Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AVC2_LEIMU

TriTrypDb:

LmxM.21.1370

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AVC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.731
CLV_C14_Caspase3-7	558	562	PF00656	0.732
CLV_C14_Caspase3-7	717	721	PF00656	0.711
CLV_NRD_NRD_1	140	142	PF00675	0.449
CLV_NRD_NRD_1	495	497	PF00675	0.558
CLV_NRD_NRD_1	891	893	PF00675	0.544
CLV_PCSK_KEX2_1	140	142	PF00082	0.449
CLV_PCSK_KEX2_1	494	496	PF00082	0.559
CLV_PCSK_KEX2_1	639	641	PF00082	0.398
CLV_PCSK_KEX2_1	891	893	PF00082	0.544
CLV_PCSK_KEX2_1	925	927	PF00082	0.482
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.398
CLV_PCSK_PC1ET2_1	925	927	PF00082	0.482
CLV_PCSK_SKI1_1	1013	1017	PF00082	0.518
CLV_PCSK_SKI1_1	140	144	PF00082	0.458
CLV_PCSK_SKI1_1	232	236	PF00082	0.476
CLV_PCSK_SKI1_1	261	265	PF00082	0.465
CLV_PCSK_SKI1_1	725	729	PF00082	0.480
CLV_PCSK_SKI1_1	802	806	PF00082	0.480
CLV_PCSK_SKI1_1	929	933	PF00082	0.470
CLV_PCSK_SKI1_1	985	989	PF00082	0.442
DEG_Nend_UBRbox_2	1	3	PF02207	0.725
DEG_SCF_FBW7_1	354	361	PF00400	0.784
DEG_SCF_FBW7_1	853	860	PF00400	0.740
DEG_SCF_FBW7_2	334	341	PF00400	0.691
DEG_SPOP_SBC_1	501	505	PF00917	0.679
DEG_SPOP_SBC_1	754	758	PF00917	0.702
DOC_ANK_TNKS_1	171	178	PF00023	0.605
DOC_ANK_TNKS_1	559	566	PF00023	0.641
DOC_CDC14_PxL_1	64	72	PF14671	0.532
DOC_CDC14_PxL_1	896	904	PF14671	0.566
DOC_CKS1_1	1007	1012	PF01111	0.732
DOC_CKS1_1	335	340	PF01111	0.691
DOC_CYCLIN_RxL_1	432	442	PF00134	0.746
DOC_CYCLIN_yClb1_LxF_4	800	805	PF00134	0.720
DOC_MAPK_DCC_7	275	284	PF00069	0.577
DOC_MAPK_gen_1	140	146	PF00069	0.665
DOC_MAPK_gen_1	258	268	PF00069	0.694
DOC_MAPK_gen_1	75	84	PF00069	0.339
DOC_MAPK_gen_1	797	805	PF00069	0.708
DOC_MAPK_gen_1	925	935	PF00069	0.681
DOC_MAPK_HePTP_8	72	84	PF00069	0.405
DOC_MAPK_JIP1_4	799	805	PF00069	0.719
DOC_MAPK_MEF2A_6	19	27	PF00069	0.708
DOC_MAPK_MEF2A_6	258	266	PF00069	0.656
DOC_MAPK_MEF2A_6	75	84	PF00069	0.339
DOC_MAPK_MEF2A_6	797	805	PF00069	0.689
DOC_MAPK_MEF2A_6	926	935	PF00069	0.634
DOC_MAPK_NFAT4_5	261	269	PF00069	0.666
DOC_PP1_RVXF_1	800	806	PF00149	0.722
DOC_PP2B_LxvP_1	332	335	PF13499	0.701
DOC_PP4_FxxP_1	351	354	PF00568	0.819
DOC_PP4_FxxP_1	924	927	PF00568	0.717
DOC_USP7_MATH_1	179	183	PF00917	0.620
DOC_USP7_MATH_1	289	293	PF00917	0.698
DOC_USP7_MATH_1	358	362	PF00917	0.832
DOC_USP7_MATH_1	37	41	PF00917	0.648
DOC_USP7_MATH_1	398	402	PF00917	0.650
DOC_USP7_MATH_1	501	505	PF00917	0.714
DOC_USP7_MATH_1	532	536	PF00917	0.666
DOC_USP7_MATH_1	595	599	PF00917	0.720
