Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVC1_LEIMU

TriTrypDb:

LmxM.21.1360

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.615
CLV_MEL_PAP_1	86	92	PF00089	0.463
CLV_NRD_NRD_1	280	282	PF00675	0.588
CLV_NRD_NRD_1	93	95	PF00675	0.560
CLV_PCSK_KEX2_1	279	281	PF00082	0.562
CLV_PCSK_KEX2_1	93	95	PF00082	0.558
CLV_PCSK_PC7_1	89	95	PF00082	0.558
CLV_PCSK_SKI1_1	240	244	PF00082	0.695
DEG_APCC_DBOX_1	239	247	PF00400	0.642
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DOC_CKS1_1	186	191	PF01111	0.617
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.334
DOC_MAPK_gen_1	212	221	PF00069	0.542
DOC_PP4_FxxP_1	221	224	PF00568	0.558
DOC_PP4_FxxP_1	293	296	PF00568	0.555
DOC_USP7_MATH_1	297	301	PF00917	0.682
DOC_USP7_MATH_1	71	75	PF00917	0.664
DOC_WW_Pin1_4	122	127	PF00397	0.766
DOC_WW_Pin1_4	13	18	PF00397	0.563
DOC_WW_Pin1_4	185	190	PF00397	0.649
DOC_WW_Pin1_4	67	72	PF00397	0.598
LIG_14-3-3_CanoR_1	148	154	PF00244	0.395
LIG_14-3-3_CanoR_1	265	273	PF00244	0.300
LIG_14-3-3_CanoR_1	325	332	PF00244	0.596
LIG_14-3-3_CanoR_1	89	93	PF00244	0.463
LIG_14-3-3_CanoR_1	94	102	PF00244	0.517
LIG_BRCT_BRCA1_1	251	255	PF00533	0.621
LIG_deltaCOP1_diTrp_1	268	278	PF00928	0.445
LIG_DLG_GKlike_1	24	31	PF00625	0.306
LIG_FHA_1	115	121	PF00498	0.468
LIG_FHA_1	258	264	PF00498	0.479
LIG_FHA_1	312	318	PF00498	0.545
LIG_FHA_1	73	79	PF00498	0.658
LIG_FHA_1	85	91	PF00498	0.372
LIG_FHA_2	106	112	PF00498	0.640
LIG_FHA_2	125	131	PF00498	0.756
LIG_FHA_2	139	145	PF00498	0.625
LIG_FHA_2	242	248	PF00498	0.702
LIG_LIR_Apic_2	183	189	PF02991	0.561
LIG_LIR_Apic_2	290	296	PF02991	0.641
LIG_LIR_Gen_1	252	263	PF02991	0.555
LIG_LIR_Gen_1	268	277	PF02991	0.496
LIG_LIR_Nem_3	160	166	PF02991	0.499
LIG_LIR_Nem_3	252	258	PF02991	0.572
LIG_LIR_Nem_3	27	31	PF02991	0.530
LIG_LIR_Nem_3	289	295	PF02991	0.676
LIG_LIR_Nem_3	37	43	PF02991	0.504
LIG_LIR_Nem_3	53	59	PF02991	0.326
LIG_MAD2	212	220	PF02301	0.512
LIG_Rb_LxCxE_1	193	211	PF01857	0.724
LIG_SH2_CRK	3	7	PF00017	0.371
LIG_SH2_NCK_1	3	7	PF00017	0.371
LIG_SH2_STAP1	149	153	PF00017	0.446
LIG_SH2_STAP1	3	7	PF00017	0.371
LIG_SH2_STAT5	112	115	PF00017	0.648
LIG_SH2_STAT5	3	6	PF00017	0.566
LIG_SH2_STAT5	54	57	PF00017	0.515
LIG_SH3_3	11	17	PF00018	0.636
LIG_TRAF2_1	178	181	PF00917	0.548
LIG_TRAF2_2	48	53	PF00917	0.505
MOD_CDK_SPxK_1	185	191	PF00069	0.602
MOD_CK1_1	118	124	PF00069	0.748
MOD_CK1_1	208	214	PF00069	0.616
MOD_CK2_1	138	144	PF00069	0.596
MOD_CK2_1	283	289	PF00069	0.517
MOD_GlcNHglycan	120	123	PF01048	0.654
MOD_GlcNHglycan	134	137	PF01048	0.697
MOD_GlcNHglycan	225	228	PF01048	0.649
MOD_GlcNHglycan	235	238	PF01048	0.647
MOD_GlcNHglycan	250	254	PF01048	0.624
MOD_GlcNHglycan	285	288	PF01048	0.588
MOD_GSK3_1	111	118	PF00069	0.655
MOD_GSK3_1	120	127	PF00069	0.740
MOD_GSK3_1	311	318	PF00069	0.469
MOD_GSK3_1	67	74	PF00069	0.535
MOD_GSK3_1	76	83	PF00069	0.546
MOD_GSK3_1	84	91	PF00069	0.432
MOD_GSK3_1	93	100	PF00069	0.518
MOD_N-GLC_1	315	320	PF02516	0.536
MOD_N-GLC_1	84	89	PF02516	0.475
MOD_NEK2_1	1	6	PF00069	0.533
MOD_NEK2_1	34	39	PF00069	0.601
MOD_NEK2_1	72	77	PF00069	0.596
MOD_NEK2_2	149	154	PF00069	0.461
MOD_NEK2_2	157	162	PF00069	0.517
MOD_NEK2_2	84	89	PF00069	0.451
MOD_PIKK_1	205	211	PF00454	0.613
MOD_PIKK_1	46	52	PF00454	0.559
MOD_PKA_1	93	99	PF00069	0.601
MOD_PKA_2	132	138	PF00069	0.681
MOD_PKA_2	264	270	PF00069	0.410
MOD_PKA_2	324	330	PF00069	0.540
MOD_PKA_2	88	94	PF00069	0.489
MOD_Plk_1	115	121	PF00069	0.557
MOD_Plk_1	157	163	PF00069	0.460
MOD_Plk_1	297	303	PF00069	0.567
MOD_Plk_1	84	90	PF00069	0.448
MOD_Plk_4	1	7	PF00069	0.525
MOD_ProDKin_1	122	128	PF00069	0.768
MOD_ProDKin_1	13	19	PF00069	0.565
MOD_ProDKin_1	185	191	PF00069	0.659
MOD_ProDKin_1	67	73	PF00069	0.610
MOD_SUMO_for_1	62	65	PF00179	0.511
MOD_SUMO_rev_2	58	64	PF00179	0.526
TRG_ENDOCYTIC_2	163	166	PF00928	0.466
TRG_ENDOCYTIC_2	3	6	PF00928	0.374
TRG_ENDOCYTIC_2	54	57	PF00928	0.462
TRG_ER_diArg_1	210	213	PF00400	0.523
TRG_ER_diArg_1	278	281	PF00400	0.524
TRG_ER_diArg_1	92	94	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1F8	Leptomonas seymouri	50%	90%
A0A0S4IMV9	Bodo saltans	25%	100%
A0A1X0NHQ9	Trypanosomatidae	25%	100%
A0A3Q8IC12	Leishmania donovani	84%	100%
A0A3R7KKV6	Trypanosoma rangeli	27%	100%
A4HBZ4	Leishmania braziliensis	66%	100%
A4HZD4	Leishmania infantum	85%	100%
D0A150	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QC59	Leishmania major	83%	100%
V5BHB3	Trypanosoma cruzi	28%	100%