	253	256	PF00017	0.736
LIG_SH2_STAT5	59	62	PF00017	0.387
LIG_SH2_STAT5	76	79	PF00017	0.239
LIG_SH3_3	15	21	PF00018	0.342
LIG_SH3_3	275	281	PF00018	0.707
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.195
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.547
LIG_WW_1	21	24	PF00397	0.385
MOD_CDK_SPxxK_3	136	143	PF00069	0.566
MOD_CDK_SPxxK_3	48	55	PF00069	0.286
MOD_CK1_1	127	133	PF00069	0.673
MOD_CK1_1	229	235	PF00069	0.607
MOD_CK1_1	261	267	PF00069	0.697
MOD_CK1_1	298	304	PF00069	0.691
MOD_CK1_1	306	312	PF00069	0.742
MOD_CK2_1	37	43	PF00069	0.465
MOD_DYRK1A_RPxSP_1	136	140	PF00069	0.566
MOD_GlcNHglycan	10	13	PF01048	0.360
MOD_GlcNHglycan	126	129	PF01048	0.534
MOD_GlcNHglycan	187	190	PF01048	0.450
MOD_GlcNHglycan	249	252	PF01048	0.454
MOD_GlcNHglycan	300	303	PF01048	0.563
MOD_GlcNHglycan	305	308	PF01048	0.564
MOD_GSK3_1	122	129	PF00069	0.649
MOD_GSK3_1	261	268	PF00069	0.766
MOD_GSK3_1	306	313	PF00069	0.787
MOD_GSK3_1	93	100	PF00069	0.596
MOD_LATS_1	174	180	PF00433	0.649
MOD_N-GLC_1	117	122	PF02516	0.436
MOD_N-GLC_1	141	146	PF02516	0.458
MOD_N-GLC_1	214	219	PF02516	0.401
MOD_N-GLC_1	274	279	PF02516	0.476
MOD_N-GLC_1	322	327	PF02516	0.390
MOD_NEK2_1	141	146	PF00069	0.663
MOD_NEK2_1	147	152	PF00069	0.668
MOD_NEK2_1	163	168	PF00069	0.641
MOD_NEK2_1	252	257	PF00069	0.640
MOD_NEK2_1	290	295	PF00069	0.607
MOD_NEK2_1	310	315	PF00069	0.652
MOD_NEK2_1	46	51	PF00069	0.429
MOD_NEK2_1	66	71	PF00069	0.262
MOD_PK_1	176	182	PF00069	0.642
MOD_PKA_2	290	296	PF00069	0.702
MOD_PKA_2	97	103	PF00069	0.613
MOD_Plk_1	117	123	PF00069	0.693
MOD_Plk_1	141	147	PF00069	0.624
MOD_Plk_1	321	327	PF00069	0.700
MOD_Plk_1	46	52	PF00069	0.444
MOD_Plk_2-3	322	328	PF00069	0.591
MOD_Plk_4	127	133	PF00069	0.679
MOD_Plk_4	258	264	PF00069	0.749
MOD_Plk_4	290	296	PF00069	0.665
MOD_Plk_4	306	312	PF00069	0.576
MOD_ProDKin_1	136	142	PF00069	0.565
MOD_ProDKin_1	226	232	PF00069	0.612
MOD_ProDKin_1	274	280	PF00069	0.764
MOD_ProDKin_1	48	54	PF00069	0.349
MOD_SUMO_rev_2	261	269	PF00179	0.599
TRG_ENDOCYTIC_2	59	62	PF00928	0.398
TRG_ENDOCYTIC_2	80	83	PF00928	0.552
TRG_ER_diArg_1	143	146	PF00400	0.605
TRG_ER_diArg_1	171	173	PF00400	0.672
TRG_NES_CRM1_1	91	102	PF08389	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA48	Leptomonas seymouri	48%	87%
A0A1X0NHI5	Trypanosomatidae	30%	100%
A0A3S7WWN2	Leishmania donovani	79%	96%
A4HC52	Leishmania braziliensis	62%	100%
A4HZD6	Leishmania infantum	79%	96%
Q4QC57	Leishmania major	76%	100%