DOC_USP7_MATH_1	610	614	PF00917	0.679
DOC_USP7_MATH_1	643	647	PF00917	0.702
DOC_USP7_MATH_1	653	657	PF00917	0.640
DOC_USP7_MATH_1	670	674	PF00917	0.610
DOC_USP7_MATH_1	718	722	PF00917	0.620
DOC_USP7_MATH_1	754	758	PF00917	0.703
DOC_USP7_MATH_1	857	861	PF00917	0.743
DOC_USP7_MATH_2	416	422	PF00917	0.662
DOC_USP7_UBL2_3	925	929	PF12436	0.671
DOC_WW_Pin1_4	1006	1011	PF00397	0.747
DOC_WW_Pin1_4	334	339	PF00397	0.724
DOC_WW_Pin1_4	354	359	PF00397	0.678
DOC_WW_Pin1_4	426	431	PF00397	0.689
DOC_WW_Pin1_4	449	454	PF00397	0.654
DOC_WW_Pin1_4	497	502	PF00397	0.681
DOC_WW_Pin1_4	581	586	PF00397	0.770
DOC_WW_Pin1_4	729	734	PF00397	0.658
DOC_WW_Pin1_4	764	769	PF00397	0.735
DOC_WW_Pin1_4	853	858	PF00397	0.774
DOC_WW_Pin1_4	883	888	PF00397	0.764
DOC_WW_Pin1_4	890	895	PF00397	0.725
LIG_14-3-3_CanoR_1	1022	1028	PF00244	0.731
LIG_14-3-3_CanoR_1	106	116	PF00244	0.623
LIG_14-3-3_CanoR_1	140	145	PF00244	0.696
LIG_14-3-3_CanoR_1	154	159	PF00244	0.771
LIG_14-3-3_CanoR_1	261	267	PF00244	0.628
LIG_14-3-3_CanoR_1	314	320	PF00244	0.768
LIG_14-3-3_CanoR_1	424	430	PF00244	0.758
LIG_14-3-3_CanoR_1	494	500	PF00244	0.754
LIG_14-3-3_CanoR_1	594	604	PF00244	0.694
LIG_14-3-3_CanoR_1	640	648	PF00244	0.599
LIG_14-3-3_CanoR_1	725	733	PF00244	0.679
LIG_14-3-3_CanoR_1	989	999	PF00244	0.642
LIG_Actin_WH2_2	541	557	PF00022	0.637
LIG_APCC_ABBA_1	633	638	PF00400	0.669
LIG_APCC_ABBAyCdc20_2	1043	1049	PF00400	0.615
LIG_BRCT_BRCA1_1	264	268	PF00533	0.669
LIG_BRCT_BRCA1_1	676	680	PF00533	0.738
LIG_Clathr_ClatBox_1	634	638	PF01394	0.669
LIG_deltaCOP1_diTrp_1	218	221	PF00928	0.653
LIG_DLG_GKlike_1	785	793	PF00625	0.699
LIG_FHA_1	137	143	PF00498	0.701
LIG_FHA_1	184	190	PF00498	0.627
LIG_FHA_1	210	216	PF00498	0.681
LIG_FHA_1	236	242	PF00498	0.606
LIG_FHA_1	345	351	PF00498	0.743
LIG_FHA_1	373	379	PF00498	0.775
LIG_FHA_1	508	514	PF00498	0.756
LIG_FHA_1	52	58	PF00498	0.405
LIG_FHA_1	630	636	PF00498	0.693
LIG_FHA_1	756	762	PF00498	0.682
LIG_FHA_1	816	822	PF00498	0.671
LIG_FHA_1	891	897	PF00498	0.726
LIG_FHA_1	967	973	PF00498	0.667
LIG_FHA_1	993	999	PF00498	0.628
LIG_FHA_2	133	139	PF00498	0.628
LIG_FHA_2	159	165	PF00498	0.737
LIG_FHA_2	355	361	PF00498	0.786
LIG_FHA_2	697	703	PF00498	0.738
LIG_FHA_2	834	840	PF00498	0.735
LIG_FHA_2	912	918	PF00498	0.668
LIG_IRF3_LxIS_1	249	255	PF10401	0.638
LIG_LIR_Apic_2	348	354	PF02991	0.816
LIG_LIR_Apic_2	921	927	PF02991	0.709
LIG_LIR_Gen_1	218	226	PF02991	0.523
LIG_LIR_Gen_1	265	276	PF02991	0.668
LIG_LIR_Gen_1	47	57	PF02991	0.376
LIG_LIR_Nem_3	1041	1045	PF02991	0.687
LIG_LIR_Nem_3	218	222	PF02991	0.649
LIG_LIR_Nem_3	265	271	PF02991	0.667
LIG_LIR_Nem_3	387	391	PF02991	0.673
LIG_LIR_Nem_3	47	52	PF02991	0.376
LIG_LIR_Nem_3	677	683	PF02991	0.733
LIG_LYPXL_yS_3	611	614	PF13949	0.593
LIG_MLH1_MIPbox_1	264	268	PF16413	0.669
LIG_MYND_3	899	903	PF01753	0.683
LIG_NRBOX	221	227	PF00104	0.651
LIG_NRBOX	983	989	PF00104	0.639
LIG_PCNA_yPIPBox_3	1000	1013	PF02747	0.668
LIG_Pex14_2	45	49	PF04695	0.296
LIG_PTAP_UEV_1	321	326	PF05743	0.724
LIG_PTB_Apo_2	38	45	PF02174	0.641
LIG_SH2_PTP2	71	74	PF00017	0.401
LIG_SH2_PTP2	81	84	PF00017	0.342
LIG_SH2_STAP1	657	661	PF00017	0.700
LIG_SH2_STAT3	649	652	PF00017	0.667
LIG_SH2_STAT3	99	102	PF00017	0.559
LIG_SH2_STAT5	125	128	PF00017	0.740
LIG_SH2_STAT5	267	270	PF00017	0.669
LIG_SH2_STAT5	665	668	PF00017	0.724
LIG_SH2_STAT5	71	74	PF00017	0.453
LIG_SH2_STAT5	710	713	PF00017	0.723
LIG_SH2_STAT5	81	84	PF00017	0.271
LIG_SH3_1	710	716	PF00018	0.691
LIG_SH3_3	20	26	PF00018	0.714
LIG_SH3_3	234	240	PF00018	0.648
LIG_SH3_3	319	325	PF00018	0.798
LIG_SH3_3	332	338	PF00018	0.714
LIG_SH3_3	388	394	PF00018	0.772
LIG_SH3_3	546	552	PF00018	0.632
LIG_SH3_3	606	612	PF00018	0.710
LIG_SH3_3	62	68	PF00018	0.471
LIG_SH3_3	710	716	PF00018	0.710
LIG_SH3_3	732	738	PF00018	0.703
LIG_SH3_3	770	776	PF00018	0.655
LIG_SH3_3	805	811	PF00018	0.735
LIG_SH3_3	81	87	PF00018	0.405
LIG_SUMO_SIM_anti_2	542	549	PF11976	0.631
LIG_SUMO_SIM_anti_2	928	934	PF11976	0.624
LIG_TRAF2_1	161	164	PF00917	0.703
LIG_TRAF2_1	370	373	PF00917	0.751
LIG_TYR_ITIM	609	614	PF00017	0.597
LIG_UBA3_1	222	228	PF00899	0.622
LIG_UBA3_1	30	34	PF00899	0.659
LIG_WRC_WIRS_1	268	273	PF05994	0.665
LIG_WRC_WIRS_1	463	468	PF05994	0.650
LIG_WRC_WIRS_1	786	791	PF05994	0.734
LIG_WW_1	68	71	PF00397	0.442
MOD_CDK_SPK_2	1006	1011	PF00069	0.661
MOD_CDK_SPxxK_3	1006	1013	PF00069	0.712
MOD_CDK_SPxxK_3	585	592	PF00069	0.749
MOD_CDK_SPxxK_3	729	736	PF00069	0.639
MOD_CK1_1	1023	1029	PF00069	0.729
MOD_CK1_1	349	355	PF00069	0.743
MOD_CK1_1	376	382	PF00069	0.772
MOD_CK1_1	40	46	PF00069	0.685
MOD_CK1_1	401	407	PF00069	0.740
MOD_CK1_1	459	465	PF00069	0.777
MOD_CK1_1	497	503	PF00069	0.698
MOD_CK1_1	584	590	PF00069	0.750
MOD_CK1_1	598	604	PF00069	0.661
MOD_CK1_1	656	662	PF00069	0.638
MOD_CK1_1	672	678	PF00069	0.700
MOD_CK1_1	742	748	PF00069	0.693
MOD_CK1_1	757	763	PF00069	0.711
MOD_CK1_1	849	855	PF00069	0.747
MOD_CK1_1	860	866	PF00069	0.727
MOD_CK1_1	895	901	PF00069	0.701
MOD_CK1_1	942	948	PF00069	0.648
MOD_CK1_1	959	965	PF00069	0.750
MOD_CK1_1	966	972	PF00069	0.737
MOD_CK2_1	132	138	PF00069	0.626
MOD_CK2_1	158	164	PF00069	0.745
MOD_CK2_1	342	348	PF00069	0.754
MOD_CK2_1	354	360	PF00069	0.717
MOD_CK2_1	454	460	PF00069	0.784
MOD_CK2_1	696	702	PF00069	0.734
MOD_CK2_1	728	734	PF00069	0.637
MOD_CK2_1	833	839	PF00069	0.725
MOD_CK2_1	911	917	PF00069	0.658
MOD_Cter_Amidation	492	495	PF01082	0.516
MOD_GlcNHglycan	1022	1025	PF01048	0.401
MOD_GlcNHglycan	163	167	PF01048	0.562
MOD_GlcNHglycan	183	186	PF01048	0.405
MOD_GlcNHglycan	309	312	PF01048	0.505
MOD_GlcNHglycan	322	325	PF01048	0.494
MOD_GlcNHglycan	366	369	PF01048	0.563
MOD_GlcNHglycan	400	403	PF01048	0.494
MOD_GlcNHglycan	420	423	PF01048	0.518
MOD_GlcNHglycan	456	459	PF01048	0.550
MOD_GlcNHglycan	481	484	PF01048	0.564
MOD_GlcNHglycan	534	537	PF01048	0.499
MOD_GlcNHglycan	557	560	PF01048	0.506
MOD_GlcNHglycan	605	608	PF01048	0.518
MOD_GlcNHglycan	641	644	PF01048	0.492
MOD_GlcNHglycan	658	662	PF01048	0.431
MOD_GlcNHglycan	714	719	PF01048	0.405
MOD_GlcNHglycan	741	744	PF01048	0.483
MOD_GlcNHglycan	839	843	PF01048	0.535
MOD_GlcNHglycan	848	851	PF01048	0.553
MOD_GlcNHglycan	859	862	PF01048	0.466
MOD_GSK3_1	1002	1009	PF00069	0.748
MOD_GSK3_1	132	139	PF00069	0.668
MOD_GSK3_1	154	161	PF00069	0.730
MOD_GSK3_1	179	186	PF00069	0.691
MOD_GSK3_1	262	269	PF00069	0.663
MOD_GSK3_1	342	349	PF00069	0.770
MOD_GSK3_1	354	361	PF00069	0.696
MOD_GSK3_1	372	379	PF00069	0.644
MOD_GSK3_1	40	47	PF00069	0.683
MOD_GSK3_1	449	456	PF00069	0.716
MOD_GSK3_1	462	469	PF00069	0.737
MOD_GSK3_1	495	502	PF00069	0.710
MOD_GSK3_1	539	546	PF00069	0.756
MOD_GSK3_1	581	588	PF00069	0.663
MOD_GSK3_1	639	646	PF00069	0.666
MOD_GSK3_1	653	660	PF00069	0.605
MOD_GSK3_1	670	677	PF00069	0.608
MOD_GSK3_1	714	721	PF00069	0.705
MOD_GSK3_1	725	732	PF00069	0.671
MOD_GSK3_1	749	756	PF00069	0.675
MOD_GSK3_1	764	771	PF00069	0.714
MOD_GSK3_1	775	782	PF00069	0.708
MOD_GSK3_1	845	852	PF00069	0.703
MOD_GSK3_1	853	860	PF00069	0.639
MOD_GSK3_1	87	94	PF00069	0.481
MOD_GSK3_1	890	897	PF00069	0.709
MOD_GSK3_1	916	923	PF00069	0.737
MOD_GSK3_1	959	966	PF00069	0.768
MOD_LATS_1	312	318	PF00433	0.738
MOD_N-GLC_1	358	363	PF02516	0.589
MOD_N-GLC_1	453	458	PF02516	0.448
MOD_N-GLC_1	532	537	PF02516	0.426
MOD_N-GLC_1	578	583	PF02516	0.567
MOD_NEK2_1	162	167	PF00069	0.606
MOD_NEK2_1	183	188	PF00069	0.701
MOD_NEK2_1	252	257	PF00069	0.590
MOD_NEK2_1	262	267	PF00069	0.585
MOD_NEK2_1	342	347	PF00069	0.750
MOD_NEK2_1	44	49	PF00069	0.576
MOD_NEK2_1	466	471	PF00069	0.743
MOD_NEK2_1	541	546	PF00069	0.709
MOD_NEK2_1	554	559	PF00069	0.687
MOD_NEK2_1	686	691	PF00069	0.662
MOD_NEK2_1	838	843	PF00069	0.713
MOD_NEK2_2	295	300	PF00069	0.620
MOD_NEK2_2	612	617	PF00069	0.666
MOD_PIKK_1	373	379	PF00454	0.775
MOD_PIKK_1	956	962	PF00454	0.744
MOD_PIKK_1	966	972	PF00454	0.686
MOD_PKA_1	140	146	PF00069	0.665
MOD_PKA_1	494	500	PF00069	0.754
MOD_PKA_1	639	645	PF00069	0.592
MOD_PKA_1	925	931	PF00069	0.660
MOD_PKA_2	140	146	PF00069	0.669
MOD_PKA_2	168	174	PF00069	0.707
MOD_PKA_2	313	319	PF00069	0.738
MOD_PKA_2	494	500	PF00069	0.756
MOD_PKA_2	554	560	PF00069	0.646
MOD_PKA_2	639	645	PF00069	0.603
MOD_PKA_2	762	768	PF00069	0.732
MOD_PKA_2	868	874	PF00069	0.765
MOD_PKA_2	925	931	PF00069	0.746
MOD_PKA_2	990	996	PF00069	0.645
MOD_PKB_1	362	370	PF00069	0.757
MOD_PKB_1	867	875	PF00069	0.738
MOD_Plk_1	17	23	PF00069	0.640
MOD_Plk_1	459	465	PF00069	0.748
MOD_Plk_1	670	676	PF00069	0.718
MOD_Plk_1	916	922	PF00069	0.695
MOD_Plk_4	262	268	PF00069	0.662
MOD_Plk_4	295	301	PF00069	0.620
MOD_Plk_4	315	321	PF00069	0.768
MOD_Plk_4	346	352	PF00069	0.740
MOD_Plk_4	40	46	PF00069	0.716
MOD_Plk_4	48	54	PF00069	0.410
MOD_Plk_4	543	549	PF00069	0.632
MOD_Plk_4	629	635	PF00069	0.678
MOD_Plk_4	776	782	PF00069	0.735
MOD_Plk_4	785	791	PF00069	0.710
MOD_Plk_4	816	822	PF00069	0.638
MOD_Plk_4	87	93	PF00069	0.387
MOD_Plk_4	94	100	PF00069	0.316
MOD_ProDKin_1	1006	1012	PF00069	0.747
MOD_ProDKin_1	334	340	PF00069	0.725
MOD_ProDKin_1	354	360	PF00069	0.679
MOD_ProDKin_1	426	432	PF00069	0.687
MOD_ProDKin_1	449	455	PF00069	0.654
MOD_ProDKin_1	497	503	PF00069	0.681
MOD_ProDKin_1	581	587	PF00069	0.770
MOD_ProDKin_1	729	735	PF00069	0.659
MOD_ProDKin_1	764	770	PF00069	0.735
MOD_ProDKin_1	853	859	PF00069	0.774
MOD_ProDKin_1	883	889	PF00069	0.764
MOD_ProDKin_1	890	896	PF00069	0.722
MOD_SUMO_for_1	33	36	PF00179	0.648
MOD_SUMO_rev_2	971	981	PF00179	0.735
TRG_DiLeu_BaEn_1	204	209	PF01217	0.639
TRG_DiLeu_BaEn_1	218	223	PF01217	0.616
TRG_DiLeu_BaEn_3	204	210	PF01217	0.704
TRG_DiLeu_BaEn_4	714	720	PF01217	0.704
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.405
TRG_ENDOCYTIC_2	611	614	PF00928	0.593
TRG_ENDOCYTIC_2	71	74	PF00928	0.402
TRG_ENDOCYTIC_2	81	84	PF00928	0.342
TRG_ENDOCYTIC_2	98	101	PF00928	0.230
TRG_ER_diArg_1	1010	1013	PF00400	0.681
TRG_ER_diArg_1	140	142	PF00400	0.649
TRG_ER_diArg_1	494	496	PF00400	0.762
TRG_ER_diArg_1	867	870	PF00400	0.687
TRG_ER_diArg_1	988	991	PF00400	0.730
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	985	990	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBZ0	Leishmania donovani	84%	100%
A4HBZ5	Leishmania braziliensis	55%	99%
A4HZD5	Leishmania infantum	83%	100%
Q4QC58	Leishmania major	81%	100